メルク株式会社ライフサイエンス（シグマ アルドリッチ ジャパン合同会社） Product Lineup

The "Certified Reference Material (CRM) for Elemental Impurity Analysis of Pharmaceuticals" is a mixed solution prepared at concentrations that correspond to the permissible daily exposure (PDE) values outlined in the ICH Q3D guidelines. It ensures the safety of your pharmaceuticals by adhering to the elemental concentration limits for oral, non-oral, and inhalation routes. With the elimination of human preparation errors, it allows for more accurate analysis and reproducibility. 【Features】 ■ Manufactured in facilities accredited to ISO/IEC 17025 and ISO 17034 ■ Improved stability through innovative container design ■ Pre-prepared mixed solution *For more details, please refer to the PDF document or feel free to contact us.

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This catalog introduces reagents related to histology and hematology research. It includes "cell separation-related reagents," as well as "Histopaque density gradient media," "the basics of centrifugation," and "selection of appropriate density gradient solutions (media)." We encourage you to read it. 【Contents (excerpt)】 ■ Cell separation-related reagents ■ Histopaque density gradient media ■ The basics of centrifugation ■ Various centrifugation methods *For more details, please refer to the PDF document or feel free to contact us.

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This catalog introduces standard substances for veterinary pharmaceuticals. Starting with "Acepromazine - (Dimethyl-d6) Maleate," it also includes "Carbazole," "Corterol - (tert-Butyl-d9) Acetate," "Corticosterone," "β-Estradiol 17-Acetate," and more. Please take a moment to read it. [Contents (Excerpt)] ■ Acrylamide ■ Iopamidol ■ Equilin ■ Oxacillin Sodium Salt Monohydrate ■ Caspofungin Hydrochloride *For more details, please refer to the PDF document or feel free to contact us.

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This catalog provides a detailed list of plant-derived food-based bioactive substances and functional food components, particularly nutrients that demonstrate physiological effects beyond normal nutritional value. It features tools to promote nutrient analysis, including high-purity biochemical substances for in vivo and in vitro research, as well as analytical standards. Please use this for product selection. [Contents] ■ Introduction ■ Plant-derived chemicals ■ Functional food components ■ Products for plant-based research ■ Standard substances for mass spectrometry metabolite library *For more details, please refer to the PDF document or feel free to contact us.

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This catalog features the "biochemical buffers" handled by our company. Starting with the Tris buffer known for its "Trizma," which was launched nearly 60 years ago, our products are offered in various grades and packaging to meet diverse needs, with consistent high quality and stable supply, and are adopted by many researchers and companies. We provide convenient packaging options such as powders, ready-to-use solutions, tablets, and pouches, as well as various packaging forms like the "Redi-Dri bottle" that prevents solidification. Please use this for selecting products. [Contents] ■ BioPerformance Certified ■ BioXtra ■ Biochemical Buffer Selection Guide ■ Other Biochemical Buffers ■ Basics of Buffers ■ Redi-Dri Bottle to Prevent Moisture Absorption of Reagents *For more details, please refer to the PDF document or feel free to contact us.

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This document is a product guide for "fluorinated reagents" handled by our company. We introduce "Baran Diversinates," which allows for the addition of various functional groups, such as fluorinated alkyl groups, onto aromatic heterocyclic frameworks with simple operations that are not affected by moisture or the atmosphere, as well as "XtalFluor," a stable solid fluorination reagent that is easy to handle. Please use this guide to assist in selecting products. [Contents (excerpt)] ■Baran Diversinates: Introduction of fluorine to aromatic heterocyclic frameworks ■PhenoFluor, PhenoFluor MIX, AlkylFluor: User-friendly deoxygenative fluorination agents ■PyFluor: Deoxygenative fluorination agent with high thermal and chemical stability ■DMPU-HF: A new nucleophilic fluorination reagent *For more details, please refer to the PDF document or feel free to contact us.

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This document is an application guide for Pd catalysts and ligands for cross-coupling reactions. Cross-coupling reactions utilizing palladium are an efficient method for forming C-C, C-N, and C-O bonds, and are one of the important reactions in modern organic synthesis. Many catalysts and precursors have been developed, and it is crucial to use the appropriate catalyst and ligand for each cross-coupling reaction. We encourage you to read it. [Contents (excerpt)] ■ Main cross-coupling reactions ■ Palladium catalysts and precursors ■ Phosphine ligands ■ Buchwald ligands ■ cataCXium ligands *For more details, please refer to the PDF document or feel free to contact us.

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This document is a 'Partial PROTAC' product guide for PROTAC design. PROTAC is a new drug discovery modality that degrades target proteins within cells. This product allows for the easy construction of a library for optimal PROTAC cross-linker design. Please take a moment to read it. PROTAC(R) is a registered trademark of Arvinas Operations, Inc. [Contents] ■ Target protein degradation ■ Partial PROTAC: Cross-linkers for target protein degradation ■ List of Partial PROTAC products ■ "Aldrich Partner Products" are now available for purchase in Japan! ■ Duolink PLA (Proximity Ligation Assay) ■ Three reasons why Sigma Aldrich's bulk service is chosen *For more details, please refer to the PDF document or feel free to contact us.

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The "Redi-Dri Bottle" prevents the clumping that often occurs with many hygroscopic powders, keeping powdered reagents in a "flowable" state that can be used at any time. No more hassle and time needed to crush reagents that have solidified during storage. We offer various sizes, from research use to bulk. 【Features】 ■ Improved efficiency and safety ■ Waste reduction ■ Reliable quality ■ Cost reduction ■ A wide range of container sizes *For more details, please refer to the PDF document or feel free to contact us.

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This document introduces the "GC Capillary Column." It includes measurements and analyses using various columns, such as "Ionic Liquid Liquid Phase GC Column" and "Chiral GC Column." The material provides clear explanations using graphs. Please feel free to download and take a look. 【Contents (Excerpt)】 ■ Ionic Liquid Liquid Phase GC Column - SLB-IL, Watercol ■ Chiral GC Column - Astec CHIRALDEX ■ Using Watercol - Moisture measurement method for liquefied petroleum gas - Simultaneous measurement of water and BTEX in gasoline *For more details, please refer to the PDF document or feel free to contact us.

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This document introduces "HPLC & UHPLC Columns." It features "Fused-core columns," which have a non-porous core at the center of silica gel microparticles, with only the surface being porous, as well as "Ascentis RP-amide," which is separated based on differences in selectivity due to the stationary phase. Additionally, it explains columns for hydrophilic interaction chromatography, such as the "ZIC-HILIC series," using tables and graphs. [Contents] ■ Fused-core columns ■ Balancing high performance and cost reduction ■ Separation based on differences in selectivity due to the stationary phase ■ Separation of related compounds through multiple interactions (MIX mode) ■ Columns for hydrophilic interaction chromatography ■ Speeding up HILIC mode ■ Low back pressure, high durability HPLC columns *For more details, please refer to the PDF document or feel free to contact us.

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This document introduces "Chiral Chromatography." It features the "CYCLOBOND" column series, which has excellent chiral recognition capabilities, as well as the unique "CLC" column that utilizes chelation with copper ions, and the classic series of cyclodextrin-based columns "α, β, γ-DEX." The explanations are made clear using diagrams and graphs. Please feel free to download and take a look. 【Contents (excerpt)】 ■ HPLC Columns ・CHIROBIOTIC ・CYCLOBOND ・CLC ・ChromegaChiral, GreenSep *For more details, please refer to the PDF document or feel free to contact us.

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"Synthia" is a retrosynthetic analysis tool developed over 15 years through a collaboration between organic chemistry and computer science. It not only verifies the interactions at the reaction centers at each step of the reaction but also evaluates the selectivity of the reaction, including stereoselectivity and regioselectivity, as well as the influence of incompatible functional groups across the entire molecule. This tool accelerates the development of organic synthesis, achieves cost reduction, and provides organic chemists with new ideas. 【Features】 ■ Organic chemists encode reaction rules ■ Advanced and sophisticated algorithms ■ Over 65,000 reaction rules ■ Proposes practical synthetic routes ■ Analyzes novel routes that have not been reported *For more details, please refer to the PDF materials or feel free to contact us.

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The "Kitalysis High-Throughput Screening Kit" is a new tool recommended for researchers who want to quickly and efficiently examine the conditions of catalytic reactions using a small amount of substrate. This product selects the most commonly used catalysts in drug discovery chemistry. It allows for the simultaneous execution of 24 different reaction conditions, enabling rapid catalyst screening. 【Features】 - Conduct 24 types of reactions with approximately 100 mg of substrate (using 3-4 mg of substrate per vial) - Selects catalysts, bases, and solvents that are frequently used in drug discovery chemistry - An all-in-one kit that includes all necessary reagents and equipment - No need for operations inside a glove box if you have the KitAlysis Inert Box *For more details, please refer to the PDF document or feel free to contact us.

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Our company provides pharmaceutical secondary standard substances, available as a convenient and affordable alternative to primary standard substances, for those engaged in the manufacturing and research of pharmaceuticals. By using secondary standard substances, there is no need for you to prepare practical standard substances yourself. Furthermore, our secondary standard substances are offered in larger quantities at lower prices than primary standard substances, allowing you to reduce costs, effort, and time. We currently offer over 700 items of secondary standard substances and will continue to expand our lineup in the future. 【Features】 ■ Traceable to the extent possible to the standards of the United States Pharmacopeia (USP), European Pharmacopoeia (EP), and British Pharmacopoeia (BP) ■ Analyzed using GMP-compliant equipment and pharmacopoeial standards ■ Certified values according to the gravimetric method, in accordance with ISO Guide 34 and ISO 17025 ■ Accompanied by a certificate in accordance with ISO Guide 31 *For more details, please refer to the PDF materials or feel free to contact us.

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This document is the Cell Culture Guide, Second Edition. It provides clear explanations using photos and graphs about "human cells," as well as "mouse and rat cells," "ES/iPS cell research products," "media (mammalian cell media)," and "buffers." Please feel free to download and take a look. 【Contents (partial)】 ■ Human Cells ■ Mouse and Rat Cells ■ ES/iPS Cell Research Products ■ Media (Mammalian Cell Media) ■ Buffers *For more details, please refer to the PDF document or feel free to contact us.

• Other polymer materials

"Trace CERT(R)" is a certified reference material (CRM) manufactured under dual accreditation of ISO/IEC 17025 and ISO Guide 34. It is traceable to at least two international standards (such as NIST(R), BAM, SI unit kg). It provides a certificate that includes uncertainty and expiration date, created in accordance with ISO Guide 31. Additionally, the certificate for the ICP standard displays measurement results for approximately 70 types of trace impurities. [Features] - Manufactured under dual accreditation of ISO/IEC 17025 and ISO Guide 34 - Traceable to international standards (such as NIST(R), BAM, SI unit kg) - Certificate includes uncertainty and expiration date, created in accordance with ISO Guide 31 - The certificate for the ICP standard displays measurement results for approximately 70 types of trace impurities *For more details, please refer to the PDF document or feel free to contact us.

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This catalog features a wide range of "Natural/Phytochemical Standard Substances" handled by Sigma Aldrich Japan. An INDEX is provided for searching in alphabetical order by plant name and substance name, making it easy to identify the corresponding catalog number at a glance. Our company offers standard substances and certified standard substances for active ingredients and markers from medicinal plants. Currently, our product lineup exceeds 600, and we are continuously expanding our new products. New products can be checked on the linked homepage. Please take a look. 【Contents ■ Phytochemical Standard Substances ■ Product List (Plant Name / Alphabetical Order) ■ Standard Substances of Plant Extracts ■ Substance Name: Index (Alphabetical Order) ■ Plant Name: Index (Alphabetical Order) *For more details, please refer to the PDF materials or feel free to contact us.

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This catalog features a wide range of "pesticide standard substances" handled by Sigma Aldrich Japan. You can search for product names in alphabetical order from the INDEX, and easily see information such as concentration, CAS number, and desired selling price at a glance. We offer a selection of over 40,000 items, including analytical standard substances and certified reference materials (CRM). [Pesticide Substances (Excerpt)] ■ Aioxynil ■ Sulfur ■ Uniconazole ■ Edifenphos ■ Eugenol *For more details, please refer to the PDF document or feel free to contact us.

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The "Supel QuE Catchers Solid Phase Extraction and Purification Tube" is a rapid, simple, cost-effective, efficient, robust, and safe sample preparation method using dispersive solid phase extraction (dSPE) that stirs and centrifuges salts and purification fillers together with the sample. It is simpler than conventional solid phase extraction methods, significantly improving the efficiency of customer operations and allowing for a reduced amount of solvent usage. Additionally, it has been adopted in "AOAC 2007.01.1" and "EN15662:2008," and is widely used in the analysis of pesticide residues in food and agricultural products. In recent years, it has also been developed for the analysis of PAHs, PCBs, PBDEs, and flame retardants. 【Features】 ■ Quick: Preparation time is about 10 minutes ■ Easy: No complicated operations ■ Cheap: No expensive equipment required ■ Effective: Applicable over a wide range with a small amount of sample ■ Rugged: Effective for routine analysis handling hundreds of samples ■ Safe: Does not use harmful chemicals or chlorinated solvents *For more details, please refer to the PDF document or feel free to contact us.

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"SPME (Solid Phase Microextraction)" allows for a series of operations including sample extraction, concentration, and desorption in chromatographic analysis to be performed quickly and easily. Since the concentrated sample can be introduced in its entirety into the GC, it is expected to achieve sensitivity that surpasses traditional headspace methods, solid-phase extraction methods, and solvent extraction methods. Furthermore, this method does not require expensive equipment like purge and trap and can be utilized with manual operation. 【Features】 ■ Extraction method that uses no solvents at all ■ Capable of extracting from solid, liquid, and gas samples ■ Enables measurement of low concentration samples from ppt to ppb levels ■ Required sample amount is extremely small (approximately 100 μL or more) ■ No need for expensive equipment like purge and trap, making it cost-effective *For more details, please refer to the PDF materials or feel free to contact us.

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This document is the 3rd edition of the Antibody Guidebook. It provides a concise overview of the main features of antibody use and immunochemical techniques in biological research. It clearly explains topics such as "theory of antibodies," "practical use of antibodies," "applications of antibodies," and "examples of protocols" using graphs and illustrations. Please feel free to download and take a look. 【Contents】 ■ Theory of antibodies ■ Practical use of antibodies ■ Applications of antibodies ■ Examples of protocols ■ Appendix ■ Glossary *For more details, please refer to the PDF document or feel free to contact us.

• Other polymer materials

"Ascentis Express" is a new HPLC column that combines Fused-Core technology with Ascentis' stationary phase technology. The Fused-Core particle technology achieves high-speed analysis and high separation equivalent to sub-2μm packing particles with half the system back pressure. Additionally, due to the low back pressure, it can be used in all HPLC systems, from general-purpose HPLC to UHPLC. 【Features】 ■ Ultra-fast separation (half the back pressure of sub-2μm particles) ■ Ultra-high separation (twice the theoretical plate count of 3μm particles) ■ Ultra-high sensitivity (improved signal-to-noise ratio with sharp peak shapes) ■ Robust construction (narrow particle size distribution of packing particles) *For more details, please refer to the PDF document or feel free to contact us.

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"Smart Chemical" is a new titration technology using the Supelco brand's Smart Titrator, which can seamlessly send data to titration devices. By simply touching the reagent bottle, you can save time, reduce errors, and ensure consistent data integrity (DI). It also recognizes opening records, and the date of the first opening is recorded and stored on the RFID tag. If the quality assurance expiration date has passed, it will automatically lock to prevent use. 【Features】 ■ Direct connection to titration devices ■ Secure data transfer using RFID technology ■ Data transfer with just a touch in a matter of seconds *For more details, please refer to the PDF materials or feel free to contact us.

• Other measurement, recording and measuring instruments

This catalog features a wide range of LC/MS solvents, additives for mobile phases, and reagents. Liquid Chromatography-Mass Spectrometry (LC/MS) has become a routine analysis method, requiring high-purity reagents, mobile phases, and additives for mobile phases for sample preparation. Additionally, it is essential to always consider the risk of contamination from reagents, solvents, and devices used in sample preparation. Our company offers a rich selection of solvents, mobile phase additives, and reagents suitable for LC/MS. [Contents] ■ Solvents for LC/MS, blended solvents ■ Reagents and additives for LC/MS ■ Derivatization reagents for LC/MS ■ LC/MS methods for impurity profiling *For more details, please refer to the PDF document or feel free to contact us.

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"High Purity Carbon Material" can be used for the adsorption/desorption of target components in water, air, soil, and serum samples. As bulk material, it can be directly sold as part of packed GC columns, air monitoring devices, and analytical pretreatment equipment. It is utilized in applications such as collection media for air sampling devices, large-scale purification of gases/liquids, and recovery of synthetic compounds from reaction mixtures. 【Features】 ■ Usable for the adsorption/desorption of target components in water, air, soil, and serum samples ■ Can be directly sold as bulk material as part of packed GC columns, air monitoring devices, and analytical pretreatment equipment ■ Over 40 years of experience and proven results with trusted patented technology *For more details, please refer to the PDF document or feel free to contact us.

• Other polymer materials

The document includes the quantification of organic compounds and discusses internal and external standard methods. Quantitative NMR (qNMR) has become an efficient tool for quantifying organic compounds, and its use has been expanding in the pharmaceutical and chemical industries in recent years. Generally, proton NMR is used, but when considering the introduction of qNMR in new fields such as metabolomics, biomarker discovery, and physiological pathways, the presence of more complex molecules and systems makes the use of 1H-qNMR challenging. In such cases, using other NMR-active nuclei, namely 31P or 19F, may be a better option. [Contents (excerpt)] ■ Quantification of organic compounds ■ Internal and external standard methods ■ Considerations to take step by step *For more details, please refer to the PDF document or feel free to contact us.

• Testing Equipment and Devices

We handle "food-derived allergen proteins" from Indoor Biotechnologies. These proteins are purified using either affinity chromatography, HPLC, or both, and their identity and amino acid composition are confirmed by InBioMS (mass spectrometry) and amino acid analysis. Additionally, their immunoreactivity is validated using monoclonal antibodies, and the purified allergens are also verified with IgE antibodies. The purified allergens are processed and validated under a quality management system certified to ISO 9001:2015, ensuring the provision of high-quality and stable allergen proteins. *For more details, please refer to the PDF document or feel free to contact us.*

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We would like to introduce our 'Supelco Analytical Products' suitable for the analysis of pharmaceuticals, food, and environmental-related substances. Our lineup includes popular products such as the "DSD-DNPH Sampler" for capturing aldehydes and ketones in indoor air, as well as the "VOC-SD Sampler" and "LpDNPH Sampler." In addition, we offer a variety of analytical products such as "ORBO-78" and "Supelclean ENVI-Carb/NH2 SPE Tubes." 【Product Lineup (Excerpt)】 ■ DSD-DNPH Passive Sampler ■ VOC-SD Passive Sampler ■ LpDNPH S10L (Cartridge Type) Active Sampler ■ LpDNPH S10 (Syringe Type) Active Sampler ■ ORBO-78 HBr Coated/Carboxen-564 ■ Supelclean ENVI-Carb/NH2 (500mg/500mg/6mL) *For more details, please refer to the PDF document or feel free to contact us.

• Food Testing/Analysis/Measuring Equipment

We would like to introduce our 'Supelco Analytical Products' suitable for environmental, food, and beverage analysis. The "MQuant Peroxide Test" is an ideal product for controlling residual peroxides after disinfection. Additionally, we offer the "MQuant Nitrate Test," which is suitable for monitoring drinking water, process water, wastewater, and aquarium rearing water. We also have popular products such as the "Reflectoquant System" and the "TDF100A-1KT Assay" in our lineup. 【Product Lineup】 ■ MQuant Peroxide Test ■ MQuant Nitrate Test ■ MQuant Ammonium Test Strips ■ Reflectoquant System ■ TDF100A-1KT Assay *For more details, please refer to the PDF document or feel free to contact us.

• Food Testing/Analysis/Measuring Equipment

"SynLectro(TM)" is an organic electrochemical synthesis platform that simplifies and standardizes batch reactors while enhancing reproducibility and safety. There is no need for cumbersome experimental setup design or preparation. By simply selecting the kit, cell, and electrodes of this product and connecting them to a commercially available power supply, you can start new organic electrochemical synthesis in your lab. 【Features】 ■ Ready-to-use setup ■ Compatible with commercially available power units ■ Simplification of experimental setup design and preparation ■ Jacket-type options that facilitate temperature control ■ PTFE stopper designed specifically to enhance safety *For more details, please refer to the PDF document or feel free to contact us.

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N-nitrosamines are chemical substances that contain a nitroso group (-N=O). This document introduces the standard substances of nitrosamines that our company handles. Product grades such as "USP standards" from the United States Pharmacopeia and "EP standards" from the European Pharmacopoeia are also listed. According to the International Agency for Research on Cancer (IARC) of the World Health Organization (WHO), many nitrosamines are carcinogenic and genotoxic to animals, and they are considered to have potential carcinogenicity in humans, leading to analysis in various fields. [Contents (excerpt)] ■ N-Nitrosodi-n-butylamine (NDBA) ■ N-Nitrosodiethylamine (NDEA) ■ N-Nitrosodiisopropylamine (DIPNA, NDIPA) ■ N-Nitrosodimethylamine (NDMA) ■ N-Nitrosodi-n-propylamine (NDPA) *For more details, please refer to the PDF document or feel free to contact us.

• Chemicals

This document includes standard substances for the analysis of nitrofurans that we handle. Products are introduced by item, such as "Nitrofurazone/SEM," "Fluoroquinolone/AOZ," and "Fluralaner/AMOZ." Nitrofurans are synthetic antibacterial agents and are regulated in Japan as "substances that are not detectable in food as pesticide components," due to their carcinogenic or genotoxic properties, with each of their metabolites being regulated. 【Contents】 ■ Nitrofurazone/SEM ■ Fluoroquinolone/AOZ ■ Fluralaner/AMOZ ■ Nitrofurantoin/AHD ■ Derivatization reagents *For more details, please refer to the PDF document or feel free to contact us.

• Chemicals

PFAS (perfluoroalkyl substances and polyfluoroalkyl compounds) are persistent organic pollutants widely found in the environment. The U.S. Food and Drug Administration (FDA) and the U.S. Environmental Protection Agency (EPA) have initiated measures regarding PFAS. Liquid chromatography-mass spectrometry (LC-MS) is used for the measurement of PFAS. Fused-Core technology and the 2.7μm particle Ascentis Express PFAS HPLC column provide excellent selectivity and peak shape for EPA methods 537.1, 533, and 8327. **Advantages of the Ascentis Express PFAS Column** - 2.7μm Fused-Core particles offer lower back pressure than sub-2μm fully porous particle columns - Excellent compatibility with MS - Lot management as a PFAS analysis column - Maximum operating pressure: 600 bar *For more details, please refer to the PDF document or feel free to contact us.*

• Separation device

Polycyclic aromatic hydrocarbons (PAHs) are carcinogenic substances found during the incomplete combustion of tobacco, tar, fuels, and more. There are official methods for analyzing PAHs present in various types of samples such as air, water, soil, and food. High-sensitivity measurement methods are required to analyze trace PAHs in water. Ascentis Express PAH has achieved rapid analysis of each of the 18 PAH components in the EPA method in under 5 minutes. 【Benefits of Ascentis Express PAH】 ■ 2.7μm Fused-Core particles provide lower back pressure than sub-2μm fully porous particle columns ■ Excellent compatibility with UV, fluorescence, and MS ■ Lot management as a PAHs analysis column ■ Maximum operating pressure: 600 bar *For more details, please refer to the PDF document or feel free to contact us.

• Separation device

This document presents the results of residual solvent analysis using both the conventional direct injection method and the economical solvent-free high-speed SPME method. SPME is a technique that eliminates the costs and hazards associated with the use of organic solvents, allowing for the high-precision extraction of analytes over a wide concentration range under consistent sampling conditions. We compare three columns equivalent to those described in both EP and USP for the analysis of 60 out of 61 solvents (those detectable by GC/FID), and provide descriptions of these columns. We encourage you to read it. [Included Items (Excerpt)] ■ Column names from USP and EP and their equivalents from Supelco ■ Interactions between the stationary phase and the analyte ■ Interactions between the stationary phase and residual solvents ■ Retention times and elution order of Class I residual solvents on the EquityTM-5, SUPELCOWAXTM 10, and OVI-G43 columns ■ Retention times and elution order of Class II residual solvents on the EquityTM-5, SUPELCOWAXTM 10, and OVI-G43 columns *For more details, please refer to the PDF document or feel free to contact us.

• Analytical Equipment and Devices

This document explains Hydrophilic Interaction Liquid Chromatography (HILIC), which is a suitable separation method for highly polar hydrophilic compounds. It includes the basic theory of HILIC and notes on precautions when using the separation mode. Additionally, it introduces the zwitterionic ZIC-HILIC series from Merck SeQuant and describes application examples for various hydrophilic compounds. We encourage you to read it. [Contents (excerpt)] ■ Introduction ■ For first-time users of ZIC-HILIC ■ Why HILIC mode? ■ Equipment ■ Principle of separation *For more details, please refer to the PDF document or feel free to contact us.

• Separation device

This document is a simple guide to help you use SPME more effectively. It summarizes the tools, processes, principles, and optimization of SPME. It includes topics such as "Sample Preparation for Chromatographic Analysis," "SPME Units," and "Distribution Coefficients and Substance Transfer." SPME (Solid Phase Microextraction) is a new method for sample extraction/concentration/introduction for chromatographic analysis, developed by Professor J. Pawliszyn and his group at the University of Waterloo in Canada, and commercialized by Supelco in 1993. [Contents (Excerpt)] ■ Introduction ■ SPME Process ■ Principles of SPME Method ■ Optimization of SPME ■ Types of SPME Fibers ■ Practical Use of SPME *For more details, please refer to the PDF document or feel free to contact us.

• Analytical Equipment and Devices

This catalog is the "Pharmaceutical Analysis Research Product Guide," which broadly includes information and products useful for chemical analysis and quality testing. We introduce a range of products, including pre-treatment filters, solid-phase extraction for pre-treatment, and HPLC columns. 【Contents (excerpt)】 ■ Pre-treatment filters ■ Ultrafiltration ■ Solid-phase extraction for pre-treatment ■ HPLC columns ■ HPLC solvents *For more details, please refer to the PDF document or feel free to contact us.

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This document provides an explanation of "RP-Amide HPLC/UHPLC columns." It introduces the "characteristics of RP-Amide," the "differences in retention for neutral analytes," and the "increased retention for hydrogen bond donors." Additionally, it includes analyses of "ulcer medications using Ascentis RP-Amide" and "UHPLC measurements of sunscreen drugs using Ascentis Express RP-Amide, 2.7μm." We encourage you to read it. 【Contents】 ■Ascentis RP-Amide HPLC column ■Analysis of ulcer medications using Ascentis RP-Amide ■UHPLC measurements of sunscreen drugs using Ascentis Express RP-Amide, 2.7μm ■Data sheet on the care and use of Ascentis Express RP-Amide columns ■LC/MS workflow products ■Ascentis RP-Amide product list ■Fused-Core product list *For more details, please refer to the PDF document or feel free to contact us.

• Analytical Equipment and Devices

This catalog is a product guide for the high-quality brand of peptide synthesis reagents, "Novabiochem(R)." By setting stricter product standards for standard Fmoc amino acids used in peptide synthesis, we have made it possible to use our products with greater confidence, from basic research to pharmaceuticals, cosmetics, and contract synthesis. We offer a wide range of packaging options, from small sizes to bulk sizes. [Contents (excerpt)] ■ Major Fmoc amino acids ■ Pseudoproline dipeptides ■ Coupling agents ■ Resins for solid-phase synthesis ■ History of Novabiochem innovations *For more details, please refer to the PDF document or feel free to contact us.

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This document provides an explanation of HILIC and features various types of HILIC stationary phase columns. HILIC technology, which has complementary properties to both reverse phase (RP) and normal phase (NP) chromatography, is often used in studies analyzing hydrophilic analytes. Additionally, we offer a lineup of products including the "Ascentis Express OH5 HPLC column," "Ascentis Express ES-Cyano HPLC column," and others. We invite you to read through it. [Contents (excerpt)] ■ Ascentis Express U/HPLC columns ■ What is HILIC and reasons to choose it ■ Development of HILIC methods ■ Ascentis Express OH5 HPLC column *For more details, please refer to the PDF document or feel free to contact us.

• Analytical Equipment and Devices

The "F5 (PFP) HPLC/UHPLC column" for metabolomics is a reversed-phase column with selectivity different from C18. By incorporating it as a second or third choice column in reversed-phase systems, the range of substances for LC analysis is broadened. Four retention mechanisms—hydrogen bonding, dipole-dipole interactions, π-π interactions, and hydrophobic interactions—complexly influence each other to exhibit unique retention characteristics and stereoselectivity. 【Features】 ■ Retains highly polar basic compounds without ion-pair reagents ■ 100% water mobile phase is usable ■ Suitable for LC/MS due to retention at high organic solvent concentrations ■ Supports both analysis and fractionation *For more details, please refer to the PDF document or feel free to contact us.

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This catalog is the product catalog for the high-precision photometer system 'Spectroquant(R) Series'. It features the "Spectroquant Dedicated Equipment Series" that can accommodate a variety of applications, as well as the "Spectroquant Dedicated Reagent Series" and "Standard Solutions for Absorbance Spectrophotometry." We introduce measurement instruments suitable for applications in various fields, ranging from simple and portable small devices to photometers capable of trace analysis. [Contents] ■ Spectroquant Dedicated Equipment Series ■ Spectroquant Dedicated Reagent Series ■ Standard Solutions for Absorbance Spectrophotometry ■ Product Number Index *For more details, please refer to the PDF document or feel free to contact us.

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Merck's microscopy reagents, a leading supplier of products for microscopy worldwide In bacteriology, cytology, hematology, and histology, we offer a wide range of products to meet diverse requirements. We provide excellent staining solutions, ready-to-use test kits, dried Certistain(R) dyes, fixatives, paraffin, and solutions for sample pretreatment or staining. ■ Staining solutions for tissues ■ Staining solutions for cytology ■ Staining solutions for blood smears and cell counts ■ Staining solutions for bacteria and microorganisms *For more details, please refer to the catalog or feel free to contact us.

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