The success rate over the past three years boasts over 90% and has been adopted by many pharmaceutical companies.
1. Strategic Selection By using control antigens for strategic selection, it is possible to produce antibodies with special specificities, such as those that recognize the presence or absence of post-translational modifications, or antibodies that recognize common parts of homologous proteins. 2. Production of Antibodies Difficult to Obtain through Animal Immunization Since it does not rely on animal immunization, it is possible to produce antibodies against human or mouse antigens regardless of immune tolerance. Additionally, it is possible to produce antibodies against toxic antigens or immunosuppressive substances. Furthermore, since there is no antigen presentation step, it is also possible to produce antibodies that recognize natural three-dimensional structures. 3. Delivery of Candidate Antibodies in Just 7 Weeks Thanks to automated screening of antibody libraries, automated sequencing, and automated ELISA analysis, the time required from receipt of the antigen to delivery of candidate antibodies (up to 5) is just 7 weeks. For points 4 to 7, please refer to the seven features of the monoclonal antibody production contract service in Feature 2. *For more details, please refer to the PDF document or feel free to contact us.
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basic information
▼First, Planning▼ The "Antibody Craftsman" monoclonal antibody production service begins with antibody planning as the first step when we receive inquiries about antibody production from our customers. To create antibodies suitable for the customer's intended use, we will ask about the characteristics of the antigen and the purpose of the antibody. Next, we will design the antigen according to the purpose of the antibody to be obtained and propose strategic selection methods tailored to the type of antigen and the intended use of the antibody, guided by experienced personnel throughout the entire process. ▼Format and Reproduction of Delivered Antibodies▼ The antibodies produced will be in the Fab format, with options for monovalent or divalent selection and two types of tags, delivered in the desired format. The obtained antibodies will be purified as recombinant proteins from E. coli, allowing us to deliver them with the same quality repeatedly. Additionally, it is easy to convert Fab into immunoglobulin isotypes such as IgA, IgE, IgG, and IgM.
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Delivery Time
※At the shortest, 7 weeks from the receipt of the antigen.
Applications/Examples of results
Antibodies produced by "Antibody Craftsman" can be used in various applications just like antibodies produced by conventional methods. Furthermore, since they are Fab antibodies, they possess properties that can provide additional advantages in certain assay systems, such as not needing to remove the Fc region to prevent binding to receptors or to minimize the reaction of human anti-mouse antibodies (HAMA). Additionally, tag-specific detection antibodies are very useful in many applications.
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Company information
Gene Frontier has been expanding its business areas that contribute to the acceleration of biopharmaceuticals, including antibody drugs, and has been advancing the development of its unique technologies. Moving forward, we aim to accelerate our research and development and business development to achieve further growth on a global scale. We will continue to provide unique technologies and services for the development of innovative pharmaceuticals and diagnostic drugs, striving to be a trusted partner for our customers and contribute to 21st-century healthcare.