*Application Closed* April Online LIVE Seminar Held! ~Battery Seminar~

Step into the utilization of thermal analysis devices. Numerous measurement examples of DSC included. Online seminar held.

This document provides a detailed introduction to the characterization of pharmaceutical substances using Differential Scanning Calorimetry (DSC). It explains the "Modulated DSC," which allows for high-sensitivity and high-resolution measurements, and the "Tzero DSC," which measures the absolute values of heat flow, over more than 40 pages based on general characterization examples. You can also find an introduction to various analytical instruments offered by our company. 【Main Contents】 ■ Amorphous structure (detection of amorphous content in crystalline compounds including glass transition) ■ Degree of crystallinity (melting and crystallization, purity, polymorphism) ■ Drug-excipient interactions ■ Protein denaturation ■ Freeze-drying ■ Other complementary thermal analysis techniques *This document is available for immediate viewing via "PDF Download."

• Analytical Equipment and Devices

This is an introduction to protein analysis cases and related equipment by analysis specialists. This time, we will cover three devices: ITC, TAM, and NanoDSC!

Measurement capabilities offered by TA Instruments ☆ Thermal analysis / glass transition, crystallization, thermogravimetric analysis, curing reactions, expansion rate, thermal conductivity, shrinkage rate, effects of moisture, etc. ☆ Viscoelastic measurements (rheology, rheometers) / viscoelasticity, elastic modulus, viscosity, stress relaxation, creep, master curves, residual strain, molecular weight, molecular weight distribution, etc. ☆ Microcalorimetry / intermolecular interactions, crystallization, amorphousness, aggregation/precipitation, dispersibility, solubility, compatibility, wettability, stability, adsorption, etc. ☆ Fatigue testing / tensile strength, temperature dependence, viscoelasticity, elastic modulus, viscosity, stress relaxation, creep, master curves, residual strain, etc.

• Analytical Equipment and Devices

How about one for the lab? Introducing the Discovery DSC series, the world's most outstanding and highly versatile differential scanning calorimeter.

TA Instruments continues to be the leading company in the world of DSC with innovative and outstanding technology. It provides reliable data and enhances workflow and productivity in laboratories. Material property analysis is essential at all stages of product design, manufacturing, processing, and application. Differential Scanning Calorimetry (DSC) is the most widely used thermal analysis instrument for evaluating the physical properties of a wide range of materials, including polymers, pharmaceuticals, food, biomaterials, organic compounds, inorganic compounds, and composites.

• Analytical Equipment and Devices

Provides high reliability! An excellent tool for measuring a wide range of molecular interactions.

The Isothermal Titration Calorimeter (ITC) is a device that detects the heat changes associated with titration at a constant temperature and is primarily used for analyzing molecular interactions. It measures the minute heat changes that occur when molecules bind to each other, allowing for the determination of binding ratio (n), binding constant (Ka), and the enthalpy change of binding (ΔH) from the resulting titration curve. Affinity ITC is an isothermal titration calorimeter that provides high sensitivity, high reproducibility, and advanced ITC technology in life science research environments. With AccuShot technology, it delivers precise amounts of titrant to the appropriate location, and the FlexSpin stirring function achieves efficient mixing and high sensitivity. The automatic cleaning function prevents contamination between samples. It offers the option of standard capacity (1.0 mL) or low capacity cells (190 µL), and a temperature-controlled auto-sampler for 96 wells is also available.

• Analytical Equipment and Devices

A differential scanning calorimeter specialized for studying biological samples. It offers the highest sensitivity and excellent operability.

TA Instruments continues to be the leading company in the world of DSC with innovative and outstanding technology. It provides reliable data and enhances workflow and productivity in laboratories. The Nano DSC is a differential scanning calorimeter (DSC) that can detect minute heat changes associated with the conformational changes of biomolecules. Characterization of materials is essential at all stages of product design, manufacturing, processing, and application. Differential scanning calorimeters/nano DSCs are the most widely used thermal analysis instruments for the physical property evaluation of a broad range of materials, including polymers, pharmaceuticals, food, biomaterials, organic compounds, inorganic compounds, and composites.

• Analytical Equipment and Devices

For the evaluation of reactions of various substances.

TAM offers the highest level of sensitivity, flexibility, and performance. By using a highly sensitive microcalorimeter along with various accessories, it precisely controls various experimental conditions. Up to four calorimeters can be used simultaneously, allowing for repeated experiments and a variety of experiments to be conducted. Additionally, its modular design allows for the addition of multiple calorimeters, enhancing sample processing capacity and functionality. Adding a multi-calorimeter with six mini-calorimeters significantly improves sample throughput. The TAM 4 employs patented thermostat technology, controlling the temperature of the liquid constant temperature bath with an accuracy of 0.0001±730°C. There are three operating modes: isothermal, step isothermal, and temperature scanning mode.

• Analytical Equipment and Devices

World leader in thermal analysis, calorimetry, and rheology / Comprehensive catalog of TA Instruments.

◆TA Instrument Handled Products◆ ■Thermal Analysis Equipment Differential Scanning Calorimeter Discovery DSC Thermogravimetric Analyzer Discovery TGA Differential Scanning Calorimeter DSC Thermogravimetric Analyzer TGA Vapor Adsorption/Desorption Measurement Device VTI-SA+ Simultaneous Differential Thermal and Thermogravimetric Analyzer SDT Thermomechanical Analyzer TMA Dynamic Mechanical Analyzer DMA ■Thermal Property Measurement Equipment Laser Flash Method Thermal Property Measurement Device DLF Xenon Flash Method Thermal Property Measurement Device DXF Thermal Conductivity Measurement Device DTC FOX Thermal Expansion Measurement Device DIL ODLT, ODHT P11 Heating Microscope HSM, HSML Fleximeter FLEX ■Viscoelasticity Measurement Equipment DHR ARES-G2 RSA-G2 Air Chiller System ACS-3 Rubber Testing Machine ■Microcalorimeters Isothermal Titration Calorimeter Nano ITC, Affinity ITC Differential Scanning Calorimeter Nano DSC Multi-Cell Differential Scanning Calorimeter MC DSC Isothermal Calorimeter TAM ●For other functions and details, please download the catalog or contact us.

• Analytical Equipment and Devices

This is the lecture material posted on YouTube ~DSC Basic Edition 1~. It is available for free download, so please feel free to make use of it.

Data Content This is a PDF version of the lecture materials from YouTube, converted for easier viewing. The video consists of a total of 12 pages and provides an easy-to-understand explanation for beginners about: - Principles - Analytical methods - Enthalpy relaxation (recovery) I think it might be difficult to understand with just the lecture materials, so please also refer to the YouTube videos below. YouTube TA Summary Site: https://www.youtube.com/channel/UCk3XzqRdsNQz1hJlqKrfujQ DSC Basics Part 1: https://www.youtube.com/watch?v=DbGpordpweg

• Analytical Equipment and Devices

This is the lecture material posted on YouTube ~Rheology: Basic Edition 1~. It is available for free download, so please feel free to make use of it.

Data Content This is a PDF version of the lecture materials from YouTube, converted for better readability. The video consists of a total of 12 pages and provides easy-to-understand explanations for beginners on the following topics: - What is rheology? - What is viscoelasticity? - About measurement modes. I think it might be difficult to understand just from the lecture materials, so please also refer to the YouTube videos below. YouTube TA Summary Site: https://www.youtube.com/channel/UCk3XzqRdsNQz1hJlqKrfujQ Rheology Basics Part 1: https://www.youtube.com/watch?v=_gPrWIK6yYo&t=4s

• Analytical Equipment and Devices

This is an introduction to analysis cases and related devices for bio research by analysis specialists. This time, we will cover three devices: ITC, TAM, and NanoDSC!

Measurement capabilities offered by TA Instruments ☆ Thermal analysis / Glass transition, crystallization, thermogravimetric analysis, curing reactions, expansion rate, thermal conductivity, shrinkage rate, effects of moisture, etc. ☆ Viscoelastic measurements (rheology) / Viscoelasticity, elastic modulus, viscosity, stress relaxation, creep, master curve, residual strain, molecular weight, molecular weight distribution, etc. ☆ Microcalorimetry / Intermolecular interactions, crystallization, amorphousness, aggregation/precipitation, dispersibility, solubility, compatibility, wettability, stability, adsorption, etc. ☆ Fatigue testing / Tensile strength, temperature dependence, viscoelasticity, elastic modulus, viscosity, stress relaxation, creep, master curve, residual strain, etc.

• Analytical Equipment and Devices

This is an introduction to a protein analysis case study by a specialist in analysis. This time, we evaluated the changes in denaturation temperature behavior with the addition of Zn2+ using NanoDSC.

Measurement capabilities offered by TA Instruments ☆ Thermal analysis / glass transition, crystallization, thermogravimetric analysis, curing reactions, expansion rate, thermal conductivity, shrinkage rate, effects of moisture, etc. ☆ Viscoelastic measurements (rheology) / viscoelasticity, elastic modulus, viscosity, stress relaxation, creep, master curve, residual strain, molecular weight, molecular weight distribution, etc. ☆ Microcalorimetry / intermolecular interactions, crystallization, amorphousness, aggregation/precipitation, dispersibility, solubility, compatibility, wettability, stability, adsorption, etc. ☆ Fatigue testing / tensile strength, temperature dependence, viscoelasticity, elastic modulus, viscosity, stress relaxation, creep, master curve, residual strain, etc.

• Analytical Equipment and Devices

This is an introduction to a protein analysis case study by a specialist in analysis. This time, we evaluated the substrate degradation rate and the effects of inhibitors using ITC.

Measurement capabilities offered by TA Instruments ☆ Thermal analysis / glass transition, crystallization, thermogravimetric analysis, curing reactions, expansion rate, thermal conductivity, shrinkage rate, effects of moisture, etc. ☆ Viscoelastic measurement (rheology) / viscoelasticity, modulus of elasticity, viscosity, stress relaxation, creep, master curve, residual strain, molecular weight, molecular weight distribution, etc. ☆ Microcalorimetry / intermolecular interactions, crystallization, amorphousness, aggregation/precipitation, dispersibility, solubility, compatibility, wettability, stability, adsorption, etc. ☆ Fatigue testing / tensile strength, temperature dependence, viscoelasticity, modulus of elasticity, viscosity, stress relaxation, creep, master curve, residual strain, etc.

• Analytical Equipment and Devices

Virus Research Case Study: Characterization of Viruses - Evaluation of Structure and Binding Properties Using Calorimetry -

Currently, the novel coronavirus infection (COVID-19) is a global issue. TA Instruments hopes to contribute, even in a small way, to addressing the challenges posed by COVID-19 by introducing examples of virus research conducted by universities and research institutions using TA equipment. Research institutions that incorporate studies using Differential Scanning Calorimetry (DSC) and Isothermal Titration Calorimetry (ITC) to understand the structure and mechanisms of viruses are rapidly advancing. Please take a look at the examples.

• Analytical Equipment and Devices

This is an introduction to case studies related to cells by a specialist in analysis. This time, we will present measurement examples using thermal analysis equipment that is useful for evaluations involving cells.

Measurement capabilities offered by TA Instruments ☆ Thermal analysis / glass transition, crystallization, thermogravimetric analysis, curing reactions, expansion rate, thermal conductivity, shrinkage rate, effects of moisture, etc. ☆ Viscoelastic measurements (rheology, rheometers) / viscoelasticity, elastic modulus, viscosity, stress relaxation, creep, master curves, residual strain, molecular weight, molecular weight distribution, etc. ☆ Microcalorimetry / intermolecular interactions, crystallization, amorphousness, aggregation/precipitation, dispersibility, solubility, compatibility, wettability, stability, adsorption, etc. ☆ Fatigue testing / tensile strength, temperature dependence, viscoelasticity, elastic modulus, viscosity, stress relaxation, creep, master curves, residual strain, etc.

• Analytical Equipment and Devices

This is an introduction to case studies of pharmaceutical analysis by a specialist in analysis. This time, we will look at the pharmacokinetics of suppositories and the viscoelastic measurement of hair wax.

The viscoelastic measurement device, the "Discovery Hybrid Rheometer," controls the surrounding environment and performs measurements over a wide range of force, strain, and strain rate. We offer three models to meet the needs for sensitivity and capability, from the high-sensitivity HR-30 to the general-purpose HR-10. This product improves various performances and specifications, achieving accurate strain, strain rate, stress control, and normal force, and is equipped with our innovative patented Smart Swap geometry and Smart Swap temperature control system. 【Main Features】 ■ Ultra-low inertia drag cup motor (patented) ■ Magnetic bearings (patented) ■ High-resolution optical encoder ■ Optical encoder dual reader (patent pending) ■ Normal force rebalance transducer (FRT)

• Analytical Equipment and Devices

This is an introduction to medical-related analysis cases by a specialist in analysis. This time, we will present measurement cases of mechanical properties and fatigue tests that are useful for evaluating the pericardium.

The planar biaxial testing machine (TestBench testing device) is designed to conduct tests similar to those performed on a load frame. This allows for the evaluation of the sample's stiffness, strength, and durability, as well as the measurement of yield strength, ultimate strength, and fatigue life. A modular approach that includes multi-channel and multi-axis options enables a wide range of configurations and performance. It uses 200N and 400N ElectroForce linear motors mounted on a horizontal base plate to accommodate various testing needs.

• Analytical Equipment and Devices

Using PLA beverage cups as measurement samples, thermal and mechanical properties were investigated utilizing thermal analysis techniques such as temperature-modulated DSC and DMA!

As the industrial sector has begun to focus more on developing and manufacturing environmentally friendly products, various new biodegradable polymers have been adopted. Poly(Lactic Acid) (PLA) is a biodegradable aliphatic polyester produced from lactic acid obtained through the saccharification and fermentation of starch. Due to its high mechanical strength comparable to PETE and good biocompatibility, PLA has been commonly used in biomedical applications such as sutures and stents, but the expansion of PLA's applications is being considered. Understanding the properties of PLA is essential for the development of new applications. We present materials that investigate the thermal and mechanical properties of PLA-based beverage cups using temperature-modulated DSC and DMA. *Please download the materials.

• Analytical Equipment and Devices

This is an introduction to a case study of insulation material analysis by a specialist in analysis. This time, we will present a measurement case using a thermal conductivity measurement device.

Measurement capabilities offered by TA Instruments ☆ Thermal analysis / glass transition, crystallization, thermogravimetric analysis, curing reactions, expansion rate, thermal conductivity, shrinkage rate, effects of moisture, etc. ☆ Viscoelastic measurements (rheology) / viscoelasticity, elastic modulus, viscosity, stress relaxation, creep, master curve, residual strain, molecular weight, molecular weight distribution, etc. ☆ Microcalorimetry / intermolecular interactions, crystallization, amorphousness, aggregation/precipitation, dispersibility, solubility, compatibility, wettability, stability, adsorption, etc. ☆ Fatigue testing / tensile strength, temperature dependence, viscoelasticity, elastic modulus, viscosity, stress relaxation, creep, master curve, residual strain, etc.

• Analytical Equipment and Devices

Evaluation of the generation process and characteristics of biofuels using a modular thermal analysis measurement device (TAM).

The calorimetry measurement device (TAM series) is an instrument known as a microcalorimeter that measures very small amounts of heat. By combining a thermostat with high isothermal performance with a calorimeter (calorimeter) suited to the sample and measurement method, it is possible to measure minute heat generated or consumed during physical processes or chemical reactions with sensitivity exceeding microwatts. It is a useful tool that can contribute to the research and development of biofuels and environmental improvement, allowing real-time calorimetry measurements while performing operations such as the addition, mixing, and titration of chemicals through module combinations. This document provides a detailed explanation of high-sensitivity calorimetry measurements of biofuels, which are difficult to observe with conventional differential scanning calorimeters (DSC), as well as real-time measurements of heat changes associated with chemical reactions. ◇ Quantification of wax based on the heat of solidification reactions ◇ Evaluation of the production rate of biofuels *Please download the document.

• Analytical Equipment and Devices

At the beginning of the seminar, the National Institute of Advanced Industrial Science and Technology will discuss the research and development related to ceramics 3D additive manufacturing that they have been working on, focusing on the 3D additive manufacturing process, powder preparation process for molding, debinding and sintering processes, as well as examples of production using ceramics 3D additive manufacturing, particularly with alumina and reaction-sintered silicon carbide. Following that, instructors from Shin-Toh V-Ceramics and As One, who are at the forefront of this field in Japan, will provide an easy-to-understand explanation for beginners about the development trends of various ceramics 3D printers from world-class companies like 3DCeram Sinto and Lithoz, as well as the latest additive manufacturing technologies that enable the creation of innovative parts, rapid part development, prototyping, and manufacturing, significant reductions in the number of parts, lightweight and compact designs, and reductions in manufacturing processes and workforce through complex shapes and integral molding, hollow and porous structures, and lattice structures that are impossible with conventional processing methods. Finally, Canon will introduce the latest trends in their newly developed high-performance ceramics materials that excel in selective laser melting (SLM) for 3D printers, which significantly reduce "shrinkage" during sintering, along with the characteristics of parts that can be produced using this method, additive manufacturing technology, target fields, and contract manufacturing services.

Nagoya Chemical Industry Co., Ltd. will be exhibiting polyimide resins at the booth of Matsuo Sangyo Co., Ltd. during the 'Chemical Material Japan 2025' event held at Tokyo Big Sight. We also plan to showcase our developed products, including soluble polyimide, transparent polyimide, and porous polyimide, so we look forward to seeing you there.

In promoting DX and business reform projects, are your initiatives becoming "system construction first"? While you may have envisioned an ideal, it may not lead to "practical reforms" rooted in the field. For those facing such challenges, this seminar will provide hints for solutions. In this seminar, we will clearly explain the specific approach from "visualizing business processes" to "IT strategy (systemization strategy)" in business reform projects, incorporating case studies and practical steps. We will also introduce the essence of our "business process-focused, supportive consulting." Additionally, details on writing business flows, creating RFPs, and formulating systemization roadmaps will be covered in a separate seminar.

～AI Chatbot Breaks Through the Barriers of Business Knowledge! A Method to Achieve Both Talent Development and Business Efficiency Simultaneously～ The burden of searching through vast amounts of documentation in quality assurance operations has been dramatically improved by the generative AI chatbot "WisTalk"! In this seminar, Panasonic Industry Co., Ltd. will present a case study on how they utilized "WisTalk" to reduce the search workload for over 4,000 pages of quality assurance documents while balancing business quality and talent development. 【What You Will Learn in This Seminar】 ● How to inherit the knowledge of experienced personnel using AI ● The effects of reducing business burdens and improving performance through the efficiency of document search operations ● Key points for implementing an AI chatbot for knowledge search 【Recommended For】 ● Those who feel challenges in searching for business manuals and various regulatory documents ● Those considering the use of AI for promoting DX and talent development ● Those struggling with knowledge inheritance in quality assurance and technical departments In the first part, we will discuss actual implementation cases, and in the second part, we will provide a detailed explanation of the potential of "WisTalk" through product introductions. We hope you will join us!

Our company will be exhibiting at the "Atoll Medical Device Fair 2025 in Kyushu." We sincerely look forward to your visit.