Femtosecond laser ablation-inductively coupled plasma mass spectrometry is a useful method for analyzing the two-dimensional distribution of elements present in trace amounts in biological tissues.
The technical information magazine The TRC News provides the latest information on analytical techniques that are useful for research and development, solving production troubles, and quality control. [Abstract] fsLA-ICP-MS (femtosecond laser ablation-inductively coupled plasma mass spectrometry) is a method capable of rapidly and sensitively analyzing inorganic elements in solid samples at a local level, and it has garnered attention as a useful technique for two-dimensional distribution analysis of elements present in trace amounts within biological tissues. This paper introduces the characteristics of fsLA-ICP-MS, examples of drug distribution evaluation in tissues, and quantitative imaging examples using custom-prepared standards. [Table of Contents] 1. Introduction 2. Overview and Characteristics of fsLA-ICP-MS 3. Evaluation of Boron Drug Distribution for BNCT 4. Quantitative Imaging of Iron and Zinc in Mouse Spinal Cord 5. Conclusion
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Technical Information Magazine The TRC News "Imaging of Trace Elements in Biological Tissues Using fsLA-ICP-MS" [Abstract] fsLA-ICP-MS (femtosecond laser ablation-inductively coupled plasma mass spectrometry) is a method capable of rapidly and sensitively analyzing inorganic elements in solid samples at a local level, and it has garnered attention as a useful technique for analyzing the two-dimensional distribution of elements that exist in trace amounts within biological tissues. This paper introduces the characteristics of fsLA-ICP-MS, examples of drug distribution evaluation in tissues, and quantitative imaging cases using custom-prepared standards. [Table of Contents] 1. Introduction 2. Overview and Characteristics of fsLA-ICP-MS 3. Evaluation of Boron Drug Distribution for BNCT 4. Quantitative Imaging of Iron and Zinc in Mouse Spinal Cord 5. Conclusion [Figures and Tables] Figure 1: Configuration of ICP-MS Figure 2: Configuration of fsLA-ICP-MS Table 1: Comparison of fsLA-ICP-MS, NanoSIMS, and TOF-SIMS Figure 3: Distribution Image of Boron Drug for BNCT in Mouse Cancer Tissue Figure 4: Calibration Curves for Fe and Zn in Spinal Cord Figure 5: Quantitative Imaging Results of Fe and Zn in Mouse Spinal Cord (n=3)
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At Toray Research Center, Inc., we provide technical support through analytical techniques and physical property analysis to address various challenges in research and development as well as production fields via contract analysis. Based on our long-standing achievements and extensive experience in analysis and physical property evaluation, we continue to strive to meet the advanced and diverse needs of our customers.
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