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  3. メルク株式会社ライフサイエンス(シグマ アルドリッチ ジャパン合同会社)
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メルク株式会社ライフサイエンス(シグマ アルドリッチ ジャパン合同会社)

number of employees700
addressTokyo/Minato-ku/1-3-1 Azabudai, Azabudai Hills, Mori JP Tower, 26th Floor
phone03-4316-8000
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last updated:Dec 16, 2024
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メルク株式会社ライフサイエンス(シグマ アルドリッチ ジャパン合同会社) List of Products and Services

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Ultra-pure water and pure water equipment (for testing and research) Ultra-pure water and pure water equipment (for testing and research)
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[Data] Antibody Guidebook 3rd Edition

We would like to introduce some important information about the quality of antibodies that you should know!

This document is the 3rd edition of the Antibody Guidebook. It provides a concise overview of the main features of antibody use and immunochemical techniques in biological research. It clearly explains topics such as "theory of antibodies," "practical use of antibodies," "applications of antibodies," and "examples of protocols" using graphs and illustrations. Please feel free to download and take a look. 【Contents】 ■ Theory of antibodies ■ Practical use of antibodies ■ Applications of antibodies ■ Examples of protocols ■ Appendix ■ Glossary *For more details, please refer to the PDF document or feel free to contact us.

  • Other polymer materials

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Ascentis Express Fused-Core Column

Taking UHPLC to a new level! Achieving sub-2um separation performance with column lifetimes comparable to 3um.

"Ascentis Express" is a new HPLC column that combines Fused-Core technology with Ascentis' stationary phase technology. The Fused-Core particle technology achieves high-speed analysis and high separation equivalent to sub-2μm packing particles with half the system back pressure. Additionally, due to the low back pressure, it can be used in all HPLC systems, from general-purpose HPLC to UHPLC. 【Features】 ■ Ultra-fast separation (half the back pressure of sub-2μm particles) ■ Ultra-high separation (twice the theoretical plate count of 3μm particles) ■ Ultra-high sensitivity (improved signal-to-noise ratio with sharp peak shapes) ■ Robust construction (narrow particle size distribution of packing particles) *For more details, please refer to the PDF document or feel free to contact us.

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Titration Technology "Smart Chemical"

If the quality assurance period has expired, it will be automatically locked to prevent use! It also recognizes the opening record, and the date of the first opening is saved in the RFID tag.

"Smart Chemical" is a new titration technology using the Supelco brand's Smart Titrator, which can seamlessly send data to titration devices. By simply touching the reagent bottle, you can save time, reduce errors, and ensure consistent data integrity (DI). It also recognizes opening records, and the date of the first opening is recorded and stored on the RFID tag. If the quality assurance expiration date has passed, it will automatically lock to prevent use. 【Features】 ■ Direct connection to titration devices ■ Secure data transfer using RFID technology ■ Data transfer with just a touch in a matter of seconds *For more details, please refer to the PDF materials or feel free to contact us.

  • Other measurement, recording and measuring instruments

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Brighter LC/MS: Solvent, mobile phase additives, reagents

A wide range of solvents for LC/MS, additives for mobile phases, and reagents are featured!

This catalog features a wide range of LC/MS solvents, additives for mobile phases, and reagents. Liquid Chromatography-Mass Spectrometry (LC/MS) has become a routine analysis method, requiring high-purity reagents, mobile phases, and additives for mobile phases for sample preparation. Additionally, it is essential to always consider the risk of contamination from reagents, solvents, and devices used in sample preparation. Our company offers a rich selection of solvents, mobile phase additives, and reagents suitable for LC/MS. [Contents] ■ Solvents for LC/MS, blended solvents ■ Reagents and additives for LC/MS ■ Derivatization reagents for LC/MS ■ LC/MS methods for impurity profiling *For more details, please refer to the PDF document or feel free to contact us.

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Water, atmosphere, soil, and serum samples contain OK 'high-purity carbon material'.

Adopted for applications such as large-scale purification of gases/liquids and recovery of synthetic compounds from reaction mixtures!

"High Purity Carbon Material" can be used for the adsorption/desorption of target components in water, air, soil, and serum samples. As bulk material, it can be directly sold as part of packed GC columns, air monitoring devices, and analytical pretreatment equipment. It is utilized in applications such as collection media for air sampling devices, large-scale purification of gases/liquids, and recovery of synthetic compounds from reaction mixtures. 【Features】 ■ Usable for the adsorption/desorption of target components in water, air, soil, and serum samples ■ Can be directly sold as bulk material as part of packed GC columns, air monitoring devices, and analytical pretreatment equipment ■ Over 40 years of experience and proven results with trusted patented technology *For more details, please refer to the PDF document or feel free to contact us.

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Quantitative NMR (qNMR)

Explaining the internal standard method, external standard method, and considerations to keep in mind step by step!

The document includes the quantification of organic compounds and discusses internal and external standard methods. Quantitative NMR (qNMR) has become an efficient tool for quantifying organic compounds, and its use has been expanding in the pharmaceutical and chemical industries in recent years. Generally, proton NMR is used, but when considering the introduction of qNMR in new fields such as metabolomics, biomarker discovery, and physiological pathways, the presence of more complex molecules and systems makes the use of 1H-qNMR challenging. In such cases, using other NMR-active nuclei, namely 31P or 19F, may be a better option. [Contents (excerpt)] ■ Quantification of organic compounds ■ Internal and external standard methods ■ Considerations to take step by step *For more details, please refer to the PDF document or feel free to contact us.

  • Testing Equipment and Devices

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Food-derived allergens

Providing high-quality and stable allergen proteins! The purified products are also validated with IgE antibodies.

We handle "food-derived allergen proteins" from Indoor Biotechnologies. These proteins are purified using either affinity chromatography, HPLC, or both, and their identity and amino acid composition are confirmed by InBioMS (mass spectrometry) and amino acid analysis. Additionally, their immunoreactivity is validated using monoclonal antibodies, and the purified allergens are also verified with IgE antibodies. The purified allergens are processed and validated under a quality management system certified to ISO 9001:2015, ensuring the provision of high-quality and stable allergen proteins. *For more details, please refer to the PDF document or feel free to contact us.*

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Supelco analytical products (pharmaceuticals/food/environment)

To our customers involved in the analysis of pharmaceuticals, food, and environmental matters! We would like to introduce our popular products.

We would like to introduce our 'Supelco Analytical Products' suitable for the analysis of pharmaceuticals, food, and environmental-related substances. Our lineup includes popular products such as the "DSD-DNPH Sampler" for capturing aldehydes and ketones in indoor air, as well as the "VOC-SD Sampler" and "LpDNPH Sampler." In addition, we offer a variety of analytical products such as "ORBO-78" and "Supelclean ENVI-Carb/NH2 SPE Tubes." 【Product Lineup (Excerpt)】 ■ DSD-DNPH Passive Sampler ■ VOC-SD Passive Sampler ■ LpDNPH S10L (Cartridge Type) Active Sampler ■ LpDNPH S10 (Syringe Type) Active Sampler ■ ORBO-78 HBr Coated/Carboxen-564 ■ Supelclean ENVI-Carb/NH2 (500mg/500mg/6mL) *For more details, please refer to the PDF document or feel free to contact us.

  • Food Testing/Analysis/Measuring Equipment

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Supelco analytical products (environment/food and beverages)

Your partner in environmental and food & beverage analysis! Introducing popular products from Supelco that we handle.

We would like to introduce our 'Supelco Analytical Products' suitable for environmental, food, and beverage analysis. The "MQuant Peroxide Test" is an ideal product for controlling residual peroxides after disinfection. Additionally, we offer the "MQuant Nitrate Test," which is suitable for monitoring drinking water, process water, wastewater, and aquarium rearing water. We also have popular products such as the "Reflectoquant System" and the "TDF100A-1KT Assay" in our lineup. 【Product Lineup】 ■ MQuant Peroxide Test ■ MQuant Nitrate Test ■ MQuant Ammonium Test Strips ■ Reflectoquant System ■ TDF100A-1KT Assay *For more details, please refer to the PDF document or feel free to contact us.

  • Food Testing/Analysis/Measuring Equipment

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Organic Electrolytic Synthesis Platform 'SynLectro(TM)'

Simplifying and standardizing batch reactors! Providing options for new synthesis methods.

"SynLectro(TM)" is an organic electrochemical synthesis platform that simplifies and standardizes batch reactors while enhancing reproducibility and safety. There is no need for cumbersome experimental setup design or preparation. By simply selecting the kit, cell, and electrodes of this product and connecting them to a commercially available power supply, you can start new organic electrochemical synthesis in your lab. 【Features】 ■ Ready-to-use setup ■ Compatible with commercially available power units ■ Simplification of experimental setup design and preparation ■ Jacket-type options that facilitate temperature control ■ PTFE stopper designed specifically to enhance safety *For more details, please refer to the PDF document or feel free to contact us.

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[Data] Nitrosamine Standard Substances

Display of product grades such as USP reference standards and EP reference standards! Introduction of nitrosamine standard substances.

N-nitrosamines are chemical substances that contain a nitroso group (-N=O). This document introduces the standard substances of nitrosamines that our company handles. Product grades such as "USP standards" from the United States Pharmacopeia and "EP standards" from the European Pharmacopoeia are also listed. According to the International Agency for Research on Cancer (IARC) of the World Health Organization (WHO), many nitrosamines are carcinogenic and genotoxic to animals, and they are considered to have potential carcinogenicity in humans, leading to analysis in various fields. [Contents (excerpt)] ■ N-Nitrosodi-n-butylamine (NDBA) ■ N-Nitrosodiethylamine (NDEA) ■ N-Nitrosodiisopropylamine (DIPNA, NDIPA) ■ N-Nitrosodimethylamine (NDMA) ■ N-Nitrosodi-n-propylamine (NDPA) *For more details, please refer to the PDF document or feel free to contact us.

  • Chemicals

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Standard substances for the analysis of nitrofurans.

CRM authentication standard materials! Introducing nitrofurans, synthetic antibacterial agents.

This document includes standard substances for the analysis of nitrofurans that we handle. Products are introduced by item, such as "Nitrofurazone/SEM," "Fluoroquinolone/AOZ," and "Fluralaner/AMOZ." Nitrofurans are synthetic antibacterial agents and are regulated in Japan as "substances that are not detectable in food as pesticide components," due to their carcinogenic or genotoxic properties, with each of their metabolites being regulated. 【Contents】 ■ Nitrofurazone/SEM ■ Fluoroquinolone/AOZ ■ Fluralaner/AMOZ ■ Nitrofurantoin/AHD ■ Derivatization reagents *For more details, please refer to the PDF document or feel free to contact us.

  • Chemicals

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LC-MS measurement of PFAS

Excellent compatibility with MS! Lot management as a PFAS analysis column.

PFAS (perfluoroalkyl substances and polyfluoroalkyl compounds) are persistent organic pollutants widely found in the environment. The U.S. Food and Drug Administration (FDA) and the U.S. Environmental Protection Agency (EPA) have initiated measures regarding PFAS. Liquid chromatography-mass spectrometry (LC-MS) is used for the measurement of PFAS. Fused-Core technology and the 2.7μm particle Ascentis Express PFAS HPLC column provide excellent selectivity and peak shape for EPA methods 537.1, 533, and 8327. **Advantages of the Ascentis Express PFAS Column** - 2.7μm Fused-Core particles offer lower back pressure than sub-2μm fully porous particle columns - Excellent compatibility with MS - Lot management as a PFAS analysis column - Maximum operating pressure: 600 bar *For more details, please refer to the PDF document or feel free to contact us.*

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Rapid separation of polycyclic aromatic hydrocarbons

Achieved rapid analysis within 5 minutes! Demonstrated excellent separation capability for methyl group positional isomer PAHs.

Polycyclic aromatic hydrocarbons (PAHs) are carcinogenic substances found during the incomplete combustion of tobacco, tar, fuels, and more. There are official methods for analyzing PAHs present in various types of samples such as air, water, soil, and food. High-sensitivity measurement methods are required to analyze trace PAHs in water. Ascentis Express PAH has achieved rapid analysis of each of the 18 PAH components in the EPA method in under 5 minutes. 【Benefits of Ascentis Express PAH】 ■ 2.7μm Fused-Core particles provide lower back pressure than sub-2μm fully porous particle columns ■ Excellent compatibility with UV, fluorescence, and MS ■ Lot management as a PAHs analysis column ■ Maximum operating pressure: 600 bar *For more details, please refer to the PDF document or feel free to contact us.

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Selection of Capillary GC Columns for Residual Solvent Analysis

The use of solid-phase microextraction (SPME)! An excellent analytical method that replaces traditional headspace analysis.

This document presents the results of residual solvent analysis using both the conventional direct injection method and the economical solvent-free high-speed SPME method. SPME is a technique that eliminates the costs and hazards associated with the use of organic solvents, allowing for the high-precision extraction of analytes over a wide concentration range under consistent sampling conditions. We compare three columns equivalent to those described in both EP and USP for the analysis of 60 out of 61 solvents (those detectable by GC/FID), and provide descriptions of these columns. We encourage you to read it. [Included Items (Excerpt)] ■ Column names from USP and EP and their equivalents from Supelco ■ Interactions between the stationary phase and the analyte ■ Interactions between the stationary phase and residual solvents ■ Retention times and elution order of Class I residual solvents on the EquityTM-5, SUPELCOWAXTM 10, and OVI-G43 columns ■ Retention times and elution order of Class II residual solvents on the EquityTM-5, SUPELCOWAXTM 10, and OVI-G43 columns *For more details, please refer to the PDF document or feel free to contact us.

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Hydrophilic interaction chromatography

It is possible to strongly retain solutes! Beneficial not only for LC/MS but also for preparative chromatography.

This document explains Hydrophilic Interaction Liquid Chromatography (HILIC), which is a suitable separation method for highly polar hydrophilic compounds. It includes the basic theory of HILIC and notes on precautions when using the separation mode. Additionally, it introduces the zwitterionic ZIC-HILIC series from Merck SeQuant and describes application examples for various hydrophilic compounds. We encourage you to read it. [Contents (excerpt)] ■ Introduction ■ For first-time users of ZIC-HILIC ■ Why HILIC mode? ■ Equipment ■ Principle of separation *For more details, please refer to the PDF document or feel free to contact us.

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[Material] SPME Handbook <Solid Phase Microextraction Method>

Sample extraction and sample detachment can be performed easily and quickly! It can be adapted to a wide range of fields and diverse specimens.

This document is a simple guide to help you use SPME more effectively. It summarizes the tools, processes, principles, and optimization of SPME. It includes topics such as "Sample Preparation for Chromatographic Analysis," "SPME Units," and "Distribution Coefficients and Substance Transfer." SPME (Solid Phase Microextraction) is a new method for sample extraction/concentration/introduction for chromatographic analysis, developed by Professor J. Pawliszyn and his group at the University of Waterloo in Canada, and commercialized by Supelco in 1993. [Contents (Excerpt)] ■ Introduction ■ SPME Process ■ Principles of SPME Method ■ Optimization of SPME ■ Types of SPME Fibers ■ Practical Use of SPME *For more details, please refer to the PDF document or feel free to contact us.

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Pharmaceutical Analysis Research Product Guide

A wide range of information and products useful for chemical analysis and quality testing!

This catalog is the "Pharmaceutical Analysis Research Product Guide," which broadly includes information and products useful for chemical analysis and quality testing. We introduce a range of products, including pre-treatment filters, solid-phase extraction for pre-treatment, and HPLC columns. 【Contents (excerpt)】 ■ Pre-treatment filters ■ Ultrafiltration ■ Solid-phase extraction for pre-treatment ■ HPLC columns ■ HPLC solvents *For more details, please refer to the PDF document or feel free to contact us.

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[Data] RP-Amide HPLC/UHPLC Column

Improvement of retention for carboxylic acids and phenolic compounds! Achieving low bleed suitable for LC-MS applications.

This document provides an explanation of "RP-Amide HPLC/UHPLC columns." It introduces the "characteristics of RP-Amide," the "differences in retention for neutral analytes," and the "increased retention for hydrogen bond donors." Additionally, it includes analyses of "ulcer medications using Ascentis RP-Amide" and "UHPLC measurements of sunscreen drugs using Ascentis Express RP-Amide, 2.7μm." We encourage you to read it. 【Contents】 ■Ascentis RP-Amide HPLC column ■Analysis of ulcer medications using Ascentis RP-Amide ■UHPLC measurements of sunscreen drugs using Ascentis Express RP-Amide, 2.7μm ■Data sheet on the care and use of Ascentis Express RP-Amide columns ■LC/MS workflow products ■Ascentis RP-Amide product list ■Fused-Core product list *For more details, please refer to the PDF document or feel free to contact us.

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Novabiochem(R) Peptide Synthesis Reagent Product Guide

The product specifications for 20 standard Fmoc amino acids have been renewed!

This catalog is a product guide for the high-quality brand of peptide synthesis reagents, "Novabiochem(R)." By setting stricter product standards for standard Fmoc amino acids used in peptide synthesis, we have made it possible to use our products with greater confidence, from basic research to pharmaceuticals, cosmetics, and contract synthesis. We offer a wide range of packaging options, from small sizes to bulk sizes. [Contents (excerpt)] ■ Major Fmoc amino acids ■ Pseudoproline dipeptides ■ Coupling agents ■ Resins for solid-phase synthesis ■ History of Novabiochem innovations *For more details, please refer to the PDF document or feel free to contact us.

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Ascentis Express HILIC Guide

Retention and separation of hydrophilic compounds made faster! Choose the right column for your needs with the HILIC stationary phase selection guide.

This document provides an explanation of HILIC and features various types of HILIC stationary phase columns. HILIC technology, which has complementary properties to both reverse phase (RP) and normal phase (NP) chromatography, is often used in studies analyzing hydrophilic analytes. Additionally, we offer a lineup of products including the "Ascentis Express OH5 HPLC column," "Ascentis Express ES-Cyano HPLC column," and others. We invite you to read through it. [Contents (excerpt)] ■ Ascentis Express U/HPLC columns ■ What is HILIC and reasons to choose it ■ Development of HILIC methods ■ Ascentis Express OH5 HPLC column *For more details, please refer to the PDF document or feel free to contact us.

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F5 (PFP) HPLC/UHPLC column

Separation of positional isomers using reverse phase and HILIC analysis! An additional step to add to C18 and HILIC columns.

The "F5 (PFP) HPLC/UHPLC column" for metabolomics is a reversed-phase column with selectivity different from C18. By incorporating it as a second or third choice column in reversed-phase systems, the range of substances for LC analysis is broadened. Four retention mechanisms—hydrogen bonding, dipole-dipole interactions, π-π interactions, and hydrophobic interactions—complexly influence each other to exhibit unique retention characteristics and stereoselectivity. 【Features】 ■ Retains highly polar basic compounds without ion-pair reagents ■ 100% water mobile phase is usable ■ Suitable for LC/MS due to retention at high organic solvent concentrations ■ Supports both analysis and fractionation *For more details, please refer to the PDF document or feel free to contact us.

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High-Precision Photometer System Spectroquant Series

Supports a variety of applications! Featuring devices and reagents specifically for Spectroquant(R).

This catalog is the product catalog for the high-precision photometer system 'Spectroquant(R) Series'. It features the "Spectroquant Dedicated Equipment Series" that can accommodate a variety of applications, as well as the "Spectroquant Dedicated Reagent Series" and "Standard Solutions for Absorbance Spectrophotometry." We introduce measurement instruments suitable for applications in various fields, ranging from simple and portable small devices to photometers capable of trace analysis. [Contents] ■ Spectroquant Dedicated Equipment Series ■ Spectroquant Dedicated Reagent Series ■ Standard Solutions for Absorbance Spectrophotometry ■ Product Number Index *For more details, please refer to the PDF document or feel free to contact us.

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Merck Microscope Reagents Price List 2019

Listing of staining solutions for organization and cytology! Microscope reagent price list.

Merck's microscopy reagents, a leading supplier of products for microscopy worldwide In bacteriology, cytology, hematology, and histology, we offer a wide range of products to meet diverse requirements. We provide excellent staining solutions, ready-to-use test kits, dried Certistain(R) dyes, fixatives, paraffin, and solutions for sample pretreatment or staining. ■ Staining solutions for tissues ■ Staining solutions for cytology ■ Staining solutions for blood smears and cell counts ■ Staining solutions for bacteria and microorganisms *For more details, please refer to the catalog or feel free to contact us.

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A must-see for those in the food and beverage industry! Pure water production equipment that achieves efficiency and cost reduction.

A must-see for those in the food and beverage industry! It helps reduce electricity and water costs compared to distillers, contributing to cost savings and a lower environmental impact.

There are various methods to secure pure water, such as using ion exchange tanks, purchasing purified water, and employing distillers. However, many people likely face various concerns, such as the heavy maintenance burden and rising running costs. 'Elix Essential' is a pure water production device that can produce stable pure water without the hassle and costs associated with these methods. It prevents interruptions in analysis and testing caused by the cumbersome task of replacing ion exchange resins. Since there are no troublesome tasks due to replacements, the workload is eliminated, leading to increased efficiency! Additionally, it helps reduce running costs such as water and electricity bills, contributing to a lower environmental impact. 【Features】 ■ Easy maintenance ■ Reduction of running costs by purchasing purified water ■ Over 95% energy savings, over 80% water savings (compared to distillers) ■ Space-saving and unobtrusive *For more details, please refer to the PDF materials or feel free to contact us.

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IROA Technologies Metabolite Library

MLSDiscovery software tool included! High quality and reasonably priced library.

The identification of metabolite biomarkers and understanding their biological roles are essential for revealing new disease diagnostic methods and therapeutic targets. Mass spectrometry, an effective technique for this purpose, continues to increase in utility. Ensuring reproducibility of results in metabolic research is very important. IROA Technologies' "Metabolite Library" provides retention times and spectra of key metabolites as standards in mass spectrometry. It supports the optimization of mass spectrometry protocols to achieve high reproducibility. 【Features】 ■ 96-well plates that are ready-to-use with over 95% purity ■ Comprehensive coverage of primary metabolites and intermediates, covering major metabolic pathways ■ Plates dispensed by solubility (water-soluble/lipid-soluble) ■ The plate map includes compound names, compound IDs, molecular formulas, molecular weights, CAS, ChEBI, HMDB ID, PubChem ID, and Substance ID *For more details, please refer to the PDF document or feel free to contact us.

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M-Clarity program / Quality Management Program

From research to commercial bulk, supply is possible at quality levels tailored to the development stage!

"M-Clarity" is a highly transparent program that clearly defines the quality levels of Merck/Sigma Aldrich products and accurately provides the quality that customers need. This catalog introduces the quality management program at Merck Life Science. It also includes easy-to-understand tables summarizing the scope of application, identification, quality standards, and more for each product. Please use it to assist in your product selection. [Contents] ■ Quality Classes ■ Merck's Raw Material Supply Services ■ List of Major Manufacturing Sites *For more details, please feel free to contact us.

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High-purity inorganic materials of perovskite grade

Inorganic salts optimized for the synthesis of perovskite compounds for solar cells and LEDs.

"High-purity inorganic material of perovskite grade" is a product that easily dissolves in solvents such as DMF and DMF:DMSO (1:1). It is possible to obtain a transparent solution at a specified concentration. Due to its high sensitivity to air and moisture, it is sealed in glass ampoules. 【Features】 ■ Suitable for the synthesis of two-dimensional perovskite for solar cells and LEDs ■ Available in large quantities *For more details, please refer to the PDF document or feel free to contact us.

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Perovskite organic thin-film solar cell materials

Easily manufacturable with high conversion efficiency and low cost! Commercially attractive solar cell technology.

Hybrid organic-inorganic halide perovskite materials have recently attracted attention as novel light-absorbing materials for solar energy conversion applications. The power conversion efficiency of single-junction perovskite solar cells has already surpassed the technological level of conventional thin-film solar cells and has become competitive with monocrystalline silicon solar cells. 【Features】 ■ High conversion efficiency ■ Easily manufacturable at low cost ■ Commercially attractive solar cell technology *For more details, please refer to the PDF document or feel free to contact us.

  • Other polymer materials

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Animal-free amino acids

From lab scale to raw material bulk supply! We support the acceleration of your research and development and stable production.

Amino acids are used as supplements in cell culture media and for various applications such as metabolic research. At Sigma Aldrich, we offer animal-free amino acids in various sizes to reduce the risk of contamination with animal-derived components for research and development of biopharmaceuticals and vaccines. They are tested for cell culture and endotoxins, ensuring safe use in cell culture. 【Features】 ■ Available in bulk ■ Extensive global adoption record ■ Capable of change management *For more details, please refer to the PDF materials or feel free to contact us.

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Antimicrobial substance

From lab scale to raw material bulk supply! We support the acceleration of your research and development and stable production.

Antimicrobial substances refer to a general term for antibiotics produced from natural sources and chemically synthesized antimicrobial agents, which are used in testing research or pharmaceutical manufacturing to prevent contamination by pathogens. Among the diverse antimicrobial substances handled by Sigma Aldrich, we present below the main products. All of these are products with a wealth of experience in the adoption of raw material bulk. [Features] ■ Bulk supply available ■ Extensive global adoption record ■ Capable of change management *For more details, please refer to the PDF materials or feel free to contact us.

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Sigma Aldrich's catalysts for organic synthesis

Diverse catalyst product portfolio! From screening to lab scale and bulk supply.

Among the numerous product groups of Sigma-Aldrich, we offer a wide range of catalysts, ligands, metal compounds, and compounds for catalytic synthesis. To support the synthesis at various research stages of our customers, we provide the desired catalysts in a timely manner from the same source, from screening to lab-scale and bulk supply. We can customize everything from product synthesis to quantity and packaging according to your needs. 【Features】 - A wide product portfolio of over 2,000 types of catalysts, precursors, ligands, and metal compounds - Provision of products with high and stable quality - Strong network with renowned scientists - Dedicated research and development department for catalysts and in-house production system - Well-established product sales system *For more details, please feel free to contact us.

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Precision polymerization of functional high polymer materials is possible! 'RAFT agent'

A lineup of approximately 70 types of RAFT agents. *We also accept inquiries for bulk purchases and bulk orders.

Introducing "RAFT agents" that enable precise polymerization of functional high polymer materials. Our lineup includes "trithiocarbonate," "dithiocarbamate," "dithiobenzoate," and "switchable RAFT agents." We also accept inquiries for bulk purchases. 【Lineup】 ■ Trithiocarbonate ■ Dithiocarbamate ■ Dithiobenzoate ■ Switchable RAFT agents ■ Macro RAFT agents *For more details, please feel free to contact us.

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NanoFabTx (TM) formulation kit

Facilitates the screening of nanoparticle formulations for drug delivery.

NanoFabTx is a formulation kit for the simple and highly reproducible synthesis of drug-filled particles ranging from nano to micro sizes. We offer reagent kits, microfluidic device kits, screening kits, and various accessories. 【Features】 ■ Rapid testing enabled by detailed protocols ■ Easy synthesis of uniform and highly reproducible nanoparticles ■ Choice between standard nano sedimentation methods or microfluidic-based synthesis methods *For more details, please refer to the PDF document or feel free to contact us.

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Understand the difference in pure water immediately! Pure Water Equipment Selection Guide

Covers everything from basic knowledge of pure water to reference data useful for equipment selection. It meets a wide range of needs, including research and manufacturing.

Our company is a well-established provider of pure water production equipment that accommodates various types such as ion exchange water, RO water, and high-purity water (RO + EDI). There are diverse purification methods for pure water, and the suitable pure water equipment varies depending on the application. By introducing the right pure water system for your needs, it is possible to enhance the reliability and reproducibility of the expected results. This document includes fundamental knowledge about pure water, as well as reference data that will help in selecting equipment. 【Recommended for those who:】 ■ Want to understand the differences in purification methods and water quality of pure water ■ Want to know the types of pure water and equipment that match their objectives ■ Want to learn about the available pure water production equipment *For more detailed information, please refer to the "PDF Download."

  • Analytical Equipment and Devices
  • Pure water production equipment

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1-Molecule Count Custom Immunoassay / Sample Measurement Service

Achieving biomarker quantification at the femtogram (fg/mL) level. We develop projects tailored to our customers' plans!

Single Molecule Counting (SMC) immunoassays quantitatively measure target proteins with a wide dynamic range and excellent precision. SMC technology is widely adopted by researchers and pharmaceutical companies around the world to accelerate scientific discoveries and drug development in various disease areas. Our "Custom SMC Services" meet the needs of those who do not have the time or resources to dedicate to assay development for target proteins or measurement of critical samples. 【Possibilities of Custom Services】 ■ Biomarker discovery and development ■ Biopharmaceutical development ■ Reagent selection ■ Sample measurement ■ Development of custom assays *For more details, please refer to the PDF document or feel free to contact us.

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  • Contract measurement

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MyMilli-Q Remote Care

Improve lab productivity! In addition to water quality management and maintenance, it enables centralized management of equipment.

"MyMilli-Q Remote Care" is a service that connects Milli-Q devices to the internet, allowing real-time remote monitoring of the device's status and water quality data. Access the portal site via the internet for centralized management of the devices. Remote support, including remote diagnostics, is also available. You will receive notifications of alarms and maintenance via email, and in the event of any issues, our technical staff will respond quickly through remote control. 【Features】 ■ Management & support through the portal site ■ Minimization of Milli-Q device downtime ■ Smarter data management ■ Smooth and planned operation of Milli-Q devices ■ Remote access to the Milli-Q device screen *For more details, please refer to the PDF document or feel free to contact us.

  • Server monitoring and network management tools

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[Technical Document] Purification Methods for Test Water Suitable for Use in Pharmaceutical Testing and Related Applications

It is necessary to verify the level of water quality used for each test! We considered the test water used for HPLC testing.

This document is a technical material regarding the purification methods for test water suitable for "Water for Testing Pharmaceuticals" as defined by the Japanese Pharmacopoeia. Using purified water grade water, which was specified as water for pharmaceutical testing in the 15th revision of the Japanese Pharmacopoeia, and ultra-pure water commonly used in HPLC, we conducted an examination of water quality suitable for testing. You can verify the differences in water quality through the data provided. We encourage you to read it. *For more details, please refer to the PDF document or feel free to contact us.

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[Information] Novabiochem(R) Peptide Synthesis Reagent Product Guide

Setting strict product standards for 20 types of standard Fmoc amino acids!

This catalog is a product guide for the high-quality brand of peptide synthesis reagents, "Novabiochem(R)." It sets strict product standards for standard Fmoc amino acids used in peptide synthesis. You can use it with confidence for everything from basic research to pharmaceuticals, cosmetics, and contract synthesis. We offer a wide range of packaging options, from small sizes to bulk sizes. [Contents (excerpt)] ■ Major Fmoc amino acids ■ Pseudoproline dipeptides ■ Coupling agents ■ Resins for solid-phase synthesis ■ History of Novabiochem innovations *For more details, please refer to the PDF document or feel free to contact us.

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  • Chemicals

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Cleaning machine system "Q-Washer"

Reduce cleaning costs and effort! You can rinse with high-quality pure water that has fewer impurities.

The "Q-Washer" is a cleaning system that combines a cleaning machine with Merck's ultrapure water and pure water equipment. Unlike regenerable SDI, it maintains stable water quality with a continuous ion exchange (EDI) mechanism that does not require regeneration. This reduces cleaning costs and frees you from the hassle of SDI replacement. Additionally, it achieves space-saving and secures new workspaces while also considering fall prevention in its design. 【Features】 ■ Reduction of manual cleaning costs ■ Conservation of cleaning water ■ Automatic determination of cleaning quality based on wastewater conductivity ■ Reduction of operational burden ■ Uniform cleaning & clarity ■ Reduction of contamination due to residues *For more details, please refer to the PDF materials or feel free to contact us.

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Ultra-pure water and pure water production equipment in accordance with the Minamata Convention and Mercury Pollution Prevention Act.

Explaining the reasons for mercury regulation. Introducing the background of the regulation and mercury-free pure water purification technology.

Mercury is a dangerous chemical substance that has extremely harmful effects on health and the environment, and various regulations have begun in recent years. The regulations regarding the purchase of mercury-containing products differ by affiliated organizations and companies, but a survey conducted by our company in 2020 found that the most common response was "it is necessary to choose products that contain as little mercury as possible," at 47%, while 19% responded that "products containing mercury cannot be purchased," resulting in a total of 66% of organizations having regulations in place. Recently, efforts towards sustainability have been increasingly emphasized. ↓↓ For more details on Merck's mercury-free technology, please see below.

  • Pure water production equipment

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Ultra-pure water and pure water system Milli-Q IQ 7003/05/10/15

Exhibiting at JASIS (water sampling experience available)! All UV lamps for sterilization, organic matter decomposition, and TOC measurement are mercury-free! Ultra-pure water and pure water systems.

Are you facing any of these issues? - The purity of water is unstable, affecting analysis and experimental results. - There is limited installation space in the lab, making it impossible to place large equipment. - Filter replacement and equipment management are complicated, leading to a higher chance of mistakes. The completely mercury-free "Ultra-Pure Water/Pure Water System Milli-Q IQ 7003/05/10/15" is designed to minimize stress in the lab with features such as: - "All UV lamps for sterilization, organic matter decomposition, and TOC measurement are mercury-free" - "Eight levels of adjustable water sampling speed" - "The main unit is compact and does not require a specific placement" Additionally, we offer validation support services (IQ/OQ, OQ), calibration services, and USP equipment conformity testing, with many successful adoptions in domestic and international inspections. We will be exhibiting at JASIS 2025. Dates: September 3 (Wed) - September 5 (Fri), 2025 Venue: Makuhari Messe International Exhibition Hall and Conference Center Booth Number: "7A-605" Admission Fee: Free (Pre-registration required) *For more details, please contact us or download the materials.

  • Pure water production equipment
  • Water treatment equipment

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Pure water system Milli-Q IX 7003/05/10/15

[New Product] All UV lamps for sterilizing the device body and tank are mercury-free! Pure water system Milli-Q IX 7003/05/10/15

Attention everyone looking for water free of microorganisms! This is a pure water production system designed to control microorganisms using mercury-free UV lamps. You can also find more details on Merck's website. ↓↓ For product details and inquiries for quotes, please contact us below ↓↓

  • Pure water production equipment

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Milli-Q EQ 7000 ultrapure water system

Can be connected to the pure water system you currently have! New features for a comfortable lab experience.

The Milli-Q EQ 7000 is designed for comfortable use and provides strong support for researchers. ● Easy Sampling with Q-POD The sampling speed can be selected from three levels according to the purpose. The Q-POD can be installed in four positions on the main unit (top, bottom, left, right) or placed away from the main unit, making it easy to sample regardless of the installation location. ● Overwhelming Ease of Use Water quality is constantly displayed on the touchscreen, and with just a few clicks, you can print water quality reports or program the volume for quantitative sampling, showcasing its user-friendly design. ● Simple Operation with Touch Panel It can be operated intuitively like a smartphone. All information, including water quality data and maintenance information, is accessible from the touchscreen. You can easily check, save, and retrieve water quality data with simple steps. ● Wide Range of Applications By changing the final filter from the standard Milli-Pak to Biopak, LC-Pak, or EDS-Pak, it accommodates a wide range of applications from equipment analysis to biochemical and molecular biology research. ● Minimization of Maintenance All purification cartridges are designed for easy replacement.

  • Pure water production equipment

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Technical Information: Selection of Suitable Water for Food Microbial Testing

ISO 11133 explains the recommended water quality for the preparation of culture media for food microbiological testing.

To ensure accurate results, prevent false positives or false negatives, and avoid contamination, it is essential to carefully select reagents containing water when preparing liquid or solid media. Tap water may contain various impurities that can affect bacterial growth or cause errors in the prepared media. Since water is a major component of the media, the removal of these contaminants from water is crucial for media preparation. The recommended water quality for media preparation is detailed in ISO 11133:2014 ("Microbiology of food, animal feed and water — Preparation, production, storage and performance testing of culture media"). Additionally, ANNEX H discusses troubleshooting for media, citing the use of inappropriate quality of pure water as a cause of incorrect pH, color anomalies, formation of precipitates, and culture inhibition. This technical document explains the ISO 11133 standards and Merck's pure water production systems that meet these criteria.

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