メルク株式会社ライフサイエンス（シグマ アルドリッチ ジャパン合同会社） Product Lineup

There are various methods to secure pure water, such as using ion exchange tanks, purchasing purified water, and employing distillers. However, many people likely face various concerns, such as the heavy maintenance burden and rising running costs. 'Elix Essential' is a pure water production device that can produce stable pure water without the hassle and costs associated with these methods. It prevents interruptions in analysis and testing caused by the cumbersome task of replacing ion exchange resins. Since there are no troublesome tasks due to replacements, the workload is eliminated, leading to increased efficiency! Additionally, it helps reduce running costs such as water and electricity bills, contributing to a lower environmental impact. 【Features】 ■ Easy maintenance ■ Reduction of running costs by purchasing purified water ■ Over 95% energy savings, over 80% water savings (compared to distillers) ■ Space-saving and unobtrusive *For more details, please refer to the PDF materials or feel free to contact us.

• Pure water production equipment

The identification of metabolite biomarkers and understanding their biological roles are essential for revealing new disease diagnostic methods and therapeutic targets. Mass spectrometry, an effective technique for this purpose, continues to increase in utility. Ensuring reproducibility of results in metabolic research is very important. IROA Technologies' "Metabolite Library" provides retention times and spectra of key metabolites as standards in mass spectrometry. It supports the optimization of mass spectrometry protocols to achieve high reproducibility. 【Features】 ■ 96-well plates that are ready-to-use with over 95% purity ■ Comprehensive coverage of primary metabolites and intermediates, covering major metabolic pathways ■ Plates dispensed by solubility (water-soluble/lipid-soluble) ■ The plate map includes compound names, compound IDs, molecular formulas, molecular weights, CAS, ChEBI, HMDB ID, PubChem ID, and Substance ID *For more details, please refer to the PDF document or feel free to contact us.

• Analytical Equipment and Devices

"M-Clarity" is a highly transparent program that clearly defines the quality levels of Merck/Sigma Aldrich products and accurately provides the quality that customers need. This catalog introduces the quality management program at Merck Life Science. It also includes easy-to-understand tables summarizing the scope of application, identification, quality standards, and more for each product. Please use it to assist in your product selection. [Contents] ■ Quality Classes ■ Merck's Raw Material Supply Services ■ List of Major Manufacturing Sites *For more details, please feel free to contact us.

• Chemicals

"High-purity inorganic material of perovskite grade" is a product that easily dissolves in solvents such as DMF and DMF:DMSO (1:1). It is possible to obtain a transparent solution at a specified concentration. Due to its high sensitivity to air and moisture, it is sealed in glass ampoules. 【Features】 ■ Suitable for the synthesis of two-dimensional perovskite for solar cells and LEDs ■ Available in large quantities *For more details, please refer to the PDF document or feel free to contact us.

• Chemicals

Hybrid organic-inorganic halide perovskite materials have recently attracted attention as novel light-absorbing materials for solar energy conversion applications. The power conversion efficiency of single-junction perovskite solar cells has already surpassed the technological level of conventional thin-film solar cells and has become competitive with monocrystalline silicon solar cells. 【Features】 ■ High conversion efficiency ■ Easily manufacturable at low cost ■ Commercially attractive solar cell technology *For more details, please refer to the PDF document or feel free to contact us.

• Other polymer materials

Amino acids are used as supplements in cell culture media and for various applications such as metabolic research. At Sigma Aldrich, we offer animal-free amino acids in various sizes to reduce the risk of contamination with animal-derived components for research and development of biopharmaceuticals and vaccines. They are tested for cell culture and endotoxins, ensuring safe use in cell culture. 【Features】 ■ Available in bulk ■ Extensive global adoption record ■ Capable of change management *For more details, please refer to the PDF materials or feel free to contact us.

• others

Antimicrobial substances refer to a general term for antibiotics produced from natural sources and chemically synthesized antimicrobial agents, which are used in testing research or pharmaceutical manufacturing to prevent contamination by pathogens. Among the diverse antimicrobial substances handled by Sigma Aldrich, we present below the main products. All of these are products with a wealth of experience in the adoption of raw material bulk. [Features] ■ Bulk supply available ■ Extensive global adoption record ■ Capable of change management *For more details, please refer to the PDF materials or feel free to contact us.

• others

Among the numerous product groups of Sigma-Aldrich, we offer a wide range of catalysts, ligands, metal compounds, and compounds for catalytic synthesis. To support the synthesis at various research stages of our customers, we provide the desired catalysts in a timely manner from the same source, from screening to lab-scale and bulk supply. We can customize everything from product synthesis to quantity and packaging according to your needs. 【Features】 - A wide product portfolio of over 2,000 types of catalysts, precursors, ligands, and metal compounds - Provision of products with high and stable quality - Strong network with renowned scientists - Dedicated research and development department for catalysts and in-house production system - Well-established product sales system *For more details, please feel free to contact us.

• Chemicals

Introducing "RAFT agents" that enable precise polymerization of functional high polymer materials. Our lineup includes "trithiocarbonate," "dithiocarbamate," "dithiobenzoate," and "switchable RAFT agents." We also accept inquiries for bulk purchases. 【Lineup】 ■ Trithiocarbonate ■ Dithiocarbamate ■ Dithiobenzoate ■ Switchable RAFT agents ■ Macro RAFT agents *For more details, please feel free to contact us.

• Chemicals

NanoFabTx is a formulation kit for the simple and highly reproducible synthesis of drug-filled particles ranging from nano to micro sizes. We offer reagent kits, microfluidic device kits, screening kits, and various accessories. 【Features】 ■ Rapid testing enabled by detailed protocols ■ Easy synthesis of uniform and highly reproducible nanoparticles ■ Choice between standard nano sedimentation methods or microfluidic-based synthesis methods *For more details, please refer to the PDF document or feel free to contact us.

• Other physicochemical equipment

Our company is a well-established provider of pure water production equipment that accommodates various types such as ion exchange water, RO water, and high-purity water (RO + EDI). There are diverse purification methods for pure water, and the suitable pure water equipment varies depending on the application. By introducing the right pure water system for your needs, it is possible to enhance the reliability and reproducibility of the expected results. This document includes fundamental knowledge about pure water, as well as reference data that will help in selecting equipment. 【Recommended for those who:】 ■ Want to understand the differences in purification methods and water quality of pure water ■ Want to know the types of pure water and equipment that match their objectives ■ Want to learn about the available pure water production equipment *For more detailed information, please refer to the "PDF Download."

• Analytical Equipment and Devices
• Pure water production equipment

Single Molecule Counting (SMC) immunoassays quantitatively measure target proteins with a wide dynamic range and excellent precision. SMC technology is widely adopted by researchers and pharmaceutical companies around the world to accelerate scientific discoveries and drug development in various disease areas. Our "Custom SMC Services" meet the needs of those who do not have the time or resources to dedicate to assay development for target proteins or measurement of critical samples. 【Possibilities of Custom Services】 ■ Biomarker discovery and development ■ Biopharmaceutical development ■ Reagent selection ■ Sample measurement ■ Development of custom assays *For more details, please refer to the PDF document or feel free to contact us.

• Other contract services
• Contract measurement

"MyMilli-Q Remote Care" is a service that connects Milli-Q devices to the internet, allowing real-time remote monitoring of the device's status and water quality data. Access the portal site via the internet for centralized management of the devices. Remote support, including remote diagnostics, is also available. You will receive notifications of alarms and maintenance via email, and in the event of any issues, our technical staff will respond quickly through remote control. 【Features】 ■ Management & support through the portal site ■ Minimization of Milli-Q device downtime ■ Smarter data management ■ Smooth and planned operation of Milli-Q devices ■ Remote access to the Milli-Q device screen *For more details, please refer to the PDF document or feel free to contact us.

• Server monitoring and network management tools

This document is a technical material regarding the purification methods for test water suitable for "Water for Testing Pharmaceuticals" as defined by the Japanese Pharmacopoeia. Using purified water grade water, which was specified as water for pharmaceutical testing in the 15th revision of the Japanese Pharmacopoeia, and ultra-pure water commonly used in HPLC, we conducted an examination of water quality suitable for testing. You can verify the differences in water quality through the data provided. We encourage you to read it. *For more details, please refer to the PDF document or feel free to contact us.

• others

This catalog is a product guide for the high-quality brand of peptide synthesis reagents, "Novabiochem(R)." It sets strict product standards for standard Fmoc amino acids used in peptide synthesis. You can use it with confidence for everything from basic research to pharmaceuticals, cosmetics, and contract synthesis. We offer a wide range of packaging options, from small sizes to bulk sizes. [Contents (excerpt)] ■ Major Fmoc amino acids ■ Pseudoproline dipeptides ■ Coupling agents ■ Resins for solid-phase synthesis ■ History of Novabiochem innovations *For more details, please refer to the PDF document or feel free to contact us.

• Other polymer materials
• Chemicals

The "Q-Washer" is a cleaning system that combines a cleaning machine with Merck's ultrapure water and pure water equipment. Unlike regenerable SDI, it maintains stable water quality with a continuous ion exchange (EDI) mechanism that does not require regeneration. This reduces cleaning costs and frees you from the hassle of SDI replacement. Additionally, it achieves space-saving and secures new workspaces while also considering fall prevention in its design. 【Features】 ■ Reduction of manual cleaning costs ■ Conservation of cleaning water ■ Automatic determination of cleaning quality based on wastewater conductivity ■ Reduction of operational burden ■ Uniform cleaning & clarity ■ Reduction of contamination due to residues *For more details, please refer to the PDF materials or feel free to contact us.

• Other cleaning machines

Mercury is a dangerous chemical substance that has extremely harmful effects on health and the environment, and various regulations have begun in recent years. The regulations regarding the purchase of mercury-containing products differ by affiliated organizations and companies, but a survey conducted by our company in 2020 found that the most common response was "it is necessary to choose products that contain as little mercury as possible," at 47%, while 19% responded that "products containing mercury cannot be purchased," resulting in a total of 66% of organizations having regulations in place. Recently, efforts towards sustainability have been increasingly emphasized. ↓↓ For more details on Merck's mercury-free technology, please see below.

• Pure water production equipment

Are you facing any of these issues? - The purity of water is unstable, affecting analysis and experimental results. - There is limited installation space in the lab, making it impossible to place large equipment. - Filter replacement and equipment management are complicated, leading to a higher chance of mistakes. The completely mercury-free "Ultra-Pure Water/Pure Water System Milli-Q IQ 7003/05/10/15" is designed to minimize stress in the lab with features such as: - "All UV lamps for sterilization, organic matter decomposition, and TOC measurement are mercury-free" - "Eight levels of adjustable water sampling speed" - "The main unit is compact and does not require a specific placement" Additionally, we offer validation support services (IQ/OQ, OQ), calibration services, and USP equipment conformity testing, with many successful adoptions in domestic and international inspections. We will be exhibiting at JASIS 2025. Dates: September 3 (Wed) - September 5 (Fri), 2025 Venue: Makuhari Messe International Exhibition Hall and Conference Center Booth Number: "7A-605" Admission Fee: Free (Pre-registration required) *For more details, please contact us or download the materials.

• Pure water production equipment
• Water treatment equipment

Attention everyone looking for water free of microorganisms! This is a pure water production system designed to control microorganisms using mercury-free UV lamps. You can also find more details on Merck's website. ↓↓ For product details and inquiries for quotes, please contact us below ↓↓

• Pure water production equipment

The Milli-Q EQ 7000 is designed for comfortable use and provides strong support for researchers. ● Easy Sampling with Q-POD The sampling speed can be selected from three levels according to the purpose. The Q-POD can be installed in four positions on the main unit (top, bottom, left, right) or placed away from the main unit, making it easy to sample regardless of the installation location. ● Overwhelming Ease of Use Water quality is constantly displayed on the touchscreen, and with just a few clicks, you can print water quality reports or program the volume for quantitative sampling, showcasing its user-friendly design. ● Simple Operation with Touch Panel It can be operated intuitively like a smartphone. All information, including water quality data and maintenance information, is accessible from the touchscreen. You can easily check, save, and retrieve water quality data with simple steps. ● Wide Range of Applications By changing the final filter from the standard Milli-Pak to Biopak, LC-Pak, or EDS-Pak, it accommodates a wide range of applications from equipment analysis to biochemical and molecular biology research. ● Minimization of Maintenance All purification cartridges are designed for easy replacement.

• Pure water production equipment

To ensure accurate results, prevent false positives or false negatives, and avoid contamination, it is essential to carefully select reagents containing water when preparing liquid or solid media. Tap water may contain various impurities that can affect bacterial growth or cause errors in the prepared media. Since water is a major component of the media, the removal of these contaminants from water is crucial for media preparation. The recommended water quality for media preparation is detailed in ISO 11133:2014 ("Microbiology of food, animal feed and water — Preparation, production, storage and performance testing of culture media"). Additionally, ANNEX H discusses troubleshooting for media, citing the use of inappropriate quality of pure water as a cause of incorrect pH, color anomalies, formation of precipitates, and culture inhibition. This technical document explains the ISO 11133 standards and Merck's pure water production systems that meet these criteria.

• Other inspection equipment and devices

Merck has a wealth of expertise not only in ultrapure water systems but also in pure water. This document includes fundamental knowledge about "distillers," which we often hear requests for, as well as three case studies covering running costs and the causes and countermeasures for silica. You may find hints to solve your problems. 【Examples included】 - Key points and basic knowledge for producing distilled water - Silica, the nemesis of water treatment systems - Which is more cost-effective: running costs of distilled water or pure water (Elix water)? In addition to the above, we provide useful information related to distillers. Please check it out via "PDF Download." ★ A special program just for distiller users! – Would you like to reduce your electricity costs? Laboratory budget-saving program! ★ By switching from a distiller, you can reduce your electricity costs to 1/16! - Recommended for those struggling with rising electricity prices - Necessary for those committed to carbon neutrality/environmental efforts For more details, please see the link below. A simulation for reducing electricity costs is also available.

• Distillation Apparatus

The confirmation and detection of microbial contamination in food and beverage products are very important for maintaining the quality of those products. The law amending part of the Food Sanitation Act, promulgated on June 13, 2018, includes a provision that, in principle, all food business operators should engage in hygiene management in accordance with HACCP. MC-Media Pad is a simple and innovative sheet-like culture medium. It does not require pre-preparation of the medium, and the operation is easy as it only requires dropping the sample, making it recommended for those who are starting testing. This product allows for rapid microbial testing and can streamline the testing procedures through a color index for each test target. ↓ Catalogs and application notes can be downloaded from the webpage!

• Food Testing/Analysis/Measuring Equipment

Since it uses an easy-to-replace cartridge system, there is no hassle of changing the regenerable ion exchange resin. ↓↓ For catalog requests, please contact us ↓↓

• Water treatment equipment

Directly supplying pure water to the equipment reduces labor. Capable of handling water volumes from several liters to 10,000 liters per day, it can widely supply water from reverse osmosis to ultra-pure water. It stably provides the water quality required for cleaning, dissolving and diluting materials, humidifying, and from experiments to evaluation and manufacturing sites. 【Addressing the Challenges of Previous Pure Water Systems】 - Proposals can be made for a wide range from small devices to large-scale pure water supply at the floor level. - Appropriate water quality is supplied at use points according to the purpose of use. - Addresses cost issues during the renovation and updating of pure water facilities and piping, as well as downsizing. - Resolves the complexity of equipment design and responds to short delivery times.

• Pure water production equipment

High-sensitivity biomarker detection can be achieved in a benchtop size using the conventional sandwich ELISA-based single molecular counting (SMC) technology.

• Other physicochemical equipment

High-purity ultra-pure water is required for trace element analysis, semiconductor cleaning, and other applications. The Milli-Q IQ 7000 and Milli-Q IQ 7005/10/15 trace element analysis types purify water suitable for trace element analysis using ICP-MS. In addition to ultra-pure water purification in the purification unit, the Milli-Q IQ Element removes trace amounts of metals to the utmost limit. This reduces water-derived background, making it possible to achieve stable results in trace element analysis! ↓↓ For inquiries about the equipment or quotes, please contact us ↓↓

• Analytical Equipment and Devices
• Water treatment equipment
• Pure water production equipment

The Milli-Q HX 7000 SD provides stable water quality pure water with a long-life EDI that does not suffer from the degradation of ion exchange resin purity. It is a pure water system that integrates a tank and pump into one unit. 【Features】 - Freedom from concerns about purity degradation due to RO + long-life EDI method - Stable production of pure water even from hard water and high silica source water - Fine adjustment to pure water demand ranging from 200 to 1,800 L per day - Supplies pure water to multiple points of use at a maximum rate of 20 L/min - Compact design allows for flexible layout options - Standard UV sterilization ensures reliable microbial control - Validation support services (IQ/OQ, OQ) with a proven track record in domestic and international inspections - Calibration service available 【Applications】 - Pharmaceuticals, quality control, manufacturing, laboratories - Weather resistance testing, environmental testing - Cleaning rooms, central material rooms

• Pure water production equipment

This is an ultrapure water system designed not only to obtain water quality suitable for its intended use but also to pursue ease of use, featuring technology that is a first in the laboratory market and designed to minimize stress in the lab. Additionally, it offers validation support services (IQ/OQ, OQ), calibration services, and compliance testing for USP equipment, with many successful adoptions in domestic and international inspections. For more details, please refer to our webpage and catalog!

• Pure water production equipment

The Milli-Q SQ 2 series is a compact ultrapure water production device with a new concept that allows for the transport and use of a tank. It can provide ultrapure water even in environments without tap water, and it is also possible to add multiple ultrapure water modules. It offers a lineup of four product types to meet the needs of various laboratories.

• Water treatment equipment

It is possible to produce ultrapure water at a rate of 900 liters per hour. Ultrapure water can be used in necessary locations such as for manufacturing and precision cleaning. It also supports equipment connections as a final polisher.

• Water treatment equipment

The Elix Essential pure water system meets water quality and price standards. The standard for future pure water systems! High water quality while being energy-saving and water-saving. Non-heating RO+EDI pure water system. - An easy-to-introduce pure water system at a low price point. - Usable for all pure water applications! - With RO+EDI technology, it can save over 95% energy and over 80% water compared to distillers. - Possible to reduce annual water and utility costs by several hundred thousand yen. - Long-life EDI eliminates the need for regeneration or replacement of ion exchange resins. - Equipped with a new lift-up mechanism for easy maintenance. - Ideal as supply water for equipment requiring pure water, such as cleaners and constant temperature and humidity devices.

• Pure water production equipment