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  1. Home
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  3. 澁谷工業
  4. What are the reasons for changes in results from the lab to mass production? Causes and countermeasures for the deterioration of distributed quality during scale-up.
OTHER
  • Apr 14, 2026
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Apr 14, 2026

What are the reasons for changes in results from the lab to mass production? Causes and countermeasures for the deterioration of distributed quality during scale-up.

澁谷工業 澁谷工業
Despite obtaining good dispersion results in the lab, the challenge of unstable quality upon mass production occurs in many settings. The main cause of this is that the dispersion conditions are not replicated due to differences in scale. In lab equipment, the smaller size leads to higher energy density, making shear and flow more uniform, while in mass production equipment, the larger scale often results in insufficient dispersion energy at the same rotational speed and processing time. Additionally, differences in equipment structure and flow patterns can cause variations in the shear history and residence time experienced by particles, leading to differences in the dispersion state. Furthermore, simple scale-up does not ensure that critical parameters such as flow rate, residence time, and shear intensity match, making it difficult to reproduce the same results as in the lab. To address these challenges, it is essential to focus on process design based on dispersion energy density and flow conditions rather than merely increasing equipment size. By designing the system so that particles pass through the processing area under consistent conditions, it is possible to achieve reproducible dispersion quality even when the scale changes, as seen in inline continuous processing.
Due to differences in device scale, the dispersion conditions will not be the same.
Due to differences in device scale, the dispersion conditions will not be the same.
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For details on the process design to reproduce lab results for mass production, click here.
In scale-up, it is important not just to increase the size of the equipment, but to replicate the dispersion energy and flow conditions. Our company ensures quality reproducibility during scale-up through consistent process design from lab testing to mass production equipment. We propose optimal dispersion conditions from an engineering perspective.

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Dispersion machine line: Powder supply - Continuous dispersion support

From powder supply to dispersion, defoaming, and transfer. A dispersion machine line compatible with high-viscosity slurries has been established.

We offer a solid-liquid mixing line that includes powder supply, dispersion, degassing, and transfer, centered around the disperser. In high solid content and high viscosity slurries, the powder supply conditions and instantaneous concentration fluctuations significantly affect dispersion quality. This system optimizes the entire process rather than just the disperser alone, achieving quality stabilization and productivity improvement. Additionally, by combining inline dispersers, batch dispersers, static mixers, etc., we can propose systems tailored to material characteristics and processing conditions. We accommodate a variety of slurry applications, including battery materials, CNTs, electronic materials, adhesives, inks, and food. We can provide consistent support from lab testing to scale-up and mass production line construction.

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Protein dispersion test service

Resolve issues of not dissolving and clumping in advance. Test the dispersibility of the protein.

The quality of protein products is greatly influenced by their dispersion state. In particular, powdered protein often faces challenges such as clumping during dissolution in water or solvents, uneven dispersion, and poor mouthfeel. Additionally, changes in formulation or raw materials can alter viscosity and dispersibility, leading to cases where there are no issues during prototyping but quality becomes unstable during mass production. This service conducts dispersion tests tailored to raw material characteristics and formulation conditions, verifying the suppression of clumping, improvement of dispersibility, and enhancement of mouthfeel. Furthermore, through process design aimed at scaling up from the lab to small machines and mass production equipment, we establish reproducible manufacturing conditions. We can support evaluations from the prototyping stage to pre-mass production verification.

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Adhesive dispersion test service

The strength is determined by the variance. Visualize quality variations through testing before mass production.

The performance of adhesives greatly depends on the dispersion state of fillers and additives, and even slight differences in dispersion can affect adhesion strength, durability, and appearance quality. Particularly in highly filled systems, issues such as clumping, undispersed particles, and poor mixing due to viscosity increases are likely to occur, leading to variations in dispersion and quality due to sedimentation and separation. These challenges often stem not from the equipment alone but from input conditions, dispersion conditions, and process composition, manifesting as problems that cannot be reproduced during mass production. In this service, we conduct dispersion tests based on the customer's materials and formulation conditions to evaluate the dispersion state, viscosity characteristics, and their impact on adhesive performance. Furthermore, we perform scale-up verification using small machines and pilot equipment to clarify the reproducible conditions for mass production. By conducting thorough verification that delves into process design, we support quality stability and reduction of development time.

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Resin material dispersion test service

Quality changes with dispersion. Pre-validation of the reproducibility of resin materials through testing.

In the dispersion process of resin materials, the dispersion state of fillers and additives greatly influences product performance. Issues such as strength reduction due to poor dispersion, appearance defects, variability in functional characteristics, and viscosity fluctuations are likely to occur, especially in high-fill and nano-filler systems where dispersion difficulty increases. Additionally, even if there are no problems during the prototype stage, it is often seen that the same quality cannot be reproduced during mass production. This service conducts dispersion tests tailored to material properties and formulation conditions, evaluating dispersion state, viscosity characteristics, and reproducibility. Furthermore, through scale-up verification using small machines and pilot equipment, risks during the transition to mass production are visualized in advance. This is not just a simple test; by delving into process design, we support quality stability and productivity improvement.

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Battery slurry dispersion testing service

Verify before failing in mass production. Confirm the reproducibility of slurry dispersion in advance.

In the dispersion process of battery slurry, it is often observed that while dispersion can be achieved without issues during the research phase, it cannot be replicated during mass production, leading to quality problems. This is particularly true for positive and negative electrode slurries and CNT conductive materials, where variations in powder input conditions, dispersion energy, viscosity changes, and differences in process configuration can significantly alter the dispersion state and coating properties. Our service conducts dispersion tests at the lab scale based on the customer's materials and formulation conditions, evaluating the dispersion state, viscosity characteristics, and reproducibility. Furthermore, we support scale-up verification using small machines and pilot equipment, visualizing risks during mass production in advance. This is not just a simple test; through verification that delves into process design, we assist in reducing troubles during the transition to mass production and shortening the startup period.

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Inline solid-liquid mixing dispersion system

Inline solid-liquid mixing dispersion system

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