サーモフィッシャーサイエンティフィック株式会社／Thermo Fisher Scientific K.K. Product Lineup

Ion contamination is a major concern for semiconductor manufacturing processes and finished devices, as it can lead to corrosion, erosion, and short circuits. Ion chromatography (IC) is an efficient analytical method that can quickly measure trace components and major constituents of various process contaminants in the semiconductor industry. We will introduce how our ion chromatography system can be utilized. *For more details, please download the PDF document or feel free to contact us.*

• Analytical Equipment and Devices
• Other measurement, recording and measuring instruments

Due to the recent shortage of helium gas supply, it has become urgent to review the operation of analytical instruments that use helium. Measures for GC and GC-MS include reducing helium consumption or using hydrogen as an alternative carrier gas. In addition to the general helium depletion issue, you can view an explanation of our solutions in the PDF download.

• Analytical Equipment and Devices

- The control panel mounted on the top allows easy access to the CryoPlus microprocessor controller. - A combination of 16 preset audio and visual alarms maximizes product protection. - In addition to high-density polyurethane insulation, two independent gaskets reduce moisture ingress and freezing into the chamber. - 24 three-color LEDs continuously display the liquid nitrogen level and high/low levels. - The sleeve for temperature retention, which comes standard, helps maintain a lower temperature at the top, making operations in the vapor phase more efficient. - A digital temperature display sensor is placed under the lid to show the highest temperature reading inside the tank. - It is equipped with 24 three-color LEDs that continuously display the actual liquid nitrogen level and the high/low set points. - The storage tank is vacuum insulated with a stainless steel interior. - It features alarm contacts for remote monitoring of the storage tank's condition. - All models come standard with an LN2 transfer hose.

• Refrigerators and freezers

The analytical methods for high-concentration sodium hydroxide (NaOH) are specified in JIS K1200 Industrial Sodium Hydroxide Parts 1 to 10. Among these, the methods for measuring chlorides include the mercuric thiocyanate spectrophotometric method, the modified Holthart method, and the ion chromatography analysis method. The mercuric thiocyanate spectrophotometric method is often avoided due to the strict handling and management of mercury compounds. The modified Holthart method quantifies chlorides by adding an excess of silver nitrate solution and performing back titration with ammonium thiocyanate solution, but it is not suitable for quantifying low-concentration chlorides in samples. The ion chromatography analysis method involves complex pretreatment operations and carries the risk of sample contamination; however, this application note introduces a method that automates the pretreatment step using cation exchange resin inline. This automated pretreatment is a technique for inline neutralization using our suppressor technology. It can accommodate not only NaOH but also many high-concentration basic samples, allowing for the analysis of anionic components in the samples.

• Other inspection equipment and devices

The industries where the use of ion chromatography is recommended are diverse, as follows. Our ion chromatograph features high speed and high separation, making it suitable for trace analysis of ionic compounds, impurities, and contaminants required in these fields, and it can be utilized in research and development as well as quality control. We have a wealth of measurement examples as listed below, so please make use of them to solve your current challenges and improve the efficiency of your analytical operations. - Semiconductors - Batteries - Electronic devices - Chemical products - Materials - Oil and gas - Biofuels - Power

• Other inspection equipment and devices

N-nitrosodimethylamine (NDMA) is an organic compound represented by the chemical formula (CH3)2NNO. NDMA is a known carcinogen found in some fermented foods. The measurement of nitrite ions can be performed using wet chemical analysis, but a representative method in instrumental analysis is ion chromatography (IC). In IC, separation is achieved using an ion exchange column, and detection is carried out using conductivity detection, electrochemical detection, UV detection, or mass spectrometry. Methods using IC typically require little to no sample pretreatment for many pharmaceutical samples, and derivatization of the target components is also unnecessary.

• Other inspection equipment and devices

The Gallery discrete automatic analyzer automates manual wet chemical analysis, spectrophotometric analysis (colorimetric and enzyme analysis), and electrochemical analysis (measurement of pH and electrical conductivity). The discrete method allows for the simultaneous measurement of many analytical components, reducing the overall analysis time and the operator's workload. The Gallery discrete automatic analyzer minimizes waste liquid volume by utilizing miniaturized components and a unique low-volume cell design, allowing analysis with a small amount of reagents, which in turn reduces the costs associated with analysis. *For more details, please refer to the PDF document or feel free to contact us.*

• Analytical Equipment and Devices
• Spectroscopic Analysis Equipment
• Water quality testing

The detection and identification of compounds of unknown origin is challenging, often involving complex volcanic processes, and it takes time to obtain results. Additionally, high reliability is required for final identification, which necessitates the confirmation of multifaceted information. By measuring the molecular weight of chemical substances with sufficient accuracy, it is possible to determine the elemental composition and identify the chemical structure of the substance using isotope ratios and fragmentation patterns. Using high-resolution GCMS allows for the reliable detection of target components from complex matrices due to its high mass resolution and mass accuracy. This technical document introduces a method for reliably identifying unknown substances almost instantaneously. It connects a direct injection probe to our high-resolution GCMS (Orbitrap GC-MS system) and rapidly identifies compounds using both electron ionization and chemical ionization.

• Analytical Equipment and Devices

The chemical components of food packaging (especially those derived from polymers, dyes, and inks) can pose health risks to consumers by migrating into food. In the United States, the migration limit applicable to residual solvents and non-volatile food additives is 50 ppm. Additionally, the accurate quantification of residual solvents in flexible packaging is regulated by established methods such as EN 13628-1:2002. When analyzing volatile impurities in solid polymers using liquid injection, a cumbersome process of dissolving the sample in an appropriate solvent is required. Furthermore, high-viscosity solutions containing non-volatile long-chain polymers can contaminate the GC injector port, leading to increased analysis costs due to frequent maintenance. On the other hand, using headspace sampling allows for the rapid and easy extraction of volatile components from food packaging samples, eliminating the need for time-consuming sample preparation. This technical document presents the quantitative results of residual solvent analysis in food packaging materials conducted using the TriPlus 500 headspace (HS) autosampler. The dual detector configuration of FID/MS enabled the detection, identification (using hydrogen flame ionization detection), and confirmation (using mass spectrometry detection) of unknown impurities.

• Analytical Equipment and Devices

We introduce water quality analysis equipment for beer brewing, such as microbreweries. The process of analyzing water quality, which is a crucial factor in determining the quality of beer, includes various stages such as brewing water, wort during fermentation, kegging, bottled beer, and even wastewater after brewing. There is a wide range of products required depending on the process. We showcase a comprehensive lineup of products used for water quality analysis on our dedicated beer brewing webpage. In addition to introducing the products needed for each stage, we provide useful information related to beer quality analysis, including technical notes that cover necessary technical information and measurement methods. By utilizing high-quality beer analysis solutions, we will continue to enhance our support to help you brew delicious beer.

• Water quality testing
• Food Testing/Analysis/Measuring Equipment
• Water treatment equipment

Organic solvents are widely used in the synthesis of pharmaceuticals, but they cannot always be completely removed during the manufacturing process. To ensure safety, the final product is tested to evaluate whether the solvents used have been efficiently removed and, if any remain, whether their concentrations are within acceptable limits. The United States Pharmacopeia (USP) method <467> provides detailed procedures for screening, confirming, and quantifying residual solvents, including sample preparation and analytical conditions. The new TriPlus 500 HS autosampler adopts an innovative design with a flow path that directly connects the heated valve to the GC column. This means high-precision sample introduction and excellent reproducibility of peak areas. Furthermore, by continuously purging the sample path, the robustness and reliability of the system are ensured, reducing the risk of contamination and carryover (which is important when analyzing high-boiling residual solvents). This technical document reports the results of residual solvent analysis conducted in accordance with USP <467>, using the TriPlus 500 HS autosampler and FID as the optimal detector.

• Analytical Equipment and Devices

In the quantitative analysis of pesticide residues in food, triple quadrupole mass spectrometers such as GC-MS/MS and LC-MS/MS are commonly used. This is because they can separate trace amounts of pesticides from the food matrix and detect peaks with high sensitivity. On the other hand, our Orbitrap mass spectrometer allows for advanced mass separation, enabling the detection of pesticide peaks without interference from the food-derived matrix. This application note introduces a simultaneous analysis of 325 pesticide components using a GC-Orbitrap mass spectrometer. The Orbitrap mass spectrometer facilitates method development for data acquisition in Full MS measurements, and its high mass accuracy allows for the precise estimation of molecular formulas for each fragment ion, providing reliable quantitative information.

• Analytical Equipment and Devices

Polycyclic aromatic hydrocarbons (PAHs) are components generated from the heating of organic materials, and due to concerns about their carcinogenicity and other health effects, PAHs present in food are regulated in some countries and regions. In particular, edible oils may undergo heating as a pretreatment during extraction from raw materials, which raises the possibility that PAHs could be generated during the thermal processing, even if the raw materials themselves do not contain PAHs. Since various countries have established standard values for PAHs, safety inspections may be required when exporting food abroad. These standard values are becoming stricter year by year, and high-sensitivity detection measurement devices are needed to accurately quantify these standard values. This application note presents a case of highly sensitive quantification of PAHs without interference from matrix components, achieved using the high mass resolution and mass accuracy of the Orbitrap GC-M system, a high-resolution GCMS. Data acquisition is performed through full scan measurements, making method development easier and enabling retrospective analysis (such as checking whether newly regulated components were present in previously measured samples).

• Analytical Equipment and Devices

The processed foods we consume develop unique flavors and aromas due to various differences in the quantities and origins of the ingredients used, as well as cooking times, even if they share the same name. Understanding these differences at the component level is crucial in food research, and the use of GC/MS methods is expected to shed light on volatile components, which are believed to be factors influencing aroma. Non-target analysis that encompasses all contained components has been considered challenging due to the vast amount of information and the complexity of analytical operations. To obtain reliable results, efficient sampling methods, chromatographic separation, advanced mass separation, and software for smooth statistical analysis of the data are required. In this technical document, we present a workflow using high-resolution GC-MS (Orbitrap GC-MS) and Compound Discoverer software for low molecular analysis, as a solution to smoothly and accurately address this complex food comparison, exemplified by the inter-sample comparison of commercially available meat sauces from three food manufacturers.

• Analytical Equipment and Devices

If your customer's GC is only operating intermittently, they are losing the profits that could have been generated by continuous operation. The Thermo Scientific TRACE 1600 series gas chromatograph (GC) was developed with time and space efficiency in mind. Our patented modular design features plug-and-play injectors and detectors, enabling offline maintenance and allowing for easy changes to different configurations with a single GC, thereby enhancing productivity. When combined with the Thermo Scientific AI/AS 1610 liquid autosampler, this system enables simple and reliable automatic sample injection, meeting a wide range of sample throughput demands. Additionally, the optional He-Saver H2-Safer module addresses helium shortages, significantly reducing helium consumption. *For more details, please refer to the PDF document or feel free to contact us.*

• Analytical Equipment and Devices

In analytical testing labs, it is desirable to obtain reliable results easily and consistently at any time. The ISQ 7610 GC-MS is a system that provides consistent results across all lab systems due to its simplified operation, automated workflow, and wide dynamic range. With NeverVent technology, long-life detectors, and intelligent software, unnecessary downtime is reduced, and sample throughput is improved. This system can be upgraded from a basic configuration to an advanced configuration to address various analytical challenges. It offers high cost-effectiveness for regulatory-compliant GC-MS analysis. *For more details, please refer to the PDF materials or feel free to contact us.*

• Analytical Equipment and Devices

Routine labs involved in food, environmental, and forensic/toxicological analysis are facing a changing environment characterized by regulatory requirement changes, lower detection levels, an increase in compounds, reduced turnaround times, decreased profits, and intensified competition. In such circumstances, your GC-MS/MS system must deliver high performance and consistently reliable quantitative results. The Thermo Scientific TSQ 9610 Triple Quadrupole GC-MS/MS system features a vacuum-free ion source and column exchange with NeverVent technology, a long-life detector, and intelligent software, which reduce unnecessary downtime, improve sample throughput, and provide a high return on investment (ROI). Additionally, the optional He-Saver H2-Safer module addresses helium shortages by significantly reducing consumption when using helium or hydrogen gas, ensuring safety. *For more details, please refer to the PDF document or feel free to contact us.*

• Analytical Equipment and Devices

Introducing the Thermo Scientific Samco Capillary Transfer Pipette, which allows for efficient blood collection and dispensing. This is a must-see for customers like: - Those concerned about breakage with glass products - Users finding their current products difficult to handle due to air bubbles and low accuracy - Those who want to dispense within seconds and prefer not to use coagulants ■ Applications • Testing with whole blood samples, such as infectious disease tests, cardiac marker tests, cholesterol tests, etc. • POC or OTC test kits • Tests conducted outside of testing facilities • Rapid tests that provide results within minutes ■ How to Use STEP 1: Suction using capillary action STEP 2: Accurately suction to the mark horizontally STEP 3: Press the valve ■ Features • Capillary action allows for suction without air bubbles • Safer to handle than glass due to its plastic construction • Fixed volume ensures good accuracy with no waste of samples • Can dispense quickly (within seconds), eliminating the need for coagulants ■ Sizes Available in two types: 25 μL and 50 μL For samples, requests for materials, or inquiries, please contact us first.

• Pipettes and Droppers

Don't you think all consumables are the same? Subtle differences in size, shape, and ease of use can affect usability. Please try the actual products as samples. ■ Plastic Tubes We offer sterilized products suitable for tissue culture, available in sizes of 5 mL, 14 mL, and 16 mL. ■ Standalone Conical Tubes 30 mL A perfect size with a maximum capacity of 25 mL. Proven performance in COVID testing labs. ■ Petri Dishes Essential for culturing fungi, bacteria, and other microorganisms. Available in 90 mm and 140 mm types. The contact dish is 57 mm with a 1 cm square grid. ■ Inoculating Loops & Needles The loop type is available in 1 μL and 10 μL with capacity calibration certification. Needle types are also available. Both are sterilized with electron beams. ■ Mini Trays Available in 60-well and 72-well formats. They have low protein adsorption and allow for efficient mixing of samples and reagents. ■ Sample Storage Vials Available in high-demand sizes of 90 mL and 120 mL. The click cap allows you to confirm that the cap is securely closed by sight, sound, and touch. For samples, requests for information, or inquiries, please contact us first.

• container
• Other experimental consumables

This is a stable isotope ratio mass spectrometer (IRMS) primarily designed for light elements such as carbon, nitrogen, sulfur, oxygen, and hydrogen. It is the latest model in the DELTA series, which has over 30 years of proven performance as a standard in stable isotope ratio analysis. ■ Compatible with various pretreatment devices to support a wide range of isotope ratio analysis applications <Representative pretreatment devices> - Bulk analysis of solid powder samples: EA IsoLink elemental analyzer pretreatment device - Analysis of components separated by GC: GC IsoLink II gas chromatograph pretreatment device - Analysis of oxygen and hydrogen in water, carbon and oxygen in carbonates, etc.: GasBench Plus general-purpose pretreatment device - Analysis of aqueous solutions or components separated by LC: LC IsoLink II liquid chromatograph pretreatment device <Application examples> - Determining the origin of food, additives, and authenticity - Criminal investigations, anti-doping analysis - Environmental dynamics analysis, biogeochemical research, etc. ■ Enables stable analysis and operation of the device - Inherits the high robustness and stability of conventional models ■ Allows for high-sensitivity analysis more easily than conventional models - Equipped with the Qtegra ISDS software, which is even more user-friendly and visually appealing than the traditional ISODAT software - Improved manufacturer-guaranteed sensitivity

• Analytical Equipment and Devices

The "Nicolet RaptIR" is an infrared microscope equipped with the ability and precision for visible observation, allowing for a broad overview of the analysis target, quick identification of areas of interest, and insights at the micrometer scale. Using this product significantly enhances productivity in terms of both sample size and analysis time. Moreover, it is adaptable to various users and can flexibly accommodate use across different industries. The objective lens, infrared spectral capabilities, and clear images are beneficial in diverse research fields such as art restoration, quality control, and materials science. 【Features】 ■ Accurately identifies complex samples ■ Quickly obtains analysis results at the micrometer scale ■ Significantly reduces the time from sample to report generation ■ Scalability to achieve various objectives *For more details, please refer to the PDF document or feel free to contact us.

• Analytical Equipment and Devices

The Thermo Scientific Process 16 twin-screw extruder adopts a segmented screw design, allowing for a shorter overall length, which enables control over residence time within the extruder and accommodates a wide range of materials with low processability. Additionally, it offers various options for barrels and feeders with different features, ensuring that even materials requiring delicate and advanced processing can achieve the optimal processing conditions due to its flexibility.

• Extrusion Machine

The Luminex xMAP INTELLIFLEX System offers a compact design with a wide dynamic range. It features a touchscreen user interface, and its startup, shutdown, and maintenance processes are automated, making it user-friendly and easy to maintain. Additionally, it includes a lineup of models such as the DR-SE model, which can measure two parameters, the Luminex 200 Instrument System, and the Luminex FLEXMAP 3D Instrument System. 【Features】 ■ Wide dynamic range ■ Compact footprint ■ Improved ease of use ■ Supports high-throughput applications We are currently running a campaign offering a special price for a limited number of 10 units. 【Eligible Products】 Luminex 200 System Luminex xMAP INTELLIFLEX System Luminex xMAP INTELLIFLEX DR-SE System 【Campaign Period】 From May 24, 2024 (Friday) to September 27, 2024 (Friday) for orders received *For more details, please refer to the PDF materials and campaign page.

• Analytical Equipment and Devices

The high-end model "Bigfoot Spectral Cell Sorter" enables both spectral analysis and conventional compensation. It allows sampling from 1.5 mL, 5 mL, and 15 mL tubes, equipped with automatic tube type identification and crash detection features. Automated 5-axis stream alignment and QC enhance usability and reduce variability from short to long durations. 【Features】 ■ Convenient storage space that helps organize lab space ■ Automatic mixing of sheath fluid and system cleaning without human intervention ■ Equipped with stirring and temperature control (4–37°C) functions ■ Built-in custom-designed Class II safety cabinet ■ Flexibly accommodates various cell sorting applications *For more details, please refer to the PDF document or feel free to contact us.

• Analytical Equipment and Devices

**Features** - Compatible volume range for nL dispensing (50 nL to 50 µL) - Achieves high-speed dispensing of 384-well plates in 6 seconds (50 nL) - Compatible microplates (height 5–50 mm): 96, 384, 1,536 well plates - Graphic user interface and color LCD display - Dispensing to any well or customizable position - Supports normal diluents, buffers, protein solutions, as well as highly viscous cell solutions and beads - Minimal dead volume to reduce reagent loss - Backflush function allows recovery of reagents from the tube **Specifications** - Compatible plates: 96, 384, 1,536 well plates - Dispensing volume range: 50 nL to 50 µL - Dispensing accuracy CV: 1–10 µL: CV ≦ 4% - Dispensing speed: 384-well plate in 28 seconds (1 µL) - Dimensions (W×D×H): 355 × 375 × 220 mm - Weight: 9.6 kg - Robot connectivity available

• Dispenser

The Thermo Scientific Multidrop Pico 1 and Pico 8 Digital Dispensers use a non-contact dispensing method with dedicated dispensing head cassettes, eliminating the risk of sample mix-ups and contamination. 【Features】 - Reduces dead volume of reagents and samples by up to 10 times - Completes a task that takes 10 minutes by manual dilution in just 15 seconds - Speeds up qPCR workflows - PicoIT software features a flexible and intuitive design ◎ Supports the creation of complex dilution series, such as IC50 and drug-drug interactions - Capable of dispensing DMSO, aqueous solutions, and PCR master mixes - Pico 8 can set up to 8 different reagents simultaneously 【Specifications】 - Compatible plates: 12, 24, 48, 96, 384, 1,536 well plates - Dispensing volume range: 11 pL to 20 μL, 1 nL to 200 μL - Dispensing accuracy CV: ≤8% - Dispensing speed: 11 pL to 10 μL in a few seconds - Dimensions (W×D×H): Pico 8: 47×38×23 cm Pico 1: 31×28×20 cm - Robot connection: Only possible with Pico 8

• pipette

Thermo Scientific Samco Clicktainer vials support the careful handling of your valuable samples. • Easy sample collection • Safe sample transport • Large opening and leak-proof cap • Multi-click design that allows visual, auditory, and tactile confirmation of cap closure • Choice of packaging

• Plastic utensils and containers
• Other safety and hygiene products

Whether your application's needs involve separation, large-volume pelletization, protein purification, or DNA isolation, Thermo Scientific Nalgene and Nunc centrifuge containers offer reliable solutions with a wide range of sizes from 10 mL to 2 L. The extensive product lineup includes numerous centrifuge tubes, tubes, bottles, caps, and sealing caps for various centrifugation applications.

• Plastic utensils and containers
• centrifuge

In recent years, there has been a rapid diversification of pharmaceutical modalities, including the widespread use of high molecular weight proteins such as antibodies, viral vectors for gene therapy, and cell medicines like CAR-T cell therapy. Maintaining the highest levels of safety, efficacy, and quality in the manufacturing of these biopharmaceuticals has become a challenge. The Thermo Scientific CentriPAK bioprocess container (BPC) is a new batch centrifugation system that provides innovative value in the recovery, separation, and purification processes of biopharmaceutical manufacturing. Features: - Gamma-ray sterilized & single-use, eliminating the need for cleaning and sterilization validation - Supports large volumes with a maximum capacity of 10.2 L (6 bags x 1.7 L capacity) - Employs a manifold system for filling in a closed system: eliminates contamination risks - Capable of centrifugation at a maximum centrifugal force of 7,187 x g - Compatible with sterile connectors and sterile welding - Bags that can store separated supernatant in a closed system - Accompanied by an analysis certificate - Flexible bags contribute to waste reduction compared to bottles - A single bag with a capacity of 1.7 L is also available: suitable for small-scale applications

• Separation device

PFAS compounds include perfluorooctanoic acid (PFOA) and perfluorooctane sulfonic acid (PFOS), and due to the increasing number of organic fluorine compounds that impact the environment and precursors that cannot yet be analyzed, there is a demand for the development of suitable analytical methods. As a result, there is a growing need for a single analytical workflow that can directly quantify as many PFAS as possible. Traditional ion chromatography (IC) cannot directly analyze non-ionic perfluoroalkyl substances (PFAS). However, using continuous ion chromatography (CIC), it is possible to measure organic halogen contaminants such as AOX. Unlike the conventional titration AOX method, which only measures the total organic halogens, CIC provides additional information on adsorptive organic fluorine compounds and allows for the speciation of halogens. *Please note that the ion chromatograph introduced in this application note has been discontinued. The successor model is the Thermo Scientific Dionex Inuvion IC system.*

• Analytical Equipment and Devices

The networked or enterprise Thermo Scientific Chromeleon Chromatography Data System (CDS) is essential for compliance, efficiency, and reliable operation in modern chromatography laboratories. It manages all analytical processes, from instrument control to raw data storage and analysis, to the generation of final results. Data integrity, data security, and compliance are always prioritized, and using Chromeleon CDS facilitates audits by providing all necessary traceability. With a user management system and centralized resources, data access and backup are easily managed, ensuring data integrity.

• Analytical Equipment and Devices
• Software (middle, driver, security, etc.)
• Integrated operation management

The Thermo Scientific Chromeleon 7.3 Chromatography Data System (CDS) ensures data quality and manages all analytical processes, from instrument control to raw data storage and processing, to the creation of final results. Today, data security, data integrity, and compliance are becoming increasingly important. Therefore, comprehensive controls regarding preventive and detection technologies are extremely important. This enables compliance with the latest regulatory requirements and ensures the highest level of data quality. Various tasks arise, such as the preparation of samples before measurement and the creation of reports in HPLC analysis. Chromeleon's e-workflow automates pre- and post-analysis work time, leading to cost reductions. *The percentage of labor reduction is based on workflow analysis results conducted within our company.

• Analytical Equipment and Devices
• Software (middle, driver, security, etc.)
• Integrated operation management

Thermo Scientific SOLA products bring a major revolution to solid phase extraction (SPE). With frit-free SPE, cleaner and more consistent recoveries are achievable, resulting in excellent reproducibility. Compared to traditional phospholipid removal plates and protein removal plates, SOLA products demonstrate unparalleled superior performance. Key features: • Improved reproducibility • Enhanced extract purity • Reduced amount of organic solvent used • Increased sensitivity

• Analytical Equipment and Devices

Thermo Scientific SOLAμ solid phase extraction (SPE) well plates are designed for researchers engaged in bioanalysis and clinical studies that require cleaner, more reproducible, and robust sample extraction with very low amounts of sample and solvent in high-throughput workflows. The SOLAμ well plates achieve this with their unique innovative fritless SPE technology. The SOLAμ well plates are advanced micro-elution products that faithfully meet the requirements of bioanalysts.

• Analytical Equipment and Devices

Solid-phase extraction (SPE) is a highly effective modern bioanalytical technique for isolating analytes from complex biological matrices. It improves accuracy and precision, enables detection at very low levels, and reduces matrix effects that can be problematic in mass spectrometry.

• Analytical Equipment and Devices

Liquid chromatography aims to achieve good separation ability to obtain meaningful information through peak resolution. In mixed-mode chromatography, numerous parameters can be adjusted to optimize separation efficiency, allowing for effective control of separation performance. The Thermo Scientific Acclaim mixed-mode column features unique surface chemistry that facilitates easy adjustment of analyte elution, enabling maximum separation efficiency, which often leads to successful separation of compounds that cannot be addressed by other conventional high-performance liquid chromatography (HPLC) columns. The combination of ion exchange and reversed-phase, specifically HILIC chemistry, can extract the chemical properties of sample mixtures, allowing for complete separation of components in complex samples or high-sensitivity detection of trace samples. However, it is impossible to retain highly polar or charged analytes using only reversed-phase chromatography. Ion exchange (IEX) chromatography alone is insufficient for separating hydrophobic compounds. By using columns that combine different functionalities, a completely new toolkit is obtained for separating and evaluating samples.

• Analytical Equipment and Devices

Adeno-associated virus (AAV) is a suitable vector for many gene therapies. The Empty/Full capsid ratio of AAV is an extremely important quality characteristic that needs to be monitored throughout the entire development cycle. The Thermo Scientific ProPac column series leverages approximately 20 years of experience in ion exchange to continue supporting researchers in the biotherapeutics field. The Thermo Scientific ProPac SAX-10 LC column easily separates the Empty/Full capsid bodies of AAV serotype 6 and AAV serotype 8 in less than 10 minutes, allowing for immediate quantification results with minimal sample pretreatment.

• Analytical Equipment and Devices

Thermo Scientific SOLA products are designed for bioanalysis and clinical research analysts with the mission of providing high-quality analytical results from complex biological samples in high-throughput environments while adhering to strict regulations. Such needs continue to drive the push for more effective drugs and long-acting formulations, lowering the sensitivity requirements for accurate quantification to even lower levels. To meet these needs, bioanalytical methods must have the following: • Robustness – low analytical failure rate • Ability to process low-volume samples • High sensitivity • High reproducibility • Ease of use • High-throughput processing • High-efficiency and fast processes

• Analytical Equipment and Devices

Thermo Fisher Scientific's Bio LC columns separate biological samples with high resolution and efficiency. Our proprietary column chemical properties for biological samples are specifically designed for the separation of proteins, peptides, monoclonal antibodies, carbohydrates, nucleic acids, and more. - Protein HPLC columns - Peptide HPLC columns - Glycan HPLC columns - Oligonucleotide HPLC columns - Monoclonal antibody HPLC columns

• Analytical Equipment and Devices

Thermo Scientific Acclaim columns are ideal for high-efficiency high-performance liquid chromatography (HPLC) separations. Their unique features enable challenging and complex separations, allowing for the separation of compounds that traditional HPLC columns cannot achieve. The Thermo Scientific Acclaim columns utilize standard surface chemistry features, including standard functionalities such as 120 C18, C8, Phenyl, Polar Advantage, polar embedded phases, HILIC, as well as mixed-mode functionalities (Thermo Scientific Acclaim Trinity P1 and P2 columns), and application-specific phases (such as organic acids, surfactants, pesticides, contaminants, etc.), along with specialized columns like size exclusion columns (SEC). Furthermore, some Acclaim columns are optimized to operate under the ultra-high-performance liquid chromatography (UHPLC) requirements of the Thermo Scientific Vanquish UHPLC system.

• Spectroscopic Analysis Equipment

pH has a significant impact on the ionization state of specific analytes. For example, a base with a pKa of 8.5 is 99% ionized at pH 6.5 using the 2 pH unit rule and 99% non-ionized at pH 10.5. When the analyte is close to its own pKa, unstable chromatograms may be observed, so it is necessary to adjust the pH to achieve the appropriate ionization state. Differences in the surface activity of vial glass and the leaching of hydrolysis products that affect the sample pH can be confirmed by monitoring the pH changes of deionized water stored in the vial. To investigate how the quality of glass, represented by the expansion coefficient, affects the pH of the solution, we measured the fluctuations in the pH of 18 MΩ pure water stored in an autosampler vial for a certain period at room temperature and compared the results with those obtained using polypropylene containers as a control.

• Analytical Equipment and Devices

Thermo Scientific Orion ROSS electrodes have been helping scientists and engineers achieve accurate pH measurements for 40 years since their launch. We are now offering a 15% discount on various Orion ROSS pH electrodes and the Thermo Scientific Orion ROSS All-in-One standard solution kit. We encourage you to take advantage of this opportunity. ● Campaign products: Various Orion ROSS pH electrodes and the Orion ROSS All-in-One standard solution kit ● Campaign period: November 8, 2021 (Monday) to March 25, 2022 (Friday) Additionally, the Thermo Fisher Scientific website provides various support information, including introductions to different ROSS electrodes, the structure of ROSS electrodes, the mechanisms that demonstrate their performance, and maintenance information. Please visit thermofisher.com/ross40 for more details.

• Other measurement, recording and measuring instruments

The Nalgene bottle is a plastic bottle that achieves leak prevention without the use of liners or gaskets. Made from high-quality resin, it has low leaching from the bottle and a reduced risk of contamination, making it popular in laboratories around the world. We have now released an online seminar about the appeal, features, and clean bottle service of Nalgene bottles. All videos are available for free. [Video Lineup] - Features of Nalgene bottles - Characteristics of resins and how to choose them - Bottles with special features - Comparison of four performance metrics for PET/PETG bottles from various manufacturers for culture media - Clean bottle service The Nalgene brand offers a wide range of plastic bottles, including kit bottles, culture media bottles, and large bottles, in various materials, shapes, and sizes. We also provide a clean bottle service to ensure that you can use high-quality Nalgene bottles with even greater cleanliness. *For more details, please watch the online seminar or select "Request Contact" in the inquiry section below. *Materials related to the seminar can be downloaded from the link provided.

• Plastic utensils and containers
• plastic
• Other consumables

Using the Thermo Scientific Orbitrap Exploris GC 240 mass spectrometer elevates research capabilities to an unprecedented level of performance, accelerating scientific discoveries. Its unique features provide high-quality, information-rich data, simplifying the challenges of the most complex analyses. ■ Exceptional performance and accuracy Delivers groundbreaking 240,000 mass resolution, MS/MS capabilities, and excellent sensitivity across a wide range of applications. ■ Generating discoveries with minimal effort An integrated informatics solution for quantitation and compound exploration facilitates detailed characterization of the most challenging samples, deriving scientific understanding from the data. ■ Versatility to address diverse analytical challenges The Thermo Scientific ExtractaBrite electron ionization/chemical ionization (EI/CI) ion source, direct injection probe, MS/MS capabilities, and GC modules expand the possibilities of analysis.

• Analytical Equipment and Devices

The Thermo Scientific Orbitrap Exploris GC mass spectrometer enables reliable detection and high-precision quantification even in complex matrices, maximizing productivity with minimal method development. It combines excellent mass resolution, sensitivity, speed, and linear dynamic range, delivering accurate results even for samples that are particularly challenging to detect. ■ Increased Productivity By utilizing versatile high-resolution precise mass full scan data for screening and quantification, you can streamline your analytical workflow. ■ Assurance of Analytical Results High-resolution full scan data allows for multifaceted compound identification considering spectral matching, isotope patterns, and elemental composition, reducing the time to obtain results. ■ Maximized Uptime You can produce results on time and easily. Intuitive instrument control and method templates allow all members of the analytical team to easily access the system.

• Analytical Equipment and Devices