ナード研究所 Product Lineup

At Nerd Research Institute, we utilize the fine chemical synthesis technologies accumulated so far to offer contract synthesis and research of dendrimer raw materials (building blocks). By employing various polymerization methods, we provide novel hyperbranched polymers. Additionally, upon request, we can assist in creating dendrimers with new functionalities by combining building blocks into the core. Our company synthesizes new dendrimer raw materials and dendrimers to meet your needs. 【Features】 ■ Synthesis of new dendrimer raw materials and dendrimers ■ Utilization of fine chemical synthesis technologies ■ Acceptance of contract synthesis and research for dendrimer raw materials ■ Also conducting contract synthesis of relatively easier-to-synthesize hyperbranched polymers than dendrimers ■ Providing novel hyperbranched polymers by employing various polymerization methods *For more details, please refer to the related links page or feel free to contact us.

• Other polymer materials
• others

Polymer materials are utilized in various industries, and a wide variety of polymer materials are sold by many manufacturers. Nard Laboratory's "Contract Synthesis Service" has a track record of delivering over 50 types of custom polymer compounds annually. Our company has numerous synthesis achievements not only in general radical polymerization but also in anionic polymerization, cationic polymerization, and step-growth polymerization, with a significant number of successful syntheses of both random polymers and block polymers. [Features] - Implementation from investigation of synthesis methods - Ability to synthesize various types of resins by using different polymerization methods - Control of molecular weight and molecular weight distribution is possible by using living polymerization techniques - Capable of conducting not only polymerization but also modification reactions *For more details, please refer to the related link page or feel free to contact us.

• Other polymer materials
• others

We would like to introduce our synthesis technology for "metabolites and degradation products." In the fields of pharmaceuticals and pesticides, we carry out the synthesis of standard samples of metabolites, impurities, and degradation products necessary for overseas registration and other requirements. Additionally, in the case of compounds with unknown structures, we utilize analytical instruments such as LC-MS and NMR to perform structure analysis, determination, synthesis, analysis, and reporting. 【Features】 ■ Synthesis of standard samples of metabolites, impurities, and degradation products ■ Utilization of analytical instruments such as LC-MS and NMR for compounds with unknown structures ■ Execution of structure analysis, determination, synthesis, analysis, and reporting *For more details, please refer to the related link page or feel free to contact us.

• others

We synthesize nucleosides modified at the base or sugar parts using our accumulated organic synthesis technology, and deliver them as amides that can be immediately utilized in automated oligonucleotide synthesis devices. Additionally, we also support the phosphorylation of modified nucleosides and provide high-purity triphosphates, diphosphates, and monophosphates using advanced purification techniques. [Achievements] ■ Synthesis of non-natural nucleoside amides ■ Scale-up production of non-natural nucleoside amides ■ Synthesis of non-natural nucleotides *For more details, please refer to the related links page or feel free to contact us.

• others

Lipids include simple lipids such as acylglycerols and complex lipids such as phospholipids and glycolipids, and they are known to have various functions as important substances that constitute living organisms. On the other hand, in the field of drug delivery systems (DDS), lipid compounds are utilized with liposomes as transport carriers. Our company leverages synthetic and purification technologies to synthesize lipid compounds necessary for research and development of lipid molecules such as acylglycerols, phospholipids, and glycolipids, and provides the required samples. Furthermore, we also accommodate custom synthesis according to requests, including various fluorescent labeling, stable isotope labeling such as 2H and 13C, and PEG modification. 【Features】 ■ Synthesis of lipid compounds necessary for research and development, providing the required samples ■ Custom synthesis according to requests, including stable isotope labeling and PEG modification *For more details, please refer to the related link page or feel free to contact us.

• others

We custom synthesize peptides necessary for the development process. By providing the required samples, we contribute to the efficiency and speed of research and development. We synthesize various fluorescently labeled compounds, including stable isotopes such as D, 13C, and 15N, and propose the sites of isotope incorporation and synthesis pathways. Additionally, we provide small quantities of samples containing peptides derived from basic frameworks in multiple specimens. You can rely on us for everything from the design of the synthesis method to delivery. 【Features】 ■ Custom sample synthesis for research ■ Fluorescent and stable isotope labeling ■ Small quantity, multiple specimen synthesis ■ Research support - FTE contracts ■ Sample synthesis and purification using high-purity equipment *For more details, please refer to the related link page or feel free to contact us.

• others

Our company conducts the synthesis of glycan and glycan derivatives at various scales, from a few milligrams for research purposes to process development aimed at future commercialization. We can accommodate not only linear glycans but also the construction of complex branched glycans. We have a proven track record in the synthesis of glycan derivatives, regardless of whether they are natural or non-natural. Additionally, we support life science research through the modification of N-linked and O-linked glycans, as well as custom synthesis of glycoproteins. 【Features】 ■ Synthesis of glycans and glycan derivatives at various scales ■ Capability to construct complex branched glycans ■ Proven track record in the synthesis of glycan derivatives, both natural and non-natural ■ Support for life science research *For more details, please refer to the related link page or feel free to contact us.

• others

Our company has both batch and flow-type photoreaction devices, allowing us to carry out reactions using the most suitable methods. In the past, we have developed flow-type photoreactions for the synthesis of phenazines, achieving shorter reaction times and improved yields compared to batch methods. Based on these results, we propose improvements for effective synthesis by selecting appropriate techniques tailored to the characteristics of photoreactions. 【Features】 ■ Equipped with both batch and flow-type photoreaction devices ■ Capable of conducting reactions using suitable methods ■ Reduction in reaction time and improvement in yield compared to batch methods ■ Selection of appropriate techniques based on the characteristics of photoreactions ■ Proposals for improvements towards effective synthesis *For more details, please refer to the related links page or feel free to contact us.

• Other inspection equipment and devices
• Testing Equipment and Devices
• others

Microwaves are a type of electromagnetic wave, and when microwaves are irradiated, they are absorbed by a substance depending on its dielectric properties, causing the substance itself to heat up. This phenomenon is utilized as a new heat source for organic synthesis reactions. Due to the wide variety of applicable reactions, our company conducts various reactions using microwave synthesis equipment. **Effects of Microwaves** - Reduction of reaction time, suppression of side reactions, and improvement of yields are possible. - Since it acts directly on the substance, it allows for solvent-free reactions, uniform heating in solid-phase reactions, and promotes reactions. - The ability to conduct reactions at temperatures higher than the boiling point leads to effects such as improved solubility. - Microwave-specific effects such as positional selectivity, stereoselectivity, and high crystallization. *For more details, please refer to the related link page or feel free to contact us.*

• Other contract services

In recent years, we support continuous process development using microreactors and multi-stage continuous stirred-tank reactors (multi-stage CSTR) in the increasingly recognized field of flow synthesis. We can accommodate flash chemistry, avoidance of ultra-low temperature reactions, high-temperature reactions, high-pressure reactions, heterogeneous reactions, gas-liquid, solid-liquid, and gas-solid-liquid reactions, demonstrating effectiveness in precise reaction control, utilization of unstable intermediates, improved safety, and one-pot synthesis. Additionally, we can handle the difficult management of slurries and continuous crystallization in continuous processes. 【Features】 ■ Capable of accommodating flash chemistry (ultra-fast reactions), avoidance of ultra-low temperature reactions, high-temperature reactions, high-pressure reactions, heterogeneous reactions, gas-liquid, solid-liquid, and gas-solid-liquid reactions ■ Effective in precise reaction control, utilization of unstable intermediates, and improved safety ■ Able to handle the difficult management of slurries and continuous crystallization in continuous processes *For more details, please refer to the related link page or feel free to contact us.

• Other contract services
• Mixer/agitator

Our company has established a quality assurance system based on the international standard ISO 9001 for quality management systems. We also accommodate the production of small quantities and small lots of products. Additionally, we provide support for scaling up chemical manufacturing, offering comprehensive consulting services from process development to production management. 【Features】 ■ A quality assurance system based on the international standard ISO 9001 ■ Capable of producing small quantities and small lots ■ Support for scaling up chemical manufacturing ■ Comprehensive consulting services provided *For more details, please refer to the related link page or feel free to contact us.

• Other contract services
• ISO-related consultant

Our company provides "Process Research, Scale-Up Synthesis, and Manufacturing Services." In "Improvement of Synthesis and Manufacturing Routes," we conduct various studies aimed at improving the yield of existing routes, reducing costs, and enhancing productivity, and we propose improved routes based on medicinal chemistry routes. In "Scale-Up," we carry out syntheses on a scale of hundreds of grams to several kilograms based on laboratory synthesis results. We also develop manufacturing formulations for factory scale production based on laboratory synthesis achievements. 【Service Contents】 ■ Improvement of Synthesis and Manufacturing Routes ■ Scale-Up ■ Impurity Investigation ■ Process Development Support *For more details, please refer to the related link page or feel free to contact us.

• Other contract services

With the advancement of medicine and the aging population, there is a growing demand for improved health and quality of life, which is creating new needs for pharmaceutical development. Drugs that show effects in extremely small amounts can also pose a high risk of health hazards in the development and manufacturing processes. Our company has been operating containment facilities since April 2016 with the aim of safely and securely handling these substances. Leveraging our long-standing expertise in organic synthesis and this facility, we provide safe and secure contract synthesis and purification services for highly pharmacologically active compounds, contributing to the acceleration of development in this field. 【Facility Overview】 ■ Manufacturing Room: 17m² (2 Hazard Rooms) and DG Room / Pass Box ■ Containment Equipment: Hazard Room / Safety Cabinet / Draft Chamber ■ Static Pressure Management: -15Pa to -30Pa ■ Manufacturing Environment / External Environment: Class 100,000 HEPA performance / HEPA exhaust *For more details, please refer to the related link page or feel free to contact us.

• Other contract services

We provide a small number of samples derived from the basic framework for multiple specimens. Based on existing synthetic methods, we propose a process suitable for multi-specimen synthesis using our unique know-how, and we carry out everything from the design of the synthesis method to the execution of the reaction and purification consistently. Sample shipments are prepared in forms tailored to customer needs, and we deliver samples in a state ready for immediate use in the next tests. 【Features】 ■ Provision of a small number of samples derived from the basic framework for multiple specimens ■ Proposal of a process suitable for multi-specimen synthesis using our unique know-how ■ Consistent execution from the design of the synthesis method to the execution of the reaction and purification ■ Preparation of sample shipments in forms tailored to customer needs ■ Delivery of samples in a state ready for immediate use in the next tests *For more details, please refer to the related link page or feel free to contact us.

• Other contract services

At Nard Research Institute, we offer a "drug discovery support service" aimed at the creation of low molecular weight pharmaceuticals. Leveraging our strength in organic synthesis technology, we robustly drive the drug discovery cycle with the power of organic synthesis, supporting the creation of development candidate compounds. For inquiries from the compound design stage, our in-house medicinal chemistry experts will assist you. Additionally, we also support the examination of process routes for development candidate compounds and the scale-up synthesis of medium-scale samples. **Features** - Robustly drive the drug discovery cycle with the power of organic synthesis, supporting the creation of development candidate compounds. - Medicinal chemistry experts will assist with inquiries from the compound design stage. - Support for the examination of process routes for development candidate compounds and scale-up synthesis of medium-scale samples. - Capable of manufacturing medium-scale samples of highly pharmacologically active compounds. - In collaboration with Nard Chemicals, we can quickly respond to the manufacturing of clinical trial drugs under GMP standards. *For more details, please refer to the related link page or feel free to contact us.*

• Other contract services

In advancing research and development, acquiring high-quality molecules and materials that influence product performance is a very important factor. However, in today's society with advanced science and technology, the new development of these materials has become very complex and difficult, requiring high levels of specialized knowledge to achieve. At the Nard Research Institute, we have addressed this challenge as professionals in chemical synthesis, conducting research and development with many partners and sometimes independently. With the aspiration to provide better materials and products to society, we are committed to research and development at the molecular level, boldly challenging ourselves to contribute to the future development of industries. [Example of Research Forms] ■ Joint product development between companies ■ Collaborative research and development with academia ■ Seamless provision of materials at various stages of development *For more details, please refer to the related link page or feel free to contact us.

• Other contract services

Our company provides "Research Support (FTE) Services." We enter into contracts to allocate researchers and equipment for a specified period (from 1 month to 1 year) to advance your projects. Based on advanced technical capabilities, we propose solutions for projects and contribute to accelerating research and development. 【Service Flow】 ■ Confirmation of Request Details ■ Preparation of Project Plan ■ Implementation ■ Reporting *For more details, please refer to the related links page or feel free to contact us.

• Other contract services

Our service is a unique contract research system that combines experimental synthesis and theoretical calculations. By conducting "synthesis experiments" from Nard Institute and "theoretical calculations" from TS Technology in parallel, we can efficiently advance a wide range of research and development. We accelerate research and development by exchanging "new insights" and "proposals for reaction conditions" from theoretical calculations to synthesis experiments, and "experimental data to validate theoretical hypotheses" from synthesis experiments to theoretical calculations, while providing reliable experimental data and compounds backed by theoretical support. 【Features】 ■ Guaranteed maximum research results within a limited timeframe ■ Joint proposals from Nard Institute and TS Technology ■ Efficient advancement of a wide range of research and development ■ Confidentiality agreements established among the client and the three parties ■ In addition to compounds and reports, theoretical support related to synthesis and analysis is also available *For more details, please refer to the related link page or feel free to contact us.

• Other contract services

We propose a sublimation purification device that incorporates the experience and ideas of organic synthesis chemists. With precise temperature control, it is possible to produce high-purity organic compounds. Nard Laboratory assists in solving research and development challenges through contract synthesis, contract manufacturing, and contract research of chemical substances. We have a proven track record in a wide range of fields, including the research and development of pharmaceuticals, organic EL materials, organic semiconductors, and battery materials. 【Features】 ○ Achieves high yields through proprietary technology ○ Enables precise temperature control by optimizing heater structure ○ Maximizes prevention of thermal decomposition of substances by using high vacuum pumps For more details, please contact us or download the catalog.

• Other physicochemical equipment

At Nard Laboratory Co., Ltd., we offer a service for sublimation purification of organic compounds. We also provide optional services such as thermal analysis, HPLC purity analysis, and inorganic analysis. Additionally, we manufacture high-purity organic semiconductors with a purity of 99.9% or higher using our own sublimation purification equipment. We cater to everything from research sample sales to industrial production. We are also open to consultations regarding further purity enhancement and analysis. 【Sublimation Purification Technology】 - Train Sublimation - Sublimation under inert gas flow - High-temperature distillation - UV Cut For more details, please contact us or download our catalog.

• Other contract services

【Contract Organic Synthesis】 We provide a consistent contract service from research on the synthesis of organic materials to factory production, so we can accommodate any inquiries regarding the supply of organic materials. 【Contract Sublimation Purification】 Using high-performance vacuum pumps and our uniquely developed sublimation equipment, we accept contracts for the examination of sublimation of various organic compounds as well as large-scale sublimation of several hundred grams to several kilograms.

• Organic Natural Materials
• Other services