Day 3. Oligonucleotide Edition: The Cutting Edge of Biopharmaceutical Analysis - From Basics to Applications by Modality -

Explanation of the measurement of nitrosamine impurities using the high-resolution "Agilent 6546 LC/Q-TOF"!

Angiotensin II receptor blockers (ARBs) are widely used in the treatment of hypertension and heart failure. Recently, it has been found that some ARBs contain carcinogenic nitrosamine impurities, resulting in the recall of many products. Consequently, there is a demand for analytical methods capable of detecting these problematic nitrosamine impurities. This application note describes a high-sensitivity and high-resolution LC/MS/MS method using the "Agilent 6546 LC/Q-TOF" for the detection and quantification of six types of nitrosamines specified by the US FDA, as well as a simultaneous detection method for eleven types of nitrosamine impurities. [Contents] ■ Introduction ■ Experimental Methods ■ Results and Discussion ■ Conclusion ■ References ■ Acknowledgments *For more details, please refer to the PDF document or feel free to contact us.

• Analytical Equipment and Devices

Reliable detection and quantification of nitrosamines and mutagenic impurities.

Due to the presence of unacceptable levels of mutagenic nitrosamine impurities, several pharmaceuticals have recently been recalled. To accurately detect and quantify trace amounts of mutagenic impurities in pharmaceuticals, Agilent offers relevant GC/MS, LC/MS, and high-throughput MS-based analytical techniques. <Challenges in Nitrosamine Analysis> 1. Introducing mass spectrometers requires meeting regulatory requirements, which can be cumbersome. 2. There are many target substances, making it difficult to choose which method/device to use for GC/MS or LC/MS. 3. Due to the high cost of the equipment, results that justify the expense are expected (in terms of cost, operation, speed from introduction to startup, and decisions on outsourcing). 4. It is challenging to foresee whether the risk assessment can be completed by the deadline. <Solutions for Nitrosamine Analysis> Agilent's application guide provides various validated methods from sample preparation to measurement analysis, enabling quick setup and support from introduction to operation. Additionally, regulatory compliance, including data integrity, is achievable.

• Chemicals
• Testing Equipment and Devices
• Analytical Equipment and Devices

A customized LC system that can accommodate all applications, from routine analysis to solutions for specialized workflows.

The "Agilent InfinityLab LC Series" is a high-performance (U)HPLC that expands the possibilities of analysis. We provide customized high-speed and ultra-high-speed LC systems that can accommodate all applications, from routine analysis to solutions for specialized workflows. Our preparative scale HPLC systems achieve high-purity sample purification and excellent recovery rates. We offer LC solutions that cover various fields, achieving excellent chromatography performance while keeping costs down. Since technology is shared across the entire series, we can also respond to changes in application needs. 【Features】 ○ Covers various fields ○ Low cost ○ Achieves excellent chromatography performance ○ Technology shared across the entire series ○ Responds to changes in application needs For more details, please contact us or download the catalog.

• Separation device

Smart software that notifies you when it's time to replace or inspect consumables for analysis machines!

"CrossLab Smart Alerts" is software that monitors the usage of equipment and notifies you via email when it's time to replace consumables or perform inspections. You can receive alerts for all equipment in the lab consolidated into a single email. This provides benefits such as reducing downtime and maintaining the operational status of the equipment. It can be easily installed on various PCs within the lab, and there is no need to connect to the internet. 【Features】 ■ Notifies you when it's time to replace consumables or perform inspections on analytical equipment ■ Useful for preventive maintenance ■ Benefits such as reducing downtime and maintaining the operational status of equipment ■ Easily installable on various PCs within the lab ■ No need to connect to the internet *For more details, please refer to the PDF document or feel free to contact us.

• Software (middle, driver, security, etc.)

Support for the maintenance and operation of laboratory equipment.

To maintain the productivity and efficiency of the lab at its highest level, it is essential to uphold the performance and consistent operation of the equipment. Agilent's service engineers possess the reliable skills, qualifications, and experience to provide repair and maintenance services for all types of equipment, regardless of the manufacturer. It is Agilent, with its industry-leading advanced expertise in chromatography instruments, mass spectrometers, and spectroscopic analyzers, that can meet all of our customers' needs.

• Other measurement, recording and measuring instruments

We will be exhibiting from Wednesday, October 1 to Friday, October 3, 2025. Makuhari Messe https://www.jagri-global.jp/hub/ja-jp/visit/feature-t/plant.html Please stop by!

To construction and civil engineering companies looking for the "next" step in digitalization. This seminar will explain the currently trending topic of "AI utilization" in 45 minutes. We will clearly introduce the latest trends, specific case studies, and steps for implementation to address questions such as "What can AI do?" and "How can it be applied to our business?" Whether your company is already advancing in DX or is just starting to consider AI, you will find hints for improving operational efficiency. 【Schedule】 1: Company introduction and instructor introduction 2: Case studies of AI utilization in the construction and civil engineering industry 3: Convincing examples! Patterns of AI utilization in construction operations 4: Three steps to avoid failure in AI implementation 5: Q&A and closing remarks

We will address the issue of young employees who, despite joining the company, leave due to reasons such as "there's no time to be taught," "I don't understand when I'm told to learn by watching," and "what is written and said varies depending on the project or person in charge." We propose a system that accumulates the know-how of veterans in AI and systems, allowing young employees to search for and solve problems on their own. 【Schedule】 1: Company introduction and instructor introduction 2: Reasons why technical inheritance is not progressing (lack of time, difficulty in verbalizing) 3: "Next-generation manual and know-how sharing methods" utilizing video and AI search 4: Examples of system construction to institutionalize technical inheritance 5: Q&A and closing remarks

We are pleased to announce that our company will be exhibiting at TECHNO-FRONTIER 2026, which will be held at Tokyo Big Sight from July 15 to 17, 2026. As an import trading company dealing with components such as transformers and DC/DC converters, we take pride in our wide range of product offerings. Each of these products is a high-quality device designed for specific applications, utilized in areas such as improving power supply efficiency and miniaturization. At our exhibition booth, you will be able to see these products in person, and we will provide detailed information about their performance and applications. We sincerely look forward to welcoming those interested in the miniaturization of power supplies.

We are pleased to announce that our company will be exhibiting at the 13th Occupational Safety and Health Exhibition, which will be held at Tokyo Big Sight from July 15 to 17, 2026. At our exhibition space, we will showcase safety products such as LED line lights, shock detection labels (Shock Watch), temperature management indicators, and industrial belt partitions. At our booth, you will have the opportunity to see these products in person and learn more about their performance and applications. We sincerely look forward to your visit.