Report on the 10th COSME Tech 2020 Cosmetics Development Exhibition

Ultimate moisturizing produced by Halomonas sp. with protection (UV, BL, IRA, viruses), anti-inflammatory, and femcare ingredient Ectoin Natural.

<Ectoin Natural Features> Ectoin is a type of cyclic amino acid produced by extremophilic microorganisms (Halomonas) that inhabit salt lakes and deserts. It has 4 moles of bound water for every 1 mole of ectoin, giving it cosmotropic properties. This characteristic contributes to the stabilization of interactions between water molecules and forms a hydrocomplex. This hydrocomplex helps stabilize biological structures (such as cells, proteins, enzymes, and nucleic acids) against environmental stresses like temperature changes, high salt concentrations, strong UV exposure, and dehydration. ― About Effectiveness ― In Vivo Vaginal care effects: Reduction of vaginal atrophy symptoms, vaginal moisturization (50% improvement in dryness), improvement of vaginal heat and itching. Moisturizing persistence (lasting for 1 week), barrier recovery, erythema suppression, protection of Langerhans cells (100% protection). Anti-aging effects: Improvement in skin roughness (86% improvement), wrinkle depth (32% improvement), elasticity (82% improvement), smoothness (61% improvement), whitening effect (25% improvement). In Vitro: Promotion of heat shock protein production, anti-pollution effects (Ex-Vivo), protection against blue light, UV-A, UV-B, and IR-A.

• Cosmetic materials and raw materials
• Other pharmaceutical intermediates and cosmetic ingredients
• Other medical supplies and cosmetic manufacturing materials

Extreme environment microorganisms, long-lasting moisture, UV protection, Langerhans cell protection, anti-pollution, anti-aging, fermentation, hair care.

<Ectoin Natural Features> Ectoin is a type of cyclic amino acid produced by extremophilic microorganisms (Halomonas) that inhabit salt lakes and deserts. It has 4 moles of bound water per 1 mole of Ectoin, exhibiting cosmotropic properties. This characteristic contributes to the stabilization of interactions between water molecules, forming a hydrocomplex. This hydrocomplex helps stabilize biological structures (such as cells, proteins, enzymes, and nucleic acids) against environmental stresses like temperature changes, high salt concentrations, strong UV radiation, and dehydration. ― About Effectiveness ― Moisturizing Persistence (In-Vivo): Lasts for 1 week. Skin Barrier Function and Protection of Langerhans Cells (In-Vivo): 100% protection. Promotion of Heat Shock Protein Production (In-Vitro), Anti-Pollution Effect (Ex-Vivo), Protection against Blue Light, UV-A, UV-B, IR-A, and Heat, Anti-Aging Effects (In-Vivo): Improvement in Skin Roughness (86% improvement), Wrinkle Depth (32% improvement), Elasticity (82% improvement), Smoothness (61% improvement), Whitening Effect (In-Vivo): Improvement in Skin Pigmentation (25% improvement).

• Cosmetic materials and raw materials
• Other pharmaceutical intermediates and cosmetic ingredients
• Other medical supplies and cosmetic manufacturing materials

Achieved 100% purity of 2αGG, the most active isomer of the miraculous resurrection plant, through our unique manufacturing technology. High moisturizing, wound healing, and cell revitalization functions.

Glycoin natural is a product composed of 100% unique structural isomers manufactured using patented biotechnology by Bitop AG in Germany. These structural isomers are found only in the miraculous resurrection plant Myrothamnus flabellifolia and blue-green algae (spirulina), which are known as the miracle plants of the desert that can revive green with just a small amount of water even after being dried for 50 years. Glycoin natural activates the rejuvenating power of tired skin, stressed skin, and aging skin. <Efficacy> Stimulates cell regeneration, growth factors, and ATP synthesis Activates antioxidant enzymes (SOD1, SOD2, CAT) Immediate moisturizing effect improved by 49% (after one application) Skin elasticity improved by 93% Skin smoothness improved by 61% Skin thickness increased by 9.9% Reduces sunburn and skin redness Tissue repair and wound healing effects maintained for 48 hours

• Cosmetic materials and raw materials
• Other pharmaceutical intermediates and cosmetic ingredients
• Other medical supplies and cosmetic manufacturing materials

New hyaluronic acid crosspolymer, refreshing and moist feeling, anti-wrinkle, pore care, pore tightening, moisturizing effect.

Cross Linked HA is a hyaluronic acid cross-polymer made using Contipro's patented manufacturing method. The patented manufacturing technology creates a soft and fine gel, providing a unique sensation that is not found in conventional high molecular weight sodium hyaluronate. <About the Sensation> Immediately after application, it retains the pleasant texture of the chewy sodium hyaluronate, while the fine gel quickly penetrates the skin's grooves (such as wrinkles and pores), resulting in a moist yet refreshing sensation. <About Effectiveness> - Moisturizing effect (62% improvement) - Anti-wrinkle effect (46% reduction in wrinkles) - Sustained release effect of active ingredients (51% increase in the activity of Vitamin B3)

• Cosmetic materials and raw materials
• Other pharmaceutical intermediates and cosmetic ingredients
• Other medical supplies and cosmetic manufacturing materials

We are introducing Contipro's hyaluronic acid derivatives, such as sodium hyaluronate and hydrolyzed sodium hyaluronate, which have unique efficacy.

Contipro is a biotechnology company located in the Czech Republic. It is a global manufacturer that produces and sells various active ingredients, primarily sodium hyaluronate, in the pharmaceutical and cosmetic fields, supplying to over 60 countries for approximately 30 years. The listed products are categorized into three groups: sodium hyaluronate, natural polysaccharides, and peptides. <Sodium Hyaluronate> We offer grades with a molecular weight distribution ranging from 2.3 million Da to 10,000 Da, and we have confirmed differences in efficacy due to varying skin permeability based on molecular weight through Vivo and Vitro data. Additionally, we also have hydrolyzed sodium hyaluronate as a grade with excellent skin permeability. <Derivatives> We have confirmed through Vivo and Vitro data that sodium hyaluronate possesses not only its inherent properties of moisturizing, barrier function, anti-wrinkle, and calming effects but also efficacy in whitening, sebum secretion regulation, sebum suppression, and improvement of skin texture. *For more details, please download the PDF or feel free to contact us.

• Pharmaceutical materials and carriers
• Cosmetic materials and raw materials
• Other pharmaceutical intermediates and cosmetic ingredients

Hyaluronic Acid Na for Whitening that Maximizes the Function of Alpha-Linolenic Acid

HyWhite is a sodium hyaluronate with whitening (brightening) properties manufactured by Contipro in the Czech Republic. HyWhite is a product that has high whitening (brightening) effects, made by partially replacing low molecular weight sodium hyaluronate with alpha-linolenic acid, which has high permeability to the skin. Alpha-linolenic acid is widely known for its strong melanin production suppression effects, and in in-vitro results, it has been confirmed to have a higher suppression effect than kojic acid. On the other hand, it is also known as a component that is difficult to formulate due to its low skin permeability and instability. This product promotes the absorption of alpha-linolenic acid, which has been a problem in the past, by replacing part of the low molecular weight hyaluronate with alpha-linolenic acid, thereby improving stability and maximizing the effects of alpha-linolenic acid. *In addition to HyWhite, Contipro also manufactures sodium hyaluronate, hydrolyzed sodium hyaluronate, and other hyaluronate derivatives.

• Other additives
• Cosmetic materials and raw materials

Achieves excellent "anti-wrinkle effect," "moisture retention effect," and "skin barrier function recovery effect"! Low molecular weight hyaluronic acid oligosaccharides with excellent permeability.

OligoHyaferre is a hydrolyzed sodium hyaluronate manufactured by a company in the Czech Republic, known for its excellent "anti-wrinkle effect," "moisture retention effect," and "skin barrier function recovery effect." In vitro studies have confirmed its effects of MMP inhibition, TNF-α inhibition, promotion of angiogenesis, and gene expression of HAS2. These effects lead to favorable results in in vivo "anti-wrinkle tests" and "skin barrier function recovery tests."

• Other additives
• Cosmetic materials and raw materials
• Other pharmaceutical intermediates and cosmetic ingredients

Cancer Biomarker Discovery 2026 is an online seminar focused on the latest biomarker discovery and analysis technologies in the field of cancer research. Advanced technologies that support the understanding, diagnosis, and treatment research of cancer, such as liquid biopsy, proteomics, and spatial omics analysis, will be introduced. This seminar primarily targets basic and clinical researchers involved in cancer research, as well as those interested in biomarker discovery and analysis. In our section, we will introduce the latest techniques in fluorescent imaging for spatial biology and spatial proteomics research, centered around the Invitrogen EVOS S1000 Spatial Imaging System. Unlike traditional microscopy, which is limited in multiplex immunostaining, our spectral unmixing technology enables simultaneous imaging of up to 9 colors, allowing for rapid data acquisition with minimized sample damage. Additionally, we will explain a practical workflow using direct conjugate antibodies and TSA-based Invitrogen Aluora amplification reagents, proposing high-reproducibility analysis methods that leverage spatial information. For research use only. Not for diagnostic use.

In spatial biology/spatial proteomics research, the coexistence of "high-quality multiplex fluorescence image acquisition" and "reliable quantitative analysis" is becoming increasingly important. This webinar, co-hosted by Thermo Fisher Scientific and Indica Labs, will introduce a practical workflow that allows for a comprehensive understanding from imaging to analysis. Recommended for: - Those interested in spatial biology/spatial proteomics research who want to systematically understand the entire process from imaging to analysis. - Those who are already conducting or considering the implementation of multiplex imaging (multiplex immunostaining). - Those who feel limited by traditional four-color fluorescence observation and wish to engage in higher-dimensional spatial information analysis. This is a free seminar, so please join us. *For research use only. Not for diagnostic use.

[Speaker] Shinya Okimoto, Founder & CEO of Okiwa Studio LLC [Lecture Topics] Part 1: The tectonic shifts in the display industry and the market potential of QDEL Part 2: Business solutions to the "three major technical challenges" for the practical application of QDEL Part 3: Winning strategies for Japanese companies: Targeting the "high value-added components" sector Part 4: Redefining the business portfolio towards 2030 Part 5: Q&A

[Lecturer] Mr. Kenji Kimura, Chief Researcher, Nuclear Group, Power Unit, Japan Energy Economics Research Institute (JEA), and Research Strategy Group, Research Strategy Unit [Key Lecture Content] In recent years, the role of nuclear power has been highlighted in the context of global warming countermeasures and energy security, and more recently, in response to the increased electricity demand due to the use of AI and the expansion of data centers. Under these circumstances, new movements are being observed in countries that utilize nuclear power. In the United States, investments in nuclear power by IT companies are becoming more active, while in Europe, measures are being promoted to enhance the feasibility of new projects. In Japan, the role of nuclear power has been clarified once again, and discussions surrounding specific institutional measures are gradually progressing. This lecture will provide an overview of these movements and organize the trends that should be noted in the future. [Lecture Items] 1. Global Situation and Nuclear Power 2. Trends in Other Countries 3. Trends in New Reactor Development 4. Domestic Trends and Challenges 5. Key Points to Watch After 2026 6. Q&A / Business Card Exchange

At our booth, we will mainly showcase the following products: 〇 Our original product T-Arm 〇 Tecnospiro's product Spider 〇 Knight Global's product Air Balancer 〇 A drone for equipment inspections ▽------------------------------------------------------------▽ From April 8 (Wednesday) to April 10 (Friday) at Port Messe Nagoya ■ Manufacturing World Nagoya (Booth Number: 16-40) https://www.manufacturing-world.jp/nagoya/ja-jp.html ■ Pre-registration for attendance is convenient! https://www.manufacturing-world.jp/nagoya/ja-jp/register.html?code=1603005193330205-52G △------------------------------------------------------------△ We look forward to your visit.