The use of TOC in cleaning validation is gaining attention.
TOC is an effective tool for cleaning validation of pharmaceuticals, cosmetics, and medical devices. By using TOC for cleaning validation, improvements in quality, risk reduction, and efficient operations can be achieved. TOC is a simple analytical method that rapidly detects low concentrations of organic compounds and can identify degradation products and contaminants that HPLC cannot detect. Compared to HPLC, which is a specific analytical method that detects only specific components, TOC, being a non-specific analytical method, can comprehensively confirm that excipients, degradation products, and cleaning agents are adequately cleaned. Furthermore, TOC simplifies method development and minimizes equipment downtime, leading to increased efficiency. By using TOC, not only can the cleaning process be evaluated quickly, but it also reduces the workload, maintenance costs, and running costs compared to HPLC.
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basic information
The Sievers TOC analyzer accurately measures organic matter in samples without being affected by coexisting substances, using its unique gas-permeable membrane conductivity measurement method. Sievers helps simplify method development and sample pretreatment. If the TOC concentration of a sample is unknown, the automatic reagent feature can ensure complete oxidation of the organic matter. With Sievers' proven technical expertise, excellent accuracy and recovery rates are guaranteed.
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Pharmaceutical cleaning validation Medical device cleaning validation Chemical cleaning evaluation Food and beverage cleaning evaluation
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Since our establishment in 1967, we have been dedicated to the development and dissemination of water quality measurement devices that anyone can use quickly, easily, and with high precision. In today's world, where the effective use of water, a limited resource, is required alongside environmental conservation, we aim to be a total solution provider that responds to all water environments by utilizing our water quality measurement devices, technology, and services. Furthermore, leveraging the latest technology and years of know-how, we are committed to delivering user-friendly and reliable water quality measurement devices more affordably, quickly, and widely.