*Application Closed* February Online LIVE Seminar Held! ~Pharmaceutical Seminar~

Step into the utilization of thermal analysis devices. Numerous measurement examples of DSC included. Online seminar held.

This document provides a detailed introduction to the characterization of pharmaceutical substances using Differential Scanning Calorimetry (DSC). It explains the "Modulated DSC," which allows for high-sensitivity and high-resolution measurements, and the "Tzero DSC," which measures the absolute values of heat flow, over more than 40 pages based on general characterization examples. You can also find an introduction to various analytical instruments offered by our company. 【Main Contents】 ■ Amorphous structure (detection of amorphous content in crystalline compounds including glass transition) ■ Degree of crystallinity (melting and crystallization, purity, polymorphism) ■ Drug-excipient interactions ■ Protein denaturation ■ Freeze-drying ■ Other complementary thermal analysis techniques *This document is available for immediate viewing via "PDF Download."

• Analytical Equipment and Devices

This is an introduction to protein analysis cases and related equipment by analysis specialists. This time, we will cover three devices: ITC, TAM, and NanoDSC!

Measurement capabilities offered by TA Instruments ☆ Thermal analysis / glass transition, crystallization, thermogravimetric analysis, curing reactions, expansion rate, thermal conductivity, shrinkage rate, effects of moisture, etc. ☆ Viscoelastic measurements (rheology, rheometers) / viscoelasticity, elastic modulus, viscosity, stress relaxation, creep, master curves, residual strain, molecular weight, molecular weight distribution, etc. ☆ Microcalorimetry / intermolecular interactions, crystallization, amorphousness, aggregation/precipitation, dispersibility, solubility, compatibility, wettability, stability, adsorption, etc. ☆ Fatigue testing / tensile strength, temperature dependence, viscoelasticity, elastic modulus, viscosity, stress relaxation, creep, master curves, residual strain, etc.

• Analytical Equipment and Devices

How about one for the lab? Introducing the Discovery DSC series, the world's most outstanding and highly versatile differential scanning calorimeter.

TA Instruments continues to be the leading company in the world of DSC with innovative and outstanding technology. It provides reliable data and enhances workflow and productivity in laboratories. Material property analysis is essential at all stages of product design, manufacturing, processing, and application. Differential Scanning Calorimetry (DSC) is the most widely used thermal analysis instrument for evaluating the physical properties of a wide range of materials, including polymers, pharmaceuticals, food, biomaterials, organic compounds, inorganic compounds, and composites.

• Analytical Equipment and Devices

Provides high reliability! An excellent tool for measuring a wide range of molecular interactions.

The Isothermal Titration Calorimeter (ITC) is a device that detects the heat changes associated with titration at a constant temperature and is primarily used for analyzing molecular interactions. It measures the minute heat changes that occur when molecules bind to each other, allowing for the determination of binding ratio (n), binding constant (Ka), and the enthalpy change of binding (ΔH) from the resulting titration curve. Affinity ITC is an isothermal titration calorimeter that provides high sensitivity, high reproducibility, and advanced ITC technology in life science research environments. With AccuShot technology, it delivers precise amounts of titrant to the appropriate location, and the FlexSpin stirring function achieves efficient mixing and high sensitivity. The automatic cleaning function prevents contamination between samples. It offers the option of standard capacity (1.0 mL) or low capacity cells (190 µL), and a temperature-controlled auto-sampler for 96 wells is also available.

• Analytical Equipment and Devices

A differential scanning calorimeter specialized for studying biological samples. It offers the highest sensitivity and excellent operability.

TA Instruments continues to be the leading company in the world of DSC with innovative and outstanding technology. It provides reliable data and enhances workflow and productivity in laboratories. The Nano DSC is a differential scanning calorimeter (DSC) that can detect minute heat changes associated with the conformational changes of biomolecules. Characterization of materials is essential at all stages of product design, manufacturing, processing, and application. Differential scanning calorimeters/nano DSCs are the most widely used thermal analysis instruments for the physical property evaluation of a broad range of materials, including polymers, pharmaceuticals, food, biomaterials, organic compounds, inorganic compounds, and composites.

• Analytical Equipment and Devices

For the evaluation of reactions of various substances.

TAM offers the highest level of sensitivity, flexibility, and performance. By using a highly sensitive microcalorimeter along with various accessories, it precisely controls various experimental conditions. Up to four calorimeters can be used simultaneously, allowing for repeated experiments and a variety of experiments to be conducted. Additionally, its modular design allows for the addition of multiple calorimeters, enhancing sample processing capacity and functionality. Adding a multi-calorimeter with six mini-calorimeters significantly improves sample throughput. The TAM 4 employs patented thermostat technology, controlling the temperature of the liquid constant temperature bath with an accuracy of 0.0001±730°C. There are three operating modes: isothermal, step isothermal, and temperature scanning mode.

• Analytical Equipment and Devices

World leader in thermal analysis, calorimetry, and rheology / Comprehensive catalog of TA Instruments.

◆TA Instrument Handled Products◆ ■Thermal Analysis Equipment Differential Scanning Calorimeter Discovery DSC Thermogravimetric Analyzer Discovery TGA Differential Scanning Calorimeter DSC Thermogravimetric Analyzer TGA Vapor Adsorption/Desorption Measurement Device VTI-SA+ Simultaneous Differential Thermal and Thermogravimetric Analyzer SDT Thermomechanical Analyzer TMA Dynamic Mechanical Analyzer DMA ■Thermal Property Measurement Equipment Laser Flash Method Thermal Property Measurement Device DLF Xenon Flash Method Thermal Property Measurement Device DXF Thermal Conductivity Measurement Device DTC FOX Thermal Expansion Measurement Device DIL ODLT, ODHT P11 Heating Microscope HSM, HSML Fleximeter FLEX ■Viscoelasticity Measurement Equipment DHR ARES-G2 RSA-G2 Air Chiller System ACS-3 Rubber Testing Machine ■Microcalorimeters Isothermal Titration Calorimeter Nano ITC, Affinity ITC Differential Scanning Calorimeter Nano DSC Multi-Cell Differential Scanning Calorimeter MC DSC Isothermal Calorimeter TAM ●For other functions and details, please download the catalog or contact us.

• Analytical Equipment and Devices

This is the lecture material posted on YouTube ~DSC Basic Edition 1~. It is available for free download, so please feel free to make use of it.

Data Content This is a PDF version of the lecture materials from YouTube, converted for easier viewing. The video consists of a total of 12 pages and provides an easy-to-understand explanation for beginners about: - Principles - Analytical methods - Enthalpy relaxation (recovery) I think it might be difficult to understand with just the lecture materials, so please also refer to the YouTube videos below. YouTube TA Summary Site: https://www.youtube.com/channel/UCk3XzqRdsNQz1hJlqKrfujQ DSC Basics Part 1: https://www.youtube.com/watch?v=DbGpordpweg

• Analytical Equipment and Devices

This is the lecture material posted on YouTube ~Rheology: Basic Edition 1~. It is available for free download, so please feel free to make use of it.

Data Content This is a PDF version of the lecture materials from YouTube, converted for better readability. The video consists of a total of 12 pages and provides easy-to-understand explanations for beginners on the following topics: - What is rheology? - What is viscoelasticity? - About measurement modes. I think it might be difficult to understand just from the lecture materials, so please also refer to the YouTube videos below. YouTube TA Summary Site: https://www.youtube.com/channel/UCk3XzqRdsNQz1hJlqKrfujQ Rheology Basics Part 1: https://www.youtube.com/watch?v=_gPrWIK6yYo&t=4s

• Analytical Equipment and Devices

This is an introduction to analysis cases and related devices for bio research by analysis specialists. This time, we will cover three devices: ITC, TAM, and NanoDSC!

Measurement capabilities offered by TA Instruments ☆ Thermal analysis / Glass transition, crystallization, thermogravimetric analysis, curing reactions, expansion rate, thermal conductivity, shrinkage rate, effects of moisture, etc. ☆ Viscoelastic measurements (rheology) / Viscoelasticity, elastic modulus, viscosity, stress relaxation, creep, master curve, residual strain, molecular weight, molecular weight distribution, etc. ☆ Microcalorimetry / Intermolecular interactions, crystallization, amorphousness, aggregation/precipitation, dispersibility, solubility, compatibility, wettability, stability, adsorption, etc. ☆ Fatigue testing / Tensile strength, temperature dependence, viscoelasticity, elastic modulus, viscosity, stress relaxation, creep, master curve, residual strain, etc.

• Analytical Equipment and Devices

This is an introduction to a protein analysis case study by a specialist in analysis. This time, we evaluated the changes in denaturation temperature behavior with the addition of Zn2+ using NanoDSC.

Measurement capabilities offered by TA Instruments ☆ Thermal analysis / glass transition, crystallization, thermogravimetric analysis, curing reactions, expansion rate, thermal conductivity, shrinkage rate, effects of moisture, etc. ☆ Viscoelastic measurements (rheology) / viscoelasticity, elastic modulus, viscosity, stress relaxation, creep, master curve, residual strain, molecular weight, molecular weight distribution, etc. ☆ Microcalorimetry / intermolecular interactions, crystallization, amorphousness, aggregation/precipitation, dispersibility, solubility, compatibility, wettability, stability, adsorption, etc. ☆ Fatigue testing / tensile strength, temperature dependence, viscoelasticity, elastic modulus, viscosity, stress relaxation, creep, master curve, residual strain, etc.

• Analytical Equipment and Devices

This is an introduction to a protein analysis case study by a specialist in analysis. This time, we evaluated the substrate degradation rate and the effects of inhibitors using ITC.

Measurement capabilities offered by TA Instruments ☆ Thermal analysis / glass transition, crystallization, thermogravimetric analysis, curing reactions, expansion rate, thermal conductivity, shrinkage rate, effects of moisture, etc. ☆ Viscoelastic measurement (rheology) / viscoelasticity, modulus of elasticity, viscosity, stress relaxation, creep, master curve, residual strain, molecular weight, molecular weight distribution, etc. ☆ Microcalorimetry / intermolecular interactions, crystallization, amorphousness, aggregation/precipitation, dispersibility, solubility, compatibility, wettability, stability, adsorption, etc. ☆ Fatigue testing / tensile strength, temperature dependence, viscoelasticity, modulus of elasticity, viscosity, stress relaxation, creep, master curve, residual strain, etc.

• Analytical Equipment and Devices

Virus Research Case Study: Characterization of Viruses - Evaluation of Structure and Binding Properties Using Calorimetry -

Currently, the novel coronavirus infection (COVID-19) is a global issue. TA Instruments hopes to contribute, even in a small way, to addressing the challenges posed by COVID-19 by introducing examples of virus research conducted by universities and research institutions using TA equipment. Research institutions that incorporate studies using Differential Scanning Calorimetry (DSC) and Isothermal Titration Calorimetry (ITC) to understand the structure and mechanisms of viruses are rapidly advancing. Please take a look at the examples.

• Analytical Equipment and Devices

This is an introduction to case studies related to cells by a specialist in analysis. This time, we will present measurement examples using thermal analysis equipment that is useful for evaluations involving cells.

Measurement capabilities offered by TA Instruments ☆ Thermal analysis / glass transition, crystallization, thermogravimetric analysis, curing reactions, expansion rate, thermal conductivity, shrinkage rate, effects of moisture, etc. ☆ Viscoelastic measurements (rheology, rheometers) / viscoelasticity, elastic modulus, viscosity, stress relaxation, creep, master curves, residual strain, molecular weight, molecular weight distribution, etc. ☆ Microcalorimetry / intermolecular interactions, crystallization, amorphousness, aggregation/precipitation, dispersibility, solubility, compatibility, wettability, stability, adsorption, etc. ☆ Fatigue testing / tensile strength, temperature dependence, viscoelasticity, elastic modulus, viscosity, stress relaxation, creep, master curves, residual strain, etc.

• Analytical Equipment and Devices

This is an introduction to case studies of pharmaceutical analysis by a specialist in analysis. This time, we will look at the pharmacokinetics of suppositories and the viscoelastic measurement of hair wax.

The viscoelastic measurement device, the "Discovery Hybrid Rheometer," controls the surrounding environment and performs measurements over a wide range of force, strain, and strain rate. We offer three models to meet the needs for sensitivity and capability, from the high-sensitivity HR-30 to the general-purpose HR-10. This product improves various performances and specifications, achieving accurate strain, strain rate, stress control, and normal force, and is equipped with our innovative patented Smart Swap geometry and Smart Swap temperature control system. 【Main Features】 ■ Ultra-low inertia drag cup motor (patented) ■ Magnetic bearings (patented) ■ High-resolution optical encoder ■ Optical encoder dual reader (patent pending) ■ Normal force rebalance transducer (FRT)

• Analytical Equipment and Devices

This is an introduction to medical-related analysis cases by a specialist in analysis. This time, we will present measurement cases of mechanical properties and fatigue tests that are useful for evaluating the pericardium.

The planar biaxial testing machine (TestBench testing device) is designed to conduct tests similar to those performed on a load frame. This allows for the evaluation of the sample's stiffness, strength, and durability, as well as the measurement of yield strength, ultimate strength, and fatigue life. A modular approach that includes multi-channel and multi-axis options enables a wide range of configurations and performance. It uses 200N and 400N ElectroForce linear motors mounted on a horizontal base plate to accommodate various testing needs.

• Analytical Equipment and Devices

Using PLA beverage cups as measurement samples, thermal and mechanical properties were investigated utilizing thermal analysis techniques such as temperature-modulated DSC and DMA!

As the industrial sector has begun to focus more on developing and manufacturing environmentally friendly products, various new biodegradable polymers have been adopted. Poly(Lactic Acid) (PLA) is a biodegradable aliphatic polyester produced from lactic acid obtained through the saccharification and fermentation of starch. Due to its high mechanical strength comparable to PETE and good biocompatibility, PLA has been commonly used in biomedical applications such as sutures and stents, but the expansion of PLA's applications is being considered. Understanding the properties of PLA is essential for the development of new applications. We present materials that investigate the thermal and mechanical properties of PLA-based beverage cups using temperature-modulated DSC and DMA. *Please download the materials.

• Analytical Equipment and Devices

This is an introduction to a case study of insulation material analysis by a specialist in analysis. This time, we will present a measurement case using a thermal conductivity measurement device.

Measurement capabilities offered by TA Instruments ☆ Thermal analysis / glass transition, crystallization, thermogravimetric analysis, curing reactions, expansion rate, thermal conductivity, shrinkage rate, effects of moisture, etc. ☆ Viscoelastic measurements (rheology) / viscoelasticity, elastic modulus, viscosity, stress relaxation, creep, master curve, residual strain, molecular weight, molecular weight distribution, etc. ☆ Microcalorimetry / intermolecular interactions, crystallization, amorphousness, aggregation/precipitation, dispersibility, solubility, compatibility, wettability, stability, adsorption, etc. ☆ Fatigue testing / tensile strength, temperature dependence, viscoelasticity, elastic modulus, viscosity, stress relaxation, creep, master curve, residual strain, etc.

• Analytical Equipment and Devices

Evaluation of the generation process and characteristics of biofuels using a modular thermal analysis measurement device (TAM).

The calorimetry measurement device (TAM series) is an instrument known as a microcalorimeter that measures very small amounts of heat. By combining a thermostat with high isothermal performance with a calorimeter (calorimeter) suited to the sample and measurement method, it is possible to measure minute heat generated or consumed during physical processes or chemical reactions with sensitivity exceeding microwatts. It is a useful tool that can contribute to the research and development of biofuels and environmental improvement, allowing real-time calorimetry measurements while performing operations such as the addition, mixing, and titration of chemicals through module combinations. This document provides a detailed explanation of high-sensitivity calorimetry measurements of biofuels, which are difficult to observe with conventional differential scanning calorimeters (DSC), as well as real-time measurements of heat changes associated with chemical reactions. ◇ Quantification of wax based on the heat of solidification reactions ◇ Evaluation of the production rate of biofuels *Please download the document.

• Analytical Equipment and Devices

[Speaker] Ministry of Land, Infrastructure, Transport and Tourism, Road Bureau, Planning Division, Road Economic Research Office Planning Specialist Yuki Endo [Key Lecture Content] The Ministry of Land, Infrastructure, Transport and Tourism is advancing discussions on the realization of automated logistics roads as a new form of logistics in response to recommendations from the "Interim Summary on the State of High-Standard Road Networks," addressing logistics crises and carbon neutrality. This lecture will introduce the final summary on the state of automated logistics roads published in July of the 7th year of Reiwa, as well as the demonstration experiments planned for the 7th year of Reiwa. [Lecture Items] 1. Final summary on automated logistics roads 2. Demonstration experiments for the 7th year of Reiwa 3. Q&A / Business card exchange

[Speaker] NTT Docomo Business Inc. 5G & IoT Services Department Director in charge of Global Connected Cars, Yuji Tamai [Key Lecture Content] The value of SDV lies in continuously cycling 'updates × data × cloud', and connectivity is a prerequisite for this. In this presentation, we will organize the barriers of quality, cost, and regulation faced in global expansion, and explain the design principles and operational models from roaming enhancement, eSIM/RSP (SGP.32), integrated management (CMP), NTN, to Network API. Additionally, we will delve into security aspects related to connectivity, introducing phenomena observed in actual service operations and their countermeasures, as well as exploring other operational updates (staged delivery, avoiding simultaneous activation, monitoring/observability). [Lecture Items] 1. Positioning of connectivity in SDV 2. Barriers to global connectivity 3. Designing to "strengthen" roaming 4. eSIM/RSP and SGP.32 5. Integrated connectivity management (CMP) and operations 6. Further connectivity - NTN and Network API 7. Security and update operations 8. Q&A

"Even though I'm communicating, nothing changes." "When I give a warning, the atmosphere gets worse." — Are you trying to solve these problems just by changing how you interact? What you need is not to move people, but to create a workplace that is easy to navigate. I will explain based on numerous examples of on-site improvements that I have supported. Held on May 27 (Wednesday). Please check the LP for more details. ▼ For more information and registration (free), see below.

At the Dry Fog Humidification System Free Demo Experience, you will have the opportunity to actually experience our Dry Fog, as well as our single-fluid and dual-fluid humidifiers. We will explain the differences from conventional humidifiers and the effects of implementation. In addition to introducing the latest case studies, we will also provide time for you to consult directly with our specialized staff. Please select a convenient venue and date from the application page and apply. * The "morning session" and "afternoon session" contain the same content. Please participate at a time that suits you. * This event is intended for users only. Participation from trading companies, other companies in the same industry, or for sales purposes to our company is not permitted. Venues: ■ Yamagata Venue: 3/12 (Wed) at Yamagata International Exchange Plaza 3/13 (Thu) at Sakata Chamber of Commerce and Industry ■ Sendai Venue: 3/14 (Fri) at Kiri no Ikeuchi Sendai Branch ■ Tokyo Venue & Osaka Venue: 3/18 (Tue), 3/19 (Wed), 3/21 (Fri) at Kiri no Ikeuchi Tokyo Sales Office & Kiri no Ikeuchi Osaka Headquarters ■ Nagoya Venue & Fukuoka Venue: 4/9 (Wed), 4/10 (Thu), 4/11 (Fri) at Kiri no Ikeuchi Nagoya Sales Office & Kiri no Ikeuchi Fukuoka Sales Office

In recent years, as many companies are considering modernization, exploring methods for system renewal has become an important issue. This seminar will focus on "Rewrite," one of the solutions to such challenges, and will explain questions and issues encountered during project promotion in a Q&A format. <Program> - Opening - How to advance system renewal through "Rewrite" and key points for problem-solving - Introduction of unique tools to support migration <Recommended for> - Those who are struggling with specific methods for system renewal - Those who are concerned about the continuity of maintenance for existing systems and a shortage of personnel - Companies that own IBM i (AS/400) *We may refuse applications from competing companies or those not eligible to participate.