Cross-linked sodium hyaluronate powder (high purity, long-lasting gel formation)
Cross-linked sodium hyaluronate powder (high purity, long-lasting gel formation)
Instant formation of three-dimensional gel through re-dissolution: long-lasting, ultra-low endotoxin cross-linked hyaluronic acid powder.
This product is a freeze-dried powder of cross-linked sodium hyaluronate manufactured using a multi-crosslinking technology with BDDE. The degree of crosslinking is precisely controlled within the range of 6-8% (customization available), and it forms a three-dimensional network structure hydrogel immediately upon re-dissolution in physiological saline. Due to its uniform network structure, it exhibits excellent elastic and viscous properties, has superior retention in the body, and is suitable for long-lasting applications. Additionally, the endotoxin content is extremely low (<0.005 EU/mg), making it suitable for applications that require high safety. It is widely applied as a functional material in filler applications in the medical and cosmetic fields, joint cavity applications, and regenerative medicine-related materials (such as drug delivery carriers and microsphere composites).
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basic information
Cross-linked Sodium Hyaluronate Powder (Freeze-Dried Type) Grade Classification CSHA (High Elasticity Type) CDHA (Medium Elasticity Type) CWHA (Low Cross-linking / Micro Cross-linking Type) Corresponding Gel Types CSHA: Biphasic Cross-linked Gel CDHA: Monophasic Cross-linked Gel CWHA: Micro Cross-linked Gel Cross-linking Agent BDDE (1,4-Butanediol Diglycidyl Ether) Degree of Cross-linking 6-8% (Customizable) Manufacturing Process Fermentation-derived HA Purification Cross-linking Reaction Purification and Washing Freeze Drying Appearance White to Slightly Yellow Powder Reconstitution Properties Rapid Dissolution in Physiological Saline Formation of Three-Dimensional Network Hydrogel Rheological Properties Elastic Modulus (G') CSHA: 1000-1100 Pa CDHA: 260-470 Pa CWHA: 130-300 Pa Viscous Modulus (G") CSHA: 280-310 Pa CDHA: 50-150 Pa CWHA: 50-150 Pa Recommended Formulation Concentration CSHA: 1.0-2.5% CDHA: 0.5-2.5% CWHA: 0.2-2.0% Safety Indicators Endotoxin: <0.005 EU/mg Cross-linking Agent Residue: Reduced Design
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Applications/Examples of results
This product is a high-performance cross-linked hyaluronic acid material with a wide range of applications in the fields of medicine, beauty, and regenerative medicine. Beauty Medical Applications: - Dermal fillers (for facial contouring, wrinkle improvement, etc.) - Long-lasting volume enhancement applications The high-elasticity type (CSHA) is suitable for contouring applications, while the medium to low-elasticity types are suitable for applications seeking a natural texture. Joint Applications: - Intra-articular lubrication applications - Viscoelastic fillers The high viscoelasticity of the hydrogel is expected to improve lubrication within the joints and assist in function. Regenerative Medicine and DDS Applications: - Drug Delivery System (DDS) carriers - Microsphere composite materials - Cell scaffold materials Utilizing a three-dimensional network structure, it can be applied for controlled release of active ingredients and tissue engineering applications. Formulation Development Applications: - Custom gel design - Viscoelasticity control materials By adjusting the degree of cross-linking and molecular design, it is possible to optimize rheological properties according to specific applications. Customization Support: It is possible to adjust the degree of cross-linking, particle structure, and viscoelastic properties according to applications, allowing for optimization tailored to customer product designs.
Company information
Our company is a global raw material and technology solution provider that offers natural-derived ingredients, including herbal medicines and plant-derived extracts, as well as high value-added functional ingredient formulation technologies. We integrate knowledge of traditional natural materials with modern biotechnology and formulation techniques to cater to a wide range of fields, including pharmaceuticals, health foods, functional foods and beverages, cosmetics, personal care, and animal nutrition. Utilizing advanced technologies such as Cocrystal, Liposomal, microencapsulation, particle technology, pellet technology, and granulation technology, we provide customized solutions to address challenges related to the solubility, absorption, stability, flavor, and processability of functional ingredients. Additionally, we supply a diverse range of natural and functional ingredients, including plant extracts, natural flavors, essential oils, amino acids, and peptides. We have established a consistent global supply system that covers raw material procurement, processing, quality control, and export, allowing us to flexibly respond to development projects from small batches to mass production. Through high-quality raw materials, advanced technologies, and specialized support, we assist customers worldwide in product development and business expansion.
