Exhibited at BioJapan 2025.

Alternative methods to animal testing: Pyrogenic substance testing (compatible with endotoxin and non-endotoxin testing)

Monocyte activation test kit, an alternative method to the rabbit pyrogen test and LAL test. It uses human monocytic THP-1 cells to detect the inflammatory cytokine TNF-α. Capable of detecting gram-negative bacteria, gram-positive bacteria, fungi, and viruses.

• Other analytical and testing equipment

Using neurons as bio-digital sensors. Toxicity prediction using a digital library. High-throughput device using MEA.

Microchannel technology enables compartmentalization and co-culture. Compatibility with other companies' MEAs allows for the recording of electrical activity. Determination of toxicity and efficacy through the creation of digital signatures of compounds tested on innervated target organs. Prediction of toxicity and efficacy by comparing digital signatures of compounds using a digital library.

• Culture vessel

A biomimetic system that tests by moving cultivated mini-organs.

Mechanical stimulation of cultured tissues such as 3D cardiac microtissues using actuators to mimic heartbeats and knee joint movements. Evaluation of changes in electrical activity after drug administration allows for in vitro safety assessment of drugs. *Measurement of heart rate, electrical activity, contractility, etc.

• Cell culture contract service

Aseptic sampling system with adapter

The disposable sampling port cartridge eliminates the need for time-consuming assembly of multi-port adapters. This allows for direct attachment to the container's port, creating a simple, fast, and immediately usable sampling system. It is a gamma-irradiated disposable system for aseptic liquid sampling at various stages of pharmaceutical and biopharmaceutical processing. These systems minimize the potential for false positives compared to traditional sampling systems and reduce the need for cleaning. A sealed system that maximizes operator safety and eliminates contamination. A simpler, faster, and completely disposable ready-to-use solution for sampling applications. There is no need for the cumbersome and time-consuming assembly of sampling system ports and multi-port adapters within the cartridge.

• Animal cells

Gamma-ray irradiated disposable sampling system. Customizable.

The sterile sampling system can be customized to meet user requirements for tube size, sampling ports, and sampling containers.

• Other bio products

Stirring bag for biopharmaceuticals. With stirrer. Single-use.

Single-use mixing bags are designed for quick and uniform mixing. An impeller is attached to the bottom of the bag and rotates via a magnetic drive. It can accommodate bag capacities of up to 1000L. A 4-inch or 8-inch port can be installed on the top. It is also compatible with sanitary flanges. The bags are customizable.

• Culture vessel

Reliable single-use bags required for sterile processes such as storage and transportation of media, intermediates, buffers, etc., used in biopharmaceuticals.

AsptiBag Gold uses an inactive multilayer polyethylene film that is physically robust and inert to many chemicals and solvents, while also possessing excellent gas barrier properties. The contact surface is made of 130μm ultra-low-density polyethylene without any additives. It meets various regulatory and functional requirements, providing consistently high-quality products.

• Other bio-related products

FEP-made cell culture bags. Manufactured by TECHNOFLEX (France). Compliant with USP Class 6. DMF registered.

The SafeCell series is made of fluorinated ethylene propylene (FEP) and meets the demands of in vitro cell culture. FEP is chemically and biologically inert, making it perfectly suitable for cell suspension culture. Its anti-adhesion properties allow cells to freely float and proliferate in the medium. SafeCell bags are permeable to gases (oxygen, carbon dioxide, nitrogen), enabling the necessary exchanges for proper cell development, while also possessing another important characteristic: water impermeability. The low evaporation rate of SafeCell bags prevents issues even in humid incubators that increase the risk of bacterial and microbial growth.

• Culture vessel

To reduce contamination risks and streamline the cleaning process.

Single-use assembly tubes for biopharmaceuticals. Tube material, length, connector type, filters, etc. can be customized according to customer requirements. Manufactured in a Class 7 cleanroom. The facility is ISO 13485 and FDA certified. Compatible with gamma sterilization, with various certificates included.

• Filtration Filter

No need for centrifugation‼ Cultivation filtration depth filter

The combination of deep filtration and alluvial filtration allows for the removal of CHO cells, bacteria, etc., in a single step without the need for a centrifugation step. This reduces the cost and downtime of the bioprocess.

• Protein Extraction Kit

Sterilization applications for biopharmaceuticals and sterile preparations! Filters with high microbial retention, low protein adsorption, and extremely low elution performance.

Advanced Microdevices' sterilizing capsule filter achieves improved throughput through a pre-filter and high flow rates due to low hold-up volume. 【Features】 ■ Improved recovery rate due to low protein adsorption ■ Assurance of microbial capture performance through bacteria challenge testing ■ 100% integrity testing conducted ■ Certificate provided with each filter ■ Compatible with ethylene oxide and autoclave sterilization ■ Gamma radiation sterilization compatible

• Other bio-related products

Various lineups are prepared based on flow rate, effective surface area, and sterilization methods.

Consistent product quality using a quality management system Establishment of product traceability through lot number management Validation support through integrity tests, extractables, leachables, adsorption, and testing Compliance with various regulations such as FDA and USP Autoclave, steam sterilization Sterilization varies by each filter For details, please contact us

• Filtration Filter

Frozen storage bags for blood products, antibody drugs, vaccines, and biosimilars.

The products are manufactured in a controlled environment compliant with ISO 7 by specially trained personnel. Some of the products adhere to strict quality control protocols, including particle count, microscopic observation, and individual bag pressure tests.

• Culture vessel

EVA freezing storage bag (-196℃). Made by TECHNOFLEX (France). Compliant with USP Class 6 and ISO 10993.

EVA-based high-frequency welded tubes and connectors ensure the integrity of a completely sealed system once filling is complete. This process is already used in Technoflex's sterilization bags, preventing the risk of contamination and issues related to the transfer between the container and its contents, while also controlling the assembly costs of the fillers. EVA bags manufactured in an ISO 8 cleanroom undergo numerous tests in accordance with good manufacturing practices, including endotoxin level assessments and airtightness tests. The capacity of the bags ranges from 5 to 500 ml. Sterilization using beta or gamma rays is also available upon request. Technoflex provides global "all-in-one" sterilization for bags, tubes, and connectors.

• Human cells

Cell observation in the incubator.

▶ Compact design that fits multiple units in an incubator (height 105mm) ▶ Visualization of cellular changes through time-lapse photography ▶ Graphical display of cell count and cell area ▶ Compatible with 24-well plates, with individual imaging for each well <Features> - Equipped with 24 cameras in a compact housing - Focus and exposure can be set individually for each well - Compatible with commercially available 24-well plates - Individual display of imaging results for each well

• Other Culture

At Eihon Seiki, we handle Brookfield's rotational viscometers, which are widely used by many customers. We offer consulting services such as measurement method proposals and data analysis to assist our customers with viscometers and rheometers. As part of our ongoing commitment to customer service, we have planned a viscometer user seminar. We will invite Professor Toshiyuki Shikata, an emeritus professor at Tokyo University of Agriculture and Technology, who is active in the field of rheology, to give a lecture covering the basics of viscosity and an introduction to viscoelasticity. There will also be opportunities to ask questions to Professor Shikata and our technical staff regarding any issues or uncertainties you may have in your daily work. We encourage you to consider participating in this opportunity. Seminar Overview: - We will provide an easy-to-understand lecture on the basics of viscosity and viscosity measurement. - We will explain points that can help improve the reproducibility of daily measurements and maintenance within your company. - We will introduce the dispersion of solutions and stability evaluation through live demonstrations. - You will have the opportunity to ask questions directly to Professor Shikata and Eihon Seiki's technical staff.

[Key Lecture Content] 1. The current status of geothermal heat in our country and the Ministry of the Environment's initiatives for its promotion Ministry of the Environment, Water and Air Quality Bureau, Environmental Management Division, Environmental Pollution Control Office Assistant Director Matsui Tatsu 1. About geothermal heat 2. About groundwater heat 3. Utilization for energy conservation 4. Utilization for decarbonization 5. Q&A / Business card exchange 2. Technological trends of geothermal heat pumps and advanced examples from Japan and abroad Non-profit organization Geothermal Utilization Promotion Association Chairman Sasada Masakatsu 1. Overview of geothermal heat pumps and their energy-saving and environmental properties 2. Trends in closed-loop technology 3. Trends in open-loop technology 4. Technological trends of air conditioning systems using geothermal heat as a heat source 5. Future prospects for geothermal heat pumps 6. Q&A / Business card exchange

[Speaker] Cabinet Office, Government of Japan Science and Technology Innovation Promotion Office Planning Officer Takayuki Sato [Key Lecture Content] Japan's AI policy is structured around the fundamental directions of "balancing innovation promotion and risk response" and "international cooperation." In the AI Basic Plan established at the end of last year, we aim to pursue "trustworthy AI" that maintains a human-centered AI society where individual dignity is respected, enabling continuous collaboration between humans and AI. Our goal is to make Japan "the easiest country in the world to develop and utilize AI." This lecture will provide an overview of Japan's AI policies, including examples of initiatives. [Lecture Items] 1. Evolution and development trends of AI 2. Japan's AI policy (background of the AI law enactment, promotion system, etc.) 3. AI-related initiatives (AI Basic Plan, AI guidelines, etc.) 4. Q&A / Business card exchange

In this 5S seminar, we won't just stop at "organizing and tidying up." We will provide plenty of tips on how to utilize 5S as a "visualization of work" and a "tool for discovering waste," evolving the workplace into a more comfortable and productive environment! ✅ Improvement tips you can use starting tomorrow ✅ Engaging and practical exercises and workshops that will inspire and excite you From "doing it because I was told to" to "wanting to take action myself" Your step forward will lead to the evolution of the entire team. This is an opportunity to cultivate a "mindset for improvement" among young employees and enhance the autonomy of the entire organization. From "waiting for instructions" to "thinking and taking action" As you become more accustomed to your work, you will notice the waste and potential that exists. Now, let's gain the "power to change" with 5S! Benefits of 5S: 1. People grow 2. Time becomes more abundant 3. The workplace environment improves 4. 5S does not require significant costs 5. It can be implemented regardless of company size or job type 6. It is appreciated by stakeholders We will teach you the tips to transform 5S from something done because a superior said to do it, or only when there is time, into an enjoyable and sustainable practice. *For more details, please download the PDF or contact us.

This exhibition is one of the largest specialized symposiums in Japan, focusing on fullerenes, carbon nanotubes (CNT), graphene, nanomaterials, advanced materials, functional materials, and two-dimensional materials. Many researchers and engineers involved in material development, device applications, measurement and analysis, research and development, and mass production technology will attend. At our booth, we will introduce products and technological solutions that support research in nanocarbon, advanced material evaluation, device development, and industrial applications from fundamental research. ■ Planned Exhibits - Products from PicoQuant - Ultra-high stability interferometer "GEMINI" (NIREOS) - Superconducting nanowire single-photon detector (SNSPD) (Single Quantum) - Broadband wavelength-tunable laser 400–1000nm SuperK CHROMATUNE (NKT Photonics)