HIGUCHI INC. List of Products and Services

SBECD dramatically improves the solubility in water and the stability of drugs by encapsulating compounds, making formulation easier. It enables the application of poorly water-soluble drugs to injectable preparations such as intravenous injections. Additionally, it can also be used for oral preparations and eye drops. This product is adopted in multiple formulations and is manufactured and supplied stably. For purchases, there is usually stock available from the manufacturer, so please consult us regarding delivery times. Samples for consideration are also available.

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"Sautéed Onion Chips" are food ingredients made from finely chopped dried onions, about 2mm in size, sautéed using palm oil. The sautéing process is done in a reliable domestic factory. The onions are sourced from contracted farmers who manage the entire process from seed to harvest, ensuring a highly transparent supply chain. Additionally, since we use AD products, you can enjoy not only the roasted aroma of the sautéed onions but also a crunchy texture, along with a presence and additive effect similar to spices. 【Specifications】 ■Ingredients: Dried onions (from Spain), palm oil ■Final processing location: Japan ■Packaging: 10kg (1kg x 10) ■Shelf life: 12 months after production (store at room temperature, avoiding high temperatures, humidity, and direct sunlight) *For more details, please refer to the PDF document or feel free to contact us.

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This product is a unique ingredient for supplements that beautify the complexion from within the body. It is a powdered product extracted and refined from Hijiki, which is rich in polyphenols and fucoidan, combining the powerful bioactivity derived from fucoidan and the strong antioxidant properties derived from polyphenols. <Anti-inflammatory Effects> • Suppression of IL-6 • Inhibition of COX-1, COX-2, and LOX 152 activity • Significant reduction of inflammation in the colon during acute colitis among others <Aging Suppression> Sirtuin 1 (SIRT1): +32.4% <Tissue Integrity> Up to 99% inhibition of elastase, collagenase, and tyrosinase activity <Antioxidant Capacity> ORAC 6.0: 28,689 μmol TE/g <Immune Function> Maritech(R) Synergy may induce immune modulation effects, support immune function, and promote healthy, radiant skin.

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The milk thistle is a biennial plant that can reach a height of 1.5 meters and is characterized by its green leaves with a marble pattern and white veins. It has been known as a medicinal plant for a long time, and since the discovery of a molecule belonging to the flavonoid group called silimarin (silybin) from milk thistle in 1968, it has been used as a liver treatment. This product is an extract derived from seeds that contain the highest concentration of silybin. <Active Ingredients> Silybin ≧ 25%/MS, Taxifolin ≧ 1%/MS Other components include phenolic compounds, oligosaccharides, polysaccharides, amino acids, and proteins. <Cleansing Effects> - Inhibition of the growth of Porphyridium gingivalis - Inhibition of the growth of Streptococcus mutans - Inhibition of the growth of Streptococcus sobrinus

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It is an essential oil (aroma oil) obtained from the leaves of the tea tree. The tea tree is a tree of the Myrtaceae family that grows wild in Australia, and the Indigenous Aboriginal people have long utilized the medicinal properties of the tea tree as a panacea for infections and wounds. The tea tree is characterized by its immune-modulating effects and is rich in components that have strong antiviral, antibacterial, and antifungal properties. Its scent is characterized by a refreshing, clean, and crisp aroma.

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This is an essential oil (aroma oil) obtained from geranium (Pelargonium graveolens). Geranium is native to South Africa, and it is said that production for fragrance began in the 19th century. Its scent is sweet and heavy, reminiscent of roses and mint.

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It is an essential oil (aroma oil) obtained from lemongrass leaves. In Southeast Asia, lemongrass is used to flavor dishes and in herbal teas after meals. Lemongrass is native to South India and has long, narrow leaves with a strong fragrance. Its scent is reminiscent of lemon, with a slightly grassy and earthy aroma, and it is also well-known for repelling insects.

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This product is an essential oil (aroma oil) obtained from the flowers of the bitter orange tree. The name "Neroli" is said to have originated in the 17th century when the princess of the Duchy of Nerola in Italy used this essential oil as a perfume. Bitter orange is native to Southeast Asia, and its white flowers have a fragrant aroma. This essential oil is precious, as only a small amount can be obtained from many flowers. Its scent combines the refreshing qualities of citrus with the elegance and splendor of floral notes.

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It is an essential oil (aroma oil) obtained from lemon peels. Lemons are believed to be native to South India, but they are widely used around the world in various applications such as food, beverages, perfumes, and cosmetics, and are well-loved. While many citrus essential oils have relaxing effects, lemon invigorates the mind and body with its fresh scent. The aroma is that of fresh and refreshing lemon itself.

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Green clay is a natural mineral from the phyllosilicate family (such as talc and mica). It is composed of hydrated aluminum silicate, and its color appears green due to its high iron oxide content. Its lamellar structure provides very excellent absorption properties. Clay has the ability to absorb liquids such as water and swell like a sponge. Clay has the ability to adsorb, meaning it can fix molecules to its surface. This ability to fix molecules is due to the negative charge of the clay. The negative charge is explained by the presence of minerals (the more concentrated the clay is in inorganic salts, the more negatively charged it becomes). In the Middle Ages, clay was used for healing purposes both externally and internally. Externally, clay was mainly used in the form of masks and poultices, possessing astringent, soothing, and healing properties. 〇 Reports of effectiveness: Adsorption/absorption action (Gubitosa et al., 2019) Cleansing action (Gubitosa et al., 2019) Regenerative action (Valenti et al., 2012) 〇 Components (Williams et al., 2008) Aluminum, calcium, iron, magnesium, silicon, etc.

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HOT SPRING WATER is mineral water derived from the volcanoes of Auvergne. The richness of volcanic water comes from its passage through mineral-rich volcanic rocks from the Earth's core before it springs forth. Volcanoes originate from the deepest layers of the Earth. Volcanic rock is rich in minerals and formed from magma. Volcanic materials are highly permeable, and the hot spring water emerges from a water source near the volcano after passing through layers formed by multiple layers of scoria and ash. HOT SPRING WATER is sourced from Montpazier and is rich in minerals derived from volcanic origins. The hot springs in this region have an average temperature of 44°C and contain essential minerals for life, such as iron, selenium, zinc, calcium, magnesium, potassium, and phosphorus. Expected effectiveness: - Strengthens the skin's barrier function - Moisturizes - Calms the skin - Improves mechanical properties - Limits ROS effects - Regulates sebum production

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Golden Alga (microalgae) is known for its heavy metal absorption properties. Greentech developed this product by focusing on the beauty effects of gold and the biological characteristics of this microalgae, based on 20 years of microalgae research. The extract made from algae cultured in a medium containing gold has gold included, which suppresses the irritant properties of gold while allowing only its effectiveness to be expressed. = Effectiveness = Golden Alga stimulates the production of specific important molecules related to regeneration, antioxidant effects, whitening, and soothing effects, such as hyaluronic acid, collagen, fibrillin-1 (elastin-like protein), major markers of inflammation, antioxidant response elements (ARE), and skin growth factors. = In Vitro = Filaggrin: +110% Heparin-binding EGF-like growth factor: +60% Glutaredoxin: +50% Heme oxygenase 1: +730% Superoxide dismutase 2: +280% Decorin: +110% Fibrillin 1: +150% Hyaluronan synthase 2: +70% Type 17 collagen: +200% AZGP1: +110% DKK-1: +70% and more.

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AHA is known to be effective for peeling but also has irritant properties. GREENTECH discovered that the hibiscus flower containing Senegal acid has effects equivalent to AHA while having a higher content of keto acids, which are less irritating. Its extract, FLOWER ACIDS(R), possesses many efficacies, including peeling effects. = Efficacy = Promotes regeneration of epidermal cells Enhances moisture retention and smooths the skin's surface Low irritation compared to lactic acid Improves skin radiance and evenness Smooths wrinkles and fine lines When applied to hair, increases silkiness and shine. = Mechanism of Action = The high concentration of pyruvic acid (keto acid) contained in FLOWER ACIDS activates cell regeneration by reducing the aggregation of keratinocytes (dissolution of desmosomes) through conversion to lactic acid by epidermal dehydrogenase, thereby improving moisture retention in the upper layers of the epidermis. Pyruvic acid also stimulates the synthesis of collagen and mucopolysaccharides (Jaffary et al., 2016; Moy et al., 1996). = Efficacy = Promotes turnover: 12.5 days (Avg.) Moisturizing effect: +10%

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FERMENT'ACTIVE RASPBERRY is a raspberry fruit extract with an AHA concentration maximized through GREENTECH's fermentation technology. = Mechanism of Action = This product is expected to promote skin regeneration through the exfoliating effects of the high concentration of AHA it contains. = Efficacy = - It leaves the skin hydrated, smooth, and elastic. - It improves the color and shine of hair and skin. = AHA (Citric Acid) Content = It contains 38 times more citric acid than regular raspberries. In hair care, it can be used for moisturizing care.

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SILIDINE is a plankton extract made from microalgae rich in nutrients, cultivated under excessive oxidative stress. By cultivating it under sunlight, the excessive oxidative stress causes changes in the cellular phenotype, resulting in a high concentration of low molecular weight oligosaccharides and the bioaccumulation of trace elements from the culture medium in the microalgae extract. <Mechanism of Action> - It induces the expression of the endothelin-1 gene. The endothelin-1 gene stimulates the contraction of veins and improves blood retention. It helps improve acne and erythema caused by swelling and inflammation. When applied to the feet, SILIDINE alleviates heaviness and fatigue in the legs. <Efficacy> Reduction of facial redness: 19% improvement (improvement confirmed in 86% of subjects) Reduction of leg swelling: 36% improvement Immediate effects: moisturizing, refreshing sensation, etc.

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This product (Capillary Complex) is an anti-hair loss product made from extracts of four plants. <Active ingredients and effectiveness of each plant> - Clary Sage: Flavonoids, Terpenes, Rosmarinic Acid / Antioxidant function, Anti-inflammatory action - Cinnamon: Tannins / Relaxation effect, Activation effect, Microcirculation promotion effect - Ginkgo: Flavonoids, Diterpenes / Anti-inflammatory action, Vasodilatory effect - Kigelia: Flavonoids, Saponins / Vasodilatory effect, 5α-reductase inhibitory effect In Vivo: - Microcirculation promotion effect: +18% (60 minutes after application) - Sebum secretion suppression effect: -32% (after 60 days of application) - Hair loss suppression effect: -30% (after 60 days of application)

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This is silica derived from bamboo originating in the forests of India. Properties: White powder Particle size: ≦15μm Silica content: ≦87% Mechanism of action: The porous particles of fine micro powder absorb excess sebum and sweat, reducing shine and drying sweat. Effectiveness: - Reduces skin oiliness and controls shine, improving makeup longevity. - Absorbs sweat and keeps the skin dry, thus reducing odor. In Vitro: Artificial sebum absorption capacity: Twice its own weight In Vivo: Antiperspirant effect: -26% (after 4 hours) Odor suppression: -40% (after 4 hours)

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Papain is a protease found in the sap of the papaya tree, named by two scholars in 1879. Papaya has been used in traditional medicine for a long time in the West Indies, America, Africa, and Asia, for digestive disorders, promoting wound healing, and improving erythema. Papain enzyme is used in the fiber industry as a shrinkage preventer for wool and silk, in the food industry for dissolving malt and as a clarifying agent for beer, and for various other applications. Additionally, various studies are being conducted in the cosmetics industry, where it is primarily used as an exfoliating extract. <Functions of Papain in Cosmetics> - Exfoliating effect - Skin regeneration effect - Anti-acne - Hair removal and more.

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Exosomes are currently a focus in cosmetic ingredients. They have the ability to invigorate skin cells themselves and are well-suited for skin and body care cosmetics, as well as eyelash serums and scalp care products. 【Product Features】 This product is a human stem cell culture supernatant rich in exosomes. The display name is "Human Adipose-Derived Mesenchymal Stem Cell Exosomes." 1. Domestic Manufacturing The entire process from cultivation to productization is carried out in our domestic factory, ensuring high quality. 2. Japanese Donors Adipose stem cells are sourced from healthy Japanese female donors. Donors have been confirmed negative through various tests. 3. Safety Various tests have been conducted on the final product, confirming it is negative. *Only supernatant without cells is used. 4. Evidence Various tests, including cell activation tests, have been conducted to confirm the effectiveness of this ingredient as a cosmetic material. What are Exosomes? Exosomes are small capsules secreted by cells. In recent years, they have gained attention following research reports indicating that they contain effective components. These capsules contain a wealth of information and can deliver necessary information to various locations by moving between cells.

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This product is an enzyme refined from Bacillus subtilis using cutting-edge technology. Mechanism of Action: Skin aging leads to dysfunction between the exfoliation and adhesion mechanisms, resulting in thickening of the stratum corneum and abnormal retention of keratinocytes. The skin becomes saggy and wrinkled. By using PROTEASE (an extracellular enzyme found in the stratum corneum), peptide bonds are cleaved, inducing the dissolution of desmosomes. The processes of desquamation and cell regeneration are enhanced, slowing down skin aging. The skin's contours become smoother, and nutrient penetration is improved. Efficacy: - Improves the radiance of the complexion by stimulating the desquamation and cell turnover processes. - Smooths the skin's contours, reducing wrinkles and improving blemishes. - Promotes the penetration of nutrients. In Vitro: Approach to the stratum corneum - Adhesion improvement: +49% - Exfoliation promotion effect: +66%

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This service develops and manufactures extracts from nutrient-rich buds and young shoots tailored to customer needs using Green Tech's patented cryo-extraction method. - Cryo-extraction technology: Production of concentrated young shoot extracts Cryo-extraction is a patented technology by GT. Since extraction is performed in a frozen state, solvents are unnecessary, and extraction can be done without applying heat to the raw materials. Therefore, it is possible to extract plant-derived (active) components in high concentrations. - The most nutrient-rich parts: Young shoots of plants Plant buds and young shoots are rich in nutrients. They contain high concentrations of amino acids, trace elements, phenolic compounds, sugars, and plant growth hormones necessary for plant growth and reproduction. Green Tech's cryo-extraction technology allows for the preservation of nutrient-rich buds and young shoots in a fresh state and enables the extraction of active components in high concentrations.

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ECTOinOIL(R) is a multifunctional active ingredient composed of 100% naturally derived components. This product can be used with Ectoin in an oil phase and has been developed for sustainable water-smart product development. It can be used in formulations that do not contain water, such as lip balms and oil products. Data as ECTOinOIL (Ectoin Oil): - Skin roughness: -8% - Skin moisture level: +28% - Skin elasticity: +8% Data as Ectoin Natural (Ectoin): Moisture retention (In Vivo): Lasts for 1 week. Skin barrier function and protection of Langerhans cells (In Vivo): 100% protection. Promotion of heat shock protein production (In Vitro), anti-pollution effect (Ex Vivo), protection against blue light, UV, IRA heat, anti-aging effects (In Vivo): skin roughness (86% improvement), wrinkle depth (32% improvement), elasticity (82% improvement), smoothness (61% improvement), whitening effect (In Vivo): skin pigmentation (25% improvement).

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This product is an upcycled fruit extract made from non-standard mask melons. It is rich in free sugars, a natural moisturizing factor, which hydrates the skin and keeps it supple and healthy. In Vivo: - Skin moisture level After 1 hour: +54% After 6 hours: +36%

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Agrana Starch (Austria) is a leading supplier of various types of starches for fields such as pharmaceuticals, cosmetics, and food. Cross-linked rice starch RICE PO4 has an average particle size of 8μm and a sharp particle size distribution. It is insoluble in water and does not undergo thermal modification, making it an excellent particle for formulation. It has a high oil absorption capacity and can be used to improve the feel of products such as sebum adsorbents and creams. *The particle size of cross-linked corn-derived starch is 25μm.

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The Fiteren Hair Conditioning EGX771 is a complex product that promotes overall hair health. Green Tech has carefully selected and combined marine plants that have synergistic and supplementary effectiveness for hair health, developing a complex product that promotes scalp circulation, moisturizes, supports hair growth, and improves cuticles. <Ingredients> Uronic polysaccharides, sulfated polysaccharides, polyphenols, vitamin B group, amino acids, proteins, minerals, salts, etc. - Nutrients for hair follicles Peptides and vitamin B group are expected to have hair growth effects. - Scalp circulation promotion Polysaccharides, fucoidan, fucan, laminarin: blood pressure-lowering effects Polyphenols: improve the mechanical strength of hair. - Hair growth effects Dulse: rich in vitamin B group, which is excellent for hair growth effects. - Hair treatment, cuticle improvement effects, scalp moisturizing effects Sulfated polysaccharides: interact with amino acids in the stratum corneum and hair keratin, protecting while moisturizing the scalp and hair. - Antioxidant and anti-pollution effects Polyphenols derived from Ascophyllum and Sakhalin kelp, and vitamin C derived from wakame and dulse: neutralize reactive oxygen species. Polysaccharides: form a water-soluble film and exhibit barrier functions.

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Fiteren Hair Care EGX232 is a complex product that combines extracts from nine effective hair care ingredients. This product contains extracts with effects such as hair growth stimulation, anti-inflammatory properties, antibacterial effects, improved blood circulation, and nutritional components for hair, helping to keep hair and scalp healthy and beautiful. <Roles of Plant Extracts> - It is expected to improve blood flow to the microcirculation and increase blood flow to the hair roots, enhancing the supply of nutrients and oxygen to the hair roots. Extracts from Arnica flowers and Garlic roots: Blood pressure-lowering effects Extract from Lamium album flowers: Blood circulation-promoting effects - It is expected to protect a clean scalp environment. Extracts from Arnica flowers, Burdock roots, Garlic roots, Chamomile flowers, European Pine cones, and Rosemary leaves: Anti-dandruff effects through the antibacterial action against bacteria and fungi related to seborrhea, as well as anti-inflammatory effects. - It is expected to promote hair growth and regulate sebum secretion. Extracts from Arnica flowers, Burdock roots, Garlic roots, Chamomile flowers, and Watercress: Rich in components necessary for hair growth and regulation of sebum secretion. - It is expected to activate the scalp. Extract from English Ivy: Contains saponins and has the function of removing excess sebum.

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Caviar is known as a luxury ingredient, and among them, the eggs of four types of sturgeon—Beluga, Osetra, Sevruga, and Sterlet—are said to produce the highest quality caviar. Caviar is known for its rich nutritional components, and its extract has efficacy in various cosmetics. <Ingredients (Gessener et al., 2002)> - Amino acids, proteins: Arginine, histamine, isoleucine, lysine, methionine - Vitamins: Vitamin C, B vitamins, etc. - Trace elements: Calcium, magnesium, phosphorus, potassium, sodium, etc. <Efficacy> - Moisturizing effect - Regenerative effect - Antioxidant effect

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The eyes are said to be the most important part of interpersonal communication. During the COVID-19 pandemic, the market for eye care products has expanded as wearing masks has become the norm. Miralis is an extract obtained from the roots of the gentian, a high-altitude plant, harvested using sustainable methods, and standardized for its active ingredient, gentiopicroside. <Mechanism of Action> It suppresses six aging-promoting pathways and cares for the eyelids (upper part of the eye), tear troughs, under-eye bags, and dark circles. - Glycation suppression - Extracellular matrix aging suppression - Antioxidant - Anti-inflammatory - Lymphatic drainage promotion - Angiogenesis suppression <In Vitro> - NRF2: +21% - VEGF-A: -15% - Collagen 1 synthesis promotion: +76% - Glycation suppression Activation of glyoxalase 1: +35% Suppression of AGE (carboxymethyllysine) production: -111% - UV protection: Elastin protection: +41% <In Vivo> - Eyelid wrinkle depth: -22% - Tear trough depth: -14% - Under-eye bag swelling: -18% - Dark circle color: -14%

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Timiline is a polyglucuronic acid obtained by purifying bacterial fermentation products and chemically modifying them. Greentech developed Timiline as a cellulite removal ingredient based on transcriptome analysis using DNA chips, screening 44,000 human genes and finding that Timiline promotes the expression of the FIAF adipokine gene. <Mechanism of Action> TIMILINE targets four factors to remove cellulite: - It inhibits LPL to reduce lipid biosynthesis and fat accumulation. - It stimulates ATGL to break down accumulated fat and release it extracellularly. - It promotes the transport of fatty acids from subcutaneous tissue to peripheral tissue. - It suppresses the differentiation of preadipocytes into mature adipocytes. <Efficacy> In Vitro - Suppression of intracellular lipids: -26% - Inhibition of differentiation of preadipocytes into mature adipocytes - Promotion of production: collagen +30%, integrin +17%, glycosaminoglycan +17% - Promotion of integrin production: In Vivo - Cellulite removal: improvement in 64% of subjects - Thigh circumference: approximately 67% reduction - Improvement in elasticity: 67% reported feeling it - Improvement in dimpling: 53% reported feeling it

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KIGELINE(R)/Kigerin is an extract from the fruit of Kigelia africana (sausage tree), used as a traditional African breast enhancement agent. This product is the best-selling item from Green Tech in France. <Main Ingredients> Saponins, Phytosterols, Flavonoids <Mechanism of Action> Saponins and phytosterols act on dermal fibroblasts, promoting the synthesis of hyaluronic acid and collagen. The increase in these extracellular matrix components contributes to improving skin firmness and elasticity, as well as increasing skin moisture retention, thereby enhancing the firmness and fullness of the breasts. Flavonoids exhibit anti-aging effects by promoting blood circulation. The additive effects of these three components provide firmness and elasticity to the breasts, resulting in a lift. <Efficacy> Breast enhancement effect: Lifts the breasts by improving skin elasticity and moisture retention. Anti-aging effect: Beautifies the neck line through improved firmness. <In Vivo> Accuracy measurement by iconography - Breast enhancement: +70% - Lift: +18%

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The skin is a barrier between the internal body and the external environment. The epidermis, which is exposed to the external environment, is home to a diverse microbiome. This microbiome includes bacteria that metabolize components secreted in sweat and sebum, converting them into volatile substances. These volatile substances are the cause of body odor. The repeated use of deodorant products with antibacterial effects indiscriminately kills skin resident bacteria, posing a risk of damaging the skin's natural microbiome. Therefore, GREENTECH has focused on the antibacterial properties of the lactic acid bacterium Lactococcus lactis and developed LACTOPHYT, a component that selectively kills odor-causing bacteria. =Effects= Suppresses odor-causing bacteria Maintains beneficial bacteria Reduces axillary odor =In Vitro= <Commensal Bacteria> Staphylococcus epidermidis: 24h–72h: + <Odor-Causing Bacteria> S. HOMINIS: 24h–48h: - C. XEROSIS: 24h–72h: - C. TUBERCULOSTEARICUM: 24h–72h: - *S.: Staphylococcus, C.: Corynebacterium =In Vivo= Body odor intensity: -30% (Day 1), -35% (Day 3)

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Green Tech Co. confirmed the inhibitory effect on genes that protect the extracellular matrix and suppress cellular aging using a seaweed extract rich in glucuronic acid oligosaccharides against 44,000 human genes with DNA microarrays, and developed QT40. This product is a raw material that provides a lifting effect by inhibiting zombie cells and promoting extracellular matrix structural proteins. In Vitro: FGF1 gene expression stimulation: +35% CCNA2 gene expression stimulation: +80% *CCNA2 has a function that promotes cell cycle progression as a DNA repair and p21 inhibitor, and is expected to prevent cellular aging and the emergence of zombie cells. Collagen synthesis: +22% Hyaluronic acid synthesis: +17% MMP1: -29% MMP3: -31% In Vivo: Improvement of sagging: 2.8 times improvement V-line tightening: Over 60% of subjects experienced it Improvement of elasticity: +20.5%

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This product is an extract derived from ferns native to Polynesia. Polynesian ferns are rich in ecdysteroid, a miraculous anti-aging hormone. This plant hormone is also found in insects and is crucial for their metamorphosis. The hormone that induces radical morphological changes in insects fundamentally improves the structure of the skin when applied topically. Mechanism of Action: - Promotes the production of structural proteins at the dermal-epidermal junction, strengthening the cohesion between the dermis and epidermis, thereby improving skin elasticity. - Stimulates epidermal regeneration by promoting the proliferation and differentiation of basal cells. - The epidermis quickly becomes layered and compacted, restoring the voluminous appearance of youthful skin. - The stratum corneum regains complete cohesion and functions as a barrier once again. In Vitro: - Ki67 (cell cycle (cell proliferation promotion)): 3.3 times - Basement membrane constituent proteins: Involucrin: 5.3 times Type IV collagen: +22% Laminin 5: +12% Fibrin: +25% - Dermal thickness: 2.3 times In Vivo: - Elasticity improvement: 3.5 times - Moisture levels: 2.5 times - Skin isotropy: +16%

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- Argan oil cake (oil residue): Argania spinosa extract - Off-spec melon fruit: Melon fruit extract (moisturizing effect) - Off-spec lime fruit: Lime fruit extract - Off-spec cucumber fruit: Cucumber fruit extract - Beehive: Propolis extract - Byproduct of spice manufacturing: Saffron flower extract - Byproduct of olive oil production: Olive fruit extract - Byproduct of tea leaf screening: Tea leaf extract - Byproduct of baobab seed oil production (baobab pulp): Baobab pulp extract (moisturizing effect, lifting effect)

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Consistent product quality using a quality management system Establishment of product traceability through lot number management Validation support through integrity tests, extractables, leachables, adsorption, and testing Compliance with various regulations such as FDA and USP Autoclave, steam sterilization Sterilization varies by each filter For details, please contact us

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This product is an extract derived from the black truffle of the Tuber melanosporum species. Black truffles are known as a luxury ingredient. Their rich and robust aroma and delicate flavor are highly valued, earning them the nickname "black diamonds." Truffles produce a wide variety of compounds during their maturation period, with over 50 aroma-related compounds discovered and collected by animals and others. Due to their abundant active ingredients, truffles have been used in traditional medicine, and research is currently being conducted on their anti-cancer effects and treatment for Alzheimer's disease. <Active Ingredients> - Oligosaccharides, polysaccharides - Phenolic compounds - Phosphorus, potassium - Amino acids, proteins <Efficacy> Antioxidant effects (Villares et al., 2012): Inhibition of lipid oxidation Protection effects (Zampieri et al., 2011): Increased stimulation of various heat shock protein genes Moisturizing effects (Martini and Seiller, 2006): Cell activation effects (Martini and Seiller, 2006):

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Jelisin is an extract from a drought-resistant plant called Temarikatabiba (Selaginella lepidophylla), which is native to the Chihuahuan Desert in Texas, USA. Temarikatabiba possesses excellent active components and characteristics that allow it to adapt to the extreme environment of the desert, which has low nutrients and extreme dryness. <Features> The dried leaves fold into a spherical shape, reducing the surface area from which moisture can evaporate. <Active Components> It contains trehalose and dehydrins, which help control the osmotic pressure of cells, allowing them to be maintained even in extreme dryness. Additionally, trehalose serves as an energy source, supporting cellular activity. <Efficacy> Moisturizing and stress-relieving effects.

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Centella Asiatica Cosmelean contains triterpenes such as asiaticoside and madecassoside, and is a standardized product. It activates collagen synthesis by fibroblasts and maintains the structure and function of the skin. Triterpenes (asiaticoside and madecassoside) exhibit nutritional and regulatory effects on connective tissue, particularly enriching and regulating fibroblasts and glycosaminoglycans. They promote the synthesis of collagen I and III, enhance keratinization, and accelerate the healing process. In vitro studies have reported that asiaticoside and madecassoside improve the secretion of collagen I, while madecassoside promotes the synthesis of collagen III. In vivo: • Number of moderate wrinkles: -42% • Depth of moderate wrinkles: -3% • Number of deep wrinkles: -29% • Total area of wrinkles: -30%

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Ginseng Cosmelean is an extract derived from the root of ginseng, which is used as a tonic and activates the body's functions as a traditional herbal medicine. It contains ginsenosides as its main component. This product is expected to promote collagen production in skin cells, strengthen the extracellular matrix, enhance barrier function, and improve firmness and elasticity. <Mechanism of Action> Ginseng Cosmelean promotes collagen production in skin cells, strengthens the extracellular matrix, and improves elasticity. This product is expected to enhance barrier function and improve firmness and elasticity. *The multifunctional medicinal effects of ginseng have been well known since ancient times. Among these, its anti-aging properties have also been reported, particularly its palliative effects in elderly patients with terminal illnesses. <Efficacy> Improves skin elasticity and enhances firmness. Makes the skin appear youthful. In Vivo: Firmness improvement: up to +9% Elasticity improvement: up to +22%

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Ivy Cosme Ren is an extract derived from the stems and leaves of ivy, containing: Hedera coside: 0.4-0.6%, Saponins: 2.5-6.0%, Flavonoid glycosides, Phenolic acids, and Polyacetylenes. Cosmetic ingredient name: Hedera helix leaf/stem extract <Mechanism of action> It exerts a drainage effect (blood flow promotion effect) through two pathways: (1) Microcirculation promotion effect due to relaxation (2) Adjustment of capillary permeability through anti-hyaluronidase effect <Efficacy> Removes cellulite and improves skin unevenness Reduces the appearance of dark circles under the eyes, providing a more relaxed expression In Vitro: Blood flow promotion effect in microvessels: +4% (3 hours after application), +14% (applied twice a day for 14 days)

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Chamomile Cosme Ren is a plant extract containing 0.01-0.02% apigenin as an active ingredient derived from chamomile flower extract. <Mechanism of Action> It suppresses the production and release of inflammatory factors that cause redness. It alleviates skin tingling and brings healing. <Efficacy> Soothes the skin and suppresses redness. Relieves tingling sensations. Reduces eye congestion. In Vivo: Redness suppression: -26% Reduction of UV-induced skin temperature increase: -0.2℃

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Hawthorn Cosmelean is an extract from the flowers of the Western Hawthorn. It contains an active ingredient, Vitexin-2-O-rhamnoside, at a concentration of 0.07-0.11%. <Mechanism of Action> - The flavonoids contained in Cosmelean Hawthorn reduce congestion in capillaries and alleviate erythema. - By promoting blood flow, it enhances the oxygen levels in the skin, activating a constant process. <Efficacy> Reduces redness in the skin and brightens it. Unifies skin tone and improves transparency. Reduces skin discomfort/unpleasant sensations (tightness due to dryness, inflammation). In Vivo: Redness reduction (IR-induced): -6% Redness reduction (UV-induced): -7%

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Single-use assembly tubes for biopharmaceuticals. Tube material, length, connector type, filters, etc. can be customized according to customer requirements. Manufactured in a Class 7 cleanroom. The facility is ISO 13485 and FDA certified. Compatible with gamma sterilization, with various certificates included.

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- ARCOLYS: Anti-gray hair ingredient - HAIRILINE: Anti-hair loss ingredient, scalp microbiome regulation - DANDRILYS: Anti-dandruff ingredient, scalp microbiome regulation, sebum control - ZORYALYS: Anti-pollution, anti-UV, IRA effect ingredient - TILICINE: Cuticle improvement effect, frizz control effect, scalp care ingredient - INCA INCHI OIL: Dry oil containing 45% omega-3, hair repair effect ingredient - BAOBAB OIL: Sustainable dry oil rich in omega-6 and omega-9 - APRICOT OIL: Oil rich in omega-6 and omega-9 - HAIR STRENGTH EGX292: Scalp care extract mixed with five types of extracts - COMPLEX HAIR LUSTRE: Hibiscus flower extract that softens hair and enhances shine and texture

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Aqua Sil Oil is a self-emulsifying amino acid-based surfactant created by reacting lysine with the fatty acids of plant oils. There are six grades available, using six types of plant oils (argan oil, Inca inchi oil, sweet almond oil, apricot oil, olive oil, and sunflower oil). <Features> - Due to the differences in the fatty acid composition of the six types of plant oils, properties such as surface tension, critical micelle concentration, foaming ability, foam stability, and cleansing power vary. - It decomposes at a low pH, so the displayed name is separated into plant oil and lysine. It can be used as surfactant-free according to the displayed name. - Biodegradable - Self-emulsifying <Efficacy> - Moisturizing effect - Inhibition of Staphylococcus aureus and promotion of Staphylococcus epidermidis - Antioxidant effect <Applications> - Aqueous cleansers - Masks - Surfactant-free emulsification formulations - Utilization in formulations where adding plant oils is difficult (cleansers, shampoos, wipe-off lotions, etc.)

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