CPhI Japan Exhibition & Seminar!

Quality assessment of proteins, nucleic acids, AAV, LNP, etc. is possible with trace amounts and high throughput.

"Stunner" is a product that allows simultaneous acquisition of UV/Vis concentration, dynamic light scattering (DLS), and static light scattering (SLS) data from a 2μL identical sample. It enables detailed investigation of AAV and adenoviruses to measure total capsid titer and Empty/Full ratios, as well as to obtain payload concentration and size data of lipid nanoparticles all at once. You can analyze concentration, hydrodynamic size, polydispersity, and the presence of aggregates collectively, allowing you to assess the quality of proteins. This way, you can immediately determine whether your AAV, adenoviruses, lipid nanoparticles, or proteins are suitable for your purposes. [Features] ■ Measure up to 96 samples in a batch in 60 minutes*/12 minutes** *When measured by DLS **When measured by UV/Vis only [Applications] ■ AAV/Adenovirus capsid titer ■ AAV/Adenovirus Empty/Full ratio ■ Lipid nanoparticle (LNP) payload amount ■ Aggregate measurement ■ Concentration measurement ■ Sizing & polydispersity ■ B22 & kD *For more details, please refer to the PDF document or feel free to contact us.

• Other protein analysis

Simultaneous measurement of 12 applications such as thermal stability, sizing, and viscosity from trace samples.

"Uncle" is a product that allows for the acquisition of more data with a small amount of protein. The required sample volume is only 9μL. By combining three different measurement modes—fluorescence, SLS, and DLS—it is easy to evaluate the optimal formulation and the stability of proteins or viral vectors. 【Features】 ■ Measure up to 48 samples in as little as about 2 hours with just 9μL. 【Applications】 ■ Tm & Tagg ■ Tm via SYPRO DSF ■ Isothermal stability ■ Sizing and polydispersity ■ Sizing via thermal gradient ■ Refolding measurements ■ Viscosity ■ kD ■ B22 ■ G22 ■ ΔG ■ Stability of viral capsids *For more details, please refer to the PDF document or feel free to contact us.

• Other protein analysis

No complicated workflows needed! Only 2μL of sample volume required. Measure up to 96 samples in just 5 minutes.

"Lunatic" is a product that allows for easy simultaneous quantification of proteins, DNA, and RNA. The required sample volume is only 2μL, and up to 96 samples can be measured in 5 minutes. High-concentration samples can also be measured directly without dilution. 【Features】 ■ Measure 2μL, up to 96 samples in 5 minutes ■ Dynamic range coverage from 0.02 to 200 mg/mL* *for mAb ■ Outstanding accuracy and precision ■ Automation is also possible *For more details, please refer to the PDF document or feel free to contact us.

• Analytical Equipment
• Other protein analysis
• Other measurement and measuring equipment

Up to 8 samples can be processed simultaneously! Automatic and hassle-free buffer exchange and concentration that used to be complicated!

Buffer exchange and concentration must be performed as a sample preprocessing step. This is a labor-intensive task that takes a long time, requiring your presence throughout the process. "UNAGI" is a fully hands-free benchtop buffer exchange solution designed to take over this tedious task. It can process up to 8 samples simultaneously. The software is very easy to operate, allowing you to be anywhere during the work, eliminating the need to stay in the laboratory the entire time. 【Features】 ■ Simultaneous processing of up to 8 samples ■ Efficient solvent removal prevents sample adsorption, achieving over 96% recovery rate ■ Built-in recipes for UF/DF buffer exchange ■ User-friendly software ■ Concentrates up to 8 diluted samples from 48mL to 8mL in one go *For more details, please refer to the PDF document or feel free to contact us.

• Other Protein Research Software
• DNA analysis

[Video Available] Are you spending a lot of time and effort on buffer exchange and concentration work? You can streamline the sample preprocessing steps with this device.

Buffer exchange and concentration must be performed as a pre-treatment of the sample, which is a time-consuming task. This process takes a long time, and you have to be present the entire time. "UNAGI" is a fully hands-free benchtop buffer exchange solution designed to perform this tedious task for you. You can be anywhere during the process, eliminating the need to stay in the laboratory the whole time. 【Features】 ■ Simultaneous processing of up to 8 samples ■ Efficient solvent removal to prevent sample adsorption, achieving over 96% recovery rate ■ Built-in recipes for UF/DF buffer exchange ■ User-friendly software ■ Concentration of up to 8 diluted samples from 48mL to 8mL in one go *For more details, please refer to the PDF document or feel free to contact us.

• Other Protein Research Software
• Other filtration and separation equipment

Significantly reduces the effort and time spent on buffer exchange and concentration.

"BIGTUNA" is a high-throughput fully automated buffer exchange and concentration device that can automate buffer exchange with a setup time of just 30 minutes, accommodating a wide range of sample numbers and volumes. We offer two types of plate-based filters that can simultaneously exchange and concentrate 24 or 96 samples. With easy setup, you can have better control over your experiments and significantly reduce manual labor time. You can step away from the tedious task of buffer exchange and use the extra time for what you truly want to do. 【Features】 ■ Free yourself from manual buffer exchange ■ Accommodates a wide range of sample numbers and volumes ■ Processes at an optimal buffer exchange rate ■ Automatically concentrates from 48mL to 8mL ■ Easy condition settings *For more details, please refer to the PDF document or feel free to contact us.

• Other concentrating equipment

Efficient mass production of LNPs - Supporting everything from small-scale condition testing to scale-up.

Once we succeed in finding the optimal formulation conditions for sunscreen, let's use Sunshine to adjust the size of the LNP. Furthermore, we will optimize the protocols and processes for scaling up. We will find the ideal flow rate and explore different mixing options. Next, we will adjust these to the appropriate dilution factor that can keep them stable. Once everything is in place, Sunshine will transition to continuous mode, allowing us to produce several dozen liters in a day. In other words, we will achieve process development and scaling up on a single platform. Many researchers have likely been looking forward to the birth of such a groundbreaking system. • 10 experiments in 15 minutes • Fraction & total flow • From 1 mL to continuous flow • Flow rate 0.1 to 30 mL/min • Reusable microfluidic chips • Possible transition of protocols from sunscreen

• Other Physics and Chemistry Equipment

Accelerating formulation optimization for vaccine and pharmaceutical development.

To create the optimal LNP, it takes a tremendous amount of time and effort to examine and pursue formulation conditions. LNPs are nanoparticles composed of multiple lipids. Therefore, it is necessary to find the optimal conditions such as the mixing ratios, the ratio of lipids to payload, and the flow rates during mixing. Furthermore, we must also consider throughput issues. Sunscreen can produce up to 96 types of small LNPs within six hours, thus solving the previous throughput problems. This means that it is possible to explore a greater number of formulation condition investigations in a single day. • Fully automated execution of up to 96 types of condition investigations within six hours • 200 μL to 2 mL per experiment • Flow rate of 0.1 to 30 mL/min • Reusable microfluidic chips • Seamless scale-up through process and protocol optimization

• Other Physics and Chemistry Equipment

Introducing the details of the newly launched LNP production and screening device.

Researchers of lipid nanoparticles (LNPs) spend a tremendous amount of time on screening, optimization, and scaling up experiments to achieve optimal performance, spot-on targeting, and controlled release of active pharmaceutical ingredients (APIs). Factors such as solubility, pH stability, payload release, and encapsulation all depend on particle size, shape, and structure. In other words, to obtain the right formulation, it is necessary to explore a vast number of formulation parameters and process parameters one by one, and even if a perfect formulation is found, scaling up usually means switching equipment and re-optimizing settings. In this webinar, we will introduce a platform, Sunny Suite, that can reduce the time spent on these LNP formulations. ■ Date and Time: February 26 (Monday) 14:00~ ■ Speaker: Yuji Senoo, Field Application Scientist, Unchained Labs, Inc. ■ Register here: https://unchainedlabs.zoom.us/webinar/register/3217065146675/WN_U1o3xQoZRAKHN-A-7b1yqg

• Other protein analysis

It enables the monitoring of potency and purity throughout the entire workflow of lentivirus research and development, accelerating gene therapy development.

"Leprechaun" is a system that analyzes whether lentivirus particles are of the correct size and structure, and can measure viral titer. It allows for the determination of the titer of lentivirus present in a sample without being misled by confusing noise (such as incomplete viruses or contamination). Not only can it measure information that was previously only obtainable separately through conventional methods like ELISA, qPCR, and transduction assays, but it also enables structural analysis that those methods could not provide, all on a single platform. Capabilities: ■ Lentivirus titer ■ Lentivirus structure ■ Exosome concentration ■ Analysis of contamination (impurities such as extracellular vesicles) Features: ■ No sample purification required ■ Physical structural analysis possible ■ Distinction between virus integrity and impurities ■ Up to 16 samples can be measured at once *For more details, please refer to the PDF document or feel free to contact us.

• Other measurement and measuring equipment

You can measure 10 samples at once! There's no need to clean expensive chips that are prone to clogging!

"Honeybun" is a high-speed viscometer that can output data almost simultaneously with processing. Regardless of whether the number of samples is 1 or 10, it uses a few microliters of each sample through a microchannel and reads viscosities in the range of 0.5-150 cP within a few minutes. No pre-treatment or cleanup of samples is necessary. 【Features】 ■ Can measure up to 10 samples at once ■ Required sample volume: 35μL (can measure from 15μL; see application notes) ■ Measurement completed in under 1 minute (for viscosities below 10 cP) ■ Measurement range: 0.5-150 cP ■ No cleaning required and maintenance-free *For more details, please refer to the PDF document or feel free to contact us.

• Other bio-related products

[Exhibition Display] Demonstration of pineapple adhesion dynamics using collaborative robots Dynamic display using collaborative robots and tool changers for gripping Static display of a 5kg dual-sided gripper Comparison of ejector compressed air consumption Various suction pads Foam gripper, etc. We recommend visiting on the first or second day when you can view the exhibits with relative ease. *The third day (Friday) is expected to be very crowded. 【Gripper Sale Event】 We will be selling the following two products at a discounted price at the exhibition booth. Please inquire about the special prices at the venue. ■ 'KENOS Gripper KVGL.400.100, N214.FR6.S2' URL: https://www.youtube.com/watch?v=HsNRwrDtjW0 ■ 'Collaborative Robot Hand KCS.Q110.N301.110.FR6.SX422.V1.X.X' URL: https://www.youtube.com/watch?v=GFKg3blZzdQ These products are ideal not only for actual applications but also for use as test machines. How about taking this opportunity?

Watanabe Trading Company will be exhibiting at "SEMICON Japan 2025" in collaboration with its group companies, Amaya Manufacturing, Wacom Manufacturing, and Tomco. At our booth, we will introduce quartz chambers, silicone rubber, surface modification processing, and the AI visual inspection device "NulMiL," among others. We look forward to your visit.

[Speaker] Masato Kimura, International Journalist in London [Key Lecture Content] The 30th Conference of the Parties to the United Nations Framework Convention on Climate Change (COP30) was held in Belém, Pará, Brazil, at the mouth of the Amazon River. The much-anticipated roadmap for phasing out fossil fuels revealed deep divisions, with the only significant outcome being the tripling of adaptation funding to \$120 billion per year. Moreover, the deadline was pushed back from 2030 to 2035, becoming merely a target. The lack of leadership from Brazil, the host country prioritizing the image of being "the leader of the Amazon," the absence of the United States, Europe's financial struggles, and China's prioritization of its own interests have all contributed to these divisions. Amid escalating North-South conflicts between developed and developing countries, the United Nations' multilateralism is becoming dysfunctional. [Lecture Items] 1. The venue, Belém 2. The emerging divisions 3. The absence of the United States - Big tech and fossil fuel companies are expanding data centers across the U.S. 4. The increasing presence of China - New energy ecosystems: solar power, storage, hydrogen 5. Japan becoming a regular recipient of the Fossil Award - CCS (carbon capture and storage), co-firing of hydrogen and ammonia 6. The rebellion of indigenous peoples 7. Q&A

[Speaker] Mizuho Research & Technologies Co., Ltd. Manager Takahiro Kirihara, Sustainability Consulting Division 1 [Key Lecture Content] In February 2025, the "GX2040 Vision" was announced. Recent domestic GX policies have primarily focused on supporting the supply of GX products, as exemplified by the GX Promotion Act and GX Transition Bonds. However, this vision emphasizes the need for demand stimulation measures for companies on the purchasing side, considering the current challenges in achieving carbon neutrality solely through market principles. As measures aimed at creating a GX market are planned for the future, we will examine the responses that companies should undertake to capture the anticipated expansion of the GX market. [Lecture Items] 1. Overview of domestic GX policies and the positioning of "visualization of GHG emissions" within GX policies 2. Overview of overseas policies related to "visualization of GHG emissions" 3. Recent trends in the visualization of GHG emissions 3.1 Movements regarding inter-company data collaboration in GHG emissions calculation 3.2 New indicators for GHG emissions; reduction performance 4. Responses that companies should undertake 5. Q&A / Business card exchange

[Speaker] Takuki Abe, President and CEO of CINCA Inc. [Key Lecture Content] "I can't find the seeds for new business." "I'm making no progress in launching new businesses haphazardly." This challenge faced by many companies is largely due to the know-how relying on individual experiences and not being established within the company as a reproducible "model." CINCA specializes in the 0→1 of new business development and has established reproducible launch know-how through its experiences. In this lecture, Takuki Abe, the author of "The Ultimate Practical 0→1 Strategy Guide for Successful New Business Development," will present practical techniques for conducting reproducible business validation using generative AI. If you are struggling with launching new businesses, please join us. [Lecture Items] 1. Overview of new business 2. How to generate high-probability business ideas 3. Practical implementation of problem discovery and value validation interviews 4. Q&A