Analysis Case: Evaluation of Cell Metabolism and Drug Efficacy Using Isothermal Calorimeter TAM
This is an introduction to case studies related to cells by a specialist in analysis. This time, we will present measurement examples using thermal analysis equipment that is useful for evaluations involving cells.
Measurement capabilities offered by TA Instruments ☆ Thermal analysis / glass transition, crystallization, thermogravimetric analysis, curing reactions, expansion rate, thermal conductivity, shrinkage rate, effects of moisture, etc. ☆ Viscoelastic measurements (rheology, rheometers) / viscoelasticity, elastic modulus, viscosity, stress relaxation, creep, master curves, residual strain, molecular weight, molecular weight distribution, etc. ☆ Microcalorimetry / intermolecular interactions, crystallization, amorphousness, aggregation/precipitation, dispersibility, solubility, compatibility, wettability, stability, adsorption, etc. ☆ Fatigue testing / tensile strength, temperature dependence, viscoelasticity, elastic modulus, viscosity, stress relaxation, creep, master curves, residual strain, etc.
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This time, TA Instruments introduces a device called "TAM," which is an isothermal calorimeter. In this article, we will present a case study related to cell culture, specifically evaluating the efficacy of anticancer drugs through the measurement of tumor cell metabolism. ◆ Evaluation of Anticancer Drug Efficacy through Tumor Cell Metabolism Measurement Heat flow (the change in heat per unit time) shows higher values as the metabolism of the cells becomes more active. As the concentration of the anticancer drug increases, the heat flow values over a long period decrease, indicating that the metabolism of the tumor cells is declining. From the measurement results, a dose-response curve can also be created, and the TAM can be used as a rapid bioassay method.
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It is equipped with excellent features that provide reliable and meaningful results for the characterization and optimization of biofuels. In temperature scan (DSC) mode, the wax appearance temperature (WAT) is clearly visualized, and in isothermal mode, the reaction rate of catalytic reactions in the fuel production process can be observed over time. Among analytical instruments and calorimetry devices, the TAM can evaluate a variety of products including liquids, solids, crystals, polymers, fuels, foods, and batteries. 【Features】 - Highly responsive temperature control, adjustable in the range of 4 to 150 ℃ - Accurate and stable heat flow measurements even over long-term experiments - Up to four calorimeter positions can accommodate a maximum of four calorimeters - Calorimeters are available in various configurations such as size and sensitivity - Up to eight independent accessories can be controlled - New voltage I/O module for independent probe/source interface 【Specifications】 [Thermostat] - Heat medium: Oil - Number of calorimeters: 4 - Temperature range: 4 to 150 ℃ - Accuracy: < ± 0.1 ℃ - Long-term stability: < ± 100 μ ℃/24h - Scan speed: ≤ ± 2 ℃/h
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TA Instruments Japan is a wholly-owned subsidiary of TA Instruments in Japan. We sell and provide maintenance support for thermal analysis, rheology, microcalorimeters, and mechanical analysis equipment, conduct demonstration measurements, and hold technical seminars, offering the latest information on materials and engaging in the development of measurement technologies for materials. 【Main Equipment Handled】 ☆ Thermal Analysis / Differential Scanning Calorimeter (DSC), Thermogravimetric Analyzer (TGA), Simultaneous Differential Thermal Analysis (SDT/TG-DTA), Vapor Adsorption/Desorption Analyzer (Q5000SA) ☆ Viscoelastic Measurement (Rheology) / Rotational Rheometer (DHR・ARES), Dynamic Mechanical Analyzer (RSA・DMA・EF3200), Rubber Testing Cure Meter (RPA) ☆ Microcalorimetry / Isothermal Titration Calorimeter (ITC), Microcalorimeter (NanoDSC), Isothermal Calorimeter (TAM) ☆ Thermal Property Measurement Equipment / Thermal Conductivity Meter (DTC・FOX), Thermal Diffusivity Meter (DLF, DXF), Thermal Expansion Meter (TMA, DIL), Optical Thermal Expansion Meter (ODP, HM) ☆ Fatigue Testing Machines / ElectroForce Series, BioDynamic Series
