[Exhibition Information] 17th Annual Meeting of the Japanese Society of Safety Pharmacology

A patch clamp system that incorporates a patch clamp amplifier, achieving miniaturization and reduction of installation costs, allowing for easy data acquisition and verification.

This is a world-class patch clamp system capable of performing gigaseal recordings, optimal for safety testing/toxicity testing/pharmacological testing/screening of compounds at the cellular level in the functional structural analysis of ion channels, research on related diseases, and drug development processes. ■ No experience with manual patch clamping or difficult operations required ■ No need for microscope/vibration isolation table/manipulator/Faraday cage/puller ■ 20 to 50 data points per day ■ Automation from gigaseal formation to whole cell formation ■ Compatible with voltage-dependent and ligand-dependent channels through pipetting ■ Measurement of action potentials using current clamp is also possible ■ Supports a wide range of applications, enabling rapid assay system development ■ Reduces compound adsorption with borosilicate glass chips

• Other physicochemical equipment
• Analytical Equipment
• Patch clamp system

A world-class patch clamp system that is easy to operate for anyone, allowing for simple data acquisition and verification.

This is a patch clamp system of the world's smallest class that can perform gigaseal recordings, optimal for safety testing/toxicity testing/pharmacological testing/screening of compounds at the cellular level in the functional structural analysis of ion channels, research on related diseases, and drug development processes. 【Features】 ■ No need for manual patch clamp experience or difficult operations ■ No need for microscope, vibration table, manipulator, Faraday cage, or puller ■ 20 to 50 data points per day ■ Automation from gigaseal formation to whole cell formation ■ Compatible with voltage-dependent, ligand-dependent, and temperature-dependent channels ■ Options available for research on channel rhodopsins and mechanosensitive channels using light stimulation ■ Measurement of action potentials using current clamp is also possible ■ Supports a wide range of applications and enables rapid assay system development ■ Reduces compound adsorption with borosilicate glass chips ■ Optional temperature control (10 to 50°C), capable of extracellular/intracellular perfusion ■ Can be integrated with amplifiers such as HEKA and Axon *For details, please refer to the catalog available for download in PDF.

• Other physicochemical equipment
• Analytical Equipment
• Patch clamp system

No pipetting operations are required during the experiment. It is equipped with a benchtop dispensing device that can automatically measure up to 48 cells continuously in an auto patch clamp system.

This is a tabletop-sized auto patch clamp system that can simultaneously measure up to 8 cells with giga-seal formation. With easy experimental setup, stable whole-cell recordings, and sophisticated software, it enables highly efficient compound ion channel screening. ■ Equipped with a dispensing device, allowing for fully automated experiments (measurements) ■ Simultaneous measurement of 4 cells / 8 cells (up to 48 cells can be measured continuously) ■ 250 to 600 data points per day ■ Automation from giga-seal formation to whole-cell formation ■ Compatible with voltage-dependent and ligand-dependent channels ■ Measurement of action potentials using current clamp is also possible ■ Dynamic clamp capability (optional) ■ Temperature control and extracellular/intracellular perfusion possible ■ Cooling plate allows for cooling of cells and compounds ■ Borosilicate glass chips reduce compound adsorption ■ Comes with excellent analysis software

• Other physicochemical equipment
• Analytical Equipment
• Patch clamp system

An automated patch clamp system capable of meeting all needs, from small-scale screening projects to high-throughput screening.

Designed to seamlessly integrate fully automated compound screening into the drug discovery process, it provides the best performance in high-throughput screening of ion channels in drug discovery, pharmacology, safety, pharmaceutical research and development, and exploratory screening departments. Additionally, by using the 32-well mode, it can be optimized for small-scale compound screening and projects. ■ Simultaneous measurement of 384 cells ■ 20,000 data points per day ■ High giga-seal success rate ■ Supports a variety of ion channel targets and enables rapid assay system development ■ Measurement of action potentials using current clamp is also possible ■ Extracellular/intracellular perfusion is possible ■ High-speed external solution exchange (up to 110 µl/s) is possible ■ Measurement section and 12 decks can be individually temperature controlled (temperature range: 10–37°C) ■ Compound plate preparation on the deck is possible ■ Single & multi-well chips available (in-house manufactured) ■ Borosilicate glass chips reduce compound adsorption ■ Approximately 8 hours of unmanned operation is possible ■ Comes with powerful analysis software ■ Validated system for CiPA

• Other physicochemical equipment
• Analytical Equipment
• Patch clamp system

Measurement of impedance and extracellular potential of iPS-derived cardiomyocytes.

This is a hybrid cardiotoxicity screening device capable of impedance measurement and extracellular potential measurement similar to MEA. It can detect not only cardiomyocytes but also the minute contractions of cancer cells and liver cells due to the effects of compounds. ■ Simultaneous measurement of impedance and extracellular potential ■ 96-well simultaneous measurement ■ Label-free measurement ■ Long-term monitoring capability ■ Electrical pacing & optical pacing (optional) ■ Comes with an incubation system (temperature, humidity, and CO2 control) ■ Includes multifunctional and excellent data analysis and graph creation software ■ Validated human iPS cells: iCell, iCell², AXOL CM, Cardiosight-S, MiraCell Cardiomyocytes, etc. ■ Compact desktop size: W20.5 x D18 x H11.7cm / 3.5kg (main unit)

• Other physicochemical equipment
• Other Analysis

The Langeendorff method has been transformed into the latest high-throughput technology, allowing for the measurement of contractile force in cardiomyocytes under physiological conditions similar to the natural environment of cardiac tissue.

The FLEXcyte 96, which transforms the conventional Langendorff method into the latest high-throughput technology, can measure the contractile force (mN/mm²) of cardiomyocytes for cardiotoxicity and safety evaluation, as well as drug screening, under physiological conditions similar to the native cardiac tissue environment, without missing even slight responses to cytotoxicity, regardless of whether in the chronic or acute phase, simultaneously in 96 wells. ■ Simultaneous measurement in 96 wells ■ Label-free measurement ■ Long-term monitoring possible ■ Optical pacing (optional) ■ Comes with an incubation system (temperature, humidity, CO2 control) ■ Includes multifunctional excellent data analysis and graphing software ■ Validated human iPS cells: iCell, iCell², AXOL CM, Cardiosight-S, MiraCell Cardiomyocytes, etc. ■ Compact desktop size: W20.5 x D18 x H11.7cm / 3.5kg (main unit)

• Other physicochemical equipment
• Other Analysis

Central Science Co., Ltd. will be exhibiting in the Process Inspection and Measurement Zone at the "27th Interphex Week Tokyo" held at Tokyo Big Sight. At our booth, we will focus on products under the Sievers brand, showcasing measuring instruments used for pharmaceutical water management. - Products to be displayed: "Online TOC Analyzer Sievers M500" "Laboratory TOC Analyzer Sievers M9" "Endotoxin Analyzer Sievers Eclipse" "Bio-Burden Rapid Analysis Device Sievers Soleil," among others. Additionally, we plan to hold a seminar at the exhibitor seminar venue on the theme "How to streamline manufacturing processes while ensuring the quality of pharmaceutical water?" We sincerely look forward to your visit.

We are pleased to offer everyone the opportunity to view Foss analysis equipment at Foss Japan. In this open house, we aim to provide information to a wide audience, including tips for selecting analysis equipment and ways to further utilize the equipment you are currently using. We have planned a comprehensive seminar for those who wish to deepen their knowledge about future analysis, as well as for those seeking information on selecting analysis equipment. Additionally, we will have various NIR devices on display, and it will be possible to measure samples you bring with you. Of course, we also welcome visitors who only wish to tour the equipment! We sincerely look forward to your participation. ■ Date: June 18, 2026 (Thursday) 11:00 AM – 4:30 PM (Reception starts at 10:45 AM) ■ Venue: Kobe International Conference Center, Seminar House Room 702 / Some online participation available ■ Overview: - Greetings and introduction of Foss product lineup *Online participation available - Basics of NIR and selecting the optimal model *Online participation available - Demonstration of calibration software FossCalibrator: Let's create a calibration curve *On-site only - Sample measurement and open house *On-site only For more details, please check the PDF.

**Exhibition Content** Streamlining Software Development in the SDV Ecosystem In this exhibition, we will introduce comprehensive solutions for the arrival of the Software Defined Vehicle (SDV) era. As the value of automobiles shifts from hardware to software, there is a growing demand for balancing development efficiency and quality. Our services, which leverage advanced technologies and know-how based on our extensive track record, will strongly support your SDV development: - SDV Total Solution: An integrated approach to optimize the entire vehicle system - SDV Safety Integration: Development processes and verification techniques compliant with functional safety standards - Streamlining Software Development with Generative AI: Code generation and test automation utilizing the latest AI technologies - Integrated Simulation Environment Construction Solutions: Building an efficient development environment by linking multiple simulation tools - Simulink Model Guideline Check Tool "Model Dr. MDiA": Automatically verifying model quality to improve development efficiency and quality

On Tuesday, April 21, at Iidabashi, paperlogic will have a booth at "Canon Selection 2026." The theme of this event is "Paper Output × Data Utilization." It is a comprehensive exhibition filled with hints to promote DX in the office and achieve operational efficiency. At the venue, there will be the latest "Security Measures Seminar" to protect companies from supply chain attacks, as well as programs like creating promotional flyers that anyone can make, "Super Easy! PDF Utilization Techniques" to alleviate daily frustrations, and "Paperless Fax Experience" to support remote work, all aimed at solving on-site challenges. From paperlogic, we will introduce the 【paperlogic Electronic Contract】 as a solution for "Document Management and Back Office Digitization." We will have actual operation demonstrations at our booth and will directly address your concerns regarding document management. We also have special plans exclusively for Otsuka Corporation, so please come and visit us.

We will be holding a technical training session for MilkoScanFT3 as detailed below. In this training, we will provide a broad range of information useful for operating the equipment, including explanations of the principles and structure of the device, how to create measurement products, daily maintenance, and responses to troubleshooting. Additionally, this year we will introduce new ways to utilize digital services (such as FossCalibrator and IQX), and we have also prepared hands-on sessions where customers can experience operating the equipment using a PC. The training content is designed to be more practical and immediately applicable in real-world settings. We understand you may be busy, but we kindly ask you to consider participating. ■ Osaka Venue: June 25-26 ■ Morioka Venue: July 8-9 ■ Tokyo Venue: August 27-28 ■ Obihiro Venue: September 17-18 ■ Fukuoka Venue: October 8-9 *Please check the PDF for more details.