CPhI Japan Exhibition & Seminar!

A protein stability analysis tool that boasts high speed and high throughput.

Aunty is a protein stability analysis tool that boasts high speed and high throughput. Utilizing techniques such as fluorescence, static light scattering, and dynamic light scattering, Aunty rapidly conducts thermal denaturation and aggregation experiments. During thermal ramp experiments involving temperature changes, it can read samples across an entire 96-well plate. You can screen candidates, conditions, or formulations in large quantities and repeat experiments as many times as needed. Aunty outputs results with unprecedented data resolution, supporting you in finding the optimal samples at overwhelming speed. 【Features】 ■ Measures 8μL, up to 96 samples simultaneously in SBS format plates ■ Simultaneously measures fluorescence, static light scattering, and dynamic light scattering ■ Automation is also possible 【Application Examples】 ■ Melting temperature (Tm, Tonset) ■ Aggregation (Tagg, Tsize) ■ Colloidal stability (kD, B22, G22) ■ Long-term stability ■ Virus vector stability *For more details, please refer to the PDF materials or feel free to contact us.

• Other protein analysis

Quality assessment of proteins, nucleic acids, AAV, LNP, etc. is possible with trace amounts and high throughput.

"Stunner" is a product that allows simultaneous acquisition of UV/Vis concentration, dynamic light scattering (DLS), and static light scattering (SLS) data from a 2μL identical sample. It enables detailed investigation of AAV and adenoviruses to measure total capsid titer and Empty/Full ratios, as well as to obtain payload concentration and size data of lipid nanoparticles all at once. You can analyze concentration, hydrodynamic size, polydispersity, and the presence of aggregates collectively, allowing you to assess the quality of proteins. This way, you can immediately determine whether your AAV, adenoviruses, lipid nanoparticles, or proteins are suitable for your purposes. [Features] ■ Measure up to 96 samples in a batch in 60 minutes*/12 minutes** *When measured by DLS **When measured by UV/Vis only [Applications] ■ AAV/Adenovirus capsid titer ■ AAV/Adenovirus Empty/Full ratio ■ Lipid nanoparticle (LNP) payload amount ■ Aggregate measurement ■ Concentration measurement ■ Sizing & polydispersity ■ B22 & kD *For more details, please refer to the PDF document or feel free to contact us.

• Other protein analysis

No complicated workflows needed! Only 2μL of sample volume required. Measure up to 96 samples in just 5 minutes.

"Lunatic" is a product that allows for easy simultaneous quantification of proteins, DNA, and RNA. The required sample volume is only 2μL, and up to 96 samples can be measured in 5 minutes. High-concentration samples can also be measured directly without dilution. 【Features】 ■ Measure 2μL, up to 96 samples in 5 minutes ■ Dynamic range coverage from 0.02 to 200 mg/mL* *for mAb ■ Outstanding accuracy and precision ■ Automation is also possible *For more details, please refer to the PDF document or feel free to contact us.

• Analytical Equipment
• Other protein analysis
• Other measurement and measuring equipment

Up to 8 samples can be processed simultaneously! Automatic and hassle-free buffer exchange and concentration that used to be complicated!

Buffer exchange and concentration must be performed as a sample preprocessing step. This is a labor-intensive task that takes a long time, requiring your presence throughout the process. "UNAGI" is a fully hands-free benchtop buffer exchange solution designed to take over this tedious task. It can process up to 8 samples simultaneously. The software is very easy to operate, allowing you to be anywhere during the work, eliminating the need to stay in the laboratory the entire time. 【Features】 ■ Simultaneous processing of up to 8 samples ■ Efficient solvent removal prevents sample adsorption, achieving over 96% recovery rate ■ Built-in recipes for UF/DF buffer exchange ■ User-friendly software ■ Concentrates up to 8 diluted samples from 48mL to 8mL in one go *For more details, please refer to the PDF document or feel free to contact us.

• Other Protein Research Software
• DNA analysis

[Video Available] Are you spending a lot of time and effort on buffer exchange and concentration work? You can streamline the sample preprocessing steps with this device.

Buffer exchange and concentration must be performed as a pre-treatment of the sample, which is a time-consuming task. This process takes a long time, and you have to be present the entire time. "UNAGI" is a fully hands-free benchtop buffer exchange solution designed to perform this tedious task for you. You can be anywhere during the process, eliminating the need to stay in the laboratory the whole time. 【Features】 ■ Simultaneous processing of up to 8 samples ■ Efficient solvent removal to prevent sample adsorption, achieving over 96% recovery rate ■ Built-in recipes for UF/DF buffer exchange ■ User-friendly software ■ Concentration of up to 8 diluted samples from 48mL to 8mL in one go *For more details, please refer to the PDF document or feel free to contact us.

• Other Protein Research Software
• Other filtration and separation equipment

Significantly reduces the effort and time spent on buffer exchange and concentration.

"BIGTUNA" is a high-throughput fully automated buffer exchange and concentration device that can automate buffer exchange with a setup time of just 30 minutes, accommodating a wide range of sample numbers and volumes. We offer two types of plate-based filters that can simultaneously exchange and concentrate 24 or 96 samples. With easy setup, you can have better control over your experiments and significantly reduce manual labor time. You can step away from the tedious task of buffer exchange and use the extra time for what you truly want to do. 【Features】 ■ Free yourself from manual buffer exchange ■ Accommodates a wide range of sample numbers and volumes ■ Processes at an optimal buffer exchange rate ■ Automatically concentrates from 48mL to 8mL ■ Easy condition settings *For more details, please refer to the PDF document or feel free to contact us.

• Other concentrating equipment

Efficient mass production of LNPs - Supporting everything from small-scale condition testing to scale-up.

Once we succeed in finding the optimal formulation conditions for sunscreen, let's use Sunshine to adjust the size of the LNP. Furthermore, we will optimize the protocols and processes for scaling up. We will find the ideal flow rate and explore different mixing options. Next, we will adjust these to the appropriate dilution factor that can keep them stable. Once everything is in place, Sunshine will transition to continuous mode, allowing us to produce several dozen liters in a day. In other words, we will achieve process development and scaling up on a single platform. Many researchers have likely been looking forward to the birth of such a groundbreaking system. • 10 experiments in 15 minutes • Fraction & total flow • From 1 mL to continuous flow • Flow rate 0.1 to 30 mL/min • Reusable microfluidic chips • Possible transition of protocols from sunscreen

• Other Physics and Chemistry Equipment

Accelerating formulation optimization for vaccine and pharmaceutical development.

To create the optimal LNP, it takes a tremendous amount of time and effort to examine and pursue formulation conditions. LNPs are nanoparticles composed of multiple lipids. Therefore, it is necessary to find the optimal conditions such as the mixing ratios, the ratio of lipids to payload, and the flow rates during mixing. Furthermore, we must also consider throughput issues. Sunscreen can produce up to 96 types of small LNPs within six hours, thus solving the previous throughput problems. This means that it is possible to explore a greater number of formulation condition investigations in a single day. • Fully automated execution of up to 96 types of condition investigations within six hours • 200 μL to 2 mL per experiment • Flow rate of 0.1 to 30 mL/min • Reusable microfluidic chips • Seamless scale-up through process and protocol optimization

• Other Physics and Chemistry Equipment

Accelerating formulation optimization for vaccine and pharmaceutical development.

The transition from LNP to GMP is a costly and complicated process. Typically, this requires switching equipment, using different flow paths and mixing devices, and essentially re-developing and re-validating everything that has been painstakingly done so far. With Sunbather, the transition to GMP can be done easily thanks to its recording features, interchangeable flow paths, and easily transferable design. Sunbather uses the same mixing process and protocols as the Sunscreen and Sunshine from the same Sun series, allowing for easy transition of adjusted formulation conditions to GMP. - Up to 1.8 L/h - Integrated inline dilution - Fully interchangeable flow paths - A wide variety of mixing devices - Software compliant with 21 CFR Part 11 - Process transferable from Sunshine

• Other Physics and Chemistry Equipment

Introducing the details of the newly launched LNP production and screening device.

Researchers of lipid nanoparticles (LNPs) spend a tremendous amount of time on screening, optimization, and scaling up experiments to achieve optimal performance, spot-on targeting, and controlled release of active pharmaceutical ingredients (APIs). Factors such as solubility, pH stability, payload release, and encapsulation all depend on particle size, shape, and structure. In other words, to obtain the right formulation, it is necessary to explore a vast number of formulation parameters and process parameters one by one, and even if a perfect formulation is found, scaling up usually means switching equipment and re-optimizing settings. In this webinar, we will introduce a platform, Sunny Suite, that can reduce the time spent on these LNP formulations. ■ Date and Time: February 26 (Monday) 14:00~ ■ Speaker: Yuji Senoo, Field Application Scientist, Unchained Labs, Inc. ■ Register here: https://unchainedlabs.zoom.us/webinar/register/3217065146675/WN_U1o3xQoZRAKHN-A-7b1yqg

• Other protein analysis

It enables the monitoring of potency and purity throughout the entire workflow of lentivirus research and development, accelerating gene therapy development.

"Leprechaun" is a system that analyzes whether lentivirus particles are of the correct size and structure, and can measure viral titer. It allows for the determination of the titer of lentivirus present in a sample without being misled by confusing noise (such as incomplete viruses or contamination). Not only can it measure information that was previously only obtainable separately through conventional methods like ELISA, qPCR, and transduction assays, but it also enables structural analysis that those methods could not provide, all on a single platform. Capabilities: ■ Lentivirus titer ■ Lentivirus structure ■ Exosome concentration ■ Analysis of contamination (impurities such as extracellular vesicles) Features: ■ No sample purification required ■ Physical structural analysis possible ■ Distinction between virus integrity and impurities ■ Up to 16 samples can be measured at once *For more details, please refer to the PDF document or feel free to contact us.

• Other measurement and measuring equipment

You can measure 10 samples at once! There's no need to clean expensive chips that are prone to clogging!

"Honeybun" is a high-speed viscometer that can output data almost simultaneously with processing. Regardless of whether the number of samples is 1 or 10, it uses a few microliters of each sample through a microchannel and reads viscosities in the range of 0.5-150 cP within a few minutes. No pre-treatment or cleanup of samples is necessary. 【Features】 ■ Can measure up to 10 samples at once ■ Required sample volume: 35μL (can measure from 15μL; see application notes) ■ Measurement completed in under 1 minute (for viscosities below 10 cP) ■ Measurement range: 0.5-150 cP ■ No cleaning required and maintenance-free *For more details, please refer to the PDF document or feel free to contact us.

• Other bio-related products

Rapid evaluation of formulation conditions and physical properties of AAV samples.

AAV production, infectivity, Full/Empty ratio, and optimization of introduced genes require a lot of time. Additionally, during the formulation screening stage, many conditions need to be examined, such as different pH levels, salt concentrations, or additives. Our Unagi enables rapid and quantitative buffer exchange and concentration by pressurizing the sample solution on a dialysis membrane, allowing for the examination of numerous formulation conditions for AAV samples at once. Furthermore, Stunner can accurately assess AAV titer, Full/Empty ratio, and aggregation evaluation by simultaneously measuring UV/Vis and DLS in a high-throughput manner. In this webinar, we will explain how to accurately and quickly conduct formulation considerations and physical property evaluations of AAV samples using our Stunner and Unagi. ■ Date and Time: February 21 (Tuesday) 14:00~ (approximately 40 minutes) ■ Speaker: Yukinori Ooshiro, Field Application Scientist, Unchained Labs, Inc. ■ Register here: http://bit.ly/3WU3IM9

• Other protein analysis

Seamlessly transition from formulation condition screening to scale-up and GMP manufacturing. Accelerate LNP product development.

The development of lipid nanoparticles (LNPs) faces many challenges. The formulation, optimization, and scale-up for clinical trials are complex, costly, and a race against time. Our LNP solutions are designed to accelerate all steps of LNP synthesis and characterization. Sunscreen accelerates LNP formulation screening by reducing costs and time, generating up to 96 unique LNP formulations within 6 hours. Next, using Sunshine, you can develop, optimize, and scale up protocols with the appropriate formulations obtained from Sunscreen. When it comes to the clinical trial phase, Sunbather can accommodate LNP production in a GMP environment using the same processes and microfluidic chips (Sunny) utilized by Sunscreen and Sunshine. In this way, the Sun series allows for a seamless transition from screening formulation conditions to scale-up and GMP manufacturing, as they all use the same pumps and microchannel chips. *For product details, please download various materials.

• Other Physics and Chemistry Equipment

Advantech Toyo will be exhibiting at the trade show "JASIS 2026," which will be held at Makuhari Messe International Exhibition Hall. At this exhibition, manufacturers of analytical and scientific instruments will gather to showcase cutting-edge scientific and analytical systems and solutions. At our booth, we will display filter products for microbiological testing and environmental analysis, water quality testing products, pure and ultra-pure water production equipment, and culture-related equipment. Additionally, we will also showcase analytical balances from Mettler Toledo, along with equipment from other well-regarded manufacturers in the industry. Our sales and technical staff will be available to assist with product selection, so please feel free to stop by!

[Speakers] Nomura Research Institute, Ltd. Global Manufacturing Consulting Department Group Manager Hirokazu Shimo Senior Consultant Shoki Tokugawa Senior Consultant Wataru Hashimoto Consultant Masaaki Amano Consultant Tomoya Nakamura [Presentation Items] 1. Key Development Themes of Major OEMs 2. Development Approaches of Each OEM 2-1. Toyota 2-2. Tesla 2-3. Suzuki 2-4. Nissan 2-5. Honda 3. Development Approaches of Suppliers 4. Key Points for Strengthening Development Capabilities 5. Q&A / Business Card Exchange

[Speaker] Ayaka Motomura, Consultant, Business Transformation Unit, NTT Data Management Research Institute [Key Lecture Content] With the advancement of Physical AI, telecommunications carriers have the opportunity to evolve from being "companies that provide lines" to companies that connect and control AI and the physical world in real-time. This seminar will organize the changes in communication demand brought about by Physical AI and the business opportunities for telecommunications carriers, while explaining the role of AIOps as the first step towards entry. Furthermore, it will discuss strategies for monetizing in the Physical AI market by deploying the operational intelligence accumulated through AIOps to network APIs and industry-specific services, as well as the layers that telecommunications carriers should hold. [Lecture Topics] Chapter 1: The Competitive Structure of the "Real World" Rewritten by Physical AI Chapter 2: Reasons Why Opportunities for "Reversal" Arise for Telecommunications Carriers in the Era of Physical AI Chapter 3: The First Step Towards Physical AI Chapter 4: Shifting AIOps from "Defense" to "Offense" Chapter 5: The Layers to Hold in the Era of Physical AI [Q&A / Business Card Exchange]

[Instructor] Partner Ryoji Mori, Eichi Law Office [Key Lecture Content] This lecture will explain the revised Personal Information Protection Act of 2028. The three-year review this time is a major revision, and it is essential to first understand where and how the revisions have been made, as well as the overall picture of the amendments. Next, we will explain the individual amendments that are practically important. The key points are as follows, but it is important to note that both the strengthening and relaxation of obligations are occurring simultaneously, increasing overall complexity. At the time of the lecture, it is expected that subordinate laws and guidelines will not yet be published, but we will discuss points that require attention upon publication. We will distinguish between what is necessary across businesses and what varies by industry. [Lecture Items] 1. Expansion of consent exceptions: Relaxation of the difficulty of obtaining consent and expansion of academic research institutions 2. Statistical exceptions: System content and how to read complex provisions (plus learning about acceptability from controversies) 3. Strengthening regulations on biometric information and children's information: Caution required for age verification 4. Contactable personal-related information: Changes in external transmission responses 5. Review of outsourcing regulations: Addition and removal of obligations for contractors 6. Administrative fines: Narrow target range and low amounts (not worth fearing) 7. Q&A / Business card exchange

[Instructor] Innovation Analyst Andy Kondo [Key Lecture Content] *The latest content will be added (changed) as appropriate based on the on-site survey of IAA Transportation 2026.* From September 15 to 20, 2026, the largest commercial vehicle exhibition in Europe, IAA Transportation, will be held in Hanover, Germany. It is a gathering place for manufacturers of commercial vehicles such as trucks and buses, as well as the parts, energy, and software that support them, occurring every two years. The cost structure of logistics, urban transportation and the environment, energy transition, decarbonization efforts, and a microcosm of the industry will reveal the future business environment just a step ahead. In this seminar, an innovation analyst who has been observing major global exhibitions such as CES and Hannover Messe for many years will report shortly after the event based on on-site coverage. Has autonomous driving become the main focus in commercial vehicles? Where is the energy transition for large vehicles settling in terms of batteries, hydrogen, and alternative fuels? How far have Chinese companies come? Based on photos taken at the venue and observations of actual products, the seminar will delve into the implications for Japanese companies.