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  6. Cosmetic ingredients achieve a moist and refreshing feel - Hyaluronic acid derivative.

Cosmetic ingredients achieve a moist and refreshing feel - Hyaluronic acid derivative.

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Cross Linked HA

last updated:Jan 19, 2026

HIGUCHI INC.
HIGUCHI INC.
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New hyaluronic acid crosspolymer, refreshing and moist feeling, anti-wrinkle, pore care, pore tightening, moisturizing effect.

Cross Linked HA is a hyaluronic acid cross-polymer made using Contipro's patented manufacturing method. The patented manufacturing technology creates a soft and fine gel, providing a unique sensation that is not found in conventional high molecular weight sodium hyaluronate. <About the Sensation> Immediately after application, it retains the pleasant texture of the chewy sodium hyaluronate, while the fine gel quickly penetrates the skin's grooves (such as wrinkles and pores), resulting in a moist yet refreshing sensation. <About Effectiveness> - Moisturizing effect (62% improvement) - Anti-wrinkle effect (46% reduction in wrinkles) - Sustained release effect of active ingredients (51% increase in the activity of Vitamin B3)

    Cosmetic materials and raw materialsOther pharmaceutical intermediates and cosmetic ingredientsOther medical supplies and cosmetic manufacturing materials
20200318153843-1.jpg

Cosmetic ingredients achieve a moist and refreshing feel - Hyaluronic acid derivative.

20200318153843-1.jpg
20200318153843-1.jpg
  • Related Link - https://www.higuchi-inc.co.jp/
  • Special site - Product/service details - https://pr.mono.ipros.com/higuchi-inc/product/

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Contipro is a biotechnology company located in the Czech Republic. It is a global manufacturer that produces and sells various active ingredients, primarily sodium hyaluronate, in the pharmaceutical and cosmetic fields, supplying to over 60 countries for approximately 30 years. The products are categorized into three groups: sodium hyaluronate, natural polysaccharides, and peptides. Sodium hyaluronate has different grades with a molecular weight distribution ranging from 2.3 million Da to 10,000 Da, and the effectiveness varies due to differences in skin permeability, which has been confirmed by Vivo and Vitro data. Additionally, there is a grade of sodium hyaluronate that has excellent skin permeability, known as hydrolyzed sodium hyaluronate. Regarding derivatives, it has been confirmed through Vivo and Vitro data that sodium hyaluronate possesses not only its inherent properties of moisturizing, barrier function, anti-wrinkle, and soothing effects but also efficacy in skin whitening, sebum secretion regulation, sebum suppression, and improving skin texture. Furthermore, there are products with delivery functions, including unique derivatives that can form polymer micelles to enhance permeability or release water-soluble active ingredients gradually.

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Applications/Examples of results

Usage: Anti-wrinkle, moisturizing products, etc. Dosage forms: Cream, serum, lotion Other uses: Controlled release of water-soluble active ingredients, improvement of usability

catalog(9)

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Cosmetic ingredient: Moisturizing and refreshing sodium hyaluronate derivative microgel, cross-linked HA.

Cosmetic ingredient: Moisturizing and refreshing sodium hyaluronate derivative microgel, cross-linked HA.

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Cosmetic Ingredients: Contipro Company Formulation Example (Sodium Hyaluronate, Sodium Hyaluronate Derivative)

Cosmetic Ingredients: Contipro Company Formulation Example (Sodium Hyaluronate, Sodium Hyaluronate Derivative)

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Cosmetic Ingredients Contipro Company Comprehensive Catalog (Hyaluronic Acid, Hyaluronic Acid Derivatives, etc.)

Cosmetic Ingredients Contipro Company Comprehensive Catalog (Hyaluronic Acid, Hyaluronic Acid Derivatives, etc.)

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Cosmetic Ingredients Contipro Company Sodium Hyaluronate Comprehensive Catalog

Cosmetic Ingredients Contipro Company Sodium Hyaluronate Comprehensive Catalog

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Cosmetic ingredient OligoHyaferre Hydrolyzed Sodium Hyaluronate

Cosmetic ingredient OligoHyaferre Hydrolyzed Sodium Hyaluronate

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Cosmetic Ingredients HyWhite (Whitening Hyaluronic Acid Derivative) Product Catalog

Cosmetic Ingredients HyWhite (Whitening Hyaluronic Acid Derivative) Product Catalog

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Cosmetic ingredient Schizophyllan (natural polysaccharide Schizophyllan)

Cosmetic ingredient Schizophyllan (natural polysaccharide Schizophyllan)

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Cosmetic ingredient anti-aging hormone crotamine active site peptide clodensin.

Cosmetic ingredient anti-aging hormone crotamine active site peptide clodensin.

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Cosmetic ingredient: Oil-soluble sodium hyaluronate derivative (Caprooyl sodium hyaluronate) HA-OIL

Cosmetic ingredient: Oil-soluble sodium hyaluronate derivative (Caprooyl sodium hyaluronate) HA-OIL

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News about this product(1)

Report on the 10th COSME Tech 2020 Cosmetics Development Exhibition

  • Seminar・Event

From January 20 to 22, 2020, we exhibited at the 10th COSME Tech 2020, organized by Reed Exhibitions Japan Co., Ltd., held at Makuhari Messe. Thank you very much for visiting our booth during the event. Thanks to your support, we were able to conclude the event successfully. During the exhibition, in addition to bitop's Ectoin, we introduced products from Mirexus: ultra-high molecular weight 3D dendritic polymers, among others. If you have any questions regarding the exhibited items or the products listed in our catalogs, please feel free to reach out to us. We will respond to the inquiries received during the event in due course. We look forward to your continued support. <Product Introduced During the Event> bitop: Ectoin, Glycoin Mirexus: Ultra-high molecular weight 3D dendritic polymers Contipro: Sodium Hyaluronate, Hydrolyzed Sodium Hyaluronate, New Hyaluronic Acid Derivatives Odycea: Plankton Glass Flower, Marine Bamboo, etc.

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HIGUCHI

HIGUCHI INC.

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Starting as an import trading company in 1927, we have been developing our business with many overseas suppliers and domestic customers over the years. Through our services of connecting the two together, Higuchi has become the well trusted "Japan distribution channel" for suppliers, and the "dependable vendor" who provides a stable supply of the latest high-valued overseas products to customers. Today, we conduct not only importing but also exporting businesses, trilateral trades, and overseas business investments as well. We have also expanded to local subsidiaries in the United States and China, to which we are able to effectively network overseas. Higuchi believes in the criticalness of providing a stable supply to customers, and we also place the highest priority on the coexistence with suppliers, to whom we can mutually develop together in a long-term perspective. Your support and consideration to our corporate philosophy would be much appreciated.

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