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  4. Protein Analysis
  5. Other protein analysis
  6. All-in-One Protein Structure Stability Evaluation System 'UNCLE'

All-in-One Protein Structure Stability Evaluation System 'UNCLE'

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last updated:Sep 02, 2025

Unchained Labs (アンチェインドラブズ)
Unchained Labs (アンチェインドラブズ)
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Simultaneous measurement of 12 applications such as thermal stability, sizing, and viscosity from trace samples.

"Uncle" is a product that allows for the acquisition of more data with a small amount of protein. The required sample volume is only 9μL. By combining three different measurement modes—fluorescence, SLS, and DLS—it is easy to evaluate the optimal formulation and the stability of proteins or viral vectors. 【Features】 ■ Measure up to 48 samples in as little as about 2 hours with just 9μL. 【Applications】 ■ Tm & Tagg ■ Tm via SYPRO DSF ■ Isothermal stability ■ Sizing and polydispersity ■ Sizing via thermal gradient ■ Refolding measurements ■ Viscosity ■ kD ■ B22 ■ G22 ■ ΔG ■ Stability of viral capsids *For more details, please refer to the PDF document or feel free to contact us.

    Other protein analysis
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All-in-One Protein Structure Stability Evaluation System 'UNCLE'

image_01.png
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  • Related Link - https://www.unchainedlabs.com/

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【Specifications (Excerpt)】 ■ Minimum sample volume: 9 μL, sealed capillary ■ Number of simultaneous measurements per experiment: 48 ■ Sample temperature range: 15-95℃ ■ Sample concentration range: 0.05 to 300 mg/mL IgG (depending on the protein) ■ Heating rate: 0.1 to 10℃/min ■ Temperature control accuracy: ±1℃ (<70℃), ±1.5℃ (>70℃) ■ Physical dimensions: Width 54 cm, Depth 50 cm, Height 58 cm, Weight 50 kg *For more details, please refer to the PDF document or feel free to contact us.

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All-in-One Stability Evaluation System "Uncle"

All-in-One Stability Evaluation System "Uncle"

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AAV Research Application Note

AAV Research Application Note

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DNA leakage before the collapse of CapSID: Uncle's AAV thermal stability

DNA leakage before the collapse of CapSID: Uncle's AAV thermal stability

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Stability evaluation applications for 12 on a single platform.

Stability evaluation applications for 12 on a single platform.

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Evaluation of aggregation risk under high protein concentration using G22.

Evaluation of aggregation risk under high protein concentration using G22.

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Evaluation of AAV Thermal Stability by Uncle

Evaluation of AAV Thermal Stability by Uncle

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See everything with Uncle's full spectrum analysis.

See everything with Uncle's full spectrum analysis.

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Rapidly grasping the aggregation tendency of proteins: The advantages brought by simultaneous measurement of B22 and kD using Uncle.

Rapidly grasping the aggregation tendency of proteins: The advantages brought by simultaneous measurement of B22 and kD using Uncle.

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Overview of protein structure stability: Simultaneous measurement of Tm and Tagg, molecular sizing, and polydispersity by Uncle.

Overview of protein structure stability: Simultaneous measurement of Tm and Tagg, molecular sizing, and polydispersity by Uncle.

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Validation of the cleaning process (CIP) using Uncle

Validation of the cleaning process (CIP) using Uncle

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Uncle's Paper Publication List

Uncle's Paper Publication List

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Rapid evaluation of membrane protein stability using Uncle.

Rapid evaluation of membrane protein stability using Uncle.

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High-throughput protein stability analysis device "Aunty"

High-throughput protein stability analysis device "Aunty"

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Introduction of Aunty, the Queen of Protein Stability Evaluation Devices.

Introduction of Aunty, the Queen of Protein Stability Evaluation Devices.

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Exploration of AAV Buffer and Stability by BigTuna and Uncle

Exploration of AAV Buffer and Stability by BigTuna and Uncle

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High-throughput protein stability screening using Aunty

High-throughput protein stability screening using Aunty

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News about this product(24)

We will exhibit at Pharma Lab EXPO Tokyo 2022 [Pharmaceutical Research and Development Exhibition].

  • Seminar・Event

Our company will be exhibiting at the Pharma Lab EXPO Tokyo 2022, which will be held from Wednesday, July 13. At our booth, you can see the actual protein stability evaluation device, Stunner, as well as demo data and videos. Additionally, visitors to our booth will receive original Unchained Labs merchandise as a gift! We look forward to seeing you there.

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"Trends in Drug Discovery and Development of Biopharmaceuticals" Limited-Time On-Demand Webinar Now Available!

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We will be releasing a recorded video of the presentation from the Jihousha seminar on "Trends in Drug Discovery and Development of Biopharmaceuticals" held in June this year for a limited time! **"New Solutions" for the Evaluation of Physical Properties and Stability of Biopharmaceuticals Provided by Unchained Labs** ■ Overview Antibody-drug conjugates (ADCs) are biopharmaceuticals that have garnered attention due to their pharmacological activity and the excellent specificity of antibodies. However, evaluating their characteristics is very challenging due to the rarity of samples and their tendency to aggregate. In this webinar, we will introduce the platform from Unchained Labs that allows for the quantification, quality assessment, aggregation, conformation, and colloidal stability checks of ADCs and DARs in small amounts and high throughput, making it easy to optimize formulation conditions. ■ Speaker: Yuji Senoo | Field Application Scientist, Unchained Labs, Inc. ■ Availability: Until Tuesday, December 3, 2024 ■ For more details and to watch, click here >> https://go.unchainedlabs.com/l/907652/2024-10-23/zbln1

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[INTERPHEX Online Conference 2024 Gene Therapy Day] November 29 (Friday) Held: Simple, rapid, and highly accurate measurement of viral vectors

  • Seminar・Event

In vector development, understanding the ratios of various particles such as titers, Empty/Full, and impurities like aggregates, as well as stability, are essential evaluation criteria. We will introduce analytical methods that can perform these assessments with high precision, quickly, and conveniently using a small sample size, primarily focusing on AAV vectors. ◾️ Details and registration here >> https://eventory.cc/event/interphexonline24/schedule?day=14888 ◾️ Event name: INTERPHEX Online Conference 2024 Gene Therapy Day ◾️ Date and time: November 29 (Friday) 15:30 - 16:00 ◾️ Speaker: Takuma Iwasaki, Field Application Scientist, Unchained Labs, Inc. ◾️ Organized by: INTERPHEX Secretariat 【Pre-registration required, free of charge】 *This seminar is part of the Gene Therapy Day program at the INTERPHEX Online Conference 2024 organized by the INTERPHEX Secretariat.

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We will exhibit at BioJapan 2024.

  • Seminar・Event

Our company will be exhibiting at BioJapan 2024, which will be held from Wednesday, October 9. At our booth, we will showcase lipid nanoparticle (LNP) related products, as well as groundbreaking analytical devices for research and development in gene therapy and biopharmaceuticals. We invite you to visit us at Pacifico Yokohama! Exhibition details: ■ Dates: October 9 (Wednesday) - October 11 (Friday), 2024 ■ Venue: Pacifico Yokohama ■ Booth #: D-97

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Unchained

Unchained Labs (アンチェインドラブズ)

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Unchained Labs is a company headquartered in Silicon Valley, California, that provides next-generation life science tools. - A lineup of automation devices for biopharmaceutical research, gene therapy, and organic synthesis - Founded in 2015 - Locations in California, New Jersey, Boston, the UK, Brussels, Germany, Shanghai, and Japan - Established a Japanese subsidiary in July 2017

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