HIGUCHI INC. List of Products and Services

Cross Linked HA is a hyaluronic acid cross-polymer made using Contipro's patented manufacturing method. The patented manufacturing technology creates a soft and fine gel, providing a unique sensation that is not found in conventional high molecular weight sodium hyaluronate. <About the Sensation> Immediately after application, it retains the pleasant texture of the chewy sodium hyaluronate, while the fine gel quickly penetrates the skin's grooves (such as wrinkles and pores), resulting in a moist yet refreshing sensation. <About Effectiveness> - Moisturizing effect (62% improvement) - Anti-wrinkle effect (46% reduction in wrinkles) - Sustained release effect of active ingredients (51% increase in the activity of Vitamin B3)

• Cosmetic materials and raw materials
• Other pharmaceutical intermediates and cosmetic ingredients
• Other medical supplies and cosmetic manufacturing materials

The "resin additives" handled by our company from SI Group have been expanded to a wide range of additives that are effective for various resins and elastomers due to the integration with Addivant. We offer a wide selection of antioxidants, including phenolic, phosphite, amine, thioester types, as well as packaged products, ranging from typical ones to high-performance options with excellent extraction resistance, tailored to various applications. Additionally, we also provide light stabilizers, UV absorbers, and polymer modifiers. 【Features】 ■ A wide range of additives effective for various resins and elastomers has been expanded due to the integration with Addivant. ■ A broad selection of antioxidants is available, including phenolic, phosphite, amine, thioester types, and packaged products, from typical ones to high-performance options with excellent extraction resistance, tailored to various applications. ■ Light stabilizers, UV absorbers, and polymer modifiers are also available. * You can download the English catalog. * For more details, please refer to the PDF materials or feel free to contact us.

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Higuchi Shokai handles the traditional "Wheat/Rye Fermented Starter Powder" from the German company Dr. Suwelack. Easily impart distinctive fermented flavors and refreshing acidity. By simply adding it to existing dough recipes, you can create flavor-rich, authentic bread, which also helps in differentiating and expanding your product lineup. Not only for German bread, but it can also provide authentic fermented flavors for a wide range of applications, including French bread, baguettes, and focaccia. Additionally, it is possible to increase the water content in the dough by 1-2%. 【Features】 ■ Easily impart fermented flavors and refreshing acidity ■ Advantages of powder products compared to popular liquid starter products in Japan ■ Adding fermented starter powder allows for an increase in water content in the dough by 1-2% *For more details, please refer to the PDF materials or feel free to contact us.

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Higuchi Shokai handles "food yeast extract" from Ohly, a long-established yeast extract manufacturer in Germany. We offer a variety ranging from standard free amino acid-rich types to nucleic acid-rich types, peptide-rich types, and reaction types. Available in powder, paste, and liquid forms, they are used not only for seasoning purposes but also in fields such as improving palatability in pet food. 【Product Lineup】 ■ Free amino acid-rich type - adds umami and enhances base flavor ■ Nucleic acid-rich type - adds umami ■ Peptide-rich type - adds richness and enhances aftertaste ■ Reaction type - adds meatiness and cooking sensation, etc. *For more details, please refer to the PDF document or feel free to contact us.

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We handle various dried vegetables and fruits. This product is flakes made from Italian flat parsley (Italian parsley) using AD (hot air drying) methods. We can also provide products that have undergone mechanical and visual sorting by domestic specialists. 【Specifications】 ■Appearance - Color: Green - Particle size: Standard 1-2mm ■Microbial Standards - Total viable count: 100,000 or fewer/g - E. coli: 10 or fewer/g ■Ingredients: 100% parsley ■Country of Origin: Italy ■Shelf Life: 24 months after production ■Packaging: 15kg carton box (inner packaging: aluminum bag) *Domestic sorted product: 8kg *For more details, please refer to the PDF document or feel free to contact us.

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We handle various dried vegetables and fruits from VEGENAT, a company in Spain. Our product is made from 100% Spanish onions and is AD (air-dried), retaining the fresh flavor of "onion." Additionally, we offer "Sautéed Onion 2mm," which is made from 2mm ground material and processed domestically. 【Product Lineup】 ■ Powder ■ Ground 2mm ■ Minced ■ Small Chop ■ Large Chop ■ Sautéed Onion Chips (domestically processed) *For more details, please refer to the PDF document or feel free to contact us.

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We handle 100% orange AD (hot air dried) products. Unlike typical orange peels, we use the whole fruit, which provides a fresh flavor derived from the juice and pulp, making it well-suited as an extraction material for products like fruit beers, craft gin, and flavored teas. It also pairs exceptionally well with chocolates. Additionally, when used for confectionery purposes, the distinctive orange flavor remains. 【Specifications】 ■Ingredients: 100% orange ■Country of origin: Spain ■Packaging: 20kg carton box (inner packaging: aluminum bag) ■Shelf life: 36 months after production *However, this is valid only if stored in a cool, dark place away from high temperatures, humidity, and direct sunlight. *For more details, please refer to the PDF document or feel free to contact us.

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Since 2015, guidance on data integrity (DI) has been issued by the MHRA (UK Medicines and Healthcare products Regulatory Agency), WHO, FDA, and PIC/S, and its importance has been increasing in recent years. DI is defined as "the completeness, consistency, and accuracy of data. Data that is complete, consistent, and accurate is recorded with attributes of traceability, legibility, and contemporaneity, and is either original data or a true copy, and is accurate." It also ensures that pharmaceuticals meet the required quality standards. DWS is the optimal software for ensuring data integrity in dissolution testing. It supports access management, data tampering prevention, and backup, allowing for the management and control of dissolution testers and their peripheral devices with just this one software, making complex methods and data management easier to handle.

• Dissolution Tester

OligoHyaferre is a hydrolyzed sodium hyaluronate manufactured by a company in the Czech Republic, known for its excellent "anti-wrinkle effect," "moisture retention effect," and "skin barrier function recovery effect." In vitro studies have confirmed its effects of MMP inhibition, TNF-α inhibition, promotion of angiogenesis, and gene expression of HAS2. These effects lead to favorable results in in vivo "anti-wrinkle tests" and "skin barrier function recovery tests."

• Cosmetic materials and raw materials
• Other pharmaceutical intermediates and cosmetic ingredients
• Other additives

HyWhite is a sodium hyaluronate with whitening (brightening) properties manufactured by Contipro in the Czech Republic. HyWhite is a product that has high whitening (brightening) effects, made by partially replacing low molecular weight sodium hyaluronate with alpha-linolenic acid, which has high permeability to the skin. Alpha-linolenic acid is widely known for its strong melanin production suppression effects, and in in-vitro results, it has been confirmed to have a higher suppression effect than kojic acid. On the other hand, it is also known as a component that is difficult to formulate due to its low skin permeability and instability. This product promotes the absorption of alpha-linolenic acid, which has been a problem in the past, by replacing part of the low molecular weight hyaluronate with alpha-linolenic acid, thereby improving stability and maximizing the effects of alpha-linolenic acid. *In addition to HyWhite, Contipro also manufactures sodium hyaluronate, hydrolyzed sodium hyaluronate, and other hyaluronate derivatives.

• Cosmetic materials and raw materials
• Other additives

▶ Compact design that fits multiple units in an incubator (height 105mm) ▶ Visualization of cellular changes through time-lapse photography ▶ Graphical display of cell count and cell area ▶ Compatible with 24-well plates, with individual imaging for each well <Features> - Equipped with 24 cameras in a compact housing - Focus and exposure can be set individually for each well - Compatible with commercially available 24-well plates - Individual display of imaging results for each well

• Other Culture

Contipro is a biotechnology company located in the Czech Republic. It is a global manufacturer that produces and sells various active ingredients, primarily sodium hyaluronate, in the pharmaceutical and cosmetic fields, supplying to over 60 countries for approximately 30 years. The listed products are categorized into three groups: sodium hyaluronate, natural polysaccharides, and peptides. <Sodium Hyaluronate> We offer grades with a molecular weight distribution ranging from 2.3 million Da to 10,000 Da, and we have confirmed differences in efficacy due to varying skin permeability based on molecular weight through Vivo and Vitro data. Additionally, we also have hydrolyzed sodium hyaluronate as a grade with excellent skin permeability. <Derivatives> We have confirmed through Vivo and Vitro data that sodium hyaluronate possesses not only its inherent properties of moisturizing, barrier function, anti-wrinkle, and calming effects but also efficacy in whitening, sebum secretion regulation, sebum suppression, and improvement of skin texture. *For more details, please download the PDF or feel free to contact us.

• Cosmetic materials and raw materials
• Pharmaceutical materials and carriers
• Other pharmaceutical intermediates and cosmetic ingredients

H Media is a medium formulation for bacterial contamination testing of the aseptic (sterile filling) line that our company manufactures and sells domestically. It is granular with minimal dust generation and can be stored long-term (up to 2 years after production). There is no need for mixing or storing the individual medium raw materials. 【Features】 ■ Granular form to suppress fine powder dispersion ■ Excellent solubility ■ Performance equivalent to SCD medium ■ Individually packaged, eliminating the need for cumbersome weighing of raw materials *For more details, please refer to the materials available for download or contact us directly.

• Food Testing/Analysis/Measuring Equipment
• Beverage Production Equipment

The powder flexible joint ConnflexⓇ developed by the Swiss powder equipment manufacturer Zimmermann Verfahrenstechnik is available. It is made from materials that excel in chemical resistance, heat resistance, and pressure resistance, and we can design products tailored to customer specifications and existing equipment, including size and connection parts (JIS standards). The flexible component materials include PTFE, polyurethane, and FEP. The standard material for the connecting parts is SUS316L, with Hastelloy available as an option.

• Pipe Fittings
• joint
• Piping Materials

It is possible to apply polymer coating to fine particles using newly developed dry coating technology. Compared to conventional water-based coatings, processing time can be significantly reduced.

• Semi-dry/low moisture granulator

The "Paddle Over Disk Method" and "Cylinder Method" are testing methods already included in the USP, and Agilent Technologies has a wealth of delivery experience with them. Additionally, we offer accessories such as the "Enhancer Cell" for ointments and creams. Even when using these accessories, Agilent's dissolution testers allow for easy height adjustment (25mm). *Refer to the Japanese Pharmacopoeia and USP 1724.

• Dissolution Tester
• Other physical property measurements and component analysis
• Other quality control systems

OD-mate was developed for the automatic measurement of disintegration time of orally disintegrating tablets. The testing device is a compact and cost-effective solution. The development of this product was made possible with the cooperation of Kyoto Pharmaceutical Industry Co., Ltd. Additionally, using the small taste recognition device SA501C from Intelligent Sensor Technology Co., Ltd., it is possible to measure the bitterness intensity of solutions measured for disintegration time with OD-mate.

• Other measurement and measuring equipment
• Other physical property measurements and component analysis

The British company I HOLLAND is a global manufacturer of mortars and pestles. They have introduced innovative technologies to the industry, including "Rotary Heads" and "Universal Seal Groups." They are the producers of the "Eurostandard," the global standard for mortars and pestles. They have over 25 years of experience in the production of Multi-Chip® mortars.

• Fine chemicals (compounds, derivatives, catalysts, etc.)

Appeal Points - I want to do business with overseas suppliers I saw at trade shows or online, but I'm worried about communication. - I want to do OEM production at overseas factories, but I don't know where to outsource it. - I have a factory in mind for outsourcing, but I have concerns about technical exchanges. I believe many people in charge feel anxious about dealing with overseas suppliers. How about using our company? - We have many staff members who speak multiple languages. - Utilizing our network, we can directly contact overseas manufacturers and conduct regular factory audits based on ISO standards, ensuring a continuous supply of high-quality products. - Since we directly request from overseas manufacturers, the process is speedy and aligns with the product concept. - We have cooperative relationships with many OEM production factories overseas, and we conduct quality control during the launch of new products and mass production. - We can also address improvement items in collaboration with the factories. - For manufacturer selection, we evaluate multiple companies, visit them to confirm quality and management, and choose manufacturers that agree with the Japanese business philosophy.

• LED Module
• LED lighting
• LED fluorescent lamp

Products Handled Special Halogen Lamps Product Range: Medical-related, Aviation-related, Heaters, and Custom Products Features - Experience and know-how cultivated over more than 20 years of overseas in-house production of halogen lamps - A trading company with manufacturer-like functions, acting as a technical trading company - Many staff members who speak multiple languages - Maintains good relationships with overseas component suppliers, making it possible to obtain hard-to-find parts - Lamp manufacturing in collaboration with domestic and international partner companies - Utilizes a network to communicate directly with overseas manufacturers, conducting regular factory audits based on ISO standards, ensuring a continuous supply of high-quality products - ISO 9001 certified - Compliant with RoHS

• Other lighting equipment
• Other lighting equipment
• Other optical parts

- As it is a granular product, it can suppress the scattering of fine powder. - It has excellent solubility. - It has performance equivalent to SCD medium. - Since it is individually packaged, there is no need for the hassle of measuring raw materials.

• Food Testing/Analysis/Measuring Equipment
• Beverage Production Equipment

The LACT unit, skid, and IBC (metal container) that come into contact with charged liquids may accumulate dangerous levels of static electricity on conductive metal bodies. If static electricity accumulates on an ungrounded object, the object's charge voltage can rise sharply, posing a risk of static sparks. The energy at that time may exceed the minimum ignition energy of various flammable gases and vapors. Earth-Rite PLUS ensures grounding of IBCs and drums with two systems: "interlock" and "indicator (display)." By using it, static charges can be safely removed, preventing ignition due to static discharge, and continuously monitoring grounding resistance values to eliminate ignition risks during operation.

• Anti-static products
• Other anti-static devices
• Other safety equipment

The Earth-Rite RTR is a device that can prevent accidents caused by grounding work during filling and discharging operations in tank truck vehicles. For example, during the filling operation of a tank truck, the operator may connect the grounding wire to an incorrect grounding point on the tank truck, or the grounding wire may become disconnected during liquid transport. In such cases, the tank truck can become charged to 10-30 kV within 15-50 seconds. This level is sufficient to cause ignition or explosion due to static electricity. The Earth-Rite RTR continuously monitors to ensure that the grounding connection is correct and that the grounding resistance is appropriate. If there is a problem with the connection status, it can issue an alarm to the upper side via internal contact output (interlock function). This signal allows the customer’s equipment to stop the pump or sound a siren.

• Anti-static products
• Other anti-static devices
• Other safety equipment

Measure the condition of the test instrument in real time!

• Dissolution Tester
• Data Mining

SCAT SAFETY CAPS and SAFETY WASTE CAPS from SCAT are designed to prevent indoor diffusion and exposure of organic solvents used in HPLC experiments. The common method of sealing mobile phases/waste liquids with aluminum foil at the neck of sample vials cannot be considered a complete containment, leading to changes in the composition and volatility of the mobile phase/waste over time. By using SCAT SAFETY CAPS, evaporation of the mobile phase is minimized, ensuring reliable test data and a clean laboratory. In recent years, ISO 14001 and corporate CSR (Corporate Social Responsibility) have gained importance. SCAT SAFETY CAPS can improve operator health and working conditions.

• Liquid Chromatograph
• plug

I want to prevent the alteration of liquids during sampling! I want to sample liquids while containing them! I want to safely sample liquids from pipes under pressure or at high temperatures! We solve problems related to sampling. With a rich combination of options, liquid sampling is possible in various situations and environments. For example... High-temperature liquids ⇒ Adapters for operator protection Oxidizing liquids ⇒ Nitrogen replacement in the sampling container can be done in advance Crystallizing liquids ⇒ Heating jackets can be installed Liquids under reduced pressure ⇒ Syringe-type adapters It is also possible to change materials according to the properties of the liquid being sampled or to modify connection methods to fit existing piping (such as JIS flange connections, ferrule connections, etc.).

• Chemicals
• valve

I want to safely sample liquid from the reaction vessel! I want to prevent the alteration of the liquid during sampling! I want to sample the liquid while containing it. We solve problems related to sampling. With a rich combination of options, liquid sampling is possible in various situations and environments. Nitrogen replacement for sample containers is also possible. To sample from the reaction vessel, you have no choice but to open the manhole... With BIAR's reaction vessel sampling system, there is no need to open the manhole. Sampling can be done safely and efficiently. Since it operates with compressed air instead of an electric pump, it can be used in explosion-proof areas without any issues.

• Chemicals
• valve

I want to safely sample liquids! I want to prevent the alteration of liquids during sampling! We solve problems related to sampling. With a rich combination of options, liquid sampling is possible in various situations and environments. Nitrogen replacement for sample containers is also available. To sample from a reaction vessel, you have no choice but to open a manhole... With BIAR's reaction vessel sampling system, there is no need to open a manhole. Sampling can be done safely and efficiently. Since it operates with compressed air instead of an electric pump, it can be used in explosion-proof areas without any issues.

• Other physicochemical equipment
• valve
• Other safety and hygiene products

■Efficiency Automation enables easy and quick sampling. It eliminates the labor involved in dissolution testing and prevents variations in sampling volume and position that would be difficult to manage manually. All functions, including the pump, filter (optional), and sampler, are integrated into a device just 39 cm wide. One filter plate used for sample filtration contains the equivalent of eight 0.45 μm filters. ■Flexibility In addition to the standard pump function, you can select filter functions according to your needs. Sampling can accommodate test tubes, HPLC vials, and well plates. ■Accuracy The rotary piston syringe pump ensures precise sampling of the specified amount at designated sampling points. Uniformity The color touch panel of the 850-DS allows for input of the dissolution test program. ■Test Results Test data can be printed using the built-in printer.

• Dissolution Tester

The BIAR company's "Liquid Sampling System" is a system that allows for the safe and efficient sampling of "high-temperature liquids," "toxic liquids," and "liquids that react with oxygen" from piping and reaction vessels under high temperature and pressure. It prevents foreign matter contamination and enables liquid sampling without altering the physical properties. Additionally, you can view a cut model that clearly shows the structure of the valve. 【Features】 ■ Operates with compressed air, eliminating the need for electric pumps, making it suitable for use in explosion-proof areas. ■ Ideal for the fields of chemistry and medicine. ■ Allows for liquid sampling without exposure to air. ■ Accessories for discharge can be shared. ■ Materials can be changed to SUS316L, Hastelloy, PFA coating, etc. *For more details, please download the catalog or contact us.

• Other physicochemical equipment
• valve
• Other safety and hygiene products

The Cary 60 spectrophotometer, when combined with a pump in an online UV system, along with the sampling station 850-DS, allows for filter filtration and simultaneous sampling into test tubes or HPLC vials after filtration. **Evaluation Method for Drugs in Dissolution Testing Using Fiber Optics** Using fiber optics enables direct quantification of drugs within the vessel without the need for sampling. For example, when using fiber optics in dissolution testing for the evaluation of crystallization suppression of solid dispersions aimed at improving solubility, detailed dissolution profiles can be obtained through measurements at short intervals, as no sampling is required.

• UV/visible spectrophotometer

The 280-DS MQS measures the parameters of mechanical calibration of dissolution testers with high precision. Measurement is done hands-free thanks to sensor technology, taking only about 30 minutes per unit. It complies with 21 CFR Part 11. ★ Mechanical calibration has been included as reference information in the 17th edition revision. "To aim for reduced variability in test results through mechanical calibration, it is recommended to apply this reference information." (From the 17th Japanese Pharmacopoeia revision "Standard Methods for Mechanical Calibration of Dissolution Testers")

• Dissolution Tester

The 400-DS, which enabled dissolution testing for stent formulations, contact lenses, and microneedles that previously had no testing methods, allows for tests that require extremely small volumes and long durations.

• Dissolution Tester

BIO-DIS is a dissolution tester for conducting release rate tests, compliant with USP Apparatus 3 and EP Reciprocating Cylinder tests. It is an ideal dissolution tester for formulations that require sustained release formulations and dissolution profiles at multiple pH levels.

• Dissolution Tester

The dissolution tester 708-DS features one-touch centering with the TruAlign vessel, and its design minimizes the risk of misalignment after installation, reducing the risk of failure during mechanical calibration. It supports Japanese language, has a two-piece paddle, and significantly improves basic operability with an expanded space between the drive unit and the vessel plate. It accommodates a wide range of dosage forms for dissolution testing, including tablets, capsules, rotating cylinders, and the paddle-over-disk method.

• Dissolution Tester

The taste recognition device TS-6000A has the same mechanism as the human tongue and can quantify the "taste" of various foods, pharmaceuticals, and more. Additionally, it is possible to easily obtain analysis results through a comprehensive analysis application. As a support tool for sensory testing, it demonstrates its power in any situation where objective evaluation of "taste" is needed, such as product development, marketing, and sales.

• Food/beverage component analyzer

Coating is possible from a single tablet, allowing for consideration of whether coating is necessary at an early stage. It is also ideal for creating tablet color samples. By compressing particles granulated with a mixer, torque, and rheometer (MTR), experiments from granulation to coating can be conducted with a small amount of raw materials.

• Other factory equipment and parts

- Speeding up research and development! - Optimization of formulations - Simplification of scale-up considerations - Streamlining batch management

• Viscometer