Day 3. Oligonucleotide Edition: The Cutting Edge of Biopharmaceutical Analysis - From Basics to Applications by Modality -

Explanation of the measurement of nitrosamine impurities using the high-resolution "Agilent 6546 LC/Q-TOF"!

Angiotensin II receptor blockers (ARBs) are widely used in the treatment of hypertension and heart failure. Recently, it has been found that some ARBs contain carcinogenic nitrosamine impurities, resulting in the recall of many products. Consequently, there is a demand for analytical methods capable of detecting these problematic nitrosamine impurities. This application note describes a high-sensitivity and high-resolution LC/MS/MS method using the "Agilent 6546 LC/Q-TOF" for the detection and quantification of six types of nitrosamines specified by the US FDA, as well as a simultaneous detection method for eleven types of nitrosamine impurities. [Contents] ■ Introduction ■ Experimental Methods ■ Results and Discussion ■ Conclusion ■ References ■ Acknowledgments *For more details, please refer to the PDF document or feel free to contact us.

• Analytical Equipment and Devices

Reliable detection and quantification of nitrosamines and mutagenic impurities.

Due to the presence of unacceptable levels of mutagenic nitrosamine impurities, several pharmaceuticals have recently been recalled. To accurately detect and quantify trace amounts of mutagenic impurities in pharmaceuticals, Agilent offers relevant GC/MS, LC/MS, and high-throughput MS-based analytical techniques. <Challenges in Nitrosamine Analysis> 1. Introducing mass spectrometers requires meeting regulatory requirements, which can be cumbersome. 2. There are many target substances, making it difficult to choose which method/device to use for GC/MS or LC/MS. 3. Due to the high cost of the equipment, results that justify the expense are expected (in terms of cost, operation, speed from introduction to startup, and decisions on outsourcing). 4. It is challenging to foresee whether the risk assessment can be completed by the deadline. <Solutions for Nitrosamine Analysis> Agilent's application guide provides various validated methods from sample preparation to measurement analysis, enabling quick setup and support from introduction to operation. Additionally, regulatory compliance, including data integrity, is achievable.

• Chemicals
• Testing Equipment and Devices
• Analytical Equipment and Devices

A customized LC system that can accommodate all applications, from routine analysis to solutions for specialized workflows.

The "Agilent InfinityLab LC Series" is a high-performance (U)HPLC that expands the possibilities of analysis. We provide customized high-speed and ultra-high-speed LC systems that can accommodate all applications, from routine analysis to solutions for specialized workflows. Our preparative scale HPLC systems achieve high-purity sample purification and excellent recovery rates. We offer LC solutions that cover various fields, achieving excellent chromatography performance while keeping costs down. Since technology is shared across the entire series, we can also respond to changes in application needs. 【Features】 ○ Covers various fields ○ Low cost ○ Achieves excellent chromatography performance ○ Technology shared across the entire series ○ Responds to changes in application needs For more details, please contact us or download the catalog.

• Separation device

Smart software that notifies you when it's time to replace or inspect consumables for analysis machines!

"CrossLab Smart Alerts" is software that monitors the usage of equipment and notifies you via email when it's time to replace consumables or perform inspections. You can receive alerts for all equipment in the lab consolidated into a single email. This provides benefits such as reducing downtime and maintaining the operational status of the equipment. It can be easily installed on various PCs within the lab, and there is no need to connect to the internet. 【Features】 ■ Notifies you when it's time to replace consumables or perform inspections on analytical equipment ■ Useful for preventive maintenance ■ Benefits such as reducing downtime and maintaining the operational status of equipment ■ Easily installable on various PCs within the lab ■ No need to connect to the internet *For more details, please refer to the PDF document or feel free to contact us.

• Software (middle, driver, security, etc.)

Support for the maintenance and operation of laboratory equipment.

To maintain the productivity and efficiency of the lab at its highest level, it is essential to uphold the performance and consistent operation of the equipment. Agilent's service engineers possess the reliable skills, qualifications, and experience to provide repair and maintenance services for all types of equipment, regardless of the manufacturer. It is Agilent, with its industry-leading advanced expertise in chromatography instruments, mass spectrometers, and spectroscopic analyzers, that can meet all of our customers' needs.

• Other measurement, recording and measuring instruments

Advantech Toyo will be exhibiting at the trade show "JASIS 2026," which will be held at Makuhari Messe International Exhibition Hall. At this exhibition, manufacturers of analytical and scientific instruments will gather to showcase cutting-edge scientific and analytical systems and solutions. At our booth, we will display filter products for microbiological testing and environmental analysis, water quality testing products, pure and ultra-pure water production equipment, and culture-related equipment. Additionally, we will also showcase analytical balances from Mettler Toledo, along with equipment from other well-regarded manufacturers in the industry. Our sales and technical staff will be available to assist with product selection, so please feel free to stop by!

[Speakers] Nomura Research Institute, Ltd. Global Manufacturing Consulting Department Group Manager Hirokazu Shimo Senior Consultant Shoki Tokugawa Senior Consultant Wataru Hashimoto Consultant Masaaki Amano Consultant Tomoya Nakamura [Presentation Items] 1. Key Development Themes of Major OEMs 2. Development Approaches of Each OEM 2-1. Toyota 2-2. Tesla 2-3. Suzuki 2-4. Nissan 2-5. Honda 3. Development Approaches of Suppliers 4. Key Points for Strengthening Development Capabilities 5. Q&A / Business Card Exchange

[Speaker] Ayaka Motomura, Consultant, Business Transformation Unit, NTT Data Management Research Institute [Key Lecture Content] With the advancement of Physical AI, telecommunications carriers have the opportunity to evolve from being "companies that provide lines" to companies that connect and control AI and the physical world in real-time. This seminar will organize the changes in communication demand brought about by Physical AI and the business opportunities for telecommunications carriers, while explaining the role of AIOps as the first step towards entry. Furthermore, it will discuss strategies for monetizing in the Physical AI market by deploying the operational intelligence accumulated through AIOps to network APIs and industry-specific services, as well as the layers that telecommunications carriers should hold. [Lecture Topics] Chapter 1: The Competitive Structure of the "Real World" Rewritten by Physical AI Chapter 2: Reasons Why Opportunities for "Reversal" Arise for Telecommunications Carriers in the Era of Physical AI Chapter 3: The First Step Towards Physical AI Chapter 4: Shifting AIOps from "Defense" to "Offense" Chapter 5: The Layers to Hold in the Era of Physical AI [Q&A / Business Card Exchange]

[Instructor] Partner Ryoji Mori, Eichi Law Office [Key Lecture Content] This lecture will explain the revised Personal Information Protection Act of 2028. The three-year review this time is a major revision, and it is essential to first understand where and how the revisions have been made, as well as the overall picture of the amendments. Next, we will explain the individual amendments that are practically important. The key points are as follows, but it is important to note that both the strengthening and relaxation of obligations are occurring simultaneously, increasing overall complexity. At the time of the lecture, it is expected that subordinate laws and guidelines will not yet be published, but we will discuss points that require attention upon publication. We will distinguish between what is necessary across businesses and what varies by industry. [Lecture Items] 1. Expansion of consent exceptions: Relaxation of the difficulty of obtaining consent and expansion of academic research institutions 2. Statistical exceptions: System content and how to read complex provisions (plus learning about acceptability from controversies) 3. Strengthening regulations on biometric information and children's information: Caution required for age verification 4. Contactable personal-related information: Changes in external transmission responses 5. Review of outsourcing regulations: Addition and removal of obligations for contractors 6. Administrative fines: Narrow target range and low amounts (not worth fearing) 7. Q&A / Business card exchange

[Instructor] Innovation Analyst Andy Kondo [Key Lecture Content] *The latest content will be added (changed) as appropriate based on the on-site survey of IAA Transportation 2026.* From September 15 to 20, 2026, the largest commercial vehicle exhibition in Europe, IAA Transportation, will be held in Hanover, Germany. It is a gathering place for manufacturers of commercial vehicles such as trucks and buses, as well as the parts, energy, and software that support them, occurring every two years. The cost structure of logistics, urban transportation and the environment, energy transition, decarbonization efforts, and a microcosm of the industry will reveal the future business environment just a step ahead. In this seminar, an innovation analyst who has been observing major global exhibitions such as CES and Hannover Messe for many years will report shortly after the event based on on-site coverage. Has autonomous driving become the main focus in commercial vehicles? Where is the energy transition for large vehicles settling in terms of batteries, hydrogen, and alternative fuels? How far have Chinese companies come? Based on photos taken at the venue and observations of actual products, the seminar will delve into the implications for Japanese companies.