*Application Closed* July Online LIVE Seminar Held! ~Protein Analysis~

Provides high reliability! An excellent tool for measuring a wide range of molecular interactions.

The Isothermal Titration Calorimeter (ITC) is a device that detects the heat changes associated with titration at a constant temperature and is primarily used for analyzing molecular interactions. It measures the minute heat changes that occur when molecules bind to each other, allowing for the determination of binding ratio (n), binding constant (Ka), and the enthalpy change of binding (ΔH) from the resulting titration curve. Affinity ITC is an isothermal titration calorimeter that provides high sensitivity, high reproducibility, and advanced ITC technology in life science research environments. With AccuShot technology, it delivers precise amounts of titrant to the appropriate location, and the FlexSpin stirring function achieves efficient mixing and high sensitivity. The automatic cleaning function prevents contamination between samples. It offers the option of standard capacity (1.0 mL) or low capacity cells (190 µL), and a temperature-controlled auto-sampler for 96 wells is also available.

• Analytical Equipment and Devices

A differential scanning calorimeter specialized for studying biological samples. It offers the highest sensitivity and excellent operability.

TA Instruments continues to be the leading company in the world of DSC with innovative and outstanding technology. It provides reliable data and enhances workflow and productivity in laboratories. The Nano DSC is a differential scanning calorimeter (DSC) that can detect minute heat changes associated with the conformational changes of biomolecules. Characterization of materials is essential at all stages of product design, manufacturing, processing, and application. Differential scanning calorimeters/nano DSCs are the most widely used thermal analysis instruments for the physical property evaluation of a broad range of materials, including polymers, pharmaceuticals, food, biomaterials, organic compounds, inorganic compounds, and composites.

• Analytical Equipment and Devices

For the evaluation of reactions of various substances.

TAM offers the highest level of sensitivity, flexibility, and performance. By using a highly sensitive microcalorimeter along with various accessories, it precisely controls various experimental conditions. Up to four calorimeters can be used simultaneously, allowing for repeated experiments and a variety of experiments to be conducted. Additionally, its modular design allows for the addition of multiple calorimeters, enhancing sample processing capacity and functionality. Adding a multi-calorimeter with six mini-calorimeters significantly improves sample throughput. The TAM 4 employs patented thermostat technology, controlling the temperature of the liquid constant temperature bath with an accuracy of 0.0001±730°C. There are three operating modes: isothermal, step isothermal, and temperature scanning mode.

• Analytical Equipment and Devices

How about one for the lab? Introducing the Discovery DSC series, the world's most outstanding and highly versatile differential scanning calorimeter.

TA Instruments continues to be the leading company in the world of DSC with innovative and outstanding technology. It provides reliable data and enhances workflow and productivity in laboratories. Material property analysis is essential at all stages of product design, manufacturing, processing, and application. Differential Scanning Calorimetry (DSC) is the most widely used thermal analysis instrument for evaluating the physical properties of a wide range of materials, including polymers, pharmaceuticals, food, biomaterials, organic compounds, inorganic compounds, and composites.

• Analytical Equipment and Devices

World leader in thermal analysis, calorimetry, and rheology / Comprehensive catalog of TA Instruments.

◆TA Instrument Handled Products◆ ■Thermal Analysis Equipment Differential Scanning Calorimeter Discovery DSC Thermogravimetric Analyzer Discovery TGA Differential Scanning Calorimeter DSC Thermogravimetric Analyzer TGA Vapor Adsorption/Desorption Measurement Device VTI-SA+ Simultaneous Differential Thermal and Thermogravimetric Analyzer SDT Thermomechanical Analyzer TMA Dynamic Mechanical Analyzer DMA ■Thermal Property Measurement Equipment Laser Flash Method Thermal Property Measurement Device DLF Xenon Flash Method Thermal Property Measurement Device DXF Thermal Conductivity Measurement Device DTC FOX Thermal Expansion Measurement Device DIL ODLT, ODHT P11 Heating Microscope HSM, HSML Fleximeter FLEX ■Viscoelasticity Measurement Equipment DHR ARES-G2 RSA-G2 Air Chiller System ACS-3 Rubber Testing Machine ■Microcalorimeters Isothermal Titration Calorimeter Nano ITC, Affinity ITC Differential Scanning Calorimeter Nano DSC Multi-Cell Differential Scanning Calorimeter MC DSC Isothermal Calorimeter TAM ●For other functions and details, please download the catalog or contact us.

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This is the lecture material posted on YouTube ~DSC Basic Edition 1~. It is available for free download, so please feel free to make use of it.

Data Content This is a PDF version of the lecture materials from YouTube, converted for easier viewing. The video consists of a total of 12 pages and provides an easy-to-understand explanation for beginners about: - Principles - Analytical methods - Enthalpy relaxation (recovery) I think it might be difficult to understand with just the lecture materials, so please also refer to the YouTube videos below. YouTube TA Summary Site: https://www.youtube.com/channel/UCk3XzqRdsNQz1hJlqKrfujQ DSC Basics Part 1: https://www.youtube.com/watch?v=DbGpordpweg

• Analytical Equipment and Devices

This is the lecture material posted on YouTube ~Rheology: Basic Edition 1~. It is available for free download, so please feel free to make use of it.

Data Content This is a PDF version of the lecture materials from YouTube, converted for better readability. The video consists of a total of 12 pages and provides easy-to-understand explanations for beginners on the following topics: - What is rheology? - What is viscoelasticity? - About measurement modes. I think it might be difficult to understand just from the lecture materials, so please also refer to the YouTube videos below. YouTube TA Summary Site: https://www.youtube.com/channel/UCk3XzqRdsNQz1hJlqKrfujQ Rheology Basics Part 1: https://www.youtube.com/watch?v=_gPrWIK6yYo&t=4s

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This is an introduction to case studies related to cells by a specialist in analysis. This time, we will present measurement examples using thermal analysis equipment that is useful for evaluations involving cells.

Measurement capabilities offered by TA Instruments ☆ Thermal analysis / glass transition, crystallization, thermogravimetric analysis, curing reactions, expansion rate, thermal conductivity, shrinkage rate, effects of moisture, etc. ☆ Viscoelastic measurements (rheology, rheometers) / viscoelasticity, elastic modulus, viscosity, stress relaxation, creep, master curves, residual strain, molecular weight, molecular weight distribution, etc. ☆ Microcalorimetry / intermolecular interactions, crystallization, amorphousness, aggregation/precipitation, dispersibility, solubility, compatibility, wettability, stability, adsorption, etc. ☆ Fatigue testing / tensile strength, temperature dependence, viscoelasticity, elastic modulus, viscosity, stress relaxation, creep, master curves, residual strain, etc.

• Analytical Equipment and Devices

This is an introduction to case studies of pharmaceutical analysis by a specialist in analysis. This time, we will look at the pharmacokinetics of suppositories and the viscoelastic measurement of hair wax.

The viscoelastic measurement device, the "Discovery Hybrid Rheometer," controls the surrounding environment and performs measurements over a wide range of force, strain, and strain rate. We offer three models to meet the needs for sensitivity and capability, from the high-sensitivity HR-30 to the general-purpose HR-10. This product improves various performances and specifications, achieving accurate strain, strain rate, stress control, and normal force, and is equipped with our innovative patented Smart Swap geometry and Smart Swap temperature control system. 【Main Features】 ■ Ultra-low inertia drag cup motor (patented) ■ Magnetic bearings (patented) ■ High-resolution optical encoder ■ Optical encoder dual reader (patent pending) ■ Normal force rebalance transducer (FRT)

• Analytical Equipment and Devices

This is an introduction to medical-related analysis cases by a specialist in analysis. This time, we will present measurement cases of mechanical properties and fatigue tests that are useful for evaluating the pericardium.

The planar biaxial testing machine (TestBench testing device) is designed to conduct tests similar to those performed on a load frame. This allows for the evaluation of the sample's stiffness, strength, and durability, as well as the measurement of yield strength, ultimate strength, and fatigue life. A modular approach that includes multi-channel and multi-axis options enables a wide range of configurations and performance. It uses 200N and 400N ElectroForce linear motors mounted on a horizontal base plate to accommodate various testing needs.

• Analytical Equipment and Devices

Using PLA beverage cups as measurement samples, thermal and mechanical properties were investigated utilizing thermal analysis techniques such as temperature-modulated DSC and DMA!

As the industrial sector has begun to focus more on developing and manufacturing environmentally friendly products, various new biodegradable polymers have been adopted. Poly(Lactic Acid) (PLA) is a biodegradable aliphatic polyester produced from lactic acid obtained through the saccharification and fermentation of starch. Due to its high mechanical strength comparable to PETE and good biocompatibility, PLA has been commonly used in biomedical applications such as sutures and stents, but the expansion of PLA's applications is being considered. Understanding the properties of PLA is essential for the development of new applications. We present materials that investigate the thermal and mechanical properties of PLA-based beverage cups using temperature-modulated DSC and DMA. *Please download the materials.

• Analytical Equipment and Devices

This is an introduction to a case study of insulation material analysis by a specialist in analysis. This time, we will present a measurement case using a thermal conductivity measurement device.

Measurement capabilities offered by TA Instruments ☆ Thermal analysis / glass transition, crystallization, thermogravimetric analysis, curing reactions, expansion rate, thermal conductivity, shrinkage rate, effects of moisture, etc. ☆ Viscoelastic measurements (rheology) / viscoelasticity, elastic modulus, viscosity, stress relaxation, creep, master curve, residual strain, molecular weight, molecular weight distribution, etc. ☆ Microcalorimetry / intermolecular interactions, crystallization, amorphousness, aggregation/precipitation, dispersibility, solubility, compatibility, wettability, stability, adsorption, etc. ☆ Fatigue testing / tensile strength, temperature dependence, viscoelasticity, elastic modulus, viscosity, stress relaxation, creep, master curve, residual strain, etc.

• Analytical Equipment and Devices

Evaluation of the generation process and characteristics of biofuels using a modular thermal analysis measurement device (TAM).

The calorimetry measurement device (TAM series) is an instrument known as a microcalorimeter that measures very small amounts of heat. By combining a thermostat with high isothermal performance with a calorimeter (calorimeter) suited to the sample and measurement method, it is possible to measure minute heat generated or consumed during physical processes or chemical reactions with sensitivity exceeding microwatts. It is a useful tool that can contribute to the research and development of biofuels and environmental improvement, allowing real-time calorimetry measurements while performing operations such as the addition, mixing, and titration of chemicals through module combinations. This document provides a detailed explanation of high-sensitivity calorimetry measurements of biofuels, which are difficult to observe with conventional differential scanning calorimeters (DSC), as well as real-time measurements of heat changes associated with chemical reactions. ◇ Quantification of wax based on the heat of solidification reactions ◇ Evaluation of the production rate of biofuels *Please download the document.

• Analytical Equipment and Devices

Virus Research Case Study: Characterization of Viruses - Evaluation of Structure and Binding Properties Using Calorimetry -

Currently, the novel coronavirus infection (COVID-19) is a global issue. TA Instruments hopes to contribute, even in a small way, to addressing the challenges posed by COVID-19 by introducing examples of virus research conducted by universities and research institutions using TA equipment. Research institutions that incorporate studies using Differential Scanning Calorimetry (DSC) and Isothermal Titration Calorimetry (ITC) to understand the structure and mechanisms of viruses are rapidly advancing. Please take a look at the examples.

• Analytical Equipment and Devices

We would like to extend our heartfelt congratulations on the continued prosperity of your esteemed company. Our company will be exhibiting at the following trade show, where we will showcase a variety of products, including new ones. We sincerely invite you to visit us during this busy time. 【 Exhibition Name 】 Automotive Technology Exhibition 2025 YOKOHAMA https://aee.expo-info.jsae.or.jp/ja/yokohama/ (An "online exhibition" will also be held during and around the event period) 【 Dates 】 May 21 (Wednesday) - 23 (Friday), 2024 10:00 AM - 6:00 PM *On the final day, 9:00 AM - 4:00 PM (Online exhibition: May 14 (Wednesday) - June 4 (Wednesday)) 【 Venue 】 Pacifico Yokohama (1-1-1 Minatomirai, Nishi-ku, Yokohama, Kanagawa Prefecture) Our booth number: "Concourse 505"

We would like to extend our heartfelt congratulations on the continued prosperity of your esteemed company. Our company will be exhibiting at the following trade show, where we will showcase a variety of products, including new ones. We sincerely apologize for the inconvenience during your busy schedule, but we would like to invite you to attend this event. 【 Exhibition Name 】 27th INTERPHEX Week Tokyo https://www.interphex.jp/tokyo/ja-jp.html 【 Dates 】 July 9 (Wednesday) - 11 (Friday), 2025 10:00 AM - 5:00 PM 【 Venue 】 Tokyo Big Sight (3-11-1 Ariake, Koto-ku, Tokyo 135-0063)

Metal 3D printers are becoming increasingly diverse, with relatively affordable low-cost machines available for several tens of millions of yen, as well as binder jetting technology that enables mass production of parts. High-speed, large-scale machines for creating large components and products are continuously being introduced to the market. Furthermore, the prototyping of magnesium parts and the manufacturing of copper components, which were difficult to produce with existing technologies, have begun. Metal 3D printers eliminate the need for molds by allowing products to be created directly from 3D data. They enable the creation of complex shapes that were impossible with traditional processing methods, as well as lattice and porous structures, hollow structures, and hybrid structures. This leads to the innovative creation of metal parts and molds that are not available from conventional sources, significant reductions in prototyping and manufacturing time, drastic decreases in the number of parts, lightweight miniaturization, and reductions in manufacturing processes and workforce. Using metal 3D printers, we provide easy explanations for those considering the development of attractive new products, the creation of new businesses, differentiation from existing products, significant reductions in prototyping and manufacturing time, dramatic decreases in the number of parts, and cost-effective lightweight complex-shaped components, as well as for beginners who are interested. The world is energetically investing in metal parts and mold manufacturing as the leading candidate for the next generation, and mass production of parts has also begun in earnest. Manufacturing parts with metal 3D printers will become commonplace in a few years.

In this seminar, we will briefly explain various molding methods and technologies for plastic molds using metal 3D printers, key points and considerations in manufacturing, and examples of molding. Following this, advanced users utilizing metal 3D printers from EOS, 3D Systems, Sodick, and Matsuura Machinery will discuss cutting-edge mold manufacturing technologies and cases, as well as the factors behind failures and secrets to success. First, we will explain molding cases that have achieved low-cost, high-quality manufacturing techniques and shortened lead times through complex shapes and integrated molding, hybrid molding, and 3D cooling water pipe molding using EOS metal 3D printers at J-3D. Next, we will discuss ODEC's achievements in drastically reducing lead times and costs in mold updates by manufacturing complex molds for resin molding with metal 3D printers, as well as the latest molding cases and simulation technologies for internal structures (3D water pipes), water flow, and temperature. Finally, we will provide specific explanations of Sanko Gosei, the industry leader in plastic mold manufacturing technology using metal 3D printers, including remarkable reductions in mold cooling times through 3D cooling water pipe molding, and how porous molding effectively suppresses and prevents defects and troubles such as short shots and gas burns, along with examples of reduced injection times.

The complex shape modeling, integrated modeling, lattice/honeycomb structure modeling, porous structure modeling, hybrid structure modeling, direct modeling from 3D data, as well as topology optimization and collaboration with generative design, which were difficult with conventional processing methods and technologies, can lead to the creation of innovative aluminum parts that are not available from traditional or other companies. This includes rapid development, prototyping, and modeling of parts, dramatic reductions in the number of parts, ultra-lightweight and compact designs, and significant reductions in costs, manufacturing time, number of processes, and workforce. In this seminar, pioneering users such as J.3D, ODEC, and the pioneers of white copper, who are utilizing metal 3D printers to rapidly develop, prototype, and manufacture complex aluminum parts, will provide specific explanations on key points and precautions for implementation and utilization, various modeling methods and technologies, unique next-generation AM technologies developed in-house, and groundbreaking modeling examples that significantly differentiate from other companies, sharing both success and failure stories. With the remarkable advancements in metal AM technology, the use of metal 3D printers for aluminum part modeling and manufacturing will become commonplace in a few years. The secrets to success will be explained in an easy-to-understand and concrete manner by instructors with numerous research achievements and extensive modeling experience, aimed at those considering implementation, beginners with interest, and those who are new to the field.