ナード研究所 Product Lineup

We would like to introduce our "Synthesis of Organic Compounds." We deliver over 1,000 compounds annually and have a proven track record in most organic reactions. We can propose syntheses even for compounds that have not been reported in literature or patents. Please feel free to contact us when you need assistance. 【Refining Techniques】 ■ Recrystallization ■ Distillation ■ Chromatography ■ Sublimation purification ■ Clean environment *For more details, please download the PDF or feel free to contact us.

We would like to introduce our company's "Synthesis of Polymer Processing Materials." We carry out the synthesis of terminal functionalized polymers using chain transfer agents, the synthesis of polybutadiene through anionic polymerization, and the introduction of functional group terminals using chain transfer agents. Please feel free to contact us when you need our services. 【Features of Our Contract Synthesis】 ■ No need for synthesis data; we can propose synthesis methods even for new compounds. ■ Researchers engage in direct dialogue to smoothly reflect your requests in planning and results. ■ We work together with customers to think of solutions for research challenges. *For more details, please download the PDF or feel free to contact us.

We would like to introduce our "Synthesis of Inorganic Compounds." We conduct the synthesis of nanoparticle-supported catalysts, raw material mixing using a planetary ball mill, and investigations into the sublimation purification of inorganic compounds. Please feel free to contact us when you need our services. 【Features of Our Contract Synthesis】 ■ No synthesis data? No problem; we can propose synthesis methods for new compounds. ■ Researchers engage in direct dialogue to smoothly reflect your requests in planning and results. ■ We work together with customers to think of solutions to research challenges. *For more details, please download the PDF or feel free to contact us.

Our company conducts the synthesis of glycan and glycan derivatives at various scales, from a few milligrams for research purposes to process development aimed at future commercialization. We can accommodate not only linear glycans but also the construction of complex branched glycans. We have a proven track record in the synthesis of glycan derivatives, regardless of whether they are natural or non-natural. Additionally, we support life science research through the modification of N-linked and O-linked glycans, as well as custom synthesis of glycoproteins. 【Features】 ■ Synthesis of glycans and glycan derivatives at various scales ■ Capability to construct complex branched glycans ■ Proven track record in the synthesis of glycan derivatives, both natural and non-natural ■ Support for life science research *For more details, please refer to the related link page or feel free to contact us.

【Contract Organic Synthesis】 We provide a consistent contract service from research on the synthesis of organic materials to factory production, so we can accommodate any inquiries regarding the supply of organic materials. 【Contract Sublimation Purification】 Using high-performance vacuum pumps and our uniquely developed sublimation equipment, we accept contracts for the examination of sublimation of various organic compounds as well as large-scale sublimation of several hundred grams to several kilograms.

Our service is a unique contract research system that combines experimental synthesis and theoretical calculations. By conducting "synthesis experiments" from Nard Institute and "theoretical calculations" from TS Technology in parallel, we can efficiently advance a wide range of research and development. We accelerate research and development by exchanging "new insights" and "proposals for reaction conditions" from theoretical calculations to synthesis experiments, and "experimental data to validate theoretical hypotheses" from synthesis experiments to theoretical calculations, while providing reliable experimental data and compounds backed by theoretical support. 【Features】 ■ Guaranteed maximum research results within a limited timeframe ■ Joint proposals from Nard Institute and TS Technology ■ Efficient advancement of a wide range of research and development ■ Confidentiality agreements established among the client and the three parties ■ In addition to compounds and reports, theoretical support related to synthesis and analysis is also available *For more details, please refer to the related link page or feel free to contact us.

We provide a small number of samples derived from the basic framework for multiple specimens. Based on existing synthetic methods, we propose a process suitable for multi-specimen synthesis using our unique know-how, and we carry out everything from the design of the synthesis method to the execution of the reaction and purification consistently. Sample shipments are prepared in forms tailored to customer needs, and we deliver samples in a state ready for immediate use in the next tests. 【Features】 ■ Provision of a small number of samples derived from the basic framework for multiple specimens ■ Proposal of a process suitable for multi-specimen synthesis using our unique know-how ■ Consistent execution from the design of the synthesis method to the execution of the reaction and purification ■ Preparation of sample shipments in forms tailored to customer needs ■ Delivery of samples in a state ready for immediate use in the next tests *For more details, please refer to the related link page or feel free to contact us.

With the advancement of medicine and the aging population, there is a growing demand for improved health and quality of life, which is creating new needs for pharmaceutical development. Drugs that show effects in extremely small amounts can also pose a high risk of health hazards in the development and manufacturing processes. Our company has been operating containment facilities since April 2016 with the aim of safely and securely handling these substances. Leveraging our long-standing expertise in organic synthesis and this facility, we provide safe and secure contract synthesis and purification services for highly pharmacologically active compounds, contributing to the acceleration of development in this field. 【Facility Overview】 ■ Manufacturing Room: 17m² (2 Hazard Rooms) and DG Room / Pass Box ■ Containment Equipment: Hazard Room / Safety Cabinet / Draft Chamber ■ Static Pressure Management: -15Pa to -30Pa ■ Manufacturing Environment / External Environment: Class 100,000 HEPA performance / HEPA exhaust *For more details, please refer to the related link page or feel free to contact us.

We custom synthesize peptides necessary for the development process. By providing the required samples, we contribute to the efficiency and speed of research and development. We synthesize various fluorescently labeled compounds, including stable isotopes such as D, 13C, and 15N, and propose the sites of isotope incorporation and synthesis pathways. Additionally, we provide small quantities of samples containing peptides derived from basic frameworks in multiple specimens. You can rely on us for everything from the design of the synthesis method to delivery. 【Features】 ■ Custom sample synthesis for research ■ Fluorescent and stable isotope labeling ■ Small quantity, multiple specimen synthesis ■ Research support - FTE contracts ■ Sample synthesis and purification using high-purity equipment *For more details, please refer to the related link page or feel free to contact us.

Lipids include simple lipids such as acylglycerols and complex lipids such as phospholipids and glycolipids, and they are known to have various functions as important substances that constitute living organisms. On the other hand, in the field of drug delivery systems (DDS), lipid compounds are utilized with liposomes as transport carriers. Our company leverages synthetic and purification technologies to synthesize lipid compounds necessary for research and development of lipid molecules such as acylglycerols, phospholipids, and glycolipids, and provides the required samples. Furthermore, we also accommodate custom synthesis according to requests, including various fluorescent labeling, stable isotope labeling such as 2H and 13C, and PEG modification. 【Features】 ■ Synthesis of lipid compounds necessary for research and development, providing the required samples ■ Custom synthesis according to requests, including stable isotope labeling and PEG modification *For more details, please refer to the related link page or feel free to contact us.

We synthesize nucleosides modified at the base or sugar parts using our accumulated organic synthesis technology, and deliver them as amides that can be immediately utilized in automated oligonucleotide synthesis devices. Additionally, we also support the phosphorylation of modified nucleosides and provide high-purity triphosphates, diphosphates, and monophosphates using advanced purification techniques. [Achievements] ■ Synthesis of non-natural nucleoside amides ■ Scale-up production of non-natural nucleoside amides ■ Synthesis of non-natural nucleotides *For more details, please refer to the related links page or feel free to contact us.

We would like to introduce our synthesis technology for "metabolites and degradation products." In the fields of pharmaceuticals and pesticides, we carry out the synthesis of standard samples of metabolites, impurities, and degradation products necessary for overseas registration and other requirements. Additionally, in the case of compounds with unknown structures, we utilize analytical instruments such as LC-MS and NMR to perform structure analysis, determination, synthesis, analysis, and reporting. 【Features】 ■ Synthesis of standard samples of metabolites, impurities, and degradation products ■ Utilization of analytical instruments such as LC-MS and NMR for compounds with unknown structures ■ Execution of structure analysis, determination, synthesis, analysis, and reporting *For more details, please refer to the related link page or feel free to contact us.

Polymer materials are utilized in various industries, and a wide variety of polymer materials are sold by many manufacturers. Nard Laboratory's "Contract Synthesis Service" has a track record of delivering over 50 types of custom polymer compounds annually. Our company has numerous synthesis achievements not only in general radical polymerization but also in anionic polymerization, cationic polymerization, and step-growth polymerization, with a significant number of successful syntheses of both random polymers and block polymers. [Features] - Implementation from investigation of synthesis methods - Ability to synthesize various types of resins by using different polymerization methods - Control of molecular weight and molecular weight distribution is possible by using living polymerization techniques - Capable of conducting not only polymerization but also modification reactions *For more details, please refer to the related link page or feel free to contact us.

At Nerd Research Institute, we utilize the fine chemical synthesis technologies accumulated so far to offer contract synthesis and research of dendrimer raw materials (building blocks). By employing various polymerization methods, we provide novel hyperbranched polymers. Additionally, upon request, we can assist in creating dendrimers with new functionalities by combining building blocks into the core. Our company synthesizes new dendrimer raw materials and dendrimers to meet your needs. 【Features】 ■ Synthesis of new dendrimer raw materials and dendrimers ■ Utilization of fine chemical synthesis technologies ■ Acceptance of contract synthesis and research for dendrimer raw materials ■ Also conducting contract synthesis of relatively easier-to-synthesize hyperbranched polymers than dendrimers ■ Providing novel hyperbranched polymers by employing various polymerization methods *For more details, please refer to the related links page or feel free to contact us.

Our company offers contract synthesis services for inorganic materials, with a track record of over 500 custom syntheses. We can propose synthesis methods not only for those with established procedures but also for requests where only the compound structure is determined and the synthesis method is not. We utilize our in-house know-how and conduct literature research to suggest synthesis formulations. We possess various equipment related to inorganic synthesis and analysis of inorganic materials, allowing us to carry out everything from formulation proposals to analysis of the synthesized products. 【Synthesis Achievements (Excerpt)】 <Methods> ■ Solid-phase method, co-precipitation method, sol-gel method, hydrothermal synthesis method, solvothermal method, melt-quenching method, etc. <Materials> ■ Various solid materials for batteries (positive electrode active materials, negative electrode active materials, solid electrolytes, precious metal-supported catalysts), glass materials, MOF materials, metal nanoparticle materials, catalyst materials, etc. *For more details, please refer to the related link page or feel free to contact us.

Our company uses a method called the bottom-up approach for the synthesis of metal nanoparticles and the synthesis of composite materials that support metal nanoparticles on a carrier. Compared to the top-down approach, it is possible to achieve a narrower particle size distribution. We have a track record of various synthesis methods and a wide range of elements. Our materials are used in a variety of industries for applications such as conductive materials, magnetic materials, luminescent materials, DDS materials, cosmetic materials, battery materials, and catalyst materials. 【Features】 ■ It is possible to disperse in organic solvents by introducing organic substances onto the particle surface. ■ Compared to the top-down approach, it is possible to achieve a narrower particle size distribution. ■ We have a track record of various synthesis methods and a wide range of elements. ■ We actively try elements and synthesis methods that have not been implemented before. *For more details, please refer to the related link page or feel free to contact us.

Our company conducts the synthesis of various compounds, including fluorescent substances such as DOTA, TAMRA, Alexa, Biotin, and stable isotopes like deuterium, 13C, and 15N. We can introduce these compounds to your desired sites and also provide suggestions for compounds tailored to your intended applications. Based on our extensive synthesis experience, we support the labeling of a wide range of compounds, including general organic compounds, glycans, nucleic acids, and more. For inquiries or questions regarding product and technology information, please feel free to contact us. 【Features】 ■ Synthesis of compounds containing stable isotopes ■ Suggestions for compounds tailored to your intended applications ■ Support for the labeling of a wide range of compounds *For more details, please refer to the related link page or feel free to contact us.

Molecular imaging refers to a technique that non-invasively visualizes changes in molecular groups within living organisms (such as enzymes, genes, membrane proteins, etc.) and observes them dynamically and quantitatively. A representative method in this field is positron emission tomography (PET), which is well-known in current research. In recent years, technologies utilizing fluorescence and near-infrared light have also been applied in the fields of biochemistry and regenerative medicine. As it lies at the intersection of medicine, pharmacy, and engineering, this field is expected to see further development. Nard Institute will continue to support this area from the standpoint of organic compound development. [Theme] ■ VARGULA LUCIFERIN ■ Fluorescent labeling of organelles *For more details, please refer to the related links page or feel free to contact us.

"Organic dyes" are attracting attention as highly efficient light absorbers and key materials for functionalization in the fields of electronic information and medical diagnostics. Our company has a proven track record in the synthesis of a wide variety of organic dyes, including Ru-based sensitizing dyes, phthalocyanine-based dyes, and squarilium-based dyes, utilizing the synthetic techniques we have developed over the years. For compounds with unknown synthetic routes, if you provide the structure, we can propose a synthetic route from our side. [Features] - Proven track record in the synthesis of a wide variety of organic dyes - For compounds with unknown synthetic routes, if you provide the structure, we can propose a synthetic route *For more details, please refer to the related link page or feel free to contact us.

In the Material Science Research Department Group 6, we synthesize products such as "-3-Hydroxybutanoic" and "-Pentanediol" using asymmetric reduction catalysts. In addition to the compounds listed below, we also offer custom synthesis using asymmetric reduction catalysts. For inquiries or questions regarding product and technology information, please feel free to contact us. 【Compounds】 ■ (R): -3-Hydroxybutanoic Acid Ethylester 98% ee ■ (R): -3-Hydroxybutanoic Acid Methylester 98% ee ■ (S): -3-Hydroxybutanoic Acid Ethylester 98% ee ■ (S): -3-Hydroxybutanoic Acid Methylester 98% ee ■ (2R, 4R): -Pentanediol 98% ee ■ (2S, 4S): -Pentanediol 98% ee *For more details, please refer to the related link page or feel free to contact us.

Our company is particularly focused on polymerization catalysts, and we have built a track record in synthesizing homogeneous transition metal catalysts starting from ligand synthesis. Based on our extensive knowledge and experience in organic synthesis, we can accommodate not only existing metal complexes but also newly designed metal complexes, as well as next-generation rare earth metal complexes and non-metallocene type transition metal catalysts. [Features] - Particularly focused on polymerization catalysts - Wide-ranging support based on extensive knowledge and experience in organic synthesis *For more details, please refer to the related links page or feel free to contact us.

Alkoxysilane compounds have been used as silane coupling agents for a long time and have recently gained attention as raw materials for unique mesoporous silica structures. Our company has a proven track record of synthesizing various alkoxysilane compounds, with supply capabilities of up to several hundred grams. Please feel free to contact us for inquiries or questions regarding product and technology information. 【Features】 ■ Long-standing use as silane coupling agents ■ Also gaining attention as raw materials for mesoporous silica ■ Proven track record in synthesizing various alkoxysilane compounds ■ Supply capabilities of up to several hundred grams *For more details, please refer to the related link page or feel free to contact us.

"Metal complexes" exhibit a wide variety of properties, such as catalysts and dye sensitizers, depending on the combination of ligands and metals. Our company conducts commissioned synthesis, including various ligand synthesis and complexation. Additionally, the synthesized metal complexes can be analyzed using techniques such as NMR, XRD, and ICP-OES. [Features] ■ We perform commissioned synthesis that includes various ligand synthesis and complexation. ■ The synthesized metal complexes can also be analyzed using techniques like NMR. ■ We have dark rooms and multiple glove boxes, allowing synthesis under various conditions. *For more details, please refer to the related links page or feel free to contact us.

Our company provides "Process Research, Scale-Up Synthesis, and Manufacturing Services." In "Improvement of Synthesis and Manufacturing Routes," we conduct various studies aimed at improving the yield of existing routes, reducing costs, and enhancing productivity, and we propose improved routes based on medicinal chemistry routes. In "Scale-Up," we carry out syntheses on a scale of hundreds of grams to several kilograms based on laboratory synthesis results. We also develop manufacturing formulations for factory scale production based on laboratory synthesis achievements. 【Service Contents】 ■ Improvement of Synthesis and Manufacturing Routes ■ Scale-Up ■ Impurity Investigation ■ Process Development Support *For more details, please refer to the related link page or feel free to contact us.

In the drug discovery industry, there is a demand for the rapid provision of diverse compound libraries for lead exploration. To enhance the efficiency of candidate compound exploration, it is crucial to efficiently synthesize compounds with diverse structures and provide them for screening. Our compound library synthesis service offers a small number of samples derived from basic scaffolds in a multi-sample format, strongly supporting lead exploration in drug discovery research. Keywords: Combinatorial Chemistry, Compound Library, Multi-Sample Synthesis, Parallel Synthesis 【Usage Scenarios】 - Exploration of lead compounds - SAR (Structure-Activity Relationship) studies - Optimization of hit compounds 【Benefits of Implementation】 - Improved screening efficiency through the rapid provision of diverse compounds - Reduction of research duration - Discovery of optimal compounds for drug targets - Acquisition of reliable research data through the provision of high-quality compounds

In the development of new formulations in the pesticide industry, comprehensive and efficient screening of diverse compounds is key to success. The expansion of resistance to existing pesticides and the increasing demands for safety and environmental impact make the continuous creation of new modes of action and improved compounds essential. However, the synthesis of candidate compounds requires significant time and cost, necessitating the establishment of a more efficient research and development process. Our compound library synthesis service strongly supports the design, development, and optimization of candidate structures in pesticide (insecticides, fungicides, herbicides, etc.) research and development. 【Application Scenarios】 - Exploration of new pesticide candidate compounds (insecticides, fungicides, herbicides, etc.) - Structural development and improvement considerations for existing pesticide active ingredients - Design and evaluation of compound series with new modes of action - Library synthesis for SAR studies around candidate compounds 【Benefits of Implementation】 - Synthesis of diverse structural libraries with multiple samples in a short period - Reduction of research and development costs and man-hours by complementing in-house synthesis resources - Stable supply of high-quality compounds based on reproducible synthesis processes - Consistent synthesis support from the exploration stage to the optimization stage

In the automotive industry, the development of high-performance exhaust gas purification catalysts is required to comply with exhaust gas regulations. In particular, improving the durability of catalysts and achieving more efficient exhaust gas purification performance are crucial. Inadequate catalysts can make it difficult to meet exhaust gas regulations and may increase environmental impact. Our inorganic compound synthesis services support the development of high-performance exhaust gas purification catalysts through processes such as the preparation of ceramic precursors using the sol-gel method and firing treatments in various atmospheres. 【Application Scenarios】 - Development of exhaust gas purification catalysts - Manufacturing of automotive parts 【Benefits of Implementation】 - Improved exhaust gas purification performance - Compliance with environmental regulations

In the field of environmental catalyst development, there is a demand for both improved reaction efficiency and durability. In particular, high-performance catalysts are essential for exhaust gas purification and improving energy conversion efficiency. The synthesis technology of inorganic compounds precisely controls the composition and structure of catalysts to address these challenges. Our company supports customers' catalyst development through the preparation of ceramic precursors using the sol-gel method and various firing treatments in different atmospheres. 【Application Scenarios】 - Exhaust gas purification catalysts - Fuel cell catalysts - Photocatalysts 【Benefits of Implementation】 - Improved catalyst performance - Enhanced durability - Reduced development time

The battery industry is seeking the development of high-performance electrode materials. In particular, improving energy density and durability are important challenges. Appropriate material synthesis is a crucial factor that influences battery performance. Our inorganic compound synthesis services support the synthesis of electrode materials that meet our customers' needs. 【Application Scenarios】 - Electrode materials for lithium-ion batteries - Electrode materials for all-solid-state batteries - Electrode materials for next-generation batteries 【Benefits of Implementation】 - Improved performance of electrode materials - Extended battery lifespan - Increased energy density

In the field of regenerative medicine, the quality of materials that serve as scaffolds for cells greatly influences therapeutic effects. In particular, the biocompatibility of scaffold materials is crucial for promoting cell adhesion and proliferation. Glycans play an important role in cell recognition and signal transduction, and by introducing glycans into scaffold materials, it may be possible to enhance scaffold formation by cells and improve the efficiency of regenerative medicine. Our glycan synthesis technology supports problem-solving in regenerative medicine through glycan modification of scaffold materials. 【Application Scenarios】 - Glycan modification of scaffold materials - Cell culture - Tissue regeneration 【Effects of Implementation】 - Improved cell adhesion - Promotion of cell proliferation - Increased efficiency of tissue regeneration

In the drug discovery industry, it is important to understand the interactions with target molecules and design effective drugs in the development of new medications. Glycans play a crucial role in cell recognition and signal transduction, and they are also gaining attention as drug discovery targets. Glycan synthesis technology is essential to accelerate research on these targets. Our company conducts glycan and glycan derivative synthesis at various scales, from a few milligrams for research purposes to process development aimed at future commercialization. 【Application Scenarios】 - Research on glycans as drug discovery targets - Development of novel drugs based on glycans - Enhancement of drug functionality through glycan modification 【Effects of Implementation】 - Acceleration of drug discovery research - Expansion of possibilities for new drug development - Deepening understanding of target molecules

In the cosmetics industry, skin hydration is a crucial factor that influences customer satisfaction. The development of products for dry and sensitive skin requires high moisturizing effects and gentleness on the skin. Glycans are expected to be utilized as moisturizing ingredients due to their high biocompatibility and excellent water retention properties. Our company supports the development of moisturizing ingredients that meet customer demands using glycan synthesis technology. 【Application Scenarios】 - Development of highly moisturizing cosmetic ingredients - Development of cosmetics with minimal skin irritation - Exploration of new moisturizing ingredients 【Effects of Implementation】 - Realization of high value-added cosmetic development - Improvement of customer satisfaction - Differentiation from competitors