*Application Closed* February Online LIVE Seminar Held! ~Pharmaceutical Seminar~

Step into the utilization of thermal analysis devices. Numerous measurement examples of DSC included. Online seminar held.

This document provides a detailed introduction to the characterization of pharmaceutical substances using Differential Scanning Calorimetry (DSC). It explains the "Modulated DSC," which allows for high-sensitivity and high-resolution measurements, and the "Tzero DSC," which measures the absolute values of heat flow, over more than 40 pages based on general characterization examples. You can also find an introduction to various analytical instruments offered by our company. 【Main Contents】 ■ Amorphous structure (detection of amorphous content in crystalline compounds including glass transition) ■ Degree of crystallinity (melting and crystallization, purity, polymorphism) ■ Drug-excipient interactions ■ Protein denaturation ■ Freeze-drying ■ Other complementary thermal analysis techniques *This document is available for immediate viewing via "PDF Download."

• Analytical Equipment and Devices

This is an introduction to protein analysis cases and related equipment by analysis specialists. This time, we will cover three devices: ITC, TAM, and NanoDSC!

Measurement capabilities offered by TA Instruments ☆ Thermal analysis / glass transition, crystallization, thermogravimetric analysis, curing reactions, expansion rate, thermal conductivity, shrinkage rate, effects of moisture, etc. ☆ Viscoelastic measurements (rheology, rheometers) / viscoelasticity, elastic modulus, viscosity, stress relaxation, creep, master curves, residual strain, molecular weight, molecular weight distribution, etc. ☆ Microcalorimetry / intermolecular interactions, crystallization, amorphousness, aggregation/precipitation, dispersibility, solubility, compatibility, wettability, stability, adsorption, etc. ☆ Fatigue testing / tensile strength, temperature dependence, viscoelasticity, elastic modulus, viscosity, stress relaxation, creep, master curves, residual strain, etc.

• Analytical Equipment and Devices

How about one for the lab? Introducing the Discovery DSC series, the world's most outstanding and highly versatile differential scanning calorimeter.

TA Instruments continues to be the leading company in the world of DSC with innovative and outstanding technology. It provides reliable data and enhances workflow and productivity in laboratories. Material property analysis is essential at all stages of product design, manufacturing, processing, and application. Differential Scanning Calorimetry (DSC) is the most widely used thermal analysis instrument for evaluating the physical properties of a wide range of materials, including polymers, pharmaceuticals, food, biomaterials, organic compounds, inorganic compounds, and composites.

• Analytical Equipment and Devices

Provides high reliability! An excellent tool for measuring a wide range of molecular interactions.

The Isothermal Titration Calorimeter (ITC) is a device that detects the heat changes associated with titration at a constant temperature and is primarily used for analyzing molecular interactions. It measures the minute heat changes that occur when molecules bind to each other, allowing for the determination of binding ratio (n), binding constant (Ka), and the enthalpy change of binding (ΔH) from the resulting titration curve. Affinity ITC is an isothermal titration calorimeter that provides high sensitivity, high reproducibility, and advanced ITC technology in life science research environments. With AccuShot technology, it delivers precise amounts of titrant to the appropriate location, and the FlexSpin stirring function achieves efficient mixing and high sensitivity. The automatic cleaning function prevents contamination between samples. It offers the option of standard capacity (1.0 mL) or low capacity cells (190 µL), and a temperature-controlled auto-sampler for 96 wells is also available.

• Analytical Equipment and Devices

A differential scanning calorimeter specialized for studying biological samples. It offers the highest sensitivity and excellent operability.

TA Instruments continues to be the leading company in the world of DSC with innovative and outstanding technology. It provides reliable data and enhances workflow and productivity in laboratories. The Nano DSC is a differential scanning calorimeter (DSC) that can detect minute heat changes associated with the conformational changes of biomolecules. Characterization of materials is essential at all stages of product design, manufacturing, processing, and application. Differential scanning calorimeters/nano DSCs are the most widely used thermal analysis instruments for the physical property evaluation of a broad range of materials, including polymers, pharmaceuticals, food, biomaterials, organic compounds, inorganic compounds, and composites.

• Analytical Equipment and Devices

For the evaluation of reactions of various substances.

TAM offers the highest level of sensitivity, flexibility, and performance. By using a highly sensitive microcalorimeter along with various accessories, it precisely controls various experimental conditions. Up to four calorimeters can be used simultaneously, allowing for repeated experiments and a variety of experiments to be conducted. Additionally, its modular design allows for the addition of multiple calorimeters, enhancing sample processing capacity and functionality. Adding a multi-calorimeter with six mini-calorimeters significantly improves sample throughput. The TAM 4 employs patented thermostat technology, controlling the temperature of the liquid constant temperature bath with an accuracy of 0.0001±730°C. There are three operating modes: isothermal, step isothermal, and temperature scanning mode.

• Analytical Equipment and Devices

World leader in thermal analysis, calorimetry, and rheology / Comprehensive catalog of TA Instruments.

◆TA Instrument Handled Products◆ ■Thermal Analysis Equipment Differential Scanning Calorimeter Discovery DSC Thermogravimetric Analyzer Discovery TGA Differential Scanning Calorimeter DSC Thermogravimetric Analyzer TGA Vapor Adsorption/Desorption Measurement Device VTI-SA+ Simultaneous Differential Thermal and Thermogravimetric Analyzer SDT Thermomechanical Analyzer TMA Dynamic Mechanical Analyzer DMA ■Thermal Property Measurement Equipment Laser Flash Method Thermal Property Measurement Device DLF Xenon Flash Method Thermal Property Measurement Device DXF Thermal Conductivity Measurement Device DTC FOX Thermal Expansion Measurement Device DIL ODLT, ODHT P11 Heating Microscope HSM, HSML Fleximeter FLEX ■Viscoelasticity Measurement Equipment DHR ARES-G2 RSA-G2 Air Chiller System ACS-3 Rubber Testing Machine ■Microcalorimeters Isothermal Titration Calorimeter Nano ITC, Affinity ITC Differential Scanning Calorimeter Nano DSC Multi-Cell Differential Scanning Calorimeter MC DSC Isothermal Calorimeter TAM ●For other functions and details, please download the catalog or contact us.

• Analytical Equipment and Devices

This is the lecture material posted on YouTube ~DSC Basic Edition 1~. It is available for free download, so please feel free to make use of it.

Data Content This is a PDF version of the lecture materials from YouTube, converted for easier viewing. The video consists of a total of 12 pages and provides an easy-to-understand explanation for beginners about: - Principles - Analytical methods - Enthalpy relaxation (recovery) I think it might be difficult to understand with just the lecture materials, so please also refer to the YouTube videos below. YouTube TA Summary Site: https://www.youtube.com/channel/UCk3XzqRdsNQz1hJlqKrfujQ DSC Basics Part 1: https://www.youtube.com/watch?v=DbGpordpweg

• Analytical Equipment and Devices

This is the lecture material posted on YouTube ~Rheology: Basic Edition 1~. It is available for free download, so please feel free to make use of it.

Data Content This is a PDF version of the lecture materials from YouTube, converted for better readability. The video consists of a total of 12 pages and provides easy-to-understand explanations for beginners on the following topics: - What is rheology? - What is viscoelasticity? - About measurement modes. I think it might be difficult to understand just from the lecture materials, so please also refer to the YouTube videos below. YouTube TA Summary Site: https://www.youtube.com/channel/UCk3XzqRdsNQz1hJlqKrfujQ Rheology Basics Part 1: https://www.youtube.com/watch?v=_gPrWIK6yYo&t=4s

• Analytical Equipment and Devices

This is an introduction to analysis cases and related devices for bio research by analysis specialists. This time, we will cover three devices: ITC, TAM, and NanoDSC!

Measurement capabilities offered by TA Instruments ☆ Thermal analysis / Glass transition, crystallization, thermogravimetric analysis, curing reactions, expansion rate, thermal conductivity, shrinkage rate, effects of moisture, etc. ☆ Viscoelastic measurements (rheology) / Viscoelasticity, elastic modulus, viscosity, stress relaxation, creep, master curve, residual strain, molecular weight, molecular weight distribution, etc. ☆ Microcalorimetry / Intermolecular interactions, crystallization, amorphousness, aggregation/precipitation, dispersibility, solubility, compatibility, wettability, stability, adsorption, etc. ☆ Fatigue testing / Tensile strength, temperature dependence, viscoelasticity, elastic modulus, viscosity, stress relaxation, creep, master curve, residual strain, etc.

• Analytical Equipment and Devices

This is an introduction to a protein analysis case study by a specialist in analysis. This time, we evaluated the changes in denaturation temperature behavior with the addition of Zn2+ using NanoDSC.

Measurement capabilities offered by TA Instruments ☆ Thermal analysis / glass transition, crystallization, thermogravimetric analysis, curing reactions, expansion rate, thermal conductivity, shrinkage rate, effects of moisture, etc. ☆ Viscoelastic measurements (rheology) / viscoelasticity, elastic modulus, viscosity, stress relaxation, creep, master curve, residual strain, molecular weight, molecular weight distribution, etc. ☆ Microcalorimetry / intermolecular interactions, crystallization, amorphousness, aggregation/precipitation, dispersibility, solubility, compatibility, wettability, stability, adsorption, etc. ☆ Fatigue testing / tensile strength, temperature dependence, viscoelasticity, elastic modulus, viscosity, stress relaxation, creep, master curve, residual strain, etc.

• Analytical Equipment and Devices

This is an introduction to a protein analysis case study by a specialist in analysis. This time, we evaluated the substrate degradation rate and the effects of inhibitors using ITC.

Measurement capabilities offered by TA Instruments ☆ Thermal analysis / glass transition, crystallization, thermogravimetric analysis, curing reactions, expansion rate, thermal conductivity, shrinkage rate, effects of moisture, etc. ☆ Viscoelastic measurement (rheology) / viscoelasticity, modulus of elasticity, viscosity, stress relaxation, creep, master curve, residual strain, molecular weight, molecular weight distribution, etc. ☆ Microcalorimetry / intermolecular interactions, crystallization, amorphousness, aggregation/precipitation, dispersibility, solubility, compatibility, wettability, stability, adsorption, etc. ☆ Fatigue testing / tensile strength, temperature dependence, viscoelasticity, modulus of elasticity, viscosity, stress relaxation, creep, master curve, residual strain, etc.

• Analytical Equipment and Devices

Virus Research Case Study: Characterization of Viruses - Evaluation of Structure and Binding Properties Using Calorimetry -

Currently, the novel coronavirus infection (COVID-19) is a global issue. TA Instruments hopes to contribute, even in a small way, to addressing the challenges posed by COVID-19 by introducing examples of virus research conducted by universities and research institutions using TA equipment. Research institutions that incorporate studies using Differential Scanning Calorimetry (DSC) and Isothermal Titration Calorimetry (ITC) to understand the structure and mechanisms of viruses are rapidly advancing. Please take a look at the examples.

• Analytical Equipment and Devices

This is an introduction to case studies related to cells by a specialist in analysis. This time, we will present measurement examples using thermal analysis equipment that is useful for evaluations involving cells.

Measurement capabilities offered by TA Instruments ☆ Thermal analysis / glass transition, crystallization, thermogravimetric analysis, curing reactions, expansion rate, thermal conductivity, shrinkage rate, effects of moisture, etc. ☆ Viscoelastic measurements (rheology, rheometers) / viscoelasticity, elastic modulus, viscosity, stress relaxation, creep, master curves, residual strain, molecular weight, molecular weight distribution, etc. ☆ Microcalorimetry / intermolecular interactions, crystallization, amorphousness, aggregation/precipitation, dispersibility, solubility, compatibility, wettability, stability, adsorption, etc. ☆ Fatigue testing / tensile strength, temperature dependence, viscoelasticity, elastic modulus, viscosity, stress relaxation, creep, master curves, residual strain, etc.

• Analytical Equipment and Devices

This is an introduction to case studies of pharmaceutical analysis by a specialist in analysis. This time, we will look at the pharmacokinetics of suppositories and the viscoelastic measurement of hair wax.

The viscoelastic measurement device, the "Discovery Hybrid Rheometer," controls the surrounding environment and performs measurements over a wide range of force, strain, and strain rate. We offer three models to meet the needs for sensitivity and capability, from the high-sensitivity HR-30 to the general-purpose HR-10. This product improves various performances and specifications, achieving accurate strain, strain rate, stress control, and normal force, and is equipped with our innovative patented Smart Swap geometry and Smart Swap temperature control system. 【Main Features】 ■ Ultra-low inertia drag cup motor (patented) ■ Magnetic bearings (patented) ■ High-resolution optical encoder ■ Optical encoder dual reader (patent pending) ■ Normal force rebalance transducer (FRT)

• Analytical Equipment and Devices

This is an introduction to medical-related analysis cases by a specialist in analysis. This time, we will present measurement cases of mechanical properties and fatigue tests that are useful for evaluating the pericardium.

The planar biaxial testing machine (TestBench testing device) is designed to conduct tests similar to those performed on a load frame. This allows for the evaluation of the sample's stiffness, strength, and durability, as well as the measurement of yield strength, ultimate strength, and fatigue life. A modular approach that includes multi-channel and multi-axis options enables a wide range of configurations and performance. It uses 200N and 400N ElectroForce linear motors mounted on a horizontal base plate to accommodate various testing needs.

• Analytical Equipment and Devices

Using PLA beverage cups as measurement samples, thermal and mechanical properties were investigated utilizing thermal analysis techniques such as temperature-modulated DSC and DMA!

As the industrial sector has begun to focus more on developing and manufacturing environmentally friendly products, various new biodegradable polymers have been adopted. Poly(Lactic Acid) (PLA) is a biodegradable aliphatic polyester produced from lactic acid obtained through the saccharification and fermentation of starch. Due to its high mechanical strength comparable to PETE and good biocompatibility, PLA has been commonly used in biomedical applications such as sutures and stents, but the expansion of PLA's applications is being considered. Understanding the properties of PLA is essential for the development of new applications. We present materials that investigate the thermal and mechanical properties of PLA-based beverage cups using temperature-modulated DSC and DMA. *Please download the materials.

• Analytical Equipment and Devices

This is an introduction to a case study of insulation material analysis by a specialist in analysis. This time, we will present a measurement case using a thermal conductivity measurement device.

Measurement capabilities offered by TA Instruments ☆ Thermal analysis / glass transition, crystallization, thermogravimetric analysis, curing reactions, expansion rate, thermal conductivity, shrinkage rate, effects of moisture, etc. ☆ Viscoelastic measurements (rheology) / viscoelasticity, elastic modulus, viscosity, stress relaxation, creep, master curve, residual strain, molecular weight, molecular weight distribution, etc. ☆ Microcalorimetry / intermolecular interactions, crystallization, amorphousness, aggregation/precipitation, dispersibility, solubility, compatibility, wettability, stability, adsorption, etc. ☆ Fatigue testing / tensile strength, temperature dependence, viscoelasticity, elastic modulus, viscosity, stress relaxation, creep, master curve, residual strain, etc.

• Analytical Equipment and Devices

Evaluation of the generation process and characteristics of biofuels using a modular thermal analysis measurement device (TAM).

The calorimetry measurement device (TAM series) is an instrument known as a microcalorimeter that measures very small amounts of heat. By combining a thermostat with high isothermal performance with a calorimeter (calorimeter) suited to the sample and measurement method, it is possible to measure minute heat generated or consumed during physical processes or chemical reactions with sensitivity exceeding microwatts. It is a useful tool that can contribute to the research and development of biofuels and environmental improvement, allowing real-time calorimetry measurements while performing operations such as the addition, mixing, and titration of chemicals through module combinations. This document provides a detailed explanation of high-sensitivity calorimetry measurements of biofuels, which are difficult to observe with conventional differential scanning calorimeters (DSC), as well as real-time measurements of heat changes associated with chemical reactions. ◇ Quantification of wax based on the heat of solidification reactions ◇ Evaluation of the production rate of biofuels *Please download the document.

• Analytical Equipment and Devices

Our company will be exhibiting at the "Fukushima Tech Create 2026 Results Presentation" held in Okuma Town, Fukushima Prefecture. At this event, promising startups aiming for entrepreneurship and technological development in areas such as Hamadori, Fukushima Prefecture, will present their research and business results. ★ Participating Industry Fields Decommissioning / Robotics and Drones / Energy, Environment, and Recycling Agriculture, Forestry, and Fisheries / Medical-related / Aerospace On the 29th (Thursday), a talk event featuring notable figures and local entrepreneurs will also be held. A collection of attention-grabbing technologies that will shape the future will be gathered, so please feel free to stop by the IIDA booth when you visit. [Limited Company Iida Seisakusho Fukushima No. 2 Factory] 〒969-1204 21-2 Mizukami, Nukazawa, Motomiya City, Fukushima Prefecture TEL: 0243-64-2320 FAX: 0243-64-2571

Our company will be exhibiting at the "New Functional Materials Exhibition 2025," which will be held at Tokyo Big Sight starting from January 29, 2025 (Wednesday). We would be delighted if you could visit us at the venue if you have the time. ┏━━━━━━━━━━━━━━━━━━━━━━━━━━ ■ Exhibition Information Details ┗━━━━━━━━━━━━━━━━━━━━━━━━━━ Exhibition Name: "New Functional Materials Exhibition 2025" Exhibition Venue: Tokyo Big Sight, East Hall 5 Booth Number: 5W-23 Teijin/Teijin Frontier Co., Ltd. Event Dates: January 29 (Wednesday) to 31 (Friday), 2025, 10:00 AM to 5:00 PM ■ About the Exhibited Products At this exhibition, we will broadly introduce our newly developed high-performance non-woven fabrics. We will showcase ultra-thin and ultra-light non-woven fabrics, newly developed marine biodegradable PLA, carbon paper, porous high-performance membrane "MiraimⓇ," graphene heat dissipation paint that enhances heat dissipation effects and lowers the temperature of objects, heat dissipation and electromagnetic wave absorption sheets, water treatment technology, oil-water separation technology, and various other new high-performance products. All of our exhibition staff sincerely look forward to your visit.

We will be exhibiting at the "1st [Nagoya] High-Performance Plastics Exhibition -PLASTIC JAPAN-" held at Port Messe Nagoya. We will introduce samples and characteristics of our carbon nanofibers blended with various resins. The conductive carbon nanofiber (high dispersion) ALP-NK1 (550W/mK) has also been added to our product lineup, and we will propose materials tailored to customer needs, starting with heat dissipation applications. Additionally, we will showcase extruded round bars of PEEK blended with carbon nanofibers and their processed products, as well as doctor blades designed for battery materials. As a business model for our nanomaterial business, we offer sales of CNF powder and prototype sales of resin blends (pellets and liquid resins) according to customer requests. Furthermore, we will introduce various silicon materials, including silicon monoxide, which is gaining attention as electrode materials for high-capacity lithium-ion secondary batteries, as well as magnesium balls. We welcome various requests regarding compounds, alloys, purity, particle size, and shapes, so please feel free to stop by our booth for consultation. We sincerely look forward to your visit.

[Speaker] Yuichi Ikejiro, Deputy Director, Innovation Center, NTT Docomo Business Inc. [Key Lecture Content] NTT Docomo Business is responsible for corporate ICT business within the NTT Group. It provides a one-stop solution for corporate clients across the entire group, aiming to solve social issues and become a platform for industrial and regional digital transformation (DX) through support for large enterprises and local small and medium-sized enterprises. In this context, the Innovation Center plays a role in exploring and nurturing new business ideas, driving the creation of new businesses and their implementation in society. In this lecture, I would like to introduce the initiatives aimed at creating new businesses utilizing advanced technologies such as AI and IOWN that are promoted by the Innovation Center. [Lecture Items] 1. About NTT Docomo Business / Innovation Center 2. Technology roadmap looking towards 2030 3. Creation of new businesses through open innovation 4. Value creation promoted through design thinking 5. Initiatives for business creation utilizing advanced technologies such as AI, IoT/OT, and IOWN 6. Q&A / Business card exchange

[Speaker] President and CEO of ICT Solution Consulting Co., Ltd. / Creator Takashi Tominaga [Lecture Topics] 1. Review of last year's future predictions 2. Signs of a major upheaval (from 10 news stories) 3. Background of the major upheaval (triggered by Trump 2.0) - The U.S.-China space war and the emergence of disruptors (not innovators but destroyers) - Disruptors' destructive business models (subscription services, overwhelming cost competitiveness) 4. The essence of the major upheaval - The intersection of two massive revolutions (VC revolution and operation revolution) 5. What the major upheaval brings (making industry hierarchy (scale) meaningless) - Industries disintegrating (the risk of existing industries being taken over by platforms, especially in finance, healthcare, administration, national defense, IT, etc.) - Companies disintegrating (the possibility of bankruptcies of companies exceeding one trillion yen, encirclement by disruptors from small and medium-sized enterprises with technology) - Operations disintegrating (operation models using minimal human resources) - Employees disintegrating (the disappearance of the middle class, talent filtering by AI) 6. Overcoming the major upheaval and the concept of transformation (metamorphosis) 7. Q&A and business card exchange