Advantages of 3'-azidomethyl-2'-deoxy-nucleoside!
We are pleased to introduce a groundbreaking building block series, "3'-Azidomethyl-2'-deoxy-nucleosides" (dA, dG, dC, dU), that will accelerate your company's next-generation nucleic acid drug development program. The key feature of this strategic material is the unique azidomethyl group at the 3' position of deoxyribose. This structure provides a powerful advantage that is not found in conventional modified nucleosides. - Utilization and Three Powerful Advantages Here are three powerful advantages gained by utilizing this reagent: 1) High-efficiency functionalization (click chemistry) 2) Improved stability and persistence 3) Chain terminator
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Applications/Examples of results
1) High-efficiency functionalization (Click Chemistry) Details: Azide groups (-N3) are ideal for click chemistry with alkynes. Under mild conditions, functional molecules such as fluorescent dyes, drugs, and peptides can be easily conjugated to the 3' end of oligonucleotides. Application examples: Development of diagnostic drugs, DDS (targeting ligand-conjugated nucleic acid medicines) 2) Improvement of stability and persistence Details: By introducing modifications at the 3' end, resistance to 3'-exonucleases in vivo is enhanced. This is expected to improve the blood stability and persistence of oligonucleotides. Application examples: Enhancement of pharmaceutical properties of nucleic acid medicines (stabilization) 3) Extension terminators Details: The absence of a 3'-hydroxyl group (-OH) ensures that the extension reaction by DNA polymerase is reliably halted. Application examples: Applications in PCR and sequencing technologies
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Ayurveda is well-known, but historically, India has been significantly involved with "medicine." Sapala Organics was established in 2005 in Hyderabad, located in the central part of the Deccan Plateau. The state government is actively investing to make this area a "Pharma City" (a treasure trove of medicine). Sapala has gained recognition from major pharmaceutical companies in the United States and Europe, steadily achieving results. To further provide the technological capabilities developed globally to Japan, Sapala Corporation was established in February 2018 as a local subsidiary in Japan. Recently, the Japanese government has also been focusing on projects that promote advanced pharmaceutical development and drug discovery, including nucleic acid-related drugs. We encourage you to consider the technological expertise of "Sapala," which excels in these fields.
