Exhibited at BioJapan 2025.

Alternative methods to animal testing: Pyrogenic substance testing (compatible with endotoxin and non-endotoxin testing)

Monocyte activation test kit, an alternative method to the rabbit pyrogen test and LAL test. It uses human monocytic THP-1 cells to detect the inflammatory cytokine TNF-α. Capable of detecting gram-negative bacteria, gram-positive bacteria, fungi, and viruses.

• Other analytical and testing equipment

Using neurons as bio-digital sensors. Toxicity prediction using a digital library. High-throughput device using MEA.

Microchannel technology enables compartmentalization and co-culture. Compatibility with other companies' MEAs allows for the recording of electrical activity. Determination of toxicity and efficacy through the creation of digital signatures of compounds tested on innervated target organs. Prediction of toxicity and efficacy by comparing digital signatures of compounds using a digital library.

• Culture vessel

A biomimetic system that tests by moving cultivated mini-organs.

Mechanical stimulation of cultured tissues such as 3D cardiac microtissues using actuators to mimic heartbeats and knee joint movements. Evaluation of changes in electrical activity after drug administration allows for in vitro safety assessment of drugs. *Measurement of heart rate, electrical activity, contractility, etc.

• Cell culture contract service

Aseptic sampling system with adapter

The disposable sampling port cartridge eliminates the need for time-consuming assembly of multi-port adapters. This allows for direct attachment to the container's port, creating a simple, fast, and immediately usable sampling system. It is a gamma-irradiated disposable system for aseptic liquid sampling at various stages of pharmaceutical and biopharmaceutical processing. These systems minimize the potential for false positives compared to traditional sampling systems and reduce the need for cleaning. A sealed system that maximizes operator safety and eliminates contamination. A simpler, faster, and completely disposable ready-to-use solution for sampling applications. There is no need for the cumbersome and time-consuming assembly of sampling system ports and multi-port adapters within the cartridge.

• Animal cells

Gamma-ray irradiated disposable sampling system. Customizable.

The sterile sampling system can be customized to meet user requirements for tube size, sampling ports, and sampling containers.

• Other bio products

Stirring bag for biopharmaceuticals. With stirrer. Single-use.

Single-use mixing bags are designed for quick and uniform mixing. An impeller is attached to the bottom of the bag and rotates via a magnetic drive. It can accommodate bag capacities of up to 1000L. A 4-inch or 8-inch port can be installed on the top. It is also compatible with sanitary flanges. The bags are customizable.

• Culture vessel

Newly released, TPE (thermoplastic elastomer) tubes, highly resistant to chemicals, for applications such as antibody and vaccine production. Pump tubes.

Manufactured in an ISO Class 7 cleanroom Compliant with USP Class 6, various certifications BPA, phthalate, latex, and animal-free Operating temperature: -45℃ to 135℃ Low gas permeability Thermal bonding possible Please inquire about delivery time.

• Other bio products

Reliable single-use bags required for sterile processes such as storage and transportation of media, intermediates, buffers, etc., used in biopharmaceuticals.

AsptiBag Gold uses an inactive multilayer polyethylene film that is physically robust and inert to many chemicals and solvents, while also possessing excellent gas barrier properties. The contact surface is made of 130μm ultra-low-density polyethylene without any additives. It meets various regulatory and functional requirements, providing consistently high-quality products.

• Other bio-related products

FEP-made cell culture bags. Manufactured by TECHNOFLEX (France). Compliant with USP Class 6. DMF registered.

The SafeCell series is made of fluorinated ethylene propylene (FEP) and meets the demands of in vitro cell culture. FEP is chemically and biologically inert, making it perfectly suitable for cell suspension culture. Its anti-adhesion properties allow cells to freely float and proliferate in the medium. SafeCell bags are permeable to gases (oxygen, carbon dioxide, nitrogen), enabling the necessary exchanges for proper cell development, while also possessing another important characteristic: water impermeability. The low evaporation rate of SafeCell bags prevents issues even in humid incubators that increase the risk of bacterial and microbial growth.

• Culture vessel

To reduce contamination risks and streamline the cleaning process.

Single-use assembly tubes for biopharmaceuticals. Tube material, length, connector type, filters, etc. can be customized according to customer requirements. Manufactured in a Class 7 cleanroom. The facility is ISO 13485 and FDA certified. Compatible with gamma sterilization, with various certificates included.

• Filtration Filter

No need for centrifugation‼ Cultivation filtration depth filter

The combination of deep filtration and alluvial filtration allows for the removal of CHO cells, bacteria, etc., in a single step without the need for a centrifugation step. This reduces the cost and downtime of the bioprocess.

• Protein Extraction Kit

Sterilization applications for biopharmaceuticals and sterile preparations! Filters with high microbial retention, low protein adsorption, and extremely low elution performance.

Advanced Microdevices' sterilizing capsule filter achieves improved throughput through a pre-filter and high flow rates due to low hold-up volume. 【Features】 ■ Improved recovery rate due to low protein adsorption ■ Assurance of microbial capture performance through bacteria challenge testing ■ 100% integrity testing conducted ■ Certificate provided with each filter ■ Compatible with ethylene oxide and autoclave sterilization ■ Gamma radiation sterilization compatible

• Other bio-related products

Various lineups are prepared based on flow rate, effective surface area, and sterilization methods.

Consistent product quality using a quality management system Establishment of product traceability through lot number management Validation support through integrity tests, extractables, leachables, adsorption, and testing Compliance with various regulations such as FDA and USP Autoclave, steam sterilization Sterilization varies by each filter For details, please contact us

• Filtration Filter

Frozen storage bags for blood products, antibody drugs, vaccines, and biosimilars.

The products are manufactured in a controlled environment compliant with ISO 7 by specially trained personnel. Some of the products adhere to strict quality control protocols, including particle count, microscopic observation, and individual bag pressure tests.

• Culture vessel

EVA freezing storage bag (-196℃). Made by TECHNOFLEX (France). Compliant with USP Class 6 and ISO 10993.

EVA-based high-frequency welded tubes and connectors ensure the integrity of a completely sealed system once filling is complete. This process is already used in Technoflex's sterilization bags, preventing the risk of contamination and issues related to the transfer between the container and its contents, while also controlling the assembly costs of the fillers. EVA bags manufactured in an ISO 8 cleanroom undergo numerous tests in accordance with good manufacturing practices, including endotoxin level assessments and airtightness tests. The capacity of the bags ranges from 5 to 500 ml. Sterilization using beta or gamma rays is also available upon request. Technoflex provides global "all-in-one" sterilization for bags, tubes, and connectors.

• Human cells

Cell observation in the incubator.

▶ Compact design that fits multiple units in an incubator (height 105mm) ▶ Visualization of cellular changes through time-lapse photography ▶ Graphical display of cell count and cell area ▶ Compatible with 24-well plates, with individual imaging for each well <Features> - Equipped with 24 cameras in a compact housing - Focus and exposure can be set individually for each well - Compatible with commercially available 24-well plates - Individual display of imaging results for each well

• Other Culture

The latest published paper utilized Abby. This will be an online seminar featuring Associate Professor Yosuke Katsuta from the Graduate School of Advanced Science and Technology, Kumamoto University, who is also a co-founder of StapleBio. He is working on RNA hacking technology development aimed at altering the higher-order structure of target mRNA using short nucleic acids named Staple nucleic acids, with the goal of controlling gene expression. He will present the latest data focusing on the results of cell experiments and animal experiments in the development of this technology. Related paper on the lecture content: "Staple oligomers induce a stable RNA G-quadruplex structure for protein translation inhibition in therapeutics" | Nature Biomedical Engineering

Nitto Kohki will hold the "2025 Attack Fair in Meiko" for two days from July 23 (Wednesday) to July 24 (Thursday), 2025, at the "Kowa Seminar Plaza 2F Training Room NO.12 (inside Kowa Sports Land)." The Attack Fair is an exhibition where you can actually "see, touch, and operate" Nitto Kohki's products. Additionally, there will be wonderful souvenirs for attendees and many fun activities planned. We look forward to welcoming everyone!

The "Building Maintenance Human Fair & Clean EXPO 2025," which will be held from November 19 (Wednesday) to 21 (Friday), 2025, is an annual exhibition specializing in the building maintenance field, organized by the National Building Maintenance Association and the Japan Management Association. The field reporting app "Smart Attack" is celebrating its 15th anniversary this year since its release. It has a proven track record of being used by many customers as an efficiency tool for various building maintenance tasks such as cleaning, security, and facility management! At our exhibition booth, we will present a demonstration and the latest information about the completely renewed new app "Smart Attack V3." ★★★ Points ★★★ Fully renewed version: New app "Smart Attack V3" The fully renewed version of the new app "Smart Attack" is here! You can see the latest version "Smart Attack V3," which has improved processing speed and a completely revamped design, in a demonstration. All of us at the company look forward to your visit.

Naviace Co., Ltd. will be exhibiting at the "39th Hokkaido Technology and Business Exchange Meeting" business expo held in Sapporo, Hokkaido (https://www.business-expo.jp/). Under the theme "Change Challenges into Strengths with Carbon Neutrality!!", we will showcase our environmentally friendly cardboard pallet, "Navi Pallet". <Product Features> - Lightweight and high load capacity to improve work efficiency - 100% recyclable and ideal for one-way operations - No heat treatment required, making it suitable for export - High design flexibility for adaptable solutions - Contributes to addressing the logistics 2024 problem and reducing CO₂ emissions The Navi Pallet not only supports the transition from manual loading and unloading to palletization but also contributes to achieving carbon neutrality. We will also display actual Navi Pallets that have been implemented at the venue. Please come and experience the "strength" and "lightness" for yourself. Exhibition Area: Sapporo Chamber of Commerce and Industry Manufacturing Corner

Techne Measurement Co., Ltd. will be exhibiting at the 66th Battery Discussion Conference, which will be held at Wink Aichi from November 18 (Tuesday) to November 20 (Thursday), 2025. This time, we will showcase dew point meters and low dew point calibrators for the battery industry. Please be sure to visit the Techne Measurement booth.