[Exhibition Information] 19th Annual Transporter Research Conference

Direct measurement of transporter currents in a label-free and real-time manner without using fluorescent probes or radiolabeled ligands.

Currently, the mainstream method for evaluating transporter activity is the uptake assay using RI-labeled substrates. However, there are several issues, such as the need for specialized experimental facilities, the complexity of waste liquid treatment, the fact that the desired substrates are not always commercially available as RI-labeled, and the measurement of endpoints after uptake. SURFE²R (Surface Electrogenic Event Reader) technology does not require RI labeling, specialized experimental facilities, or waste liquid treatment, and it allows for real-time evaluation of the activity of transporters (symporters, exchangers, unipoters) and pumps. ■ Direct measurement of transporter currents using Solid Supported Membrane (SSM) ■ Experiments can be conducted using membrane fragments prepared from biological membranes or proteoliposomes reconstituted with the target membrane proteins ■ Light stimulation is possible (optional) ■ An all-in-one device that integrates a dispensing machine, measurement section, and computer ■ 150 data points per day

• Other physicochemical equipment
• Analytical Equipment
• Other Analysis

Direct measurement of transporter currents in a label-free and real-time manner without using fluorescent probes or radiolabeled ligands.

Currently, the mainstream method for evaluating transporter activity is the uptake assay using RI-labeled substrates. However, there are several issues, such as the need for specialized experimental facilities, complicated waste disposal processes, the fact that the desired substrates are not always commercially available as RI-labeled, and that the endpoint is measured after uptake. The SURFE²R (Surface Electrogenic Event Reader) technology does not require RI labeling, does not need specialized experimental facilities or waste disposal, and allows for real-time evaluation of the activity of transporters (symporters, exchangers, unipoters) and pumps. ■ Direct measurement of transporter currents using Solid Supported Membrane (SSM) ■ Experiments can be conducted using membrane fragments prepared from biological membranes or proteoliposomes reconstituted with the target membrane proteins ■ Simultaneous measurement in 96 wells ■ 10,000 data points per day

• Other physicochemical equipment
• Analytical Equipment
• Other Analysis

You can provide a list of validated targets for the transporter activity measurement device SURFE²R.

Can you provide the list of validated targets for the transporter activity measurement device SURFE²R? *For more details, please refer to the PDF document or feel free to contact us.*

• Other physicochemical equipment
• Analytical Equipment
• Other Analysis

Nanion Technologies realizes the automation of electrophysiology experiments and supports a wide range of membrane protein-related research.

**Catalog Products** ■ Auto Patch Clamp System Ideal for evaluating the effects of compounds on ion channels and for functional and structural analysis of ion channels. From a compact system that allows you to check data immediately at hand to high-throughput systems for compound screening in pharmaceutical research and development. ■ Artificial Lipid Bilayer Experimental Device For functional and structural evaluation of target membrane proteins reconstituted into artificial lipid bilayers, as well as for evaluating drug actions. ■ Liposome Preparation Device Quickly and easily automates the preparation of liposomes without hassle. ■ Transporter Activity Measurement Device Enables label-free and real-time direct measurement of transporter currents without using fluorescent probes or radiolabeled ligands. ■ iPS-Derived Cardiomyocyte Measurement System For assessing cardiotoxicity, contractility, and drug screening using iPS-derived cardiomyocytes. ■ Cell Monitoring Device Allows for label-free and real-time high-throughput measurement of cell kinetics (up to 6 x 96-well plates).

• Analytical Equipment
• Patch clamp system
• Other Analysis

We will be exhibiting at the J AGRI (J Agri) / Agricultural Materials EXPO held at Gran Messe Kumamoto from May 22 (Wednesday) to May 24 (Friday), 2024. 【Booth Number】: B1-43 Outdoor Exhibition Area Japan's largest comprehensive exhibition for agriculture and livestock, Agricultural WEEK, will be renamed J AGRI starting in 2024. This is a place where you can actually see, touch, and compare products. At our booth, we will showcase our lightweight resin flooring boards "JULIGHT / SUPER JULIGHT / RAKURAKUBAN" along with new products. Starting with the agricultural-specific flooring board "RAKURAKUBAN," which can be easily laid in various scenes such as around greenhouses, agricultural work sites, temporary parking lots, for the movement of agricultural machinery and light trucks, and for protecting truck beds, there are various ways to use the lightweight resin flooring boards "JULIGHT / SUPER JULIGHT series." We offer a variety of sizes and protrusion shapes tailored to customer needs, and they are lightweight enough to be carried by hand, with excellent impact resistance, as well as superior water resistance, weather resistance, and durability, providing outstanding features not found in plywood or steel plates. We sincerely look forward to your visit.

Dear Sir or Madam, We hope this message finds you well and that your company continues to prosper. FUKUDA will be exhibiting at the 28th INTERPHEX Week Tokyo. At the exhibition, we will be showcasing 100% inspection equipment compliant with Container Closure Integrity Testing (CCIT) standards, as well as sampling inspection machines. We sincerely invite you to visit our booth at this opportunity and would greatly appreciate your attendance despite your busy schedule. Yours sincerely, [Dates] May 20 (Wed) - 22 (Fri), 2026 10:00-17:00 (JST) [Venue] Makuhari Messe, Japan 8 Hall Booth No. 41 - 36

Dear Sir or Madam, We hope this message finds you well and that your company continues to prosper. FUKUDA will be exhibiting at the AUTOMOTIVE ENGINEERING EXPOSITION 2026 YOKOHAMA. At this exhibition, we will be showcasing testing equipment such as Air Leak Tester for EV and Equipment Mounted Type Hydrogen Leak Detector. We sincerely hope you will take this opportunity to visit us. Yours sincerely, [Official Site] https://aee.expo-info.jsae.or.jp/en/yokohama/ [DATES] Wednesday, May 27, through Friday, May 29, 2026 10:00 a.m. - 5:00 p.m. [VENUE] PACIFICO Yokohama, Exhibition Hall, Booth No. ２７４ ※Online Exposition Website：Tuesday, May 19, through Tuesday, June 9, 2026

[Speaker] Toshio Fujimura, Ph.D. (Engineering) Representative, Touson Automotive Strategy Research Institute Automotive and Environmental Technology Strategy Analyst Visiting Professor, Aichi Institute of Technology [Former Toyota Motor Corporation] [Lecture Topics] <Chapter 1> Urgent Issue: CO2 Reduction Cannot Wait! <Chapter 2> Achieving a 48% Reduction in CO2 by 2030 Compared to 2019 is Impossible Without Carbon Neutrality in Fuels as Well as Electricity <Chapter 3> Technical Challenges in Electrification <Chapter 4> Pathways to Achieve a 48% Reduction in CO2 Emissions from Owned Vehicles by 2030 <Chapter 5> The Intentions Behind Electrification Strategies of Various Governments (Mainly in Europe, the U.S., and China) <Chapter 6> Electrification Strategies of Major Global Automakers and Sales Trends in Different Regions: Which Manufacturers Will Survive by 2030? <Chapter 7> Conclusion

[Speaker] Masayuki Sawada, Director of Sawada Masayuki Engineering Office [Lecture Topics] 1. The battle in Ukraine is the first large-scale drone war in history. 2. The battle in Iran also sees drones shifting the paradigm of strategy and tactics. 3. Efforts by major European countries (producing drones in Ukraine and collaborating with Ukrainian drone manufacturers). 4. Efforts by the United States (providing intercept drones and other support to Ukraine). 5. Efforts by Taiwan (producing drones in collaboration with U.S. manufacturers that have combat experience in Ukraine). 6. Efforts by Japan's Ministry of Defense (establishing a multi-layered coastal defense system using drones [SHIELD]). 7. Efforts by Japan's Terra Drone Corporation (collaborating with Ukrainian drone manufacturers). 8. Q&A / Business card exchange.