This presentation introduces the features of the ion mobility mass spectrometer introduced at the Toray Research Center, along with examples of disulfide bond position analysis and glycan structure analysis.
The technical information magazine The TRC News provides the latest information on analytical techniques that are useful for research and development, solving production troubles, and quality control. [Abstract] Ion mobility mass spectrometry can separate structural isomers with the same mass that traditional mass spectrometers cannot, making it promising for various applications such as characterization of antibody drugs and ADCs, glycan structure analysis, binding site analysis, peptide mapping, impurity analysis of nucleic acid drugs, bioanalysis of oligonucleotides, and comprehensive analysis of biomarkers. This article introduces the features of the ion mobility mass spectrometer introduced at the Toray Research Center and presents examples of disulfide bond position analysis and glycan structure analysis. [Table of Contents] 1. Introduction 2. Overview of the Analytical Method 3. Analytical Examples 4. Conclusion
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Technical Information Magazine The TRC News "Introduction of Analytical Methods Using Ion Mobility Mass Spectrometry" [Abstract] Ion mobility mass spectrometry allows for the separation of structural isomers with the same mass that cannot be separated by conventional mass spectrometry. This capability is expected to be utilized in various applications such as characterization of antibody drugs and ADCs, glycan structure analysis, binding site analysis, peptide mapping, impurity analysis of nucleic acid drugs, bioanalysis of oligonucleotides, and comprehensive analysis of biomarkers. Here, we introduce the features of the ion mobility mass spectrometer introduced at the Toray Research Center, along with examples of disulfide bond position analysis and glycan structure analysis. [Table of Contents] 1. Introduction 2. Overview of Analytical Methods 3. Analytical Examples 4. Conclusion [Figures and Tables] Figure 1: Schematic Diagram of TIMS Device Figure 2: Hinge Region of Fragmented Antibody Figure 3: Mobility Diagram of Two Types of Peptides Figure 4: Mobility Diagram of a Mixture of Two Types of Glycan Standards with the Same Mass Figure 5: Reduction of Background through Cleanup Processing
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Please see https://www.toray-research.co.jp/service/trcnews/.
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At Toray Research Center, Inc., we provide technical support through analytical techniques and physical property analysis to address various challenges in research and development as well as production fields via contract analysis. Based on our long-standing achievements and extensive experience in analysis and physical property evaluation, we continue to strive to meet the advanced and diverse needs of our customers.
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