セントラル科学 List of Products and Services

In a refinery, strict management of water quality and quantity is necessary for efficient operations. An average refinery consumes about 1.5 barrels of water to produce 1 barrel of crude oil. Rapid decision-making using real-time data contributes to cost and time savings, as well as water reuse and recycling. The water used in refineries varies widely, including cooling water and boiler feedwater, each with different water quality requirements. In particular, boiler feedwater requires high purity. To quickly assess the deterioration of water quality, responsive measuring instruments are necessary. Refineries primarily use large amounts of water for cooling and heating, but significant water is also used in other processes. Water quality monitoring helps facilitate decisions on regeneration/discharge/processes while managing and minimizing water usage and complying with regulatory requirements. Since most of the incoming pollutants originate from natural organic matter, and the main products are organic matter with the primary discharge standards being organic matter concentration, TOC monitoring allows for real-time decision-making and process control improvement. Directly monitoring organic matter throughout the refinery, from river intake to river discharge, aids in operational efficiency, cost management, and plant sustainability.

• Water quality testing

Pharmaceutical companies are always required to demonstrate validated cleaning programs. Here, we present five ways to successfully implement a cleaning validation program.

• Analytical Equipment and Devices

I will explain the long-term test regarding the measurement methods for COD and nitrate without the use of reagents, conducted at the Paisenberg wastewater treatment plant. The test began in early November 2015 and was carried out to evaluate the effects of seasonal changes.

• Analytical Equipment and Devices

Customers measuring COD using the JIS method. By introducing a simple COD meter, you can expect a reduction in measurement time and an improvement in work efficiency! For example, simple COD meters using electric titration methods or spectrophotometry allow for rapid and accurate measurements. This enables immediate response on-site and enhances operational efficiency. Let's first take a look at what benefits there are!

• Analytical Equipment and Devices

Chemical Oxygen Demand (COD) It is the amount of oxidizing agent consumed when organic matter in water is decomposed by an oxidizing agent, converted into an equivalent amount of oxygen. It indicates the degree of organic pollution in lakes and marine areas (unit: mg/L).

• Analytical Equipment and Devices

TOC allows for the direct measurement of organic matter load. It is preferred over traditional oxygen demand methods like BOD and COD because it does not require hazardous chemicals and results can be obtained in less than 10 minutes.

• Analytical Equipment and Devices

The TOC method for cleaning validation is an important technique for evaluating the cleanliness of equipment. The TOC method is recognized as a way to assess the carbon content in samples and is used to evaluate the cleanliness of equipment. In accordance with ICH Q2B guidance, examples of the evaluation of various parameters related to the validation of analytical methods using TOC will be introduced.

• Analytical Equipment and Devices

✓ Rapid measurement of TOC over a wide measurement range Measurement time: 4 seconds Initial response time: 6 minutes (ICR off), 10 minutes (ICR on) Response time: 3.25 minutes Measurement range: 0.20 ppb to 10 ppm ✓ Three models to choose from Lab type / Portable type / Online type ✓ Three measurement modes to choose from Online measurement / Grab measurement / Auto-sampler measurement

• Analytical Equipment and Devices

In cleaning validation, it is important to select the appropriate analytical method according to the purpose. By choosing the optimal analytical method for each phase (design, validation, verification), the risk of product contamination can be minimized.

• Analytical Equipment and Devices

Data integrity is a crucial requirement in pharmaceutical manufacturing, and there is a strong demand to easily manage electronic data and metadata in one place. Pharmaceutical companies must not only ensure patient safety and meet data integrity requirements but also improve production efficiency to respond to production demands. By reviewing data in real-time and conducting trend analysis, processes can be streamlined through encrypted data transfer. Additionally, utilizing electronic signature functionality allows for even faster record reviews. Features of DataShare Elite Software: - Compatibility with both new and old models of Sievers TOC analyzers - Management of metadata including error history and audit trails - Electronic signatures for data (measurement results, audit trails) - Access to lab/online TOC analyzers from a single PC

• Analytical Equipment and Devices

The Sievers M9 can accommodate a variety of applications due to its unique gas-permeable membrane conductivity measurement method and wide measurement range (0.03 ppb to 50 ppm). Features of the Sievers M9: - No carrier gas required - Stability in ultra-low concentration range - 12 months of calibration stability - Three models to choose from based on application (laboratory type/portable type/online type) - Compliance with data integrity requirements based on 21 CFR Part 11 (optional) - The sample conductivity measurement function allows simultaneous measurement of TOC and conductivity (USP<645> Stage 1) (optional) - An auto-sampler can automatically analyze up to 63 samples (40mL) (optional)

• Analytical Equipment and Devices

- Rapid measurement (initial response 4 minutes, measurement interval 15 seconds *during online measurement) - Simultaneous monitoring of TOC and conductivity - Capable of online/offline analysis with a single unit - Excellent portability suitable for maintenance of pure water systems (compact and lightweight) - Built-in sample pump allows users to perform calibration on-site - Easy part replacement by users and low maintenance - Calibration standard solution provided - Capable of displaying TOC trend graphs

• Analytical Equipment and Devices

- Rapid measurement (initial response 4 minutes, measurement interval 15 seconds *during online measurement) - Simultaneous monitoring of TOC and conductivity - Capable of online/offline analysis with a single unit - Excellent portability suitable for maintenance of pharmaceutical water systems (compact and lightweight) - Compliant with pharmacopoeias of various countries (USP <643>/EP<2.2.44>) - Built-in sample pump allows users to perform calibration and system suitability tests on-site - Standard solutions provided for calibration and system suitability testing - Screen and documentation available in Japanese - Capable of displaying TOC trend graphs

• Analytical Equipment and Devices

Water quality monitoring using the Sievers TOC analyzer enables equipment maintenance, protection, reduction of downtime, and mitigation of process failures.

• Analytical Equipment and Devices

Product lineup according to purpose: Corresponding to each process such as raw water, RO water, reclaimed water, UF/EDI, and use points.

• Ultrapure water production equipment
• Pure water production equipment
• Other water quality analysis

- Low concentration stability (quantitative lower limit: 4 ppb) - Operates immediately after power on - No carrier gas required - Calibration frequency is once a year - Short measurement time (4 measurements per sample in 14 minutes) - Compact design - Three types: lab type / portable type / online type - Inorganic carbon removal device (ICR) is built-in as standard - Optional auto-sampler for automatic measurement of up to 63 samples (40 mL vials) - Custom multi-point calibration protocol compliant with notification methods for the water sector

• Analytical Equipment and Devices

The Sievers M9e can accommodate a variety of applications thanks to its unique gas-permeable membrane conductivity measurement method and wide measurement range (0.03 ppb to 50 ppm). The optional turbo mode (analysis time of 4 seconds) is useful for monitoring recovery water. Features of the Sievers M9e: - Matching of measurement deviations - Stability in ultra-low concentration ranges - Automatic operation (calibration / verification / data analysis, etc.) - 12 months of calibration stability - Three models to choose from based on application (laboratory type / portable type / online type) - Sample conductivity measurement function (optional) allows simultaneous measurement of TOC and conductivity - Auto-sampler (optional) can automatically analyze up to 63 samples (40mL each).

• Analytical Equipment and Devices

Various industries are advancing the development of biodegradable materials as part of their efforts to address environmental issues. Research on biodegradable plastics is also included as one of the research and development projects under the Moonshot Research and Development Program led by the Cabinet Office (Goal 4). There are challenges with biodegradability testing... - Large testing equipment is required - Requesting external inspection agencies significantly increases costs and time - There is a limit to the number of samples that can be measured simultaneously For those who want to start with simple screening, OxiTop is recommended! - Cost-effective testing can be done in-house - Changes over time can be monitored even during measurement - Automatic recording of measurement values with data logger functionality - Up to 100 samples can be measured simultaneously - Can be conducted under OECD301F testing conditions

• Analytical Equipment and Devices

**Challenges Faced by Wastewater Treatment Plants** - High power consumption (over 50% due to aeration and mixing in reaction tanks) - DO levels fluctuate with a delay from ammonia treatment - Conventional DO control leads to excessive aeration - In combined sewer systems, DO levels fluctuate due to rainfall - Excessive addition of hydrogen donors (such as methanol) **What the Online Ammonia/Nitrate Sensor VARiON Can Do** - Clarifies the timing of nitrification completion for controlling aeration flow rate - Measures in disinfection equipment to adjust chlorine dosage - Controls the injection amount of methanol and other substances that promote denitrification = Reduction in power consumption and chemical costs

• Water quality testing

The IQ Sensor Net system helps collect the necessary data for monitoring and controlling processes by freely combining 21 types of sensors. It supports small-scale operations with 2 sensors up to large-scale processing processes with a maximum of 20 sensors, providing optimal water quality management tailored to users. It also supports remote monitoring, allowing data to be viewed from anywhere using a smartphone, tablet, or computer as long as there is an internet connection. This enables operation from outside the facility when urgent on-site response is needed. Types of sensors: DO (marine water compatible model available), pH/ORP (marine water compatible model available), conductivity (marine water compatible model available), turbidity (marine water compatible model available), color, SS (marine water compatible model available), MLSS, ammonia, nitrate, nitrite, organic matter, sludge interface.

• Water quality testing
• Wastewater treatment equipment, technology and maintenance
• Wastewater/wastewater treatment equipment

We offer electrodes that can accommodate various applications. ■pH Electrodes - SensoLyt SEA … For wastewater measurement (high turbidity, AgCl-free internal liquid, suitable for samples containing sulfides) - SensoLyt SEA-HP … For inline measurement (inside piping, pressure and heat resistant) - SensoLyt DWA … For drinking water measurement (suitable for low conductivity samples) - SensoLyt ECA … For wastewater measurement (single pin pole design, long-term stability) - SensoLyt TFA … For industrial wastewater measurement ■ORP Electrodes - SensoLyt PtA … For wastewater measurement (suitable for high turbidity samples) - SensoLyt PtFA … For industrial wastewater measurement

• Water quality testing

The 4-electrode conductivity sensor TetraCon 700IQ is particularly suitable for a wide range of applications in high concentration areas compared to 2-electrode sensors, such as in treatment plants handling heavily loaded wastewater and effluent. It employs a unique measurement technology that reduces the effects of polarization, achieving high-precision measurements. The 4-electrode TetraCon 700 uses two pairs of independent electrodes, with the voltage electrodes generating a stable and consistent reference potential. The advantage of this technology is the reduction of measurement errors caused by polarization effects in high concentration areas. *There are also sensors available for seawater.

• Water quality testing

■Space-saving design & easy operation: Compact design approximately the size of A3 paper. After starting operation, it automatically performs standard liquid calibration and blank measurement at user-defined intervals. ■Easy maintenance: Essentially only requires reagent replenishment! The electrode activation function also simplifies electrode maintenance. ■Compatible with diverse samples: Suitable for a wide range of applications in freshwater and seawater. Measurement principle is resistant to coloring and turbidity. ■Environmental consideration: The reagents used do not contain harmful components, reducing the burden of wastewater treatment. ■Automatic measurement with a minimum cycle of 10 minutes: Capable of measuring 24-hour temporal changes that are difficult with manual analysis or laboratory equipment.

• Water quality testing

Accurate water quality measurement and management are essential for land-based aquaculture. By visualizing water quality in real-time, we can optimize the aquaculture environment, protect the health of farmed fish, and support sustainable production. ■ Water Quality Monitoring Network System: IQ Sensor Net (Controller) ■ Optical Online DO Sensor: FDO 70x IQ SW ■ Online pH/ORP Sensor: SensoLyt 700IQ SW ■ Online Conductivity Sensor: TetraCon 700IQ SW ■ Online Turbidity Sensor: VisoTurb 700IQ SW ■ Online SS Sensor: ViSolid 700IQ SW ■ Coulometric Ammonia Meter: Quick Ammonia AT-3000 Model We offer a wide range of stable water quality measurement devices suitable for marine environments. If you have any other requests or inquiries, please feel free to contact us.

• Water quality testing

Sievers TOC vials guarantee the best performance in any test, including pharmaceutical water, cleaning validation, and difficult-to-recover compounds, while minimizing risks. 【Features of Sievers vials】 - Cleaning guarantee - Traceable - Manufactured by a global leader in TOC analyzers - Usable with TOC analyzers other than Sievers - OOS investigation support

• Water quality testing

The water quality of the water source shows a trend of complex pollution, and there is a demand for advanced and strict chlorine treatment and management in water purification processes. The traditional feedback method, which seeks appropriate values after chlorine injection, has posed health and economic issues. Therefore, it is desirable to establish a feed-forward method that captures the chlorine demand of raw water in advance and processes it. From sampling to measurement, all substances in raw water, such as ammonia nitrogen, iron, manganese, and organic matter, will be continuously and fully automatically measured for their chlorine demand in a short time. It can be used as a monitor for surveillance and, in combination with chlorine injection equipment, for accurate chlorine injection control as an automatic proportional injection system. 【Features of the CD-12MF model】 - Improved rotating platinum electrode for residual chlorine detection - No pre-treatment by filtration required even for high turbidity samples - Continuous measurement of chlorine demand in raw water - Follows rapid changes in raw water quality - Expanded screen size for improved visibility - Easy operation via touch panel - Equipped with USB functionality

• Analytical Equipment and Devices

TOC is an effective tool for cleaning validation of pharmaceuticals, cosmetics, and medical devices. By using TOC for cleaning validation, improvements in quality, risk reduction, and efficient operations can be achieved. TOC is a simple analytical method that rapidly detects low concentrations of organic compounds and can identify degradation products and contaminants that HPLC cannot detect. Compared to HPLC, which is a specific analytical method that detects only specific components, TOC, being a non-specific analytical method, can comprehensively confirm that excipients, degradation products, and cleaning agents are adequately cleaned. Furthermore, TOC simplifies method development and minimizes equipment downtime, leading to increased efficiency. By using TOC, not only can the cleaning process be evaluated quickly, but it also reduces the workload, maintenance costs, and running costs compared to HPLC.

• Other physicochemical equipment

Do you have any concerns about wastewater treatment? Our company listens to your issues regarding wastewater treatment optimization and introduces the most suitable measuring instruments from a variety of products! ● Water Quality Monitoring Network System IQ Sensor Net This is an online system that allows real-time monitoring of water quality. You can freely combine from 1 to a maximum of 20 sensors to build a system tailored to the scale of your facility and the type of wastewater. 【Main Sensors Introduced】 - Ammonia/Nitrate Sensor VARiON System: Equipped with electrodes that can correct for interfering substances such as potassium and chloride, achieving high-precision measurements. - Optical Dissolved Oxygen Sensor FDO 700IQ: Long lifespan with green LED. - UV-VIS Organic Matter/Nitrate/Nitrite Sensor CarboVis/NiCaVis: Capable of measuring organic matter (BOD, COD, TOC), nitrate, and nitrite. Additionally, we offer various sensors such as pH/ORP sensors, turbidity sensors, SS sensors, and sludge interface sensors. ● Pressure-type BOD Measuring Instrument OxiTop: A unique BOD measuring instrument using a pressure sensor method. It measures and records (automatically records up to 5 days) with just one measurement head.

• Water quality testing

This is a set of standard solutions that comply with USP<643> Total Organic Carbon, accompanied by a NIST certificate. It can be used with Sievers brand TOC analyzers as well as TOC analyzers from other manufacturers. Since it is pre-prepared, it can be used immediately.

• Water quality testing

This is a set of standard solutions that conforms to the Japanese Pharmacopoeia General Test Method 2.59 for organic carbon testing. It is used for performance evaluation of total organic carbon (TOC) analyzers and comes with a NIST certificate. It can be used with Sievers brand TOC analyzers as well as those from other manufacturers. Since it is pre-prepared, it can be used immediately.

• Water quality testing

"CheckBoy SOIL" is a rapid measurement set for harmful substances in soil that can be used for soil contamination analysis and more. In the case of soil contamination measures for heavy metals and other substances, high costs are required for the analysis of contaminants and the treatment of contaminated land. Therefore, to reduce the costs of contaminant analysis and shorten the investigation period, it is very effective to utilize simple analysis methods in combination with official methods as appropriate. 【Features】 ■ Contaminants can be analyzed on-site, in a short time, by anyone. ■ There are delivery records in private companies and other sectors. *For more details, please refer to the related links or feel free to contact us.

• Other measurement, recording and measuring instruments

The "CD-2000" is an easy-to-use coulometric chlorine demand meter designed for research on chlorine consumption reactions. It allows for the quick and simple measurement of chlorine demand in raw water such as rivers, lakes, reservoirs, groundwater, and seawater using the coulometric method. It manages the chlorine injection amount for chlorine treatment appropriately at a low running cost. 【Features】 ■ Easy operation and low running cost for research on chlorine consumption reactions ■ Adopts a feed-forward method *For more details, please refer to the related links or feel free to contact us.

• Other measurement, recording and measuring instruments

The "Check Boy CB-01 Type" is an interface detector that alerts you with a buzzer when it detects the sludge interface during wastewater treatment. It is a compact and lightweight measuring device, with a standard cable length of 5 meters, used for measuring sludge interfaces in applications such as sludge management, sedimentation tanks, and sludge thickening tanks. Additionally, the cable has markings at 1-meter intervals, allowing for position measurement using these marks. 【Features】 ■ Detects liquid interfaces and internal concentration differences with sensors, and alerts with a buzzer ■ The cable has markings at 1-meter intervals, enabling position measurement using these marks ■ Sealed structure, making it suitable for use in rainy conditions ■ Cable lengths are available in standard 5m, as well as 10m and 15m options *For more details, please refer to the related links or feel free to contact us.

• Other measurement, recording and measuring instruments

The bio-burden test is one of the important quality control processes to ensure the safety, quality, and compliance of pharmaceuticals. The culture method requires microbial cultivation, which takes about a week to determine results. The bio-burden rapid analysis device Soleil, developed by Sievers, can detect fewer than 10 viable microorganisms in 100 mL with ultra-high purity in under 45 minutes. It has a strong correlation with the culture method, enhancing the safety of pharmaceuticals and the efficiency of the manufacturing process while minimizing risks. In 2023, the PIC/S GMP Annex 1 was implemented, and rapid methods have begun to be adopted as a means of contamination control. This will be useful for the validation of pharmaceutical water/cleaning/process samples/raw materials/final products.

• Analytical Equipment and Devices

The endotoxin measurement device Eclipse, developed by Sievers, aims to make endotoxin testing easy for anyone. Many users have experienced challenges with traditional endotoxin measurements, such as the time and effort required for pipetting operations and the occurrence of human errors. Eclipse has achieved semi-automation of endotoxin measurement by developing a dedicated microplate and microfluidic technology. For measuring 21 samples, pipetting operations are reduced to fewer than 30 times, and since the standard samples are pre-filled, the preparation time and effort for testing are significantly reduced. Additionally, the amount of lysate reagent used is reduced by 90% to just 1mL, contributing to the ecological protection of horseshoe crabs. The IQ/OQ can also be completed in just a few days, so you can rest assured.

• Testing Equipment and Devices

■New Technology ◇90-Degree Multi-Pass Turbidity Detection Technology This is a patented technology unique to Lovibond, which installs two detectors at a 90-degree angle to the light source. By automatically switching between the two detectors, it consistently provides reliable results regardless of the size or shape of the particles. ◇BLAC Technology This is a new technology that removes stray light through a light absorption trap. It can measure with extreme accuracy even at low turbidity levels of 0.01 NTU.

• Water quality testing

Starting from April 2022, a method using portable residual chlorine meters has been added to the "testing methods for free residual chlorine and combined residual chlorine established by the Minister of Health, Labour and Welfare." ↓↓↓ The use of portable residual chlorine meters has been officially recognized as a testing method for drinking water! - Compact handheld type that is easy to hold with one hand - Display section with backlight for visibility in dark places It is excellent for use in the field!

• Water quality testing

The MD100 series SS water quality meter is easy to operate, compact, and lightweight, making it ideal for measurements at construction sites. It is compatible with various applications and can be used by a wide range of customers. <Features> ● Compact handheld design that is easy to hold with one hand ● Backlit display for visibility in dark environments ● Can measure without reagents ● IP68 waterproof design

• Analytical Equipment and Devices

The online TOC analyzer Sievers M500e is the third generation of online TOC analyzers that has developed Sievers' long-standing analytical technology in the electronics industry. It adopts Sievers' reagent-free gas-permeable membrane conductivity measurement technology, achieving accuracy, reproducibility, and stability of TOC below 1 ppb. ● Removal of interfering ions using gas-permeable membrane conductivity measurement method ● Significant reduction in running costs due to reagent-free measurement ● Up to 50% reduction in analysis time (compared to the previous model) It is the successor model to the Sievers 500RLe. It enhances accuracy and efficiency, supporting the stable production of ultra-pure water (UPW).

• Analytical Equipment and Devices

The online TOC analyzer Sievers M500 is the third generation of online TOC analyzers that has developed Sievers' long-standing reagent-free gas permeable membrane conductivity measurement technology. While inheriting the conventional "accuracy," "reproducibility," and "stability," it has achieved rapid measurement and enhanced data management functions. 【Unique technology compliant with the Japanese Pharmacopoeia】 - Complies with the Japanese Pharmacopoeia General Test Method <2.59 Organic Carbon Test> - Complies with various national pharmacopoeias (USP <643>, EP 2.2.44) - Measures by separating carbon dioxide: gas permeable membrane conductivity measurement method - Calibration using potassium hydrogen phthalate - Detects sodium dodecylbenzenesulfonate with a recovery rate of over 90% 【High performance & high functionality】 - Real-time measurement at 3-minute intervals - Flexible sampling functions - Abundant system protocols - Data integrity compliant with 21 CFR Part 11

• Analytical Equipment and Devices

This is the successor model of the highly acclaimed ML-54! 《Points of Evolution》 ■ Easy daily calibration It has a function to continuously measure reference light inside the sensor, automatically correcting the light intensity to keep it constant and reducing the likelihood of drift. 　ML-55: Zero calibration only 　Previous model: Filter calibration + zero calibration ■ Disturbance light prevention function It is equipped with a feature that does not affect sludge concentration measurements against a certain amount of disturbance light. ■ Compact body (approximately 30% smaller) 　ML-55: Body dimensions 185W×80D×60.5H mm 　Previous model: Body dimensions 210W×85D×78H mm ■ Data output available from USB port ■ Changed to easily obtainable AA batteries for power supply ■ Longer operating time 　ML-55 (AA batteries): 70 hours of continuous use (at 25°C) 　Previous model (rechargeable batteries): 20 hours of continuous use

• Analytical Equipment and Devices

Hydrogen peroxide is used for the purpose of sterilizing and bleaching food, and it is necessary to manage the residual trace amounts of hydrogen peroxide in packaged products, kazunoko, fresh noodles, milk, etc., using a hydrogen peroxide meter. The Hypa M-7 model can measure hydrogen peroxide simply and quickly using the standard method of oxygen electrode measurement. 【Improvements from the conventional model, the Protector M-5】 - Measurement can be performed without a constant temperature water tank due to the inclusion of a constant temperature plate. - Easy replacement of the electrode membrane. - Large display showing measurement values and graphs. *We also have comparative materials available, so please feel free to contact us.

• Other physicochemical equipment

●Measurement of organic substances that cannot be detected by UV ●Higher sensitivity than differential refractive index detector (RI) The Sievers TOC Analyzer M9 SEC is a detector for organic substances separated by molecular weight using a GPC/SEC system. It is capable of measuring organic substances that do not absorb UV light (such as alcohols and polysaccharides) with higher sensitivity than a differential refractive index detector (RI). Application examples: Measurement of refractory organic substances in environmental water, optimization of membrane treatment for wastewater, management of activated carbon injection amounts, measurement of precursor substances for disinfection by-products, quality control of pharmaceuticals, cosmetics, and plastics.

• Water quality testing

On-site water quality testing can be easily and accurately conducted to determine the suitability for drinking. It is also ideal for emergency situations in addition to regular water quality testing.

• Water quality testing

This is a set consisting of a UV-visible spectrophotometer and a decomposition device that can perform measurements based on the specified measurement method under the total amount regulation of the Ministry of the Environment.

• Water quality testing