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  4. Concentration Equipment
  5. Other concentrating equipment
  6. High-throughput fully automatic buffer exchange concentration device "BIGTUNA"

High-throughput fully automatic buffer exchange concentration device "BIGTUNA"

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last updated:Sep 02, 2025

Unchained Labs (アンチェインドラブズ)
Unchained Labs (アンチェインドラブズ)
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Significantly reduces the effort and time spent on buffer exchange and concentration.

"BIGTUNA" is a high-throughput fully automated buffer exchange and concentration device that can automate buffer exchange with a setup time of just 30 minutes, accommodating a wide range of sample numbers and volumes. We offer two types of plate-based filters that can simultaneously exchange and concentrate 24 or 96 samples. With easy setup, you can have better control over your experiments and significantly reduce manual labor time. You can step away from the tedious task of buffer exchange and use the extra time for what you truly want to do. 【Features】 ■ Free yourself from manual buffer exchange ■ Accommodates a wide range of sample numbers and volumes ■ Processes at an optimal buffer exchange rate ■ Automatically concentrates from 48mL to 8mL ■ Easy condition settings *For more details, please refer to the PDF document or feel free to contact us.

    Other concentrating equipment
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High-throughput fully automatic buffer exchange concentration device "BIGTUNA"

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  • Related Link - https://www.unchainedlabs.com/big-tuna/

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【Application Specifications】 ■ Buffer Exchange Capacity Range ・Unfilter24: 0.45 to 8 mL ・Unfilter96: 100 to 450 μL ■ Number of Formulations for Unfilter24 ・Unfilter24: Up to 24 formulations can be processed simultaneously ・Unfilter96: Up to 96 formulations can be processed simultaneously ■ Sample Types ・Antibodies and other proteins, nucleic acids, lipid nanoparticles (LNP), adeno-associated viruses (AAV), virus-like particles (VLP) ■ Exchange Time at Full Volume (using 96%, 10 mg/mL IgG) ・Unfilter24: 4.5 hours ・Unfilter96: 3 hours ■ Protein Concentration (Range): Up to 200 mg/mL ■ Target Concentration Accuracy: ±10% ■ Sample Recovery Rate: Over 96% *For more details, please refer to the PDF document or feel free to contact us.

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Big Tuna

Big Tuna

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High-throughput fully automatic buffer exchange and concentration device 'BIG TUNA'

High-throughput fully automatic buffer exchange and concentration device 'BIG TUNA'

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Exploration of AAV Buffer and Stability by BigTuna and Uncle

Exploration of AAV Buffer and Stability by BigTuna and Uncle

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Let's speed up and simplify the prescription screening with Big Tuna and Stunner.

Let's speed up and simplify the prescription screening with Big Tuna and Stunner.

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We will exhibit at LADEC 2025.

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Our company will be exhibiting at LADEC 2025 (Laboratory Automation Developers Conference). At our booth, you can see the automation equipment in operation. Please come visit us. Dates: September 25 (Thursday) - 26 (Friday), 2025 Venue: National Museum of Emerging Science and Innovation Details: https://laboratoryautomation.connpass.com/event/333560/

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CPhI Japan Exhibition & Seminar!

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CPhI Japan Exhibition & Seminar! April 9 (Wednesday) - 11 (Friday) @ Tokyo Big Sight Unchained Labs, Inc. will be exhibiting in the biopharmaceutical zone at CPhI Japan this year as well. Additionally, we will hold a seminar on the second day! Please visit our booth at Tokyo Big Sight. <Exhibitor Seminar> Date and Time: April 10 (Thursday) 13:00-13:30 Venue: 5B "Stability Evaluation of Biopharmaceuticals - Towards a New Era of High-Speed and High-Throughput" *No prior reservation required, free of charge.

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CPhI Japan Exhibition & Mini Seminar!

  • Seminar・Event

CPhI Japan Exhibition & Mini Seminar! April 19 (Wed) - April 21 (Fri) @ Tokyo Big Sight Unchained Labs, Inc. will be exhibiting in the biopharmaceutical zone at CPhI Japan this year as well. This time, we will also hold a mini seminar at our booth with plenty of participation benefits! Please come visit our booth at Tokyo Big Sight. <Mini Seminar> - "Mastering the Research and Development of Lipid Nanoparticles (LNP) to Earn Your Black Belt" - "Let Automation Handle Buffer Exchange and Go Home on Time" *Please check the [Pre-registration Form] for the schedule. <Mini Seminar Participation Benefits> [Benefit 1] Pre-register to receive our original eco-bag that fits a PC! [Benefit 2] Attend on the day to gain a chance to win a 3000 yen QUO card! [Benefit 3] Get technical questions and consultations answered on the spot. <Pre-registration Form> Register now using the link below to get [Benefit 1]! *Separate web pre-registration or invitation is required for entry to the exhibition.

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CPhI Japan Exhibition & Seminar!

  • Seminar・Event

CPhI Japan Exhibition & Seminar! April 17 (Wednesday) - 19 (Friday) @ Tokyo Big Sight Unchained Labs, Inc. will be exhibiting in the biopharmaceutical zone at CPhI Japan this year as well. This time, we will also hold an exhibitor seminar on the first day! Please come visit our booth at Tokyo Big Sight. <Exhibitor Seminar> April 17 (Wednesday) 11:30 - 12:00 【5B】 "Unchained Ecosystem Supporting Drug Development and Scale-Up with Lipid Nanoparticles" *No prior reservation required, free of charge.

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Unchained

Unchained Labs (アンチェインドラブズ)

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Unchained Labs is a company headquartered in Silicon Valley, California, that provides next-generation life science tools. - A lineup of automation devices for biopharmaceutical research, gene therapy, and organic synthesis - Founded in 2015 - Locations in California, New Jersey, Boston, the UK, Brussels, Germany, Shanghai, and Japan - Established a Japanese subsidiary in July 2017

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[Webinar] Buffer Exchange and Concentration of LNP & AAV Samples
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