The technical information magazine The TRC News provides the latest information on analytical techniques that are useful for research and development, solving production troubles, and quality control.
**Abstract** With the diversification of drug discovery modalities and changes in healthcare, the required analytical techniques are becoming increasingly sophisticated. At the Toray Research Center, we are engaged in the development of new analytical methods and technologies to support the development of cutting-edge pharmaceuticals and biomarkers. Here, we will introduce analytical case studies related to nucleic acid medicines, antibody drugs/ADCs, and biomarkers/diagnostics. **Table of Contents** 1. Introduction 2. Analysis of Nucleic Acid Medicines 3. Analysis of Protein Medicines 4. Analysis of Biomarkers and Diagnostics 5. Conclusion
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Technical Information Magazine The TRC News "Challenges of Diversifying Modalities" [Abstract] With the diversification of drug discovery modalities and changes in healthcare, the required analytical techniques are becoming increasingly sophisticated. The Toray Research Center is engaged in the development of new analytical methods and technology to support the development of cutting-edge pharmaceuticals and biomarkers. This article presents analytical case studies related to nucleic acid medicines, antibody drugs/ADCs, and biomarkers/diagnostics. [Table of Contents] 1. Introduction 2. Analysis of Nucleic Acid Medicines 3. Analysis of Protein Medicines 4. Analysis of Biomarkers and Diagnostics 5. Conclusion [Figures and Tables] Table 1: Error compared to theoretical values of S-modified oligonucleotides Figure 1: MS/MS analysis of glycopeptides using ETD Figure 2: Measurement of ADCs Figure 3: Calculation of molecular weight and DAR through deconvolution Figure 4: Concentration ratio of D-serine and L-serine in urine of normal rats and renal failure model rats Figure 5: CD spectrum of Protein A integrated with gold nanoparticles
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At Toray Research Center, Inc., we provide technical support through analytical techniques and physical property analysis to address various challenges in research and development as well as production fields via contract analysis. Based on our long-standing achievements and extensive experience in analysis and physical property evaluation, we continue to strive to meet the advanced and diverse needs of our customers.
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