Nitrosamine Analysis Webinar Part 2

Explanation of the measurement of nitrosamine impurities using the high-resolution "Agilent 6546 LC/Q-TOF"!

Angiotensin II receptor blockers (ARBs) are widely used in the treatment of hypertension and heart failure. Recently, it has been found that some ARBs contain carcinogenic nitrosamine impurities, resulting in the recall of many products. Consequently, there is a demand for analytical methods capable of detecting these problematic nitrosamine impurities. This application note describes a high-sensitivity and high-resolution LC/MS/MS method using the "Agilent 6546 LC/Q-TOF" for the detection and quantification of six types of nitrosamines specified by the US FDA, as well as a simultaneous detection method for eleven types of nitrosamine impurities. [Contents] ■ Introduction ■ Experimental Methods ■ Results and Discussion ■ Conclusion ■ References ■ Acknowledgments *For more details, please refer to the PDF document or feel free to contact us.

• Analytical Equipment and Devices

Reliable detection and quantification of nitrosamines and mutagenic impurities.

Due to the presence of unacceptable levels of mutagenic nitrosamine impurities, several pharmaceuticals have recently been recalled. To accurately detect and quantify trace amounts of mutagenic impurities in pharmaceuticals, Agilent offers relevant GC/MS, LC/MS, and high-throughput MS-based analytical techniques. <Challenges in Nitrosamine Analysis> 1. Introducing mass spectrometers requires meeting regulatory requirements, which can be cumbersome. 2. There are many target substances, making it difficult to choose which method/device to use for GC/MS or LC/MS. 3. Due to the high cost of the equipment, results that justify the expense are expected (in terms of cost, operation, speed from introduction to startup, and decisions on outsourcing). 4. It is challenging to foresee whether the risk assessment can be completed by the deadline. <Solutions for Nitrosamine Analysis> Agilent's application guide provides various validated methods from sample preparation to measurement analysis, enabling quick setup and support from introduction to operation. Additionally, regulatory compliance, including data integrity, is achievable.

• Chemicals
• Testing Equipment and Devices
• Analytical Equipment and Devices

On Tuesday, April 21, at Iidabashi, paperlogic will have a booth at "Canon Selection 2026." The theme of this event is "Paper Output × Data Utilization." It is a comprehensive exhibition filled with hints to promote DX in the office and achieve operational efficiency. At the venue, there will be the latest "Security Measures Seminar" to protect companies from supply chain attacks, as well as programs like creating promotional flyers that anyone can make, "Super Easy! PDF Utilization Techniques" to alleviate daily frustrations, and "Paperless Fax Experience" to support remote work, all aimed at solving on-site challenges. From paperlogic, we will introduce the 【paperlogic Electronic Contract】 as a solution for "Document Management and Back Office Digitization." We will have actual operation demonstrations at our booth and will directly address your concerns regarding document management. We also have special plans exclusively for Otsuka Corporation, so please come and visit us.

We will be holding a technical training session for MilkoScanFT3 as detailed below. In this training, we will provide a broad range of information useful for operating the equipment, including explanations of the principles and structure of the device, how to create measurement products, daily maintenance, and responses to troubleshooting. Additionally, this year we will introduce new ways to utilize digital services (such as FossCalibrator and IQX), and we have also prepared hands-on sessions where customers can experience operating the equipment using a PC. The training content is designed to be more practical and immediately applicable in real-world settings. We understand you may be busy, but we kindly ask you to consider participating. ■ Osaka Venue: June 25-26 ■ Morioka Venue: July 8-9 ■ Tokyo Venue: August 27-28 ■ Obihiro Venue: September 17-18 ■ Fukuoka Venue: October 8-9 *Please check the PDF for more details.

■Connecting Biomarker Discovery to Clinical Application - Explained with Real Cases of Neurodegenerative Diseases Although biomarkers are discovered, many do not reach clinical application. The reasons for this lie in multiple hurdles that arise after discovery, such as "narrowing down candidates," "reproducibility," and "connecting to clinical practice." 1. How should promising candidates obtained from comprehensive exploration be narrowed down? 2. How can reproducibility and scalability be ensured? 3. What are the key points for smoothly transitioning to clinical research? 4. What should be considered in data science throughout the overall flow? In this online seminar, we will clearly explain specific strategies for advancing from discovery to clinical application based on actual research cases of Alzheimer's disease and multiple sclerosis, in an easy-to-understand manner in Japanese. *Olink products and services are for research purposes only. Please note that they cannot be used for diagnostic purposes.

We would like to extend our heartfelt congratulations on the continued prosperity of your esteemed company. Our company will be exhibiting at the following trade show, where we will showcase a variety of products, including new ones. We sincerely invite you to visit us during this busy time. 【 Exhibition Name 】 Automotive Technology Exhibition 2025 YOKOHAMA https://aee.expo-info.jsae.or.jp/ja/yokohama/ (An "online exhibition" will also be held during and around the event period) 【 Dates 】 May 21 (Wednesday) - 23 (Friday), 2024 10:00 AM - 6:00 PM *On the final day, 9:00 AM - 4:00 PM (Online exhibition: May 14 (Wednesday) - June 4 (Wednesday)) 【 Venue 】 Pacifico Yokohama (1-1-1 Minatomirai, Nishi-ku, Yokohama, Kanagawa Prefecture) Our booth number: "Concourse 505"

We would like to extend our heartfelt congratulations on the continued prosperity of your esteemed company. Our company will be exhibiting at the following trade show, where we will showcase a variety of products, including new ones. We sincerely apologize for the inconvenience during your busy schedule, but we would like to invite you to attend this event. 【 Exhibition Name 】 27th INTERPHEX Week Tokyo https://www.interphex.jp/tokyo/ja-jp.html 【 Dates 】 July 9 (Wednesday) - 11 (Friday), 2025 10:00 AM - 5:00 PM 【 Venue 】 Tokyo Big Sight (3-11-1 Ariake, Koto-ku, Tokyo 135-0063)