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  6. Capping agent for nucleic acid pharmaceutical synthesis

Capping agent for nucleic acid pharmaceutical synthesis

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last updated:Jan 27, 2022

林純薬工業 試薬化成品部
林純薬工業 試薬化成品部
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Patented capping agent

In the process of capping for nucleic acid synthesis, it has been reported that the presence of 1,3,5-trimethylhexahydro-1,3,5-triazine in the capping agent leads to the formation of undesirable adducts. Honeywell's patent describes an invention of a nucleic acid synthesis method using a capping agent that essentially does not contain 1,3,5-trimethylhexahydro-1,3,5-triazine, proposing ultra-high purity capping agents.

    Other pharmaceutical intermediates and cosmetic ingredients
capping.png

Capping agent for nucleic acid pharmaceutical synthesis

capping.png
capping.png
  • Related Link - https://direct.hpc-j.co.jp/page/nc_lineup_honeywel…

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basic information

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Applications/Examples of results

Nucleic acid pharmaceutical synthesis applications, PCR primer synthesis applications, DNA array manufacturing applications.

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Capping agents for the synthesis of nucleic acid pharmaceuticals

Capping agents for the synthesis of nucleic acid pharmaceuticals

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Announcement of the publication of the procedure for nucleic acid synthesis and reagents used - Phosphoramidite method -

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The reagent purchasing site for corporations operated by Hayashijun Pharmaceutical Co., Ltd. has published "Procedures for Nucleic Acid Synthesis and Reagents Used - Phosphoramidite Method." We provide details on the procedures and necessary reagents for the phosphoramidite method, which is the most mainstream nucleic acid synthesis method. Please make use of it. [Procedures for Nucleic Acid Synthesis and Reagents Used - Phosphoramidite Method] https://direct.hpc-j.co.jp/shop/pages/nc_phosphoramidite.aspx

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[On-Demand Seminar] Improving the Efficiency and Sustainability of Oligonucleotide Synthesis

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**On-Demand Seminar** Using Honeywell Burdick & Jackson™ BioSyn™ solvents and reagents can help improve the efficiency and sustainability of oligonucleotide synthesis. We will provide details in the on-demand seminar. -------------------------------------- Nucleic acid drugs are a new modality in drug discovery, following small molecule drugs and antibody drugs, and have been particularly anticipated in recent years. However, nucleic acid drugs are typically oligonucleotides ranging from a dozen to several dozen bases in length, and there have been challenges in obtaining the desired oligonucleotides unless the reaction efficiency is improved in the processes of deblocking, coupling, capping, and oxidation during the base elongation process. Honeywell provides support for ideal oligonucleotide synthesis with high-quality products based on strict quality control. Organizer: Honeywell Japan K.K. Cooperation: [Domestic Distributor] Hayashi Pure Chemical Industries, Ltd. *This webinar will be conducted in English. You can watch it for free at any time during the public viewing period.*

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林純薬工業

林純薬工業 試薬化成品部

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Since its establishment in 1904 (Meiji 37) with the aim of manufacturing and selling chemical products, our company has been actively engaged in production and sales activities to contribute to various industries through research and development and production. We provide not only reagents for testing and research but also custom reagent preparation for specific applications, liquid preparation services, and contract services for organic synthesis. In recent years, we have specialized in small-scale production of research reagents related to pharmaceuticals, metabolites, functional materials, and environmental substances, and we propose contract synthesis of hard-to-obtain minor compounds to various institutions. In 2016, we signed a general agency agreement with Honeywell (Currently at Solstice) for sales in Japan, particularly expanding our lineup of Karl Fischer moisture measurement reagents, high-purity solvents, analytical standards, and inorganic reagents. In 2019, we launched "Reagent Direct," allowing customers to place product orders and request quotes through our website, as well as check inventory and regulatory compliance, search and download SDS/product specifications/test reports, and access various services and content such as technical articles and evaluation cases. We will continue to respond quickly and accurately to our customers' diverse requests and strive to be a company that contributes to society.

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