Report on the 10th COSME Tech 2020 Cosmetics Development Exhibition

Ultimate moisturizing produced by Halomonas sp. with protection (UV, BL, IRA, viruses), anti-inflammatory, and femcare ingredient Ectoin Natural.

<Ectoin Natural Features> Ectoin is a type of cyclic amino acid produced by extremophilic microorganisms (Halomonas) that inhabit salt lakes and deserts. It has 4 moles of bound water for every 1 mole of ectoin, giving it cosmotropic properties. This characteristic contributes to the stabilization of interactions between water molecules and forms a hydrocomplex. This hydrocomplex helps stabilize biological structures (such as cells, proteins, enzymes, and nucleic acids) against environmental stresses like temperature changes, high salt concentrations, strong UV exposure, and dehydration. ― About Effectiveness ― In Vivo Vaginal care effects: Reduction of vaginal atrophy symptoms, vaginal moisturization (50% improvement in dryness), improvement of vaginal heat and itching. Moisturizing persistence (lasting for 1 week), barrier recovery, erythema suppression, protection of Langerhans cells (100% protection). Anti-aging effects: Improvement in skin roughness (86% improvement), wrinkle depth (32% improvement), elasticity (82% improvement), smoothness (61% improvement), whitening effect (25% improvement). In Vitro: Promotion of heat shock protein production, anti-pollution effects (Ex-Vivo), protection against blue light, UV-A, UV-B, and IR-A.

• Cosmetic materials and raw materials
• Other pharmaceutical intermediates and cosmetic ingredients
• Other medical supplies and cosmetic manufacturing materials

Extreme environment microorganisms, long-lasting moisture, UV protection, Langerhans cell protection, anti-pollution, anti-aging, fermentation, hair care.

<Ectoin Natural Features> Ectoin is a type of cyclic amino acid produced by extremophilic microorganisms (Halomonas) that inhabit salt lakes and deserts. It has 4 moles of bound water per 1 mole of Ectoin, exhibiting cosmotropic properties. This characteristic contributes to the stabilization of interactions between water molecules, forming a hydrocomplex. This hydrocomplex helps stabilize biological structures (such as cells, proteins, enzymes, and nucleic acids) against environmental stresses like temperature changes, high salt concentrations, strong UV radiation, and dehydration. ― About Effectiveness ― Moisturizing Persistence (In-Vivo): Lasts for 1 week. Skin Barrier Function and Protection of Langerhans Cells (In-Vivo): 100% protection. Promotion of Heat Shock Protein Production (In-Vitro), Anti-Pollution Effect (Ex-Vivo), Protection against Blue Light, UV-A, UV-B, IR-A, and Heat, Anti-Aging Effects (In-Vivo): Improvement in Skin Roughness (86% improvement), Wrinkle Depth (32% improvement), Elasticity (82% improvement), Smoothness (61% improvement), Whitening Effect (In-Vivo): Improvement in Skin Pigmentation (25% improvement).

• Cosmetic materials and raw materials
• Other pharmaceutical intermediates and cosmetic ingredients
• Other medical supplies and cosmetic manufacturing materials

Achieved 100% purity of 2αGG, the most active isomer of the miraculous resurrection plant, through our unique manufacturing technology. High moisturizing, wound healing, and cell revitalization functions.

Glycoin natural is a product composed of 100% unique structural isomers manufactured using patented biotechnology by Bitop AG in Germany. These structural isomers are found only in the miraculous resurrection plant Myrothamnus flabellifolia and blue-green algae (spirulina), which are known as the miracle plants of the desert that can revive green with just a small amount of water even after being dried for 50 years. Glycoin natural activates the rejuvenating power of tired skin, stressed skin, and aging skin. <Efficacy> Stimulates cell regeneration, growth factors, and ATP synthesis Activates antioxidant enzymes (SOD1, SOD2, CAT) Immediate moisturizing effect improved by 49% (after one application) Skin elasticity improved by 93% Skin smoothness improved by 61% Skin thickness increased by 9.9% Reduces sunburn and skin redness Tissue repair and wound healing effects maintained for 48 hours

• Cosmetic materials and raw materials
• Other pharmaceutical intermediates and cosmetic ingredients
• Other medical supplies and cosmetic manufacturing materials

New hyaluronic acid crosspolymer, refreshing and moist feeling, anti-wrinkle, pore care, pore tightening, moisturizing effect.

Cross Linked HA is a hyaluronic acid cross-polymer made using Contipro's patented manufacturing method. The patented manufacturing technology creates a soft and fine gel, providing a unique sensation that is not found in conventional high molecular weight sodium hyaluronate. <About the Sensation> Immediately after application, it retains the pleasant texture of the chewy sodium hyaluronate, while the fine gel quickly penetrates the skin's grooves (such as wrinkles and pores), resulting in a moist yet refreshing sensation. <About Effectiveness> - Moisturizing effect (62% improvement) - Anti-wrinkle effect (46% reduction in wrinkles) - Sustained release effect of active ingredients (51% increase in the activity of Vitamin B3)

• Cosmetic materials and raw materials
• Other pharmaceutical intermediates and cosmetic ingredients
• Other medical supplies and cosmetic manufacturing materials

We are introducing Contipro's hyaluronic acid derivatives, such as sodium hyaluronate and hydrolyzed sodium hyaluronate, which have unique efficacy.

Contipro is a biotechnology company located in the Czech Republic. It is a global manufacturer that produces and sells various active ingredients, primarily sodium hyaluronate, in the pharmaceutical and cosmetic fields, supplying to over 60 countries for approximately 30 years. The listed products are categorized into three groups: sodium hyaluronate, natural polysaccharides, and peptides. <Sodium Hyaluronate> We offer grades with a molecular weight distribution ranging from 2.3 million Da to 10,000 Da, and we have confirmed differences in efficacy due to varying skin permeability based on molecular weight through Vivo and Vitro data. Additionally, we also have hydrolyzed sodium hyaluronate as a grade with excellent skin permeability. <Derivatives> We have confirmed through Vivo and Vitro data that sodium hyaluronate possesses not only its inherent properties of moisturizing, barrier function, anti-wrinkle, and calming effects but also efficacy in whitening, sebum secretion regulation, sebum suppression, and improvement of skin texture. *For more details, please download the PDF or feel free to contact us.

• Pharmaceutical materials and carriers
• Cosmetic materials and raw materials
• Other pharmaceutical intermediates and cosmetic ingredients

Hyaluronic Acid Na for Whitening that Maximizes the Function of Alpha-Linolenic Acid

HyWhite is a sodium hyaluronate with whitening (brightening) properties manufactured by Contipro in the Czech Republic. HyWhite is a product that has high whitening (brightening) effects, made by partially replacing low molecular weight sodium hyaluronate with alpha-linolenic acid, which has high permeability to the skin. Alpha-linolenic acid is widely known for its strong melanin production suppression effects, and in in-vitro results, it has been confirmed to have a higher suppression effect than kojic acid. On the other hand, it is also known as a component that is difficult to formulate due to its low skin permeability and instability. This product promotes the absorption of alpha-linolenic acid, which has been a problem in the past, by replacing part of the low molecular weight hyaluronate with alpha-linolenic acid, thereby improving stability and maximizing the effects of alpha-linolenic acid. *In addition to HyWhite, Contipro also manufactures sodium hyaluronate, hydrolyzed sodium hyaluronate, and other hyaluronate derivatives.

• Other additives
• Cosmetic materials and raw materials

Achieves excellent "anti-wrinkle effect," "moisture retention effect," and "skin barrier function recovery effect"! Low molecular weight hyaluronic acid oligosaccharides with excellent permeability.

OligoHyaferre is a hydrolyzed sodium hyaluronate manufactured by a company in the Czech Republic, known for its excellent "anti-wrinkle effect," "moisture retention effect," and "skin barrier function recovery effect." In vitro studies have confirmed its effects of MMP inhibition, TNF-α inhibition, promotion of angiogenesis, and gene expression of HAS2. These effects lead to favorable results in in vivo "anti-wrinkle tests" and "skin barrier function recovery tests."

• Other additives
• Cosmetic materials and raw materials
• Other pharmaceutical intermediates and cosmetic ingredients

We will be exhibiting at "Mechatrotech (or Monozukuri World)" held at Port Messe Nagoya (Nagoya International Exhibition Hall). During the event, we will showcase various products. We invite all related parties to come and visit us. 【Suppliers】 - Pferd - DC Swiss - Ensitec - Erichsen (Sheet metal) - EPK (if space allows) - Pipetite (if space allows)

We would like to extend our heartfelt congratulations on the continued prosperity of your esteemed company. Our company will be exhibiting at the following trade show, where we will introduce a number of products, including our new product, the Pillow Packaging Full Air Tightness Inspection Machine MSQ-2003. We sincerely apologize for the inconvenience during your busy schedule, but we would like to invite you to visit us at this opportunity. 【 Exhibition Name 】 JAPAN PACK 2025 Japan Packaging Industry Exhibition https://www.japanpack.jp/ 【 Dates 】 October 7 (Tuesday) to October 10 (Friday), 2025 *4 days 10:00 AM to 5:00 PM 【 Venue / Booth Number 】 Tokyo Big Sight / East Hall 8, Booth 8-505

Our company will be exhibiting at the "14th Fukushima Renewable Energy Industry Fair (REIF Fukushima 2025)" held at Big Palette Fukushima from Thursday, October 16, 2025, to Friday, October 17, 2025. Focusing on energy visualization solutions that can be started "immediately," we will introduce power monitoring solutions for each equipment and load through examples of the overall system configuration. 【Main Exhibited Products】 - Gateway BOX We will showcase the "Gateway BOX," a product that packages the necessary equipment for easy adoption of the visualization system. - PAL-Plus type E2 (Scheduled for release soon) We will introduce a "smart" clamp CT that can easily measure power for three-phase three-wire and single-phase three-wire systems (scheduled for release soon). - CEW-M4 / PAL-Plus As a monitoring system that can display power consumption and remaining power capacity, we will present the manager software "CEW-M4," which supports up to 20,000 points, and the Modbus-compatible AC current sensor "PAL-Plus." We sincerely look forward to your visit.

Toyo Machinery Co., Ltd. will be exhibiting at the high-performance film exhibition held at Makuhari Messe. The High-Performance Film Exhibition - FILMTECH JAPAN - is a specialized exhibition where molding processing technologies, materials, and functional films themselves are showcased all in one place. Experts from various fields, including the technology departments of film manufacturers, electronics, automotive, batteries, construction and building materials, and food and beverages, will attend in search of functional films. At Toyo Machinery, we will display actual machines for waviness correction and wrinkle removal while running film, allowing you to see their effects and functions. We will also introduce the quality management system (weight, thickness, moisture, etc.) from the German company Marlo. ↓↓↓Toyo Machinery's exhibitor information↓↓↓ https://www.material-expo.jp/tokyo/ja-jp/search/2025/directory/details.org-a11cd7f5-2a7b-4ea7-85ce-cde885acd2dd.html#/ *If you wish to attend, you can pre-register via the "Details & Application" link below. We sincerely look forward to your visit.

We will be exhibiting at the Okayama Technology Exhibition (OTEX) 2025, which will be held at Convex Okayama from November 12 (Wednesday) to November 13 (Thursday), 2025. We will showcase our eco-board pallets (paper pallets) as well as comprehensive packaging solutions suitable for one-way shipments such as exports. Our products will assist in addressing challenges related to environmental considerations in the context of the SDGs and the promotion of white logistics. ■ Our booth: 46 (Company products) We sincerely look forward to your visit, and we hope you can come together.