パトコア Product Lineup

"ChemAIRS," which supports next-generation chemical R&D, is an AI-assisted reverse synthesis analysis and process optimization platform that integrates deep learning algorithms with over 80 million extensive chemical big data. It addresses challenges such as the "prolongation of synthetic route design" and "cost increases due to trial and error in experiments" in pharmaceutical and new material development through a data-driven approach. 【Dramatically Improving the Speed and Quality of Research and Development】 This system presents various synthetic routes for target compounds in just a few minutes (e.g., suggesting 15 routes in 11 minutes). With the condition examination feature utilizing AI optimization, it has achieved a 50% reduction in the number of experiments while attaining an initial yield that is 48% higher than conventional methods. AI complements the expertise of specialists, facilitating the discovery of innovative synthetic strategies. 【Advanced Predictive Functions to Prevent Experimental Risks in Advance】 Not limited to merely suggesting routes, it minimizes the risk of experimental failure through functional group compatibility assessments and impurity predictions boasting an accuracy of 83% to 90%. Additionally, by integrating with commercially available raw material databases and internal experimental records (ELN), it can identify the optimal "feasible routes" from both cost and feasibility perspectives.

• Pharmaceutical synthesis and fermentation

ChemAssess is a reliable web system that adopts a mathematical model to estimate risk levels, based on the design standards of the support tool "CREATE-SIMPLE" published by the Ministry of Health, Labour and Welfare. It resolves all the issues associated with Excel tools through web systemization, supporting the establishment of an efficient and reliable autonomous management system. ■Features 1. Intuitive and user-friendly interface 2. Input streamlining and evaluation standardization through master registration functionality 3. Sharing of results across the organization and reduction of duplicate work 4. Consideration and simulation of risk reduction measures 5. Automatic compliance with legal and tool updates

• Software (middle, driver, security, etc.)

GOSTAR Large Molecules is a fully custom curation-type database focused on macromolecular drugs (peptides, oligonucleotides, antibodies). It aims to provide only the necessary data precisely according to the research theme and target molecules. ■Features 1. Macromolecule datasets constructed according to research themes 2. Manual curation by experts 3. Data structure designed for analysis and secondary use 4. Support for AI/machine learning applications 5. Flexible delivery formats (Excel, CSV, TSV)

• Patent/Copyright related services

●Unmatched Data Quality and Scale GOSTAR Small Molecules is one of the largest low molecular weight SAR databases in the world, containing over 11 million low molecular weight compounds and over 36.8 million SAR data points. Thanks to manual curation by specialized medicinal chemists and a three-tier quality control process certified by ISO 9001:2015, you can utilize organized and standardized reliable data directly in your research. 【Features】 ■ A centralized data source for one of the largest low molecular weight SAR information ■ Comprehensive understanding of low molecular weight SAR, including not only activity but also physicochemical properties and ADMET ■ Automatically adjusted for different types of ligands, making it easy to read ■ Sortable by any data column and color-coded based on values *For more details, please refer to the PDF document or feel free to contact us.

• Patent/Copyright related services

Eureka R&D - IDEAS is an AI-driven innovation support platform that covers the discovery, resolution, verification, and investigation of challenges in research and development, automating tasks that traditionally took weeks to complete in just a few minutes. It utilizes patents, papers, and technical information across various fields to provide seamless support from idea generation to execution planning. 【Features】 ■ Comprehensive support from technical Q&A to problem-solving AI provides evidence-based information and solutions instantly in response to technical questions from R&D environments. ■ Cross-analysis of patents, papers, and news Integrates multiple reliable information sources to quickly extract high-accuracy technical insights. ■ Idea generation support based on TRIZ theory Employs a systematic approach to derive applications from different fields and non-obvious technical solutions. ■ Feasibility assessment and execution plan presentation Clearly visualizes the reality of implementation, costs, and steps for proposed technical solutions. ■ Instant creation of technology and market reports Automates competitive research and technical analysis of new fields, enabling the production of high-quality reports without external outsourcing. *For more details, please request a catalog or contact us with your inquiries.

• Data Search Software

Patsnap Eureka Material is a group of AI agents that dramatically enhances the efficiency of material exploration and alloy research in the fields of chemistry, materials, and metals. Utilizing a unique structured data model (SPUM / MACE) and PatsnapGPT, it automates the search, comparison, and reporting based on physical properties and compositions. It resolves challenges faced by researchers, such as "time for material selection," "information dispersion," and "difficulty in comparison," in just a few minutes. **Features** - Material exploration based on physical properties, compositions, and applications: Narrow down material candidates using numerical filters (e.g., thermal conductivity, tensile strength, etc.). - Structured material data from patents and literature: High-accuracy information extraction is possible with the unique models SPUM and MACE. - Generated report format: Outputs analysis results in a format that can be directly used for proposals and reports, combining text with visual information (such as box plots). - Simple operation by just entering prompts in natural language: No need to create search queries, allowing anyone to conduct specialized material exploration.

• Data Search Software

Eureka LS Suite is a collection of support tools consisting of five AI agents specialized for the pharmaceutical and biotech industries, focusing on drug discovery, intellectual property, competitive analysis, and antibody research. Based on vast amounts of life sciences data such as patents, literature, market information, and sequences, it achieves efficiency in daily operations and accelerates decision-making. AI addresses the information processing challenges faced by experts. **Features** - A group of AI agents specialized in the life sciences field: With a modular structure that caters to specialized tasks in the biotech and pharmaceutical industries, such as drug discovery, antibodies, patents, and competitive research, it delivers outputs directly linked to practical work. - A high-precision database that is updated daily: Life sciences-specific data, including clinical trial and approved drug information, patents, and literature, is continuously updated to ensure analysis accuracy and reliability. - Q&A and document analysis in natural language: The interface is designed to be intuitive, allowing users to operate in a question format without needing specialized knowledge. - Support for unstructured data, automatically extracting insights from vast amounts of information: It can process documents in various formats, including PDFs, reports, and news articles. *For more details, please request a catalog or contact us with your inquiries.*

• Data Search Software

■One of the largest and most reliable databases in the industry GOSTAR TPD is a specialized database that encompasses detailed structural information, activity data, and target protein information for over 51,000 target decomposition inducing agents (TPD) compounds. This product is certified with QMS (Quality Management System) and provides the latest and most reliable data through regular monthly updates. Researchers can quickly identify TPD compounds that meet their objectives using a flexible search function that combines multiple conditions of structure, target, and activity. It significantly reduces the effort of manually searching through vast literature and complex data. GOSTAR TPD dramatically improves the quality and speed of drug discovery research, strongly supporting the discovery of new therapeutic drugs. It provides an environment where complex TPD-related data can be understood simply and deeply, allowing researchers to focus on the core tasks of drug discovery. 【Features】 ■One of the largest domestic databases specializing in TPD structure, activity, and target ■High-quality data updated monthly, compatible with AI drug discovery ■Intuitive search UI maximizes research efficiency *For more details, please refer to the PDF materials or feel free to contact us.*

• Patent/Copyright related services

Enhancing FTO and prior art searches with AI tools, collaboration, and global data. Strong intellectual property intelligence for risk management. Enter a product, invention idea, or the publication number of a patent of interest to search and analyze over 180 million patents and more than 130 million documents from 170 jurisdictions. Supporting innovation defense and new business opportunities. 【Features】 ■ Billions of data points - Seamlessly linking patents, literature, laws, and key data such as value assessment, name standardization, and translation, updated daily. ■ Comprehensive search options - A variety of search functionalities to meet all needs, from rapid image searches to detailed FTO investigations. ■ Facilitating collaboration between IP teams and R&D teams - Streamlining workflows and enhancing collaboration using workspace modules to overcome bottlenecks. ■ Industry-leading analytical tools - Intelligent review tools that cater to all users, allowing for the immediate identification and verification of key details across records or entire datasets.

• Patent/Copyright related services

Chemical is Patsnap's chemical substance search and analysis tool. It identifies chemical substances through searches based on chemical structure, CAS registration, names, and various properties, and organizes and displays related patents, literature, and lists. Furthermore, it seamlessly integrates with the patent analysis application Analytics, enabling one-stop searching and analysis of chemical structures and patents. 【Features】 ■ Comprehensive chemical substance database - Contains over 270 million chemical structures, more than 49 million patents across 113 jurisdictions, and over 25.6 million pieces of literature information. ■ Powerful chemical substance search - Equipped with the widely used Marvin Sketch, allowing for diverse structural searches (exact match, partial match, R-groups, similarity, Markush search - currently only in U.S. jurisdiction). - Searches can also be conducted using keys such as CAS registration numbers, compound names, InChIKey, InChI, and SMILES. ■ Seamless integration with Analytics - Collaborates with the patent analysis platform Analytics to provide detailed analysis of patent information related to identified substances.

• Computational Chemistry

PatSnap's Bio, specialized in the pharmaceutical, biotechnology, and agriculture industries, identifies patent information and a wealth of non-patent literature resources through the search of DNA, RNA, and protein sequences. It integrates with PatSnap's patent search and analysis tool, Analytics, allowing for more detailed patent analysis. Advanced data processing technology and a unique search AI algorithm significantly improve the FTO of biological sequences and reduce the risk of search omissions. 【Features】 ■ Large-scale sequence database Utilizes a highly comprehensive sequence database extracted from millions of patents, literature, and public databases through manual and AI methods. ■ Degenerate sequence search With cutting-edge degenerate search technology and proprietary AI, it enables degenerate sequences with various combinations. This enhances search comprehensiveness and reduces risk. ■ Extensive sequence search options Includes numerous sequence search options such as antibodies, motifs, fragments, and bulk searches of multiple sequences.

• Literature Management

Synapse is a pharmaceutical R&D intelligence research tool that allows you to search for drugs, clinical trials, news, literature, and patents all at once. It supports drug research and development, consideration of licensing, M&A, and joint research partners, as well as marketing decision-making. It can also be used to identify patents and competitive risks, understand disease areas and approval information, promoting R&D efficiency and cost reduction. Currently, some features are available for free trial. 【Features】 ■ Patsnap Copilot Summarizes searched patents and creates reports, answering various questions. ■ Core Patent Organizes and displays information on key patents related to specific drugs (compounds, sequences, combinations, formulations, crystal forms, processes, etc.). Supports competitive patent strategy and third-party IP infringement investigations. ■ Drug Insight Provides the latest trends in drug development for specific disease areas, including indications, R&D status, and approval information. ■ Knowledge Graph Visualizes the relationships of subjects of interest (organizations, diseases, targets) in a knowledge graph, with detailed views available through drill-down. Evaluates reusability and discovers potential partners and competitors. ■ Due Diligence Overview of specific companies, disease areas, modalities, targets, pipelines, ongoing projects, and deals.

• Patent/Copyright related services

"Quick Request" is a testing request system that solves various issues related to test requests and realizes an efficient laboratory. It can manage the increasing number of compounds, diversifying and complicating tests, and various other tasks all in one system. Not only can you visually confirm the tests you are handling, but by consolidating communication channels between the requesting department and the testing department, it is possible to prevent communication and coordination errors in advance. 【Features】 ■ Flexible workflow ■ Access control tailored to operational forms ■ Visualization of testing status ■ Various options to enhance usability *For more details, please refer to the PDF materials or feel free to contact us.

• Other IT tools

Standard knowledge bases often cannot solve the specific challenges faced by customers. Excelra's senior experts and consultants understand the specific issues of customers and provide tailored solutions that meet their precise needs. Excelra has the expertise and experience to extract, structure, and organize unstructured data, transforming it into high-quality formats suitable for analysis, enabling data-driven decision-making based on information in drug discovery. When handling customer data, we adhere to the highest standards of data privacy and confidentiality, as proven by over a decade of partnerships with top-tier pharmaceutical companies and scientific publishers. We respond flexibly to short turnaround jobs without compromising on quality.

• Other contract services
• Contract Analysis

●Unmatched data quality and scale GOSTAR is one of the world's largest databases of low molecular weight compounds, curated manually by top experts. It is organized, integrated, and updated through manual curation, allowing for immediate use in analysis and AI model development. By using GOSTAR, you can free yourself from the tasks of collecting and organizing data, enabling you to focus your valuable time on the most important research activities. GOSTAR is one of the largest low molecular SAR databases in the world, containing approximately 9 million low molecular weight compounds and nearly 30 million SAR data points. The database is built from 80,000 patents filtered from about 40 million and 200,000 research articles filtered from about 10 million, with data extracted through manual work by experts and standardized and structured based on specified rules. 【Features】 ■ A centralized data source for one of the largest low molecular SAR information collections in the world ■ Automatically adjusted for display based on the type of ligand, making it easy to read ■ Sortable by any data column and color-coded based on values *For more details, please refer to the PDF materials or feel free to contact us.*

• Patent/Copyright related services

We would like to introduce a case study of the system handled by Patocoa Co., Ltd. Eisai Co., Ltd. has been facing an increasing need to determine the presence or absence of legal regulations before engaging in activities such as the synthesis of chemical substances, the purchase of compounds, and import/export, amid strengthened regulations regarding the handling of chemical substances. To address this, they implemented the regulatory substance check system "CRAIS Checker," along with "CRAIS Reagent" and "SMARTS." As a result, they were able to comprehensively solve the challenges of managing increasingly complex chemical substances. 【Implemented Products】 ■ CRAIS Checker: Regulatory Substance Check System ■ CRAIS Reagent: Reagent Management System ■ SMARTS: Reagent Catalog Database ■ Plexus Connect: Web-based Core System for Drug Discovery Research *For more details, please refer to the related links or feel free to contact us.

• Other production management systems

"Crais Checker Cloud" is a cloud version of the regulatory check system CRAIS Checker, widely used by pharmaceutical and chemical companies, designed for easy access. With just a computer connected to the internet, you can instantly draw structural formulas and check for conflicting regulations. Compared to setting up a system in-house, there is no need for IT personnel to manage hardware investments or operations, making it easy and cost-effective for venture companies and small chemical import trading firms to strengthen and streamline their compliance with chemical substance management regulations. The regulations supported and the accuracy of regulatory checks are the same as CRAIS Checker, and it also accommodates new substances and comprehensive regulations. ◆NEW◆ Supports the 30-year storage requirement for carcinogenic substances. 【Features】 ■ Achieves high-precision regulatory substance verification with extremely few false positives ■ High reliability supported by a large user base ■ Rapid response to legal amendments ■ Accurately processes chemical structures with various notations ■ Accommodates ambiguous regulatory structures and comprehensive regulations ■ Easily integrates with in-house systems such as electronic lab notebooks and reagent management *For more details, please refer to the catalog or feel free to contact us.

• Software (middle, driver, security, etc.)

"SARvision SM" is software that supports chemists in one of their important tasks: the examination of structure-activity relationships. With its unique Maximum Common Substructure (MCS) extraction engine, it can classify chemical structure data by scaffold, making SAR analysis easier. Scaffold-based data mining allows for evaluations that are closer to a chemist's intuition compared to descriptor-based clustering, proving effective in assessing screening data and formulating synthetic strategies during the Hit to Lead and lead optimization stages. 【NEW!】 A PROTAC analysis module has been released, allowing for routine and easy execution of SAR studies for bivalent ligands. For details, please visit the product page. 【Features】 ■ Automatically extracts common substructures from a group of structural formulas and presents a tree classified by scaffold. ■ Sorts scaffolds by physical properties or activity data, and allows dynamic filtering using sliders. ■ Rich graphic features (bar graphs, 2D scatter plots, 3D scatter plots). *For more information, please refer to the related links or feel free to contact us.

• Software (middle, driver, security, etc.)

The "Compliance Checker" combines a software system with a regulatory database, providing a quick and easy way to check which laws and regulations apply to the compounds under investigation in various countries, ensuring proper handling of compounds in accordance with relevant laws in each country. It is used by many users, including pharmaceutical companies, CROs, and reagent suppliers, and we continuously improve the system by reflecting feedback from these customers. 【Features】 ■ Check global drug regulations from structures (related laws from 18 countries and 5 international regulations) ■ Easy system integration and scalability ■ Intuitive GUI *For more details, please refer to the PDF document or feel free to contact us.

• Other production management systems

"AMEDEO" functions as an idea generator that allows non-experts to easily utilize advanced tools available in data science (AI and machine learning) to accelerate the lead optimization cycle. It learns about the data and builds and selects predictive models. It then clearly suggests which compounds should be created next. By simply answering a few easy questions regarding goals such as optimization items, it proposes candidates for biopharmaceuticals or small molecule drugs. 【Features】 ■ Idea generator to accelerate the lead optimization cycle ■ Learns about data and builds and selects predictive models ■ Clearly suggests which compounds should be created next ■ Just answer a few easy questions regarding goals such as optimization items ■ Proposes candidates for biopharmaceuticals or small molecule drugs *For more details, please refer to the PDF document or feel free to contact us.

• Software (middle, driver, security, etc.)

The commercial reagent catalog database has high usage fees and lacks sufficient information on domestic regulations and SDS. Pharmaceutical and chemical companies have had to go through the trouble of requesting catalogs from individual reagent manufacturers to ensure proper management in compliance with domestic regulations, such as hazardous materials management, and to organize the necessary information for reagent management and purchasing systems. SMARTS is a reagent catalog database with structural formulas that addresses these issues all at once and complies with domestic regulations.

• others

A reagent management system ideal for pharmaceutical and pesticide companies handling various types of chemical substances, enabling reliable and easy compliance with regulations. Researchers' productivity significantly increases as they can search for reagents by CAS registration number, reagent name, or structural formula, facilitating inventory and ordering! During legal revisions, it works in conjunction with CRAIS Checker to provide comprehensive regulatory checks and updates on legal information, allowing for timely and proper management of chemical substances. It can also manage biological reagents composed of multiple containers appropriately. ＼ Outstanding Usability ／ ■ Supports structural searches ■ Easy to use anywhere with handheld devices! ■ Compatible with RFID tags (IC tags) ＼ Strong Support for Chemical Substance Regulations ／ ■ Clear legal information ■ Management standards based on regulations can be set ■ SMARTS catalog can be utilized, making it easy to maintain legal master and reagent catalogs ■ Management and aggregation tables compliant with laws such as the Fire Service Act, PRTR, and Poisonous and Deleterious Substances Control Act ■ Prevents unauthorized use by linking with electronic safes and key boxes 【System Configuration】 ■ Can integrate with internal and external purchasing systems, electronic lab notebooks, and CRAIS Checker ■ Installation possible on both cloud (AWS) and on-premises systems

• Software (middle, driver, security, etc.)

The "CRAIS Checker" is a system that allows for instant verification of legal regulations regarding narcotics, designated drugs, toxic substances, and other hazardous materials based on their chemical structures. This product enables immediate determination of compliance with various regulations, thereby effectively and efficiently strengthening compliance systems. By promoting the automation of regulatory checks, it allows for more reliable regulatory responses without diminishing research efficiency. ◆NEW◆ Compliance with chemicals causing skin disorders Identification of substances that require the use of chemical protective gloves and equipment based on Article 594-2 of the Occupational Safety and Health Regulations. With the amendment to the Occupational Safety and Health Act coming into effect on April 1, 2024, the use of protective equipment such as chemical protective gloves will be mandatory for chemicals causing skin disorders. Using the CRAIS Checker, relevant substances can be easily identified from chemical structures, and threshold values can be confirmed. 【Features】 ■ Achieves high-precision verification of regulated substances with extremely low misjudgment rates ■ High reliability supported by a large user base ■ Rapid response to legal amendments ■ Accurate processing of various representations of chemical structures ■ Compliance with ambiguous regulatory structures and comprehensive regulations ■ Easily integrates with internal systems such as electronic lab notebooks and reagent management *For more details, please feel free to contact us.

• Software (middle, driver, security, etc.)