A screening device that accelerates crystallization and reaction condition exploration!!
Technobis Corporation Crystal16, CrystalBreeder, Crystalline, ReactALL
Research and development platform to accelerate the understanding of crystallization and reaction processes through multi-criteria parallel evaluation.
Technobis' crystallization solutions consistently support everything from exploring crystallization conditions to understanding processes. CrystalBreeder is a small-scale device suitable for crystallization studies with small sample sizes, making it ideal for initial screening and understanding crystallization behavior. Crystal16 can evaluate up to 16 conditions in parallel and quantitatively obtain solubility curves and precipitation behavior. Crystalline allows for an integrated evaluation of crystallization processes, including reactive crystallization, and strongly supports process optimization and understanding. ReactALL is a research and development reaction device that can screen reaction conditions in parallel across multiple conditions. It precisely controls temperature, stirring, and reagent addition, and supports automatic sampling. It enables efficient exploration of reaction conditions with small sample sizes, accelerating route scouting and initial process development. By combining it with crystallization devices, a consistent research and development flow from reaction to crystallization can be established.
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basic information
CrystalBreeder A small-scale crystallization screening device equipped with 32 parallel reactors. Working volume of 0.06 to 0.1 mL, temperature setting range of -15 to 150°C. Turbidity measurement is possible for all reactors. Compatible with evaporation and vapor diffusion modules, suitable for initial solid screening and polymorph exploration. Crystal16 A parallel crystallization and solubility measurement device using up to 16 standard HPLC vials (0.5 to 1.0 mL). Temperature setting range of -20 to 150°C (with chiller down to -25°C). Turbidity measurement and stirring control enable solubility curve generation, MSZW evaluation, and crystallization behavior analysis. Crystalline A crystallization and reaction crystallization evaluation device compatible with 8 vials of 8 mL (working volume of 2.5 to 5 mL). Temperature setting range of -25 to 150°C. Can connect particle observation cameras and Raman spectrometers for inline analysis of particle size, shape, and chemical state. ReactALL A reaction screening device with 5 parallel reactors. Working volume of 5 to 10 mL, temperature setting range of -10 to 150°C (with chiller down to -25°C). Automatically quenches reactions during sampling, allowing recovery in diluted form into HPLC vials, and supports reaction and particle monitoring via camera and Raman connection.
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Applications/Examples of results
CrystalBreeder Used for observing crystallization behavior and exploring initial conditions with small sample sizes, it has a track record in the crystallization study of pharmaceutical active ingredients and intermediates, polymorph screening, and evaluation of nucleation behavior. It is suitable for rapid condition screening in the early stages of research. Crystal16 Widely used for solubility measurement, MSZW acquisition, and polymorph, salt, and co-crystal screening through parallel evaluation of up to 16 conditions. It has numerous implementations in crystallization condition exploration and process development in pharmaceutical and chemical manufacturers. Crystalline Used for examining reactive crystallization and recrystallization processes, it is utilized in process development that integrates reaction and crystallization, as well as for process understanding and optimization based on QbD. It has a track record in the pharmaceutical and functional chemicals fields. ReactALL Used for screening reaction conditions, route scouting, and initial process examination, it has a proven record in reaction optimization in the pharmaceutical and chemical fields. It allows for efficient evaluation of reaction conditions with small sample sizes.
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Company information
Physio-Machina Co., Ltd. is a company that primarily sells products such as formulation development equipment and dissolution testers, conducts validation and calibration of peripheral devices, and engages in the import and export of software and various equipment. Additionally, it actively provides translation and interpretation of technical documents and seminars, as well as support for the creation of SOPs and conducts training sessions.