HIGUCHI INC. List of Products and Services

FabRx, a UK company specializing in pharmaceuticals and biotechnology that spun out from University College London, has launched a 3D printer aimed at the manufacturing of solid dosage forms focused on personalized medicine. The Printlet, a tablet manufactured using a 3D printer with three different nozzles (for powder, gel, and filament), has been tested in various research institutions, hospitals, and pharmacies overseas, and is now available for sale domestically. By using registered formulations and manufacturing conditions in dedicated software, it can be applied in medical settings for personalized medicine, as well as in drug discovery and clinical trial drug manufacturing.

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Advanced Microdevices' sterilizing capsule filter achieves improved throughput through a pre-filter and high flow rates due to low hold-up volume. 【Features】 ■ Improved recovery rate due to low protein adsorption ■ Assurance of microbial capture performance through bacteria challenge testing ■ 100% integrity testing conducted ■ Certificate provided with each filter ■ Compatible with ethylene oxide and autoclave sterilization ■ Gamma radiation sterilization compatible

• Other bio-related products

Since the population of the silver generation (aged 65 and over) surpassed that of the population aged 5 and under in 2020, the number of people in the silver generation has been increasing year by year. In particular, the proportion of women in the silver generation is expected to reach 13.4% by 2030. Modern silver generation women tend to prefer aging gracefully, and "Heberis" has been developed as an ingredient for positive aging. This product is a fermented extract from a bacterium called Sphingomonas, which can survive in extreme environments. It contains various active ingredients, including polar lipids, that have a zombie cell effect. ■In Vitro - Induction suppression of zombie cells: p21: -58%, p16: -20% - Suppression of zombie cells: -78% (β-galactosidase) - Suppression of SASP: IL-8: -32%, IL-6: -33% - Recovery of extracellular matrix: collagen production: +&%, fibrin: +22%, proteoglycan: +7% ■In Vivo - Depth of crow's feet wrinkles: -8% - Skin roughness: +14% - Elasticity: +12% - Tone (sensory evaluation): brightness: 74%, uniformity: 83% - Psychological aspect: self-esteem: +10.5%, mood state: +9%

• Cosmetic materials and raw materials
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It is said that 85% of individuals aged 12 to 24 struggle with oily and acne-prone skin, and this trend is increasing in older age groups as well. The main causes of acne are (1) excessive sebum production, (2) irregular keratinization, (3) inflammation, and (4) sebaceous gland involvement. These causes lead to inflammatory responses. Furthermore, clogged pores create a low-oxygen environment that facilitates the proliferation of acne bacteria. Whether acne bacteria act symbiotically or worsen acne symptoms depends on the balance of their strain types. There are mainly six strain types of acne bacteria: IA1, IA2, IB, IC, II, and III. It has been confirmed that strain type IA1 is the dominant type in acne-prone skin. This product suppresses the IA1 strain of acne bacteria and the C. granulosum that increases within papules, maintaining and improving the balance of symbiotic bacteria. In Vitro: - Sebum suppression effect: - Inhibition of 5-alpha reductase - Inhibition of acne bacteria IA1 - Anti-inflammatory action In Vivo: - Maintenance of major pore balance - Suppression of C. granulosum - Improvement of acne - Brightness improvement - Uniformity improvement

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Today, it is said that 50% of women in Europe, America, and Japan have sensitive skin. Regardless of the presence of erythema, sensitive skin experiences excessive reactions to environmental factors, accompanied by sensations such as stinging and itching. These factors can be external (such as UV rays and chemicals) or internal (such as stress and hormones), and in most cases, they cause discomfort to the skin and visible symptoms. Additionally, it is believed that skin microbiota are involved in the symptoms of sensitive skin. In response to this significant challenge, GREENTECH has developed a functional product, ExpoZen, to protect the skin from harmful exposomes. In Vitro: Effects on inflammation and neurogenic inflammation suppression: - TRPV-1: -67% - TNF-α: -21% - NK1-R: -43% - VEGF: -16% Effects on barrier function improvement: - Increased epidermal thickness: +12% In Vivo: Microbiome regulation: - Suppression of bacteria associated with inflammation and redness (C. Kroppenstedtii) - Increase of beneficial bacteria (S. epidermis) Improvement of sensitive skin symptoms: - Skin irritation: -34% - Pain: -33% - Tingling: -40% - Erythema: -24%

• Cosmetic materials and raw materials
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Human skin is a complex and diverse ecosystem. It is home to not only human skin cells but also bacteria, fungi, viruses, and mites, making it one of the very complex ecosystems that are still not well understood. When the balance of the skin microbiome is disrupted, it can affect skin health. Changes in resident skin bacteria have been confirmed to be related to skin concerns (such as acne, dryness, redness, hair loss, and dandruff) that are focused on in skincare and haircare. Green Tech Company believes that cosmetics targeting the microbiome could become one of the effects that consumers will prioritize in the future, and they are developing various products. <Product Information> - EXPOZEN: Reduces the stinging sensation and redness of sensitive skin, anti-wrinkle effect - BIOTILYS: Promotes the production of antimicrobial peptides, suppresses harmful bacteria, enhances the diversity of symbiotic bacteria, restores barrier function - ACNILYS: Suppresses acne-causing bacteria IA1 (maintains the balance of symbiotic bacteria), improves acne, reduces sebum, inhibits 5-alpha reductase - DANDRILYS: Improves dandruff, alleviates itching, reduces sebum, suppresses bacteria related to sebum secretion, improves the balance of resident bacteria - HAIRILINE: Suppresses bacteria related to hair loss, restores bacterial balance, promotes hair growth

• Cosmetic materials and raw materials

- Circadian Rhythm Circadian rhythm is a physiological phenomenon that regulates certain processes in the body on an approximately 25-hour cycle. Most processes in the body, including wakefulness rhythm, autonomic nervous system, endocrine hormone system, immune system, and metabolic system, are regulated by circadian rhythms. Disruptions in these rhythms are correlated with numerous diseases (obesity, cancer, new vascular diseases, diabetes, sleep disorders, etc.) and skin conditions (dark circles, wrinkles, fatigue, etc.). - Circadian Rhythm Monitor Cells This product is a monitor cell developed to find components that regulate circadian rhythms. It is a mouse embryonic fibroblast that can measure the expression rhythm of the bmal1 gene, one of the clock genes that form the body clock. It is derived from a transgenic mouse (Bmal1-ELuc mouse) created using a construct that links the luminescent protein Eluc downstream of the bmal1 gene promoter, prepared from mouse embryos. - Details Cell Name: Circadian Rhythm Evaluation Cells (Bmal1-Eluc MEF) Origin: Mouse Cell Count: 5.0×10^5 cells/vial Storage Method: Liquid nitrogen tank Ultra-low temperature freezer (-140°C) Deep freezer (-80°C)

• Animal cells
• Other Analysis
• Other pharmaceutical intermediates and cosmetic ingredients

In 2020, the Covid-19 pandemic redefined our communication styles. The lockdown created distance between us and our social lives, forcing us to change and adapt the way we engage with society and understand the state of the world. Additionally, protecting ourselves from the virus became our primary concern, leading to a life where wearing masks was mandatory. Wearing masks causes an increase in temperature and humidity inside the mask, resulting in various adverse effects such as erythema, itching, dryness, seborrheic dermatitis, and impetigo. 1) EXPOZEN: Microbiome ingredient for sensitive skin - Suppression of the TRPV-1 receptor, which causes stinging, inflammation, and redness - Inhibition of the redness-causing bacteria C. kroppenstedtii - Erythema suppression effect 2) ACNILYS: Microbiome ingredient for acne - Inhibition of the acne-causing bacteria C. acnes IA1 - Suppression of the bacteria C. granulosum that proliferate in acne 3) BIOTILYS: Microbiome ingredient for enhancing barrier function - Promotion of antimicrobial peptide production - Improvement of barrier function - Enhancement of skin microbiome diversity 4) POLEVAN S: Sugars for restoring barrier function and dry skin - Increased resistance to osmotic shock

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This product is an anti-pollution ingredient developed with a focus on the antioxidant and anti-inflammatory effects of plant-derived lignans and silymarin, which have been known for a long time. It protects the skin from damage caused by pollutants through four approaches: 1) Molecular level: Maintaining the redox balance of skin tissue and detoxification effects - Redox balance: Suppression of hydrogen peroxide and hydroperoxide by glutathione - Epidermal densification: Promotion of sebocyte differentiation and production of keratin structure proteins - Detoxification function: Conversion of harmful epoxides to dihydrodiols - Lipid oxidation suppression: Accumulation of iron 2) Cellular level: Prevention of cell damage - Promotion of DJ-1 CYTO: Suppression of inflammatory responses and oxidative stress 3) Skin tissue level: Strengthening barrier function - Promotion of the production of cornefin, occludin, and filaggrin: Densification of the epidermis (+63%) to protect against pollutants. 4) Organ level: Improvement of appearance through a holistic approach Moisture: +34% Radiance: +47% Whitening: +154% Suppression of pigmentation: +155%

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Exposure of the skin to UV, BL, and IR can lead to the formation of free radicals and inflammatory responses, resulting in apoptosis and the breakdown of the extracellular matrix (ECM). These can cause short-term issues such as sunburn, dryness, sensitive skin, and erythema, while long-term effects may include dark spots, uneven skin tone, and photoaging. Sorberlin focuses on the flowers of the Japanese bush clover, which are rich in phenylpropanoids that absorb UV, BL, and IR, particularly standardizing high contents of verbascoside and echinacoside, which have strong light-absorbing effects. - UV irradiation: Inhibition of lipid oxidation: 54% Inhibition of isomerization of urocanic acid: 70% Inhibition of apoptosis: 57% Inhibition of sunburn cells: 40% Inhibition of MMP-1: 30% Promotion of elastin production: 7% Inhibition of TNF-α: 36% Inhibition of melanin: 62% - BL irradiation: Inhibition of ROS production: 43% Inhibition of TGF-β1: 88% Promotion of decorin production: 29% Reduction of aging spots: 81% - Under IRA irradiation: Inhibition of MMP-1: 22% Inhibition of IL-6: 27% Inhibition of TGF-β1: 35% - In Vivo: Inhibition of erythema (L value): 33% ITA value: 189%

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BIOTILYS enhances the expression of antimicrobial peptides, improving antibacterial activity, anti-inflammatory effects, barrier function recovery, and the diversity of the skin microbiome. <Effects of Antimicrobial Peptides> - Antimicrobial peptides have a broad range of antibacterial activity and have been reported to exhibit antibacterial activity against Gram-positive Staphylococcus aureus, Gram-negative Pseudomonas aeruginosa, and even drug-resistant bacteria. - They have also been confirmed to improve tight junction barrier function and have anti-inflammatory effects on the skin, showing promise for the treatment of atopic dermatitis and psoriasis. <Stimuli for Antimicrobial Peptide Expression> - β-defensin 2 (hBD2): +229% - β-defensin 3 (hBD3): +19% - S100A7 (soriacin): +237% <Anti-inflammatory> - Toll-like receptor 2 (TLR2): -57% - IL-8: -58% <In Vivo: Barrier Function Recovery Effects> - Water vapor loss: -31% (after 6 hours) - Moisturizing function: +27% (after 3 hours) - Improvement in the diversity of the skin microbiome

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Aging and pregnancy increase the skin's sensitivity to sunlight, leading to excessive pigmentation and the formation of spots and melasma. The three types of plant extracts included in this product approach spots in three different ways, thereby improving spots and melasma, as well as enhancing skin uniformity and brightness. <Three Approaches> - Mulberry bark extract: Suppresses melanin production through tyrosinase inhibition - Hibiscus flower extract: Promotes turnover by exfoliating dead skin cells - Cucumber seed extract: Inhibits the transfer of melanin to epidermal cells <Efficacy> In Vitro: - Tyrosinase inhibition effect: -18% - Melanin production inhibition: -22% - Melanin transfer inhibition: -22% In Vivo: Brightness improvement: 1.5 times increase Improvement of pigmentation: 6.5 times improvement

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Alopecia is a common disorder caused by the miniaturization of hair follicles, leading to the softening of hair. The most common type of hair loss is androgenetic alopecia, which accounts for 90% of cases, with 28% of men aged 18-29 and 53% of men over 40 being affected by this condition. From a pathophysiological perspective, the causes of alopecia are multifactorial, including stress, nutrition, exposome, genetic predisposition, and hormonal sensitivity. The scalp microbiome has a significant relationship with hair growth disorders. Finding the optimal balance of both bacterial and fungal communities in hair is a step towards maintaining healthy hair. GREENTECH has developed anti-hair loss ingredients aimed at normalizing the scalp microbiome and regenerating follicular cells, focusing on the Wnt pathway, which plays a key role in the hair follicle and hair growth cycle. In Vitro 1) Inhibition of key signaling pathways for hair growth: - DDK-1 inhibition: 89% - TGFβ1 inhibition: 55% - sFRP-1 inhibition: 21% - Endothelin-1 inhibition: 21% 2) Increased proliferation of dermal papilla cells: 41% increase (better than minoxidil) 3) Adjustment of the microbiome In Vivo Hair density: 28.5% improvement

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The structure of hair fibers is the most important factor for the quality and health of hair. When the fiber structure deteriorates, the shine and smoothness of the hair decrease. Hair is constantly exposed to external stress factors such as sunlight and pollutants. These stress factors are referred to as "exposome." The structure of hair fibers deteriorates due to the exposome, leading to a decrease in the mechanical strength, shine, and smoothness of the hair. ZORYALYS is a raw material composed of three extracts developed to protect hair from the exposome. The extracts used are derived from ginger root, magnolia bark, and placasia, each serving a specific role: ginger provides antioxidant functions, magnolia offers protection against light damage, and placasia oil contains components similar to sebum in hair, improving hair quality. In Vivo (Caucasian, Asian) - Cortex protection against UV-A, cuticle protection, overall hair protection (evaluation of carbonylation) - Protection of keratin fiber structure against xenon (sunlight), prevention of tryptophan (melanin precursor) decomposition, prevention of cysteine participation, maintenance of mechanical strength, improvement of shine (twice as much), prevention of hair color fading.

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Dandruff is a scalp disorder that affects 50% of the world's population and is said to impact men more than women. Dandruff causes itching and skin flaking along with mild irritation and inflammation. In addition to discomfort and the worsening appearance of the scalp, dandruff also affects self-esteem and confidence from social and psychological perspectives. Current treatments often use zinc pyrithione overseas, which is known to have strong effects but also side effects such as skin irritation, dryness, and allergies. GREEN TECH has developed Dandrilys, a natural active ingredient that controls the scalp microbiome, cleanses the scalp, and effectively removes dandruff, redness, and sebum, as an alternative to products with side effects like zinc pyrithione. In Vivo: Examined with shampoo containing 1% Dandrilys. - Control of fungal and bacterial flora - One-week sebum suppression effect - Duration of dandruff suppression effect: 72 hours - Dandruff suppression effect: 83% improvement - Itch suppression effect: 86% improvement

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In the midst of rapid social development, our bodies are being attacked by various environmental and stress factors (night shifts, overtime, lack of sleep, etc.). This stress disrupts the body's natural rhythms (circadian rhythms). Skin homeostasis is also maintained by circadian rhythms, and disturbances in these rhythms can lead to a decline in skin health and beauty (symptoms of fatigue appearing on the face: dark circles, bags under the eyes, fine lines, dull complexion, etc.). A decrease in perceived beauty may also lead to a reduction in mental health and feelings of happiness. SARCALIS helps regulate circadian rhythms and cares for skin, mind, and fatigue. In Vitro - Restores the expression levels of clock genes CLOCK, CRY1, and PER to youthful levels. - SIRT1 (anti-aging gene): +56% - KLOTHO (anti-aging gene): +33% - HIF-1α (maintenance of skin homeostasis): +89% - 8-OHdG (marker of DNA damage): -51% - Oxytocin levels: +31% (feelings of happiness) - Endocannabinoid levels: +68% (stress reduction) - Endorphin levels: +55% (good mood) and more. In Vivo - Size of bags under the eyes: -28% - Darkness of dark circles: -13% - Wrinkles under the eyes: -21% - Skin stress relief and more.

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This product is an extract derived from the new buds of linden using GREENTECH's patented cryo-extraction technology. Linden is a long-lived tree that can live for centuries and was considered a sacred tree in ancient Germany. The extract of its flowers has anti-inflammatory and protective properties and has been used for various purposes. In particular, the new buds consist of embryonic tissue from the proliferation process, are full of vitality, and are rich in active components necessary for growth, such as plant hormones, proteins, amino acids, and sugars. The company's patented technology allows for the preservation and extraction of the active components of the new buds without damage. <Mechanism> It forms a film on the surface of the hair, suppressing moisture release, protecting the cuticle, smoothing the hair surface, and making it less prone to tangling. Additionally, by simultaneously providing flavonoids, the helical bonds of keratin (the fibrous protein that makes up 95% of hair) are stabilized. Furthermore, using free sugars (components of natural moisturizing factors) forms a water complex in the upper layer of the scalp, providing constant hydration. <Efficacy> - Improvement in hair moisture levels: +83% - Improvement in scalp moisture levels: +33% - Cuticle improvement - Volume enhancement - Static electricity prevention

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The Baobab (scientific name: Adansonia) is a deciduous tree native to regions such as Africa and Madagascar, belonging to the Malvaceae family and the Baobab genus. In Africa, its fruit has been consumed as a panacea since ancient times and is referred to as the "Tree of Life." The trunk of the Baobab tree has a shape resembling a sake bottle, is hollow inside, and can store up to 10 tons of moisture in its trunk, allowing it to survive by shedding its leaves and entering dormancy during the dry season, relying on the moisture stored within its trunk. LIFTISSTM is an extract obtained from the fruit of this Tree of Life, and it is a gel-like product rich in organic acids (AHA) and natural moisturizing factors (NMF), containing natural sugar components (77% galacturonic acid). <Mechanism of Action> Organic acids (alpha-hydroxy acids) break down keratin on the skin's surface, promoting exfoliation and epidermal regeneration, resulting in smoother skin and providing moisturizing and wrinkle-smoothing effects. Natural sugars (components of NMF), such as glucose and xylose, bind with keratin to form complexes that attract water molecules, thereby providing moisturizing effects. Additionally, natural sugars form a film on the epidermis, creating a tightening effect. <Efficacy> - Number of wrinkles: -41% - Area of wrinkles: -24% - Lifting effect, etc.

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Inca Inchi (Plukenetia volubilis (seeds)) is a plant from the Amazon that has been used for various purposes since the time of the Inca Empire due to its high content of fatty acids and proteins. This product was developed as part of the Omega Program in Peru, a fair trade and sustainable project that started in 2003, aimed at the cultivation and industrialization of Inca Inchi. *Green Tech is a founding member of the Omega Program. It contains the highest amount of unsaturated fatty acids (94%) among all seed oils, surpassing baobab seed oil and jojoba oil. The unsaturated fatty acids in this product help maintain the lipid balance of the skin, prevent keratinization disorders, and improve and heal skin elasticity. Additionally, this product is a highly penetrating dry oil that smooths the skin and makes hair supple. <In Vitro:> - Stimulation of keratinocyte proliferation <In Vivo> - Improvement of skin smoothness: +66% - Cuticle improvement effect - Prevention of hair tangling - Improvement of hair volume and more.

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HyRetin is a product that introduces retinoids to low molecular weight sodium hyaluronate, enhancing the stability and skin permeability of retinoic acid. =In Vitro= - Anti-inflammatory effects: IL-8: -15%, IL-6: -40% - Promotion of collagen type 1 production: +40% - Promotion of fibronectin production: 1.4 times (vs control) =In Vivo= - Dermal density: +10% improvement - Number of dermal papilla cells: +48% - Improvement in skin elasticity: -34% (recovery time) - Reduction in wrinkle depth: -36% - Skin radiance: +43% - Skin moisture level: +7% - Erythema suppression effect: -6% - Sebum reduction effect: -36% - Pore size: -25% - Anti-acne effect: size: -50%, number: -68.75% and more.

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Evaluation of Drug Permeability from Cell Membranes Using Artificial Membranes In the development of new drugs, the examination of the pharmacological properties and toxicity of compounds, along with the study of absorption characteristics from intestinal membranes, is considered one of the important factors. The evaluation of absorption characteristics is generally conducted using Caco-2 cell tests. To perform Caco-2 tests, cell culture on the membrane of test well plates is required, but this cultivation demands significant time and effort. Issues may arise with the reproducibility of permeability tests due to the heterogeneity of the culture. The Permeapad Plate, which laminates phospholipids with a special film, serves as an alternative method for compounds where membrane permeability is rate-limiting in Caco-2 tests. Since the phospholipids are laminated with a film, they can be stored at room temperature and used immediately. The homogeneous film allows for high measurement reproducibility.

• Filtration Equipment
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- Ingredients: Contains Fucoidan ≧ 85% - Efficacy: 1) Anti-aging function - Wrinkle depth: -9% - Stimulation of anti-aging gene SIRT1 expression (+28%) - Glycation inhibition effect (-50%) - Inhibition of collagenase and elastase by up to 99% 2) Protection effect - Suppression of erythema after UV exposure by 45% - Antiviral effect (multiple including herpes simplex) 3) Moisturizing and smoothing - Increase in moisture by 30% after UV exposure - Increase in stimulation of skin cell expression after UV exposure - Inhibition of myeloperoxidase by up to 99%

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MARINOVA is a biotechnology company established in 2003 in Tasmania, Australia. It is the manufacturer of the world's only high-purity organic fucoidan extract derived from brown algae, using its unique green chemistry technology. The company's product, MARITECH BRIGHT, is made from sustainable raw materials. =Sustainable Manufacturing Process= 1) Sustainable Sourcing: Wild seaweed is sourced from four regions around the world, employing harvesting methods that consider regeneration. 2) Zero Waste: Renewable energy (zero CO2 emissions) is used, and waste is utilized in agriculture. 3) Extraction with water, with 50% being reused. =About the Product= - Ingredients: Contains ≥90% fucoidan and polyphenols - Efficacy: 1) Anti-aging functions - Improves skin radiance - Reduces wrinkle depth - Stimulates expression of anti-aging gene SIRT1 - Inhibits glycation (50%) - Suppresses collagenase, tyrosinase, and elastase by up to 99% 2) Whitening functions - Improves pigmentation (20%) 3) Antioxidant functions - Removes free radicals - Against UVA/B: Suppresses erythema and TEWL caused by irradiation - Oxygen radical absorption capacity (twice that of VC)

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The Earth-Rite Multipoint2 from NewsonGale (UK) is an excellent product that monitors the grounding to ensure that static electricity generated during powder handling is effectively prevented. When the ground connection is interrupted during cleaning or disassembly, it is essential that it is reliably re-grounded during reassembly. By using the Earth-Rite Multipoint2, it is possible to monitor the grounding of up to eight points simultaneously. If proper grounding is not achieved, the interlock mechanism detects the hazard and ensures that the system does not operate. This helps prevent serious industrial accidents caused by human error.

• Anti-static products
• Other safety equipment
• Safety Sensors

The esters handled by our company, ZSCHIMMER & SCHWARZ (abbreviated as Z & S, headquartered in Germany), are environmentally friendly and highly biodegradable. We offer a variety of monoesters, polyol esters, complex esters, and food-grade esters. These lubricants can be widely used in natural environments such as oceans, ports, agriculture, and forestry, as well as in food machinery oils (for detailed applications, please refer to the URLs of each product listed in the catalog). 【Features】 ◎ Lubricity ◎ Low-temperature fluidity ◎ Thermal stability ◎ Excellent oxidation stability ◎ High viscosity index Some products are HX-1 registered additives (lubricant raw materials and additive standards approved for use in areas that may come into incidental contact with food as defined by NSF). Additionally, some products comply with the Biopreferred label (environmentally friendly products as defined by the U.S. Department of Agriculture) and the EU Ecolabel (environmentally friendly products established by regulations of the European Parliament and Council). *For more details, please request materials or view the PDF data available for download.

• Lubricants

The Nano Dis system is a new option that uses conventional dissolution testing equipment. Currently, many new drug candidates are poorly soluble compounds, and improving the solubility of these compounds is important. One attractive solution for improving solubility is nanoparticle formulation. To facilitate the selection of compounds in nanoparticle development, an efficient dissolution testing method is necessary. In the current dissolution testing systems, insufficient filtration of nanoparticles from the test solution leads to variability in test results, resulting in unreliable outcomes. The Agilent NanoDis system addresses these issues and provides researchers with accurate dissolution profiles of active pharmaceutical ingredients through an automated system. This functionality allows researchers to optimize nanoparticle formulations more quickly and bring them to market faster. The automated process yields consistent and reliable dissolution test results for nanoparticle formulations.

• Other Physics and Chemistry Equipment
• Dissolution Tester
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Yeast extract," widely used in the fermentation industry, is aimed at enhancing the productivity and yield of microbial cultures. Yeast extract comes in various types, including amino acid-rich, nucleic acid-rich, and peptide-rich varieties. By reviewing the combinations and formulations of these yeast extracts, there is potential for improving fermentation and culture processes. This document presents test data related to the above. The yeast extract handled by Higuchi Shokai is manufactured by Ohly, a long-established yeast extract producer in Germany. It has a proven track record not only in lactic acid bacteria culture but also widely in the fermentation industry. Please take a look at our catalog if you are interested! *For more details, please refer to the PDF document or feel free to contact us.

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BOREALG TM is a fat-soluble active substance derived from a large brown kelp called Laminaria hyperborea, known as the queen of longevity. Laminaria hyperborea inhabits the rocky surfaces of coastal areas. It has a strong adaptability to withstand the impact of powerful waves crashing against the reefs. In Brittany, for instance, when winter winds reach 130 km/h, the coastline is exposed to waves exceeding 10 meters. The pressure of the waves exerts 12 tons per square meter on the rocks and kelp forests. Odycea discovered that Laminaria hyperborea possesses ultimate restorative abilities to counteract strong waves. Borealg TG collected data focusing on the leptin receptor gene, fatty acid binding protein 3 gene, and Cyclin D1 gene, which are related to skin regeneration, activation, and rejuvenation processes. - Increase in leptin receptor gene expression stimulation: 139% improvement - Increase in fatty acid binding protein 3 gene expression stimulation: 220% improvement - Suppression of Cyclin D1 gene expression stimulation: -36% - Mitochondrial survival rate: 18% improvement - Suppression of erythema: -10%

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The manual sampling of the dissolution tester typically uses a cannula. The cannula is submerged into the vessel, and the sampling zone is confirmed visually. However, visual work is cumbersome for confirmation, and it is not easy to sample accurately and reproducibly. By using the Agilent manual sampling bracket, the hassle of visual confirmation for the operator is reduced, allowing for manual sampling that enhances the accuracy and reproducibility of the sampling zone.

• Dissolution Tester
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Krodesin is a nonapeptide (synthetic human nonapeptide-4) that mimics the active site of the anti-aging gene Klotho. The Klotho gene decreases with age and has been proven to have anti-aging effects. The name is derived from Klotho, the goddess in Greek mythology who spins the thread of fate. Klotho can protect the skin from the fate of aging and provide true rejuvenating effects. =In Vitro= Inhibition of insulin signaling (100%) Stimulation of SIRT1 gene expression (45%) Reduction of reactive oxygen species induced by peroxides (-10%) Inhibition of cellular aging Suppression of UV-induced inflammatory cytokine IL6 (-35%) =In Vivo= Anti-wrinkle (-50%) Fig.1 Elasticity (+200%), Pore size (-10%), number (-8%), Dermal papillae (+15%), luster (+20%), Sebum suppression (-10%)

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TanActine (glucomannan) is a yeast cell wall polysaccharide extracted from the culture of the yeast Candida utilis. TanActine is a yeast cell wall polysaccharide that has been shown to reduce skin redness and maintain melanin production. Data also suggests that TanActine may help in the repair of skin cells and protect against UV-induced cellular and DNA damage. <Efficacy> =In Vitro= - Promotion of melanocyte-stimulating hormone stimulation: 40% increase - Suppression of cell death due to UV irradiation - Improvement of keratinocyte cell survival rate: 10% improvement - Suppression of apoptosis: 30% suppression - DNA protective effect through inhibition of thymine dimer formation (UV irradiation): 60% suppression - Suppression of inflammatory cytokine (IL-1α) (UV irradiation): 50% suppression - Suppression of inflammatory cytokine (PGE2) (UV irradiation): 50% suppression =In Vivo= - Suppression of erythema (UV irradiation)

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Carboxymethyl glucan (CMG) is a derivative of β-glucan isolated from yeast cell walls and is a natural yeast polysaccharide. While β-glucan is insoluble, this product has been made water-soluble while maintaining its biological activity through carboxymethylation. CMG significantly increases superoxide dismutase (SOD) activity, which shows important immune-regulating and antioxidant effects. These mechanisms help protect the skin from UV stress. = In Vitro = - Maintenance of glutathione pool (UV) - Promotion of SOD (reactive oxygen species-decomposing enzyme) production (UV): 40% increase - Inhibition of cellular phospholipid oxidation (UV): 80% inhibition - Inhibition of cellular protein oxidation (UV, vs TiO2): 22% inhibition - Inhibition of inflammatory cytokine (IL-6) (UV): 20% inhibition - Inhibition of inflammatory cytokine (IL-1beta) (UV): 40% inhibition - Promotion of anti-inflammatory cytokine (IL-10) production (UV): 60% increase = In Vivo = - Increase in collagen fibers and dermal papilla cells - Improvement in skin smoothness - Reduction in pore size - Improvement in skin elasticity - Improvement in crow's feet wrinkles

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Schizophyllan is a water-soluble high molecular weight polysaccharide produced in the cell walls of the fungus Schizophyllum commune. It can regulate various types of cellular responses to external stimuli and influence cell survival rates and protein synthesis. Skin aging caused by UV stress can lead to a deterioration of immune processes, resulting in the formation of wrinkles and dehydration. Schizophyllan has been confirmed to improve skin moisture levels and reduce wrinkles by regulating the underlying immune processes. <Efficacy> =In Vitro= Improvement in cell survival rate: 40% increase Promotion of TGF-β production: 150% increase Enhancement of IL-6 production: 60% increase Enhancement of IL-1beta production: 20% increase Inhibition of MMP1 expression (UV irradiation): 40% inhibition =In Vivo= Barrier function recovery effect Increase in skin moisture levels Suppression of skin erythema Improvement of crow's feet wrinkles

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• Cosmetic materials and raw materials
• Other pharmaceutical intermediates and cosmetic ingredients

Pearl Alga is a fraction of fluorotannins and other components extracted from Sargassum muticum, a brown alga known as pearl algae. The coastal waters of Brittany, France, where pearl algae inhabit, have a high probability of organisms attaching to and parasitizing seaweeds due to the presence of many estuaries, making it a sea with a much higher likelihood of such occurrences compared to the open ocean. However, Odycea discovered that pearl algae are not affected by this phenomenon. The reason is that this alga produces unique substances that have convergent, antibacterial, and antifungal properties. These substances include high concentrations of gallic acid (an average of 3 mg/100 g) and fluorotannins. As a result, the surface of pearl algae remains clean and free from parasitic organisms. Due to the effects of these substances, Pearl Alga can purify the skin and provide excellent benefits for skin care, including pore care, suppression of sebum secretion, and reduction of shine. - Efficacy - - Reduction in pore density, diameter, and surface area - Improvement in skin smoothness - Suppression of sebum secretion - Reduction of shine

• Cosmetic materials and raw materials
• Other pharmaceutical intermediates and cosmetic ingredients
• others

Himantalia elongata is a bamboo-like seaweed that grows on the seabed at depths of 10 to 20 meters in the Brittany region of France. Marine Bamboo grows to lengths of over 3 meters and is named for its shape. Marine BambooTM is a patented lipophilic active substance, a product derived from the extraction of fucosterol and phycocyanin from Himantalia elongata. Marine BambooTM is an excellent product for absorbing UV, blue light, and IRA. Its high absorption effect, particularly for blue light, is attributed to the extreme environment at its habitat depth. In Vitro: - Inhibition effect on MMP1 gene expression: -38% - Stimulation of elastin gene expression: +40% - Blue light protection effect: Damage reduction effect on fibroblasts: +23% Inhibition effect on MMP1 production: -26% In Vivo: - Tightening effect: +8% - Smoothing effect: +12% - Tone improvement effect: +4.1%

• Other medical supplies and cosmetic manufacturing materials
• Cosmetic materials and raw materials
• Other pharmaceutical intermediates and cosmetic ingredients

This is a tabletop type compact device that allows for the production of granulation, extrusion granulation, and spherical granulation on a small scale with just one unit. Pellets can be completed from powder in just 30 minutes. It is space-saving, easy to operate, and easy to clean. It minimizes waste of valuable raw materials and contributes to your formulation development!

• Extrusion Granulator
• Granulator
• Other granulators and granulators

Odesia: A French cosmetic ingredient manufacturer that offers products centered around extracts from algae native to the Brittany region of France. The company's products apply the special defensive properties that allow algae to survive in various harsh natural environments to cosmetics. Jade Alga TM: A patented active ingredient rich in native ulvan (sulfated polysaccharide) derived from the green seaweed of the Enteromorpha genus found along the Brittany coast. It is the only algae with "shape memory capability." The Enteromorpha in Brittany is significantly affected by the tides that occur every six hours. Its shape memory capability allows it to withstand repeated cellular deformation (contraction and expansion) caused by the tides without damage. Sustainability efforts: The large Enteromorpha has proliferated due to pesticide runoff and global warming, becoming a social issue. Jade Alga is a cosmetic ingredient that utilizes this large Enteromorpha. <Efficacy> - Maintenance and recovery of normal stratum corneum arrangement (shape memory technology) - Soft peeling effect - Improved skin plasticity and flexibility - Photoprotection effect - Antioxidant effect

• Cosmetic materials and raw materials
• Other pharmaceutical intermediates and cosmetic ingredients
• Other medical supplies and cosmetic manufacturing materials

Glycoin natural is a product composed of 100% unique structural isomers manufactured using patented biotechnology by Bitop AG in Germany. These structural isomers are found only in the miraculous resurrection plant Myrothamnus flabellifolia and blue-green algae (spirulina), which are known as the miracle plants of the desert that can revive green with just a small amount of water even after being dried for 50 years. Glycoin natural activates the rejuvenating power of tired skin, stressed skin, and aging skin. <Efficacy> Stimulates cell regeneration, growth factors, and ATP synthesis Activates antioxidant enzymes (SOD1, SOD2, CAT) Immediate moisturizing effect improved by 49% (after one application) Skin elasticity improved by 93% Skin smoothness improved by 61% Skin thickness increased by 9.9% Reduces sunburn and skin redness Tissue repair and wound healing effects maintained for 48 hours

• Cosmetic materials and raw materials
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• Other medical supplies and cosmetic manufacturing materials

<Ectoin Natural Features> Ectoin is a type of cyclic amino acid produced by extremophilic microorganisms (Halomonas) that inhabit salt lakes and deserts. It has 4 moles of bound water per 1 mole of Ectoin, exhibiting cosmotropic properties. This characteristic contributes to the stabilization of interactions between water molecules, forming a hydrocomplex. This hydrocomplex helps stabilize biological structures (such as cells, proteins, enzymes, and nucleic acids) against environmental stresses like temperature changes, high salt concentrations, strong UV radiation, and dehydration. ― About Effectiveness ― Moisturizing Persistence (In-Vivo): Lasts for 1 week. Skin Barrier Function and Protection of Langerhans Cells (In-Vivo): 100% protection. Promotion of Heat Shock Protein Production (In-Vitro), Anti-Pollution Effect (Ex-Vivo), Protection against Blue Light, UV-A, UV-B, IR-A, and Heat, Anti-Aging Effects (In-Vivo): Improvement in Skin Roughness (86% improvement), Wrinkle Depth (32% improvement), Elasticity (82% improvement), Smoothness (61% improvement), Whitening Effect (In-Vivo): Improvement in Skin Pigmentation (25% improvement).

• Cosmetic materials and raw materials
• Other pharmaceutical intermediates and cosmetic ingredients
• Other medical supplies and cosmetic manufacturing materials

The Earth-RiteⓇ series, an earth monitoring system from Newson Gale in the UK, has added the Earth-RiteⓇ FIBC for Type C flexible containers! Type C bags may lose their initial conductivity due to aging or friction from long-term use, posing a risk of static electricity hazards. The Earth-RiteⓇ FIBC continuously monitors the resistance of the Type C bags in use and alerts the operator if the resistance exceeds 10MΩ (or 100MΩ, which can be selected). Additionally, it is possible to set an interlock to force the system to stop in case of an emergency.

• Anti-static products
• Other anti-static devices
• Other safety equipment

The pH setting of the test solution in the dissolution test is an important parameter. Measuring the pH during the test requires the cumbersome task of sampling the test solution. This system allows for the direct insertion of a pH electrode into the vessel, enabling real-time display via software. With the optional relay output unit, it is also possible to supply two types of gases and control the pH.

• Dissolution Tester
• pH Meter
• Other Physics and Chemistry Equipment

<Ectoin Natural Features> Ectoin is a type of cyclic amino acid produced by extremophilic microorganisms (Halomonas) that inhabit salt lakes and deserts. It has 4 moles of bound water for every 1 mole of ectoin, giving it cosmotropic properties. This characteristic contributes to the stabilization of interactions between water molecules and forms a hydrocomplex. This hydrocomplex helps stabilize biological structures (such as cells, proteins, enzymes, and nucleic acids) against environmental stresses like temperature changes, high salt concentrations, strong UV exposure, and dehydration. ― About Effectiveness ― In Vivo Vaginal care effects: Reduction of vaginal atrophy symptoms, vaginal moisturization (50% improvement in dryness), improvement of vaginal heat and itching. Moisturizing persistence (lasting for 1 week), barrier recovery, erythema suppression, protection of Langerhans cells (100% protection). Anti-aging effects: Improvement in skin roughness (86% improvement), wrinkle depth (32% improvement), elasticity (82% improvement), smoothness (61% improvement), whitening effect (25% improvement). In Vitro: Promotion of heat shock protein production, anti-pollution effects (Ex-Vivo), protection against blue light, UV-A, UV-B, and IR-A.

• Cosmetic materials and raw materials
• Other pharmaceutical intermediates and cosmetic ingredients
• Other medical supplies and cosmetic manufacturing materials

The intrinsic method for dissolution testing provides important information about the active pharmaceutical ingredient by determining the dissolution rate from a test solution with a constant pH, temperature, and surface area. The Biopharmaceutics Classification System (BCS) classifies the characteristics of a drug's solubility and membrane permeability, while the intrinsic method can characterize solubility.

• Other Physics and Chemistry Equipment
• Dissolution Tester

Solid dispersions are used to improve the solubility of poorly soluble drugs. Although solid dispersions are in a supersaturated state, it is important to maintain this state. Using Fiber Optic for real-time monitoring allows for more detailed data acquisition and is more effective. By changing the chip (optical path length), it can accommodate a wide range of drug concentrations. 【Features】 - Data acquisition at intervals as short as 45 seconds - Direct absorbance measurement within the vessel - Reduced risk of contamination and carryover - Correction function for excipient interference and background - No need for flow path cleaning - Reduced maintenance costs as it does not use pumps (moving parts) or filters - 21 CFR Part 11 compliant UV dissolution software

• UV/visible spectrophotometer
• Other Physics and Chemistry Equipment

Bridge-type rice starch RICE PO4 has an average particle diameter of 8μm and a sharp particle size distribution. It is insoluble in water and does not undergo thermal modification, making it an excellent particle for formulation. It has high oil absorption capacity and can be used to improve the feel of products such as sebum adsorbents and creams (reducing stickiness).

• Cosmetic materials and raw materials
• Other pharmaceutical intermediates and cosmetic ingredients
• Other medical supplies and cosmetic manufacturing materials