We exhibited at the Interphex Week Tokyo - 9th Bio Pharmaceutical EXPO!

A biomimetic system that tests by moving cultivated mini-organs.

Mechanical stimulation of cultured tissues such as 3D cardiac microtissues using actuators to mimic heartbeats and knee joint movements. Evaluation of changes in electrical activity after drug administration allows for in vitro safety assessment of drugs. *Measurement of heart rate, electrical activity, contractility, etc.

• Cell culture contract service

Using neurons as bio-digital sensors. Toxicity prediction using a digital library. High-throughput device using MEA.

Microchannel technology enables compartmentalization and co-culture. Compatibility with other companies' MEAs allows for the recording of electrical activity. Determination of toxicity and efficacy through the creation of digital signatures of compounds tested on innervated target organs. Prediction of toxicity and efficacy by comparing digital signatures of compounds using a digital library.

• Culture vessel

Alternative methods to animal testing: Pyrogenic substance testing (compatible with endotoxin and non-endotoxin testing)

Monocyte activation test kit, an alternative method to the rabbit pyrogen test and LAL test. It uses human monocytic THP-1 cells to detect the inflammatory cytokine TNF-α. Capable of detecting gram-negative bacteria, gram-positive bacteria, fungi, and viruses.

• Other analytical and testing equipment

Sterilization applications for biopharmaceuticals and sterile preparations! Filters with high microbial retention, low protein adsorption, and extremely low elution performance.

Advanced Microdevices' sterilizing capsule filter achieves improved throughput through a pre-filter and high flow rates due to low hold-up volume. 【Features】 ■ Improved recovery rate due to low protein adsorption ■ Assurance of microbial capture performance through bacteria challenge testing ■ 100% integrity testing conducted ■ Certificate provided with each filter ■ Compatible with ethylene oxide and autoclave sterilization ■ Gamma radiation sterilization compatible

• Other bio-related products

Various lineups are prepared based on flow rate, effective surface area, and sterilization methods.

Consistent product quality using a quality management system Establishment of product traceability through lot number management Validation support through integrity tests, extractables, leachables, adsorption, and testing Compliance with various regulations such as FDA and USP Autoclave, steam sterilization Sterilization varies by each filter For details, please contact us

• Filtration Filter

Reliable single-use bags required for sterile processes such as storage and transportation of media, intermediates, buffers, etc., used in biopharmaceuticals.

AsptiBag Gold uses an inactive multilayer polyethylene film that is physically robust and inert to many chemicals and solvents, while also possessing excellent gas barrier properties. The contact surface is made of 130μm ultra-low-density polyethylene without any additives. It meets various regulatory and functional requirements, providing consistently high-quality products.

• Other bio-related products

FEP-made cell culture bags. Manufactured by TECHNOFLEX (France). Compliant with USP Class 6. DMF registered.

The SafeCell series is made of fluorinated ethylene propylene (FEP) and meets the demands of in vitro cell culture. FEP is chemically and biologically inert, making it perfectly suitable for cell suspension culture. Its anti-adhesion properties allow cells to freely float and proliferate in the medium. SafeCell bags are permeable to gases (oxygen, carbon dioxide, nitrogen), enabling the necessary exchanges for proper cell development, while also possessing another important characteristic: water impermeability. The low evaporation rate of SafeCell bags prevents issues even in humid incubators that increase the risk of bacterial and microbial growth.

• Culture vessel

Aseptic sampling system with adapter

The disposable sampling port cartridge eliminates the need for time-consuming assembly of multi-port adapters. This allows for direct attachment to the container's port, creating a simple, fast, and immediately usable sampling system. It is a gamma-irradiated disposable system for aseptic liquid sampling at various stages of pharmaceutical and biopharmaceutical processing. These systems minimize the potential for false positives compared to traditional sampling systems and reduce the need for cleaning. A sealed system that maximizes operator safety and eliminates contamination. A simpler, faster, and completely disposable ready-to-use solution for sampling applications. There is no need for the cumbersome and time-consuming assembly of sampling system ports and multi-port adapters within the cartridge.

• Animal cells

To reduce contamination risks and streamline the cleaning process.

Single-use assembly tubes for biopharmaceuticals. Tube material, length, connector type, filters, etc. can be customized according to customer requirements. Manufactured in a Class 7 cleanroom. The facility is ISO 13485 and FDA certified. Compatible with gamma sterilization, with various certificates included.

• Filtration Filter

No need for centrifugation‼ Cultivation filtration depth filter

The combination of deep filtration and alluvial filtration allows for the removal of CHO cells, bacteria, etc., in a single step without the need for a centrifugation step. This reduces the cost and downtime of the bioprocess.

• Protein Extraction Kit

Sustained-release formulation testing apparatus USP Apparatus 3

BIO-DIS is a dissolution tester for conducting release rate tests, compliant with USP Apparatus 3 and EP Reciprocating Cylinder tests. It is an ideal dissolution tester for formulations that require sustained release formulations and dissolution profiles at multiple pH levels.

• Dissolution Tester

Hotron Inc. has launched its new product, the "Vehicle Count Sensor CCS3"! This product is a ceiling-mounted sensor that combines infrared and radar technology. It reliably detects vehicles in both directions with a single unit, accommodating traffic during congestion and vehicle passing, thus achieving efficient occupancy management in large parking lots. Additionally, it can be utilized for exit warning purposes in addition to vehicle counting, contributing to the safe and smooth operation of parking facilities. 'Features' - Improved detection performance against changes in road surface during rainy weather by using both infrared and radar. - Equipped with IP67 waterproof and dustproof performance, making it effective even in salt damage areas. - Various settings can be configured from a dedicated app (for Android devices), with current settings easily understandable at a glance. - The base dimensions are the same as the previous model "CCS2," allowing for smooth replacement of existing equipment. *For more details, please refer to the product information, catalog download, or contact us.*

The wooden lightweight sheet "Hyper CLT Sheet," utilizing CLT (Cross Laminated Timber), is a sponsor of the Masters Koshien (Okayama). The Masters Koshien is where those who have experienced high school baseball come together across generations to pursue their goals once again. We resonate with their "attitude of continuing to challenge" and support their activities from Okayama. The Hyper CLT Sheet is a product created to provide a new option in civil engineering sites, which have primarily relied on steel sheets until now. It is lightweight, easy to handle, and features the environmental value unique to wood. Furthermore, it is registered as a **Ministry of Land, Infrastructure, Transport and Tourism NETIS technology "TH-250021-A,"** aiming for widespread adoption in various sites, starting with public works. Wood, NETIS, civil engineering, CLT, wooden lightweight sheets. We will continue to support challenges in both the field and sports from Okayama. Masters Koshien (Okayama) https://masters-okayama.com/

Features: ● Intel Core Ultra (Series 2) processor LGA 1851 socket (CPU sold separately) ● DDR5 6400MT/s dual-channel support, CU/U-DIMM x2 (up to 128GB) (memory sold separately) ● M.2 M-Key x1, E-Key x1 ● USB 3.2 x4, USB 2.0 x8 ● Intel Ethernet Controller I226-V (2.5GbE) x2 ● SATA 6Gb/s x2 (supports RAID 0 / 1 / 5) ● PCI Express Gen5 x16 x1, PCI Express Gen4 x4 x1, PCI Express Gen4 x1 x1 * This model does not include memory, storage, or OS.

Features: ● Intel Core Ultra 200S series processor LGA 1851 socket (up to 125W) (CPU sold separately) ● DDR5 6400MT/s dual-channel compatible, CU-DIMM/U-DIMM x4 (up to 256GB) (sold separately) ● M.2 M-Key x2, E-Key x1, B-Key x1 ● USB 3.2 x8, USB 2.0 x6 ● 2.5GbE LAN x3 ● SATA 6Gb/s x2 (supports RAID 0 / 1 / 5) ● PCIe Gen5 x16 x1, PCIe Gen4 x4 x2, PCIe Gen4 x1 x1 ● Compatible with ATX power supply * This model does not include memory, storage, or OS.

Features: ● Supports Intel Core Ultra 200S series processors with Intel H810 chipset and LGA1851 socket (up to 125W) (CPU sold separately) ● DDR5 CSO-DIMM x2 (up to 128GB) (memory sold separately) ● 2.5GbE LAN x2 ● HDMI x2, DisplayPort x1, LVDS/eDP x1 (supports simultaneous output of up to 3 screens) ● SATA 6Gb/s x4, M.2 M-Key x1, M.2 E-Key x1, M.2 B-Key x1, PCI Express Gen5 x16 x1 ● USB 3.2 Gen2 x2, USB 2.0 x8, RS-232/422/485 x1, RS-232 x5 ● Compatible with ATX power supply * This model does not include memory, storage, or OS.