Accurate and reliable measurement of Fc gamma receptor binding affinity! Providing a high-throughput and rapid method.
This document is an application note introducing the method for analyzing Fc gamma receptor-IgG interactions using the "Octet" biomolecular interaction analysis system. It presents a method for analyzing the interaction between the Fc region of IgG and Fc gamma receptors, which is crucial for initiating effector functions through binding to Fc gamma receptors expressed on the surface of immune effector cells, a key mechanism of action for therapeutic monoclonal antibodies. In addition to best practices for various biosensor formats, it also discusses assay optimization, curve fitting, and data analysis. [Contents (partial)] ■ Introduction ■ Selection of biosensors ■ Assay optimization ■ Data analysis ■ Evaluation of data quality and fitting ■ Measurement of Fc gamma receptor affinity in antibody engineering, equivalence testing, lot release assays, and QC *For more details, please download the PDF or feel free to contact us.
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【Other Published Content】 ■Quality of Reagents ■Ligand Immobilization Step ■Analyte Concentration/Binding Step ■Buffer Conditions and Non-Specific Adsorption ■Reference Measurement ■Data Acquisition Speed Settings *For more details, please download the PDF or feel free to contact us.
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Sartorius is a leading global company that contributes to biopharmaceutical research and the biopharmaceutical industry, established in 1870. Sartorius's laboratory products/services division meets the needs of researchers and technicians engaged in research and development and quality control in the medical industry and various other sectors by providing innovative laboratory equipment and consumables. Our products and technologies are designed to simplify our customers' operations and contribute to accelerating research and improving operational efficiency. *Biotechnology-related products can be found at the following URL: https://premium.ipros.jp/sartorius-stedim/
