[Sending recorded video] 11/2 [Every Tuesday in Japan] Process Enhancement Series, all 3 sessions - Session 2: High-Throughput Bioreactor Supporting Process Enhancement Efforts

Process enhancement. Modify. Intensify. Amplify.

Process Intensification (PI) is a comprehensive framework aimed at maximizing overall production volume across manufacturing units, manufacturing processes, or biopharmaceutical facilities. Sartorius Stedim offers scalable and versatile modular solutions, including high-throughput process development tools. These can be implemented in current and future manufacturing facilities for a variety of upstream and downstream PI scenarios. - Enables faster drug development - Improves efficiency and productivity in GMP manufacturing - Applicable to various processes regardless of the pharmaceutical ◆ International Webinar [Process Intensification Webinar Series] This webinar series provides a comprehensive guide to maximizing process intensification. It covers upstream and downstream strategies, media management, data analysis, and more. You can watch it here: ⇒ https://bit.ly/3ihwdT1

• Other physicochemical equipment

Industry-standard high-throughput bioreactor system optimized for process characteristic analysis.

The Ambr 250 High Throughput Generation 2 is a multi-parallel bioreactor system that accelerates process development and characterization analysis schedules to achieve cost reduction. Its fully continuous gas supply system realizes similarity with large-scale bioreactors and optimizes the scale-down model. Through the integration of analysis options such as the capacitance-based BioPAT Viamass, it supports extensive feedback control.

• others
• Culture Equipment
• Bioreactor

A fully automated bioreactor system for the development of high-density cell culture processes!

The "Ambr250 Perfusion" is a fully automated multi-parallel bioreactor system that uses single-use culture vessels of 100-250 mL to accelerate the development of scalable perfusion processes. This system allows for the simultaneous execution of up to 24 different perfusion cultures while returning cells to the culture vessel using hollow fibers, which are commonly reported specifications. This system transforms the perfusion processes that could not be achieved with multi-parallel or small-scale setups, reducing experimental costs with small volumes and accelerating the optimization of high-density cell culture processes. 【Features】 ■ Increased productivity / Reduced experimental costs ■ Simultaneous parallel fed-batch and perfusion cultures are also possible ■ Exceptional scalability ■ Sampling and reagent addition are performed by a fully automated liquid handler, reducing daily working hours *For more details, please refer to the PDF document or feel free to contact us.

• Other physicochemical equipment

A fully automated tool for acquiring and fully utilizing Raman spectroscopy data to build a robust cultivation process for the production of uniform and high-quality products.

BioPAT(R) Spectro is a product specifically developed for Quality by Design (QbD). By generating more process data using this product, the potential of Raman spectroscopy can be maximized. This enables the construction of very robust processes, resulting in the production of consistently high-quality products.

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Bioreactor system for cell line development and process optimization.

The Ambr1515 Generation 2 is a high-throughput "automated micro-scale bioreactor system" that reproduces the performance of laboratory-scale bioreactors. The system consists of single-use vessels, an automated workstation, and enhanced convenience software. It is designed to be installed in a standard biosafety cabinet for aseptic operations, allowing for parallel monitoring and control of 24 or 48 micro-bioreactor cultures. As the manufacturing processes for biopharmaceuticals become more complex and the density of cultures increases, scientists around the world are facing an unprecedented challenge in developing "clone, medium, and process" that meet new demands. The Ambr15 Generation 2 system enhances equipment performance that influences the success of cultures, improves flexibility, and incorporates new features that reflect user feedback. It helps address the aforementioned challenges and supports the acceleration of research by scientists.

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A single-use bioreactor system that dramatically enhances speed, quality, and productivity from process development to scale-up.

The "Biostat STR Series" is a single-use bioreactor system designed for rapid process development and seamless scale-up to commercial production. The newly launched third generation features a new automation platform, "BIOBRAIN," and the analytical tool "BioPAT(R)," enabling exceptional speed, quality, and productivity. Stable and predictable processes greatly contribute to providing safe and reliable biopharmaceuticals to patients worldwide, accelerating our customers' manufacturing operations and business.

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Seed culture for small-scale protein production.

- The BioStat RM is a single-use rocking bioreactor that is fully compliant with GMP. < BioStat RM 20 | 50 Basic > The BioStat RM 20 | 50 Basic is a standalone bioreactor that is the ideal size for benchtop use. < BioStat RM 200 > The BioStat B and RM 200 Rocker are single-use rocking bioreactors designed for large-scale applications. - The Flexsafe bags have a proven track record with a wide range of cell lines including CHO, NS0, SF9, E. coli, T cells, and mesenchymal stem cells. Using Flexsafe RM bags in the seed train allows for easy scale-up to the BioStat STR single-use bioreactor that utilizes Flexsafe STR bags. The same polyethylene film material can be used for all cell culture steps. Flexsafe RM bags can be used with rocking bioreactors from multiple manufacturers, providing excellent growth characteristics and robustness, with stable supply.

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About ROAD: The "Roundtable on the Purpose of Autonomous Driving (ROAD)" conference series has evolved into a unique platform for interdis-ciplinary dialogue and international collaboration in the field of autonomous driving and autonomous mobility. Established in 2016, ROAD has brought together researchers, industry leaders, and public sector stakeholders from six countries across three continents. Based on this background, the upcoming ROAD 2026 will focus on "safety” and "driving AI”—the final pieces of the autonomous driving puzzle—to advance discussions on establishing the foundational framework for ensuring safety quality and obtaining regular-tory approval for autonomous driving. We also intend to discuss the international commonalities and differences regarding the social value brought about by ADS vehicles in terms of automation, intelligent driving, and mobility. We have established a total of five compelling themes for the Round Workshops, consisting of two topics related to “The Last Piece” and three topics related to the social value of ADS, as shown below. 1) Round Workshop 1 - Horizons of E2E Driving AI → Can AI Understand the Driving Environment Like Humans? 2) Round Workshop 2 - Beyond the Unknown: Safety Cases for ADS → Can Safety Ever Be Proven? 3) Round Workshop 3 - Envisioning Smart City Mobility → Can Smart City Mobility Bridge the Mobility Divide? 4) Round Workshop 4 - Logistics Enhancement Through Autonomous Tracking → Will Logistics Become Human-Free? 5) Round Workshop 5 - The Evolution of CASE: SDV/AIDV → Will Automakers Become AI Companies? We hope you’ll all join us!

[Speaker] Masashi Sugita, President and CEO of LEX Style Co., Ltd. [Key Lecture Content] The power consumption of AI servers used in data centers has significantly increased, making traditional air cooling insufficient for operation. This lecture will organize the requirements for introducing a liquid cooling system into air-cooled data centers and explain the implementation method using free cooling with specific design details. When handling high-density AI servers, energy efficiency is required, and the widely used energy efficiency indicator, as well as the Ministry of Economy, Trade and Industry's Resource and Energy Agency's PUE regulation of "1.3 or below," will be explained along with practical operational insights. [Lecture Items] 1. Heat dissipation methods for high-density, high-heat AI servers 2. Basics and importance of PUE/pPUE 3. PUE regulation of "1.3 or below" by the Ministry of Economy, Trade and Industry's Resource and Energy Agency 4. AI server implementation and requirements for new data centers 5. Summary and future outlook 6. Q&A / Business card exchange

[Key Lecture Content] 1. Promotion of SAF Introduction Yasushi Yamashita, Director, Carbon Neutral Promotion Office, Aviation Bureau, Ministry of Land, Infrastructure, Transport and Tourism 1. Importance of SAF in the decarbonization of the aviation sector 2. Initiatives to promote the introduction of SAF 3. Q&A / Business card exchange 2. Japan Airlines' Challenge Towards Net Zero CO2 Emissions by 2050 Kazuki Hirotani, Group Leader, GX Planning Group, Sustainability Promotion Department, Japan Airlines Co., Ltd. 1. Introduction of our five initiatives for CO2 emission reduction 2. Initiatives for reducing fuel consumption (introduction of fuel-efficient aircraft, operational improvements) 3. Initiatives for fuel transition (sustainable aviation fuel SAF) 4. Initiatives for reductions outside the value chain (carbon credits, new removal technologies) 5. Initiatives to deepen collaboration with society 6. Q&A / Business card exchange

[Instructor] Yuichiro Kabushiki, Partner Lawyer at TMI Comprehensive Law Office [Key Lecture Content] With the spread of AI, there is growing attention on the civil liability of developers, providers, and users of AI. The Ministry of Economy, Trade and Industry will publish "Guidelines on the Interpretation and Application of Civil Liability in AI Utilization" in April 2026, and the Ministry of Justice will also establish an expert meeting to examine civil liability related to unauthorized use of images and voices generated by AI in the same month. As the full enforcement of the AI Promotion Act and the revision of AI guidelines are underway, it is necessary to design and operate governance based on the potential responsibilities that may arise retrospectively. In this seminar, based on the guidelines from the Ministry of Economy, Trade and Industry and drawing on litigation practice experience as a judge and lawyer, we will organize the basic framework for assessing civil liability and explain fundamental methods for designing and operating governance based on risk analysis. Furthermore, we will examine the framework for civil liability and the design and operation of governance using hypothetical cases that are likely to pose practical issues.

In this seminar, we will welcome Mr. Satoru Hayami from Waseda University, who will explain the latest trends in AI utilization in manufacturing, as well as the evolution of technologies such as agent-based AI and physical AI, and the opportunities and key points for practical application in the manufacturing industry. Furthermore, Mr. Tsubasa Shibata, representative of Next Opt, will introduce processes aimed at practical implementation, incorporating actual case studies from manufacturing sites. We hope you will envision the "potential for AI utilization in your company" and take home hints that will lead to improvements in your operations starting tomorrow. We look forward to your participation.