サーモフィッシャーサイエンティフィック株式会社／Thermo Fisher Scientific K.K. Product Lineup

The Thermo Scientific benchtop shaker is highly durable and can be used for various daily research applications. It offers a wide range of speed and time settings, allowing for shaking and mixing according to the user's preferences. With adjustable stirring parameters for various applications, it enhances laboratory efficiency. ■ Models designed for a variety of stirring applications (shaking, rocking, vortex mixing, etc.) ■ All models feature digital control (LED light) ■ Angle adjustment is also controllable (no additional tools required) ■ A heavy-duty body and rubber feet ensure stable shaking * Each model comes with a variety of attachment accessories. Please inquire for more information.

Our company offers a wide range of contract services using diverse products from the well-established Applied Biosystems, Invitrogen, and Gibco brands in the life sciences field. Among these, our protein expression contract services have a rich domestic track record and have received high praise from many customers. If you are facing challenges such as "struggling with experimental methods," "wanting to efficiently advance experiments with limited resources," or "wanting to conduct experiments that exceed capacity limits," please feel free to consult with us. Our experienced technical support staff will propose suitable services tailored to your needs.

The Luminex 200 Instrument System is a standard multiplex model that provides rapid and cost-effective results. It allows for simultaneous measurement of up to 100 items per well. By enabling multi-parameter analysis at the same time, it contributes to the reduction of consumables and an increase in productivity. Additionally, there is the ultra-high throughput model, the Luminex xMAP INTELLIFLEX System, which offers rapid reading performance and is compatible with 384-well plates.

When using an imager, have you ever experienced "retakes due to overexposure or underexposure"? The Invitrogen iBright Imaging Systems is a chemiluminescence and fluorescence imaging device equipped with an easy-to-use touchscreen interface, automatic exposure time calculation, and zoom functionality through SmartExposure technology. It features a high-resolution 9.1-megapixel camera and various imaging modes, supporting multiplex Western blotting. Features: - Intuitive touchscreen interface for easy operation - High-performance camera and automation technology to reduce imaging errors - Various imaging modes to accommodate a wide range of applications - Built-in simple analysis functions - Multiplex analysis possible with 5-channel fluorescence* - Provides analysis tools through cloud applications *Only for the iBright FL1500 Imaging System *For more details, please refer to the PDF materials or feel free to contact us.

The Luminex xMAP INTELLIFLEX System offers a compact design with a wide dynamic range. It features a touchscreen user interface, and its startup, shutdown, and maintenance processes are automated, making it user-friendly and easy to maintain. Additionally, it includes a lineup of models such as the DR-SE model, which can measure two parameters, the Luminex 200 Instrument System, and the Luminex FLEXMAP 3D Instrument System. 【Features】 ■ Wide dynamic range ■ Compact footprint ■ Improved ease of use ■ Supports high-throughput applications We are currently running a campaign offering a special price for a limited number of 10 units. 【Eligible Products】 Luminex 200 System Luminex xMAP INTELLIFLEX System Luminex xMAP INTELLIFLEX DR-SE System 【Campaign Period】 From May 24, 2024 (Friday) to September 27, 2024 (Friday) for orders received *For more details, please refer to the PDF materials and campaign page.

The "AAV Production Contract Service" is a service that produces the desired Adeno-Associated Virus (AAV) using the proven Gibco AAV-MAX Helper Free AAV Production System in a suspension culture system. Depending on the application, affinity purification using the Thermo Scientific POROS CaptureSelect series and various analyses (Titer measurement by quantitative PCR and evaluation by SDS-PAGE) are also possible. All work is conducted in a domestic lab, allowing us to deliver in the shortest possible time from inquiry to delivery. We will also promptly respond to inquiries about the progress status. 【Features】 ■ Provides functional AAV at high purity and high concentration ■ Achieves high titer with multiple serotypes *For more details, please refer to the PDF document or feel free to contact us.

At Thermo Fisher Scientific, we offer contract services such as "artificial gene synthesis," which allows for the acquisition of sequences that are difficult to isolate or do not exist in nature, as well as "Invitrogen Expi293 expression / ExpiCHO expression," which can yield high amounts of protein in small-scale cultures. In our contract service catalog, we provide an overview and features of each service, so please refer to this for more details. *For more information, please refer to the PDF materials or feel free to contact us.*

The "Invitrogen Click-iT product series" generates no byproducts from the reaction components, resulting in minimal damage to cells and allowing for analysis that maintains a more natural cellular state. The reaction specificity of azides and alkynes is high, and since azides and alkynes do not exist in living organisms, data with low background can be obtained. 【Product Lineup (Partial)】 ■ Click-iT Plus EdU Assay Kit (Cell Proliferation and Cell Cycle) ■ Click-iT 5-ethynyl-uridine (EU) Imaging Assay (Nascent RNA) ■ Click-iT Chemistry Reagents (Glycans, Lipids, Nascent Proteins) ■ Click-iT Nascent RNA Capture Kit (Isolation of Nascent RNA) *For more details, please refer to the PDF materials or feel free to contact us.

We would like to introduce our Orbitrap Astral mass spectrometer. It is equipped with three analyzers: a quadrupole analyzer with high selectivity and high ion transmission, an Orbitrap analyzer that achieves high dynamic range and high-resolution measurements, and a new Astral analyzer that enables fast and highly sensitive measurements. This allows us to achieve a new standard in mass spectrometry performance, providing up to 2 times deeper proteome coverage and up to 4 times the throughput compared to conventional mass spectrometers. With accurate and precise quantification over a wider dynamic range using label-free quantification or multiplex quantification, you can discover important biological insights. 【Features】 ■ Equipped with quadrupole, Orbitrap, and Astral analyzers ■ Orbitrap: Maximum resolution (FWHM @ m/z 200): 480,000 ■ Astral: Resolution (FWHM @ m/z 524) 80,000 and maximum scan speed > 200 Hz *For more details, please refer to the PDF document or feel free to contact us.

The "Invitrogen iBlot 3 Western Blot Transfer system" is an advanced dry protein transfer system that achieves high performance and convenience using ready-to-use consumables. It realizes excellent transfer efficiency, maximizing lab productivity and providing consistent, reproducible results. It can achieve transfer efficiency equal to or greater than other transfer methods and devices, such as time-consuming wet or semi-dry methods. 【Features】 ■ Protein transfer in as little as 3 minutes ■ Achieves excellent transfer efficiency ■ Performance equivalent to two devices in one ■ Improved throughput ■ Large screen and user-friendly interface *For more details, please refer to the PDF document or feel free to contact us.

Automating antibody reactions for Western blotting! Achieving an automated process with hands-free operation. The Invitrogen iBind/iBind Flex Western System is a system that automates the process from blocking in Western blotting to washing after the secondary antibody reaction. It uses Sequential Lateral Flow (SLF) technology to control the release of antibody solutions and wash solutions in sequence. Additionally, it operates silently without the need for an external power source, making it usable anywhere in the laboratory. In addition to the convenience of hands-free operation, it provides data with superior sensitivity and reproducibility compared to manual methods. 【Features】 ■ Saves time ■ Reproducibility ■ Flexibility ■ Reliable results with a small amount of primary antibody ■ Superior performance compared to manual methods *For more details, please refer to the PDF document or feel free to contact us.

The "Thermo Scientific KingFisher Apex Nucleic Acid, Protein, and Cell Automated Extraction and Purification System" is a device that rapidly processes purification applications using magnetic beads for DNA, RNA, proteins, and cells, providing highly reproducible results. With a touch screen and intuitive interface, it simplifies operation and reduces errors. It can be operated without a computer. Additionally, the software in the main unit allows for easy creation and editing of protocols, enabling customization of each step of the protocol, including the binding of magnetic beads to the purification target, washing, and elution. 【Features】 ■ Enhanced performance ■ Easy operation via touch screen ■ Customizable protocols ■ Capability to connect to cloud and network ■ Can simultaneously incorporate up to two types of magnetic heads and heat blocks, allowing selection from multiple formats based on the number of samples *For more details, please refer to the PDF document or feel free to contact us.

Olink Explore HT is a next-generation multiplex proteomics analysis platform that extracts an overwhelming amount of information from small sample volumes. It can simultaneously measure over 5,400 proteins from just 2 µL of diverse samples such as plasma, serum, and CSF, achieving 99.5% high specificity and reproducibility through its unique PEA (Proximity Extension Assay) technology. By combining an automated workflow with NGS readouts, it enables high-precision and efficient analysis, accommodating a wide range of research phases from biomarker discovery to clinical research and drug development. Furthermore, it has been adopted in The UK Biobank Pharma Proteomics Project, the largest human proteome study in the world, demonstrating its performance and reliability in large-scale research projects. In addition to the installation of the equipment in laboratories, it is also available through service providers and Olink analysis services, with our staff supporting the experimental design phase according to research objectives and analysis needs.

Olink's neurobiomarker analysis is a proteomics method that allows for the highly sensitive and specific simultaneous measurement of neurodegenerative disease-related proteins from limited samples such as plasma, serum, and cerebrospinal fluid, using Proximity Extension Assay (PEA) technology. Olink Target 48 Neurodegeneration enables the absolute quantification of markers important in neurodegenerative disease research, such as Aß40, Aß42, pTau217, NfL, and GFAP, making it useful for longitudinal studies and inter-facility comparisons. Furthermore, by using Olink Explore HT and Target 96 Neurology, a broad protein profiling analysis including neuroinflammation and synaptic function becomes possible, supporting the identification of novel biomarkers and elucidation of pathological mechanisms. **Effects of Implementation** - Promotion of understanding disease mechanisms through comprehensive analysis of neuroinflammation-related proteins. - Increased efficiency in biomarker discovery and contribution to drug development research. - Ability to measure numerous proteins from a small amount of sample, allowing for effective use of valuable samples.

Olink Target 48 Neurodegeneration is a high-performance proteomics panel specialized in neurodegenerative disease research. It can simultaneously measure 41 types of proteins, including the latest and important central nervous system biomarkers such as Aß40, Aß42, pTau217, NfL, and GFAP, which are gaining attention in Alzheimer's and Parkinson's disease research. This panel enables the acquisition of absolute quantification (ng/mL) data, which is difficult with other technologies, allowing for data comparison between studies and institutions, as well as high reproducibility in long-term longitudinal studies. With just 1µL of plasma or cerebrospinal fluid, high-sensitivity measurements can be achieved, maximizing the use of valuable clinical samples. Furthermore, by combining analyses with Olink's cytokine panel, it comprehensively captures neurodegeneration and neuroinflammation, significantly enhancing analytical power. The standardized workflow using the Signature Q100 system contributes broadly from basic research to clinical and drug discovery research.

■Connecting Biomarker Discovery to Clinical Application - Explained through Actual Cases of Neurodegenerative Diseases Although biomarkers are discovered, many do not reach clinical application. The reasons for this lie in multiple hurdles that arise after exploration, such as "narrowing down candidates," "reproducibility," and "connecting to clinical practice." 1. How should we narrow down promising candidates obtained from comprehensive exploration? 2. How can we ensure reproducibility and scalability? 3. What are the key points for a smooth transition to clinical research? 4. What should we be mindful of in terms of data science throughout the overall flow? In this online seminar, we will clearly explain specific strategies to advance from discovery to clinical application, based on actual research cases of Alzheimer's disease and multiple sclerosis, in an easy-to-understand manner in Japanese. 【Event Overview】 Date and Time: May 21, 2026 (Thursday) 16:00 - 17:00, with on-demand viewing available later Format: Zoom Webinar, Free of Charge How to View: Please register via "Click here to apply for the web seminar" or the URL in the basic information. (Note) Olink products are for research use only and cannot be used for diagnostic purposes.

Olink Reveal is a next-generation proteomics analysis solution that utilizes NGS. It can be operated with various existing next-generation sequencers (NGS) and streamlines drug discovery research and cohort studies. The protein list included can be downloaded from the related link site or you can contact us for more information. ■Features - Simultaneous measurement of approximately 1,000 proteins from just 4 µL of serum or plasma - "Mid-Plex" panel with an excellent balance of cost and information volume - Carefully selected markers of high clinical importance, including inflammation, cancer, and neurology - Supports multi-sample and large-scale studies based on NGS ■Benefits - Ideal for screening applications where Explore HT may be excessive - Efficient data acquisition suitable for hypothesis validation phases - Maintains consistency of data with other Olink panels through PEA technology ■Applications - Biomarker discovery and validation - Cohort studies and multi-omics analysis - Drug discovery and translational research

This presentation will introduce an overview of spatial proteomics, which has been gaining attention in recent years, as well as the important role antibodies play in immunohistochemistry (IHC) and multiplex staining analysis. It will also discuss the essential concepts of antibody validation necessary for obtaining reliable data. Additionally, it will touch on fluorescent dyes, labeling techniques, and the optimization of analysis workflows, providing specific tips for common challenges faced in research settings. In the latter half, we will mention our latest imaging systems and related reagents, explaining practical insights for efficiently and accurately advancing spatial analysis. This content will be beneficial for a wide range of individuals, from those looking to introduce spatial analysis techniques to researchers who are already utilizing them. Recommended for: - Those who want to learn the fundamentals of spatial proteomics technology. - Researchers who feel challenged by antibody selection and validation in IHC and multiplex staining. - Individuals looking to optimize fluorescent labeling and analysis workflows. - Those interested in the latest imaging technologies and reagent information for spatial analysis. - Life science technicians and researchers who want to enhance the reproducibility and reliability of research data.

Spatial biology is a field that advances drug discovery and disease research, and spatial proteomics, in particular, visualizes protein distribution within tissues, providing new insights. The Invitrogen EVOS S1000 Spatial Imaging System analyzes up to 9 colors in a single capture. With its rapid and automated unmixing process and high flexibility regarding the reagents used, it is a new platform that enables efficient and reliable analysis. Recommended for: - Researchers engaged in spatial biology and spatial proteomics - Those conducting tissue-level analyses in cancer and immunology - Individuals facing challenges in optimizing multiplex staining and spectral imaging - Those involved in drug discovery and translational research - Individuals considering automation of image analysis and simplification of workflows

Combining a multiplex imaging antibody panel with nine types of markers and label-free technology, we visualize the distribution of cells and their spatial relationships within tissues using the Invitrogen EVOS S1000 Spatial Imaging System. By integrating single-cell level analysis with spatial proteomics, we explain a method to deepen the understanding of the cancer microenvironment and achieve an efficient and intuitive imaging workflow. Recommended for: - Researchers involved in tumor immunology or GBM research - Those interested in the analysis of immune cells such as macrophages - Individuals looking to implement spatial proteomics and multiplex imaging - Those considering the optimization of imaging experiments and multiplex staining