[Seminar Announcement] Membrane Physiology Symposium Japan 2026

An automated patch clamp system capable of meeting all needs, from small-scale screening projects to high-throughput screening.

Designed to seamlessly integrate fully automated compound screening into the drug discovery process, it provides the best performance in high-throughput screening of ion channels in drug discovery, pharmacology, safety, pharmaceutical research and development, and exploratory screening departments. Additionally, by using the 32-well mode, it can be optimized for small-scale compound screening and projects. ■ Simultaneous measurement of 384 cells ■ 20,000 data points per day ■ High giga-seal success rate ■ Supports a variety of ion channel targets and enables rapid assay system development ■ Measurement of action potentials using current clamp is also possible ■ Extracellular/intracellular perfusion is possible ■ High-speed external solution exchange (up to 110 µl/s) is possible ■ Measurement section and 12 decks can be individually temperature controlled (temperature range: 10–37°C) ■ Compound plate preparation on the deck is possible ■ Single & multi-well chips available (in-house manufactured) ■ Borosilicate glass chips reduce compound adsorption ■ Approximately 8 hours of unmanned operation is possible ■ Comes with powerful analysis software ■ Validated system for CiPA

• Other physicochemical equipment
• Analytical Equipment
• Patch clamp system

No pipetting operations are required during the experiment. It is equipped with a benchtop dispensing device that can automatically measure up to 48 cells continuously in an auto patch clamp system.

This is a tabletop-sized auto patch clamp system that can simultaneously measure up to 8 cells with giga-seal formation. With easy experimental setup, stable whole-cell recordings, and sophisticated software, it enables highly efficient compound ion channel screening. ■ Equipped with a dispensing device, allowing for fully automated experiments (measurements) ■ Simultaneous measurement of 4 cells / 8 cells (up to 48 cells can be measured continuously) ■ 250 to 600 data points per day ■ Automation from giga-seal formation to whole-cell formation ■ Compatible with voltage-dependent and ligand-dependent channels ■ Measurement of action potentials using current clamp is also possible ■ Dynamic clamp capability (optional) ■ Temperature control and extracellular/intracellular perfusion possible ■ Cooling plate allows for cooling of cells and compounds ■ Borosilicate glass chips reduce compound adsorption ■ Comes with excellent analysis software

• Other physicochemical equipment
• Analytical Equipment
• Patch clamp system

A world-class patch clamp system that is easy to operate for anyone, allowing for simple data acquisition and verification.

This is a patch clamp system of the world's smallest class that can perform gigaseal recordings, optimal for safety testing/toxicity testing/pharmacological testing/screening of compounds at the cellular level in the functional structural analysis of ion channels, research on related diseases, and drug development processes. 【Features】 ■ No need for manual patch clamp experience or difficult operations ■ No need for microscope, vibration table, manipulator, Faraday cage, or puller ■ 20 to 50 data points per day ■ Automation from gigaseal formation to whole cell formation ■ Compatible with voltage-dependent, ligand-dependent, and temperature-dependent channels ■ Options available for research on channel rhodopsins and mechanosensitive channels using light stimulation ■ Measurement of action potentials using current clamp is also possible ■ Supports a wide range of applications and enables rapid assay system development ■ Reduces compound adsorption with borosilicate glass chips ■ Optional temperature control (10 to 50°C), capable of extracellular/intracellular perfusion ■ Can be integrated with amplifiers such as HEKA and Axon *For details, please refer to the catalog available for download in PDF.

• Other physicochemical equipment
• Analytical Equipment
• Patch clamp system

A patch clamp system that incorporates a patch clamp amplifier, achieving miniaturization and reduction of installation costs, allowing for easy data acquisition and verification.

This is a world-class patch clamp system capable of performing gigaseal recordings, optimal for safety testing/toxicity testing/pharmacological testing/screening of compounds at the cellular level in the functional structural analysis of ion channels, research on related diseases, and drug development processes. ■ No experience with manual patch clamping or difficult operations required ■ No need for microscope/vibration isolation table/manipulator/Faraday cage/puller ■ 20 to 50 data points per day ■ Automation from gigaseal formation to whole cell formation ■ Compatible with voltage-dependent and ligand-dependent channels through pipetting ■ Measurement of action potentials using current clamp is also possible ■ Supports a wide range of applications, enabling rapid assay system development ■ Reduces compound adsorption with borosilicate glass chips

• Other physicochemical equipment
• Analytical Equipment
• Patch clamp system

Easily measure channel activity at the molecular level.

【Measurement Target Examples】 Ion channels (voltage-dependent, ligand-dependent, temperature-sensitive), DNA nanopores, antimicrobial peptides, toxins, etc. In experiments using artificial lipid bilayers, the formation of lipid membranes, reconstitution of membrane proteins, and measurement of single-channel currents can be easily performed. Purified target membrane proteins (such as ion channels in vivo or artificial ion channels) can be reconstituted on artificially formed lipid bilayers, allowing for the evaluation of drug effects and functional/structural analysis. ■ Simultaneous formation and measurement of 4 channels of artificial lipid bilayers is possible ■ Lipid membranes can be formed with just pipetting operations ■ No need for microscope, vibration isolation table, manipulator, or Faraday cage ■ Direct reconstitution of target membrane proteins or membrane fusion with proteoliposomes ■ Temperature control (10–50°C) available (optional) ■ Palm-sized, easy connection via USB

• Other physicochemical equipment
• Analytical Equipment

Easily measure channel activity at the molecular level.

【Measurement Target Examples】 Ion channels (voltage-dependent, ligand-dependent, temperature-sensitive), DNA nanopores, antimicrobial peptides, toxins, etc. Experiments using artificial lipid bilayers allow for easy formation of lipid membranes, reconstitution of membrane proteins, and measurement of single-channel currents. It is possible to reconstitute purified target membrane proteins (such as ion channels found in vivo or artificial ion channels) on artificially formed lipid bilayers for drug action evaluation and functional/structural analysis. By rapidly and automatically forming 16-channel artificial lipid bilayers at once and conducting fully simultaneous measurements, researchers are freed from the burdens of the painting method in experiments using artificial lipid bilayers. ■ Simultaneous formation and measurement of 16-channel artificial lipid bilayers is possible ■ Automatic lipid membrane formation using a stirrer bar ■ No need for microscope, vibration isolation table, manipulator, or Faraday cage ■ Direct reconstitution of target membrane proteins or membrane fusion with proteoliposomes ■ Temperature control available (10–50°C)

• Other physicochemical equipment
• Analytical Equipment

Direct measurement of transporter currents in a label-free and real-time manner without using fluorescent probes or radiolabeled ligands.

Currently, the mainstream method for evaluating transporter activity is the uptake assay using RI-labeled substrates. However, there are several issues, such as the need for specialized experimental facilities, the complexity of waste liquid treatment, the fact that the desired substrates are not always commercially available as RI-labeled, and the measurement of endpoints after uptake. SURFE²R (Surface Electrogenic Event Reader) technology does not require RI labeling, specialized experimental facilities, or waste liquid treatment, and it allows for real-time evaluation of the activity of transporters (symporters, exchangers, unipoters) and pumps. ■ Direct measurement of transporter currents using Solid Supported Membrane (SSM) ■ Experiments can be conducted using membrane fragments prepared from biological membranes or proteoliposomes reconstituted with the target membrane proteins ■ Light stimulation is possible (optional) ■ An all-in-one device that integrates a dispensing machine, measurement section, and computer ■ 150 data points per day

• Other physicochemical equipment
• Analytical Equipment
• Other Analysis

Direct measurement of transporter currents in a label-free and real-time manner without using fluorescent probes or radiolabeled ligands.

Currently, the mainstream method for evaluating transporter activity is the uptake assay using RI-labeled substrates. However, there are several issues, such as the need for specialized experimental facilities, complicated waste disposal processes, the fact that the desired substrates are not always commercially available as RI-labeled, and that the endpoint is measured after uptake. The SURFE²R (Surface Electrogenic Event Reader) technology does not require RI labeling, does not need specialized experimental facilities or waste disposal, and allows for real-time evaluation of the activity of transporters (symporters, exchangers, unipoters) and pumps. ■ Direct measurement of transporter currents using Solid Supported Membrane (SSM) ■ Experiments can be conducted using membrane fragments prepared from biological membranes or proteoliposomes reconstituted with the target membrane proteins ■ Simultaneous measurement in 96 wells ■ 10,000 data points per day

• Other physicochemical equipment
• Analytical Equipment
• Other Analysis

Measurement of impedance and extracellular potential of iPS-derived cardiomyocytes.

This is a hybrid cardiotoxicity screening device capable of impedance measurement and extracellular potential measurement similar to MEA. It can detect not only cardiomyocytes but also the minute contractions of cancer cells and liver cells due to the effects of compounds. ■ Simultaneous measurement of impedance and extracellular potential ■ 96-well simultaneous measurement ■ Label-free measurement ■ Long-term monitoring capability ■ Electrical pacing & optical pacing (optional) ■ Comes with an incubation system (temperature, humidity, and CO2 control) ■ Includes multifunctional and excellent data analysis and graph creation software ■ Validated human iPS cells: iCell, iCell², AXOL CM, Cardiosight-S, MiraCell Cardiomyocytes, etc. ■ Compact desktop size: W20.5 x D18 x H11.7cm / 3.5kg (main unit)

• Other physicochemical equipment
• Other Analysis

The Langeendorff method has been transformed into the latest high-throughput technology, allowing for the measurement of contractile force in cardiomyocytes under physiological conditions similar to the natural environment of cardiac tissue.

The FLEXcyte 96, which transforms the conventional Langendorff method into the latest high-throughput technology, can measure the contractile force (mN/mm²) of cardiomyocytes for cardiotoxicity and safety evaluation, as well as drug screening, under physiological conditions similar to the native cardiac tissue environment, without missing even slight responses to cytotoxicity, regardless of whether in the chronic or acute phase, simultaneously in 96 wells. ■ Simultaneous measurement in 96 wells ■ Label-free measurement ■ Long-term monitoring possible ■ Optical pacing (optional) ■ Comes with an incubation system (temperature, humidity, CO2 control) ■ Includes multifunctional excellent data analysis and graphing software ■ Validated human iPS cells: iCell, iCell², AXOL CM, Cardiosight-S, MiraCell Cardiomyocytes, etc. ■ Compact desktop size: W20.5 x D18 x H11.7cm / 3.5kg (main unit)

• Other physicochemical equipment
• Other Analysis

Label-free and real-time high-throughput cell kinetics measurement is possible.

【Application Examples】 CAR-T cell killing assays, cell proliferation (viability), cytotoxicity (damage), biological barrier function, cell signaling, GPCR measurements, etc. AtlaZ can measure and analyze the impedance changes of cells in up to 6 x 96-well plates in real-time. Since it allows for daily kinetics measurements while remaining in the incubator, a single assay can yield a wealth of data regarding cell responses. Additionally, by changing the measurement frequency range, it can be applied to various applications. ■ Simultaneous measurement of up to 6 x 96-well plates (independent measurements are also possible) ■ Daily kinetics measurements are possible ■ A wide measurement range through frequency range adjustments | Frequency range (0.1 kHz to 100 kHz) ■ Selectable measurement modes (TEER, Cell Monitoring, Cytolysis mode) (Measurements with different functions for each plate are also possible) ■ Management of measurement plates is possible with the included barcode scanner.

• Other physicochemical equipment
• Other Analysis

**Seminar Points** Improvement means changing standards for the better. There can be no improvement where there are no standards. If there are no standards, start by creating them. Standards are "rules." What to decide are "procedures," "methods," and "timing." This seminar is focused on determining "procedures" and creating "work instruction documents." **"Without standards, there is no improvement" — Learning from Toyota's teachings on documentation in the workplace** The source of Toyota's strength lies in the concepts of "improvement" and "standardization." At the core of this is a culture of making insights and skills visible in the workplace and documenting them. In other words, it is a system of knowledge transfer through documentation. Relying on the experience and intuition of veterans can be a strength in the workplace, but it also carries the risk that quality may change when people change. By ensuring that everyone performs tasks in the same way, we can achieve the same quality products (good products) in the same amount of time. First and foremost, the development of "work instruction documents" is essential. When presenting work instruction documents in video format, it is also a prerequisite that this "foundational document" is well established. *For more details, please download the PDF or contact us.*

We will be exhibiting at the "Livestock Materials EXPO" held at Makuhari Messe! We plan to showcase examples of our "Fermentation Drying Equipment for Livestock Manure," provide information on our "Composting Equipment and Deodorants," and introduce our "Subsidy Projects." Please feel free to stop by our booth. We will give a small gift to those who fill out our survey or have implemented our composting system! We look forward to meeting everyone. = Exhibition Information = Dates: October 1 (Wednesday) to October 3 (Friday), 2025, for three days from 10:00 to 17:00 Venue: Makuhari Messe, Halls 5-7, 9, and 10 2-1 Nakase, Mihama-ku, Chiba City Booth Number: Hall 9, 35-6

We would like to express our congratulations on the continued prosperity of your esteemed company. Our company will be exhibiting at the following trade show, where we will be showcasing a number of products, including our new product, the Packaging Container Air Leak Test (Pin Hole Inspection) Device | MSQ-2003 series. We sincerely apologize for the inconvenience during your busy schedule, but we would like to cordially invite you to attend this event. 【 Trade Show Name 】 【 Dates 】 【 Venue/Booth Number 】

Nitto Kohki will exhibit at the "30th Mechanical Components Technology Exhibition [Tokyo]" held at Makuhari Messe Hall 5 from July 9 (Wednesday) to July 11 (Friday). [Booth Number: Hall 5 31-32] At this exhibition, we will showcase a variety of products, including the electric suction hand "e-VEE" with a built-in pump that does not require compressed air, a cordless belt sander, the electric driver "Delvo" that can be mounted on robots, and the "Flow Monitor" that allows for easy visualization of the flow of cooling water in molds and other applications.

[Speaker] Mizutani Masataka Senior Researcher Energy Comprehensive Engineering Research Institute, General Incorporated Foundation Carbon Neutral Technology Center, Power System Group [Key Lecture Content] As discussions progress towards the revision of the GHG Protocol Scope 2, elements such as "when and where the electricity was generated" are gaining attention in corporate renewable energy procurement and CO2 emissions calculations. Additionally, with the expansion of renewable energy adoption, the CO2 emission intensity of electricity has begun to fluctuate significantly depending on the time of day and region. In this lecture, we will organize topics such as hourly matching, deliverability, and standard supply services (SSS) that are being discussed in the Scope 2 revision, and introduce examples of hourly CO2 emission intensities provided both domestically and internationally. Furthermore, through analysis examples using publicly available data, such as office buildings and EV charging, we will explain what can be revealed through hourly evaluations and consider the implications and responses for future renewable energy procurement, non-fossil certificates, and PPAs.