Report on the 10th COSME Tech 2020 Cosmetics Development Exhibition

Ultimate moisturizing produced by Halomonas sp. with protection (UV, BL, IRA, viruses), anti-inflammatory, and femcare ingredient Ectoin Natural.

<Ectoin Natural Features> Ectoin is a type of cyclic amino acid produced by extremophilic microorganisms (Halomonas) that inhabit salt lakes and deserts. It has 4 moles of bound water for every 1 mole of ectoin, giving it cosmotropic properties. This characteristic contributes to the stabilization of interactions between water molecules and forms a hydrocomplex. This hydrocomplex helps stabilize biological structures (such as cells, proteins, enzymes, and nucleic acids) against environmental stresses like temperature changes, high salt concentrations, strong UV exposure, and dehydration. ― About Effectiveness ― In Vivo Vaginal care effects: Reduction of vaginal atrophy symptoms, vaginal moisturization (50% improvement in dryness), improvement of vaginal heat and itching. Moisturizing persistence (lasting for 1 week), barrier recovery, erythema suppression, protection of Langerhans cells (100% protection). Anti-aging effects: Improvement in skin roughness (86% improvement), wrinkle depth (32% improvement), elasticity (82% improvement), smoothness (61% improvement), whitening effect (25% improvement). In Vitro: Promotion of heat shock protein production, anti-pollution effects (Ex-Vivo), protection against blue light, UV-A, UV-B, and IR-A.

• Cosmetic materials and raw materials
• Other pharmaceutical intermediates and cosmetic ingredients
• Other medical supplies and cosmetic manufacturing materials

Extreme environment microorganisms, long-lasting moisture, UV protection, Langerhans cell protection, anti-pollution, anti-aging, fermentation, hair care.

<Ectoin Natural Features> Ectoin is a type of cyclic amino acid produced by extremophilic microorganisms (Halomonas) that inhabit salt lakes and deserts. It has 4 moles of bound water per 1 mole of Ectoin, exhibiting cosmotropic properties. This characteristic contributes to the stabilization of interactions between water molecules, forming a hydrocomplex. This hydrocomplex helps stabilize biological structures (such as cells, proteins, enzymes, and nucleic acids) against environmental stresses like temperature changes, high salt concentrations, strong UV radiation, and dehydration. ― About Effectiveness ― Moisturizing Persistence (In-Vivo): Lasts for 1 week. Skin Barrier Function and Protection of Langerhans Cells (In-Vivo): 100% protection. Promotion of Heat Shock Protein Production (In-Vitro), Anti-Pollution Effect (Ex-Vivo), Protection against Blue Light, UV-A, UV-B, IR-A, and Heat, Anti-Aging Effects (In-Vivo): Improvement in Skin Roughness (86% improvement), Wrinkle Depth (32% improvement), Elasticity (82% improvement), Smoothness (61% improvement), Whitening Effect (In-Vivo): Improvement in Skin Pigmentation (25% improvement).

• Cosmetic materials and raw materials
• Other pharmaceutical intermediates and cosmetic ingredients
• Other medical supplies and cosmetic manufacturing materials

Achieved 100% purity of 2αGG, the most active isomer of the miraculous resurrection plant, through our unique manufacturing technology. High moisturizing, wound healing, and cell revitalization functions.

Glycoin natural is a product composed of 100% unique structural isomers manufactured using patented biotechnology by Bitop AG in Germany. These structural isomers are found only in the miraculous resurrection plant Myrothamnus flabellifolia and blue-green algae (spirulina), which are known as the miracle plants of the desert that can revive green with just a small amount of water even after being dried for 50 years. Glycoin natural activates the rejuvenating power of tired skin, stressed skin, and aging skin. <Efficacy> Stimulates cell regeneration, growth factors, and ATP synthesis Activates antioxidant enzymes (SOD1, SOD2, CAT) Immediate moisturizing effect improved by 49% (after one application) Skin elasticity improved by 93% Skin smoothness improved by 61% Skin thickness increased by 9.9% Reduces sunburn and skin redness Tissue repair and wound healing effects maintained for 48 hours

• Cosmetic materials and raw materials
• Other pharmaceutical intermediates and cosmetic ingredients
• Other medical supplies and cosmetic manufacturing materials

New hyaluronic acid crosspolymer, refreshing and moist feeling, anti-wrinkle, pore care, pore tightening, moisturizing effect.

Cross Linked HA is a hyaluronic acid cross-polymer made using Contipro's patented manufacturing method. The patented manufacturing technology creates a soft and fine gel, providing a unique sensation that is not found in conventional high molecular weight sodium hyaluronate. <About the Sensation> Immediately after application, it retains the pleasant texture of the chewy sodium hyaluronate, while the fine gel quickly penetrates the skin's grooves (such as wrinkles and pores), resulting in a moist yet refreshing sensation. <About Effectiveness> - Moisturizing effect (62% improvement) - Anti-wrinkle effect (46% reduction in wrinkles) - Sustained release effect of active ingredients (51% increase in the activity of Vitamin B3)

• Cosmetic materials and raw materials
• Other pharmaceutical intermediates and cosmetic ingredients
• Other medical supplies and cosmetic manufacturing materials

We are introducing Contipro's hyaluronic acid derivatives, such as sodium hyaluronate and hydrolyzed sodium hyaluronate, which have unique efficacy.

Contipro is a biotechnology company located in the Czech Republic. It is a global manufacturer that produces and sells various active ingredients, primarily sodium hyaluronate, in the pharmaceutical and cosmetic fields, supplying to over 60 countries for approximately 30 years. The listed products are categorized into three groups: sodium hyaluronate, natural polysaccharides, and peptides. <Sodium Hyaluronate> We offer grades with a molecular weight distribution ranging from 2.3 million Da to 10,000 Da, and we have confirmed differences in efficacy due to varying skin permeability based on molecular weight through Vivo and Vitro data. Additionally, we also have hydrolyzed sodium hyaluronate as a grade with excellent skin permeability. <Derivatives> We have confirmed through Vivo and Vitro data that sodium hyaluronate possesses not only its inherent properties of moisturizing, barrier function, anti-wrinkle, and calming effects but also efficacy in whitening, sebum secretion regulation, sebum suppression, and improvement of skin texture. *For more details, please download the PDF or feel free to contact us.

• Pharmaceutical materials and carriers
• Cosmetic materials and raw materials
• Other pharmaceutical intermediates and cosmetic ingredients

Hyaluronic Acid Na for Whitening that Maximizes the Function of Alpha-Linolenic Acid

HyWhite is a sodium hyaluronate with whitening (brightening) properties manufactured by Contipro in the Czech Republic. HyWhite is a product that has high whitening (brightening) effects, made by partially replacing low molecular weight sodium hyaluronate with alpha-linolenic acid, which has high permeability to the skin. Alpha-linolenic acid is widely known for its strong melanin production suppression effects, and in in-vitro results, it has been confirmed to have a higher suppression effect than kojic acid. On the other hand, it is also known as a component that is difficult to formulate due to its low skin permeability and instability. This product promotes the absorption of alpha-linolenic acid, which has been a problem in the past, by replacing part of the low molecular weight hyaluronate with alpha-linolenic acid, thereby improving stability and maximizing the effects of alpha-linolenic acid. *In addition to HyWhite, Contipro also manufactures sodium hyaluronate, hydrolyzed sodium hyaluronate, and other hyaluronate derivatives.

• Other additives
• Cosmetic materials and raw materials

Achieves excellent "anti-wrinkle effect," "moisture retention effect," and "skin barrier function recovery effect"! Low molecular weight hyaluronic acid oligosaccharides with excellent permeability.

OligoHyaferre is a hydrolyzed sodium hyaluronate manufactured by a company in the Czech Republic, known for its excellent "anti-wrinkle effect," "moisture retention effect," and "skin barrier function recovery effect." In vitro studies have confirmed its effects of MMP inhibition, TNF-α inhibition, promotion of angiogenesis, and gene expression of HAS2. These effects lead to favorable results in in vivo "anti-wrinkle tests" and "skin barrier function recovery tests."

• Other additives
• Cosmetic materials and raw materials
• Other pharmaceutical intermediates and cosmetic ingredients

We will solve the issues related to the deterioration of defect rates caused by fine particles and the cleaning process in manufacturing sites. The fine particle visualization system developed by Shin Nippon Air Technologies, under the ViEST brand, combines an ultra-high-sensitivity camera and light source to visualize fine particles in clean rooms and equipment. It can capture their behavior in real-time while also quantifying particle information, making it a world-class visualization system. Currently, we are expanding the sale of systems and tools, as well as contract technical services utilizing them, both domestically and internationally. We have particularly rich experience in the semiconductor industry and clean rooms. Below are some examples of applications, but by using our technology, we can strongly promote solutions to various issues such as the deterioration of defect rates due to fine foreign substances, visualization of clean airflow, and concerns regarding site cleanliness. - Visualization investigation of fine particles and airflow in the manufacturing line and environmental improvement - Promotion of cleanliness in manufacturing equipment and environments - Cleanliness evaluation of various equipment performance - Improvement of yield and quality degradation caused by contamination issues - Support for research and development requiring visualization of fine particles and airflow - Evaluation of particle generation from products.

[Speaker] Ministry of Defense, Defense Planning Bureau, Defense Planning Division Director of Early Equipment Promotion Office, Mr. Toshiyuki Hinosawa [Key Lecture Content] As the security environment surrounding our country has become the most severe and complex since the post-war period, we are advancing efforts toward early equipment procurement in areas that are particularly urgent and important from a policy perspective, while also incorporating cutting-edge technology. In particular, unmanned assets were heavily utilized during Russia's invasion of Ukraine, drastically changing the nature of combat. In the future, I will discuss how the Ministry of Defense and the Self-Defense Forces will enhance these capabilities, including the multi-layered coastal defense system concept "SHIELD." [Lecture Items] 1. Concept and Overview of Early Equipment Procurement 2. Major Efforts Toward Early Equipment Procurement to Date 3. Strengthening Defense Capabilities of Unmanned Assets 4. Establishing a Multi-Layered Coastal Defense System "SHIELD" Using Unmanned Assets 5. Q&A / Business Card Exchange

We will be exhibiting at the "Converting Technology Comprehensive Exhibition 2026," which focuses on processing machines and equipment centered around converting technology. When you visit, please be sure to stop by our booth. We sincerely look forward to your visit. 【Our Booth Number】 2W-R33

[Instructor] Shunsuke Suzuki, President and CEO, Management Techniques Co., Ltd. [Key Lecture Content] The modern business environment is changing at an unpredictable pace, and to achieve success, new approaches that go beyond traditional thinking are essential. "Normal" thinking and "conventional" solutions cannot differentiate you in a highly competitive market. True breakthroughs arise from stepping outside the box. Therefore, the ability to "discover hidden problems and create innovative ideas that others cannot think of" becomes crucial. So, how can we develop such abilities and apply them in the business field? Successful business leaders, skilled engineers, and entrepreneurs who have achieved results do not rely solely on logic; they employ creative thinking. This can be broadly categorized into four areas: associative thinking, abstract thinking, multifaceted thinking, and conceptual thinking. In this seminar, we will learn four creative thinking approaches that will be immediately applicable in business settings. Through these, let’s master the way of thinking that will keep you one step ahead in the business world.

[Speaker] President and CEO of Leading Innovation Co., Ltd. Senior Consultant Yoshizawa Yosuke [Lecture Topics] 1. Common sense is creating a sense of stagnation in new product and new business development. 2. Reasons why "latent needs are infinite." 3. How to convert technology into functionality. 4. The importance and methods of converting functionality into value. 5. How to discover attractive themes from technology through a business structure map and generative AI. 6. Formulating competitive advantage strategies. 7. Q&A Session.