Cross-linked sodium hyaluronate gel (medical use, long-lasting filler)
Superficial/Middle/Deep/Ultra-Deep Series BDDE Cross-Linked Hyaluronic Acid Gel (High Elasticity, Long-Lasting Type)
Achieving long-term sustainability and high-precision molding: Medical-grade multi-crosslinked hyaluronic acid gel.
This product is a cross-linked sodium hyaluronate gel manufactured using a multi-crosslinking technology with BDDE. The degree of crosslinking is precisely controlled within the range of 6-8%, forming a uniform three-dimensional mesh structure that achieves excellent viscoelasticity and shape retention. The duration of effect in the body is long-lasting, ranging from 6 to 18 months, ensuring stable volume maintenance and tissue compatibility. Additionally, the residual crosslinking agent (BDDE) is extremely low (<1 μg/ml), designed with safety in mind. With a lineup tailored for various applications from superficial to ultra-deep layers, it can meet diverse needs in the medical aesthetics field, such as wrinkle improvement, contouring, and volume filling. Furthermore, it is also being developed for medical applications such as joint use and adhesion prevention materials.
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basic information
Product Classification Cross-linked Sodium Hyaluronate Gel (Injectable Gel Material) Product Lineup - Superficial Layer - Middle Layer - Deep Layer - Ultra-Deep Layer Main Ingredients Sodium Hyaluronate (Fermentation-derived) Cross-linking Agent: BDDE (1,4-Butanediol Diglycidyl Ether) Cross-linking Specifications Degree of Cross-linking: 6-8% (Customizable) Multi-cross-linked Structure (Uniform 3D Network) Particle Size (Approximate) Superficial: 100-300 μm Middle: 300-600 μm Deep: 500-800 μm Ultra-Deep: 800-1000 μm Duration (Approximate) Superficial: 6-12 months Middle: 6-12 months Deep: 6-12 months Ultra-Deep: 12-18 months Rheological Properties High Elasticity and High Viscosity Balance Design Optimization of Shape Retention and Injectability Safety Indicators BDDE Residual: <1 μg/ml Low Endotoxin Design
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Applications/Examples of results
This product is a high-function cross-linked hyaluronic acid gel for medical and beauty applications, capable of a wide range of uses. Beauty medical applications: - Shallow layer: Correction of fine wrinkles around the eyes and mouth - Medium layer: Improvement of moderate wrinkles, lip volume enhancement - Deep layer: Facial contouring (cheeks, jawline, etc.) - Ultra-deep layer: Large volume enhancement (contour emphasis applications) The design for each layer allows for flexible responses, from a natural finish to high lifting effects. Shape formation and contour design: Facial contouring Volume filling Three-dimensional modeling applications The high-elasticity gel enables precise shape design and long-term maintenance. Joint applications: Assistance in joint cavity lubrication Viscoelastic filling material The high viscoelastic properties contribute to the improvement of the joint environment. Medical applications (expanded use): Adhesion prevention material (post-operative use) Tissue protection material Drug delivery substrate (DDS) It can be applied as a medical material utilizing the gel structure. Formulation development applications: Filler product development Custom viscoelastic design Medical material-based gel Adjustment of particle size, elasticity, and viscosity is possible according to the application.
Company information
Our company is a global raw material and technology solution provider that offers natural-derived ingredients, including herbal medicines and plant-derived extracts, as well as high value-added functional ingredient formulation technologies. We integrate knowledge of traditional natural materials with modern biotechnology and formulation techniques to cater to a wide range of fields, including pharmaceuticals, health foods, functional foods and beverages, cosmetics, personal care, and animal nutrition. Utilizing advanced technologies such as Cocrystal, Liposomal, microencapsulation, particle technology, pellet technology, and granulation technology, we provide customized solutions to address challenges related to the solubility, absorption, stability, flavor, and processability of functional ingredients. Additionally, we supply a diverse range of natural and functional ingredients, including plant extracts, natural flavors, essential oils, amino acids, and peptides. We have established a consistent global supply system that covers raw material procurement, processing, quality control, and export, allowing us to flexibly respond to development projects from small batches to mass production. Through high-quality raw materials, advanced technologies, and specialized support, we assist customers worldwide in product development and business expansion.
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