Rapid and easy clone selection is possible! The negative test for exogenous factors has been conducted, and cell banking has been performed under cGMP conditions.
The "CHOZN Elite Cell Line" is a CHO (Chinese Hamster Ovary) mammalian cell expression system that proliferates in a suspension culture using a chemically defined medium free of animal-derived components. It is a subclone of the CHOZN GS KO cell line, achieving performance that surpasses the parent strain in various performance indicators such as efficiency of cell line development (CLD), predictable growth, and protein production levels. A technical user guide detailing the procedures for optimizing performance will be provided along with the cell line. **Features** - High-producing clones with titers of 7 to 13 g/L can be obtained through the introduction of standard vectors, resulting in cost reduction. - Easy to adopt and can be directly integrated into the customer's existing CLD processes, compatible with both fed-batch and perfusion processes. *For more details, please download the PDF or feel free to contact us.*
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【Other Features】 ■ The obtained clones have extremely high stability, with 85% of the clones maintaining over 70% potency even after more than 60 passages. ■ In fed-batch culture, a consistent and predictable growth profile in the range of 18–24×10^6 cells/mL. ■ Traceability from CHOZN GS-/- ZFN modified CHO cell lines is possible. ■ This cell line is cGMP cell banked, and tests for the absence of exogenous factors have been conducted, ensuring regulatory compliance. *For more details, please download the PDF or feel free to contact us.
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For more details, please download the PDF or feel free to contact us.
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From research and development of pharmaceuticals to manufacturing and diagnostics, Merck is working to solve various challenges in life sciences in collaboration with the global science community. Merck's products include over 300,000 items, ranging from laboratory pure and ultra-pure water systems to gene editing tools for drug manufacturing, antibodies, cell lines, and end-to-end systems. To realize promising research more quickly and safely, we closely collaborate with customers in academia, the biotechnology industry, and the pharmaceutical industry. Please feel free to contact us for inquiries about our products or if you are interested in raw material supply. Here is the Merck ultra-pure and pure water systems webpage → https://www.merckmillipore.com/LW Here is the Merck life science reagents, raw materials, and analysis webpage → https://www.sigmaaldrich.com/JP/ja






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