OECD test guideline compliant! Supports acute toxicity tests and subchronic/chronic toxicity tests.
Inari Research supports toxicity testing necessary for new chemical substance registration applications from the screening stage. We conduct tests using standard test species such as mice, rats, rabbits, dogs, and primates, as well as alternative methods using cultured cells, which have been increasingly required both domestically and internationally in recent years. Our company is a GLP-compliant facility and has obtained certification from AAALAC International (the Association for Assessment and Accreditation of Laboratory Animal Care International). We conduct in vivo/in vitro tests that comply with regulations related to the review and manufacturing of chemical substances (Chemical Substances Control Law) and the Labor Safety and Health Law (Safety and Health Law), as well as regulations concerning new chemical substance applications in various countries. Additionally, we offer consulting on toxicity evaluation based on the regulations of each country. [General Toxicity Testing] - We handle tests from acute toxicity to subchronic and chronic toxicity testing. - The test supervisor communicates with clients while conducting the tests. - Various necessary inspections and their evaluations are supported by experienced researchers and technicians. *For more details, please refer to the PDF materials or feel free to contact us.
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**General Toxicity Testing** ■ Main Types of Tests - Limit tests, acute toxicity tests to evaluate short-term effects, 28-day repeated dose tests as specified by the Chemical Substances Control Law, 90-day chronic toxicity tests to assess medium- to long-term effects, various dose-setting tests, and general toxicity tests aimed at screening. ■ Animal Species - Mice, rats, rabbits, dogs, and optionally, monkeys. ■ Routes of Administration - Oral (forced, mixed feed), ocular, dermal (application, patch), and optionally, intravenous, intraperitoneal, etc. ■ Observations, Tests, and Measurements - General condition, body weight measurement, food and water intake measurement, ophthalmological examinations, clinical tests, necropsy, organ weight measurement, and pathological histological examinations. - Optionally, auditory tests, electrocardiogram tests, blood pressure measurements, body temperature measurements, etc. ■ Toxicokinetics - Measurement of the concentration of the test substance and its metabolites in biological samples. *For more details, please refer to the PDF document or feel free to contact us.*
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For more details, please refer to the PDF document or feel free to contact us.
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Our company is located in the nature-rich city of Ina, Nagano Prefecture, surrounded by two Alps, and has been serving our customers as a non-clinical trial contract research organization (CRO) for 50 years. Since 2022, we have become a member of the Shin Nippon Science Group, expanding and enhancing our contract testing items and analyses, and we can quickly respond to the procurement of various testing materials (such as animals). Non-Clinical Trial Business We accept safety and efficacy testing for pharmaceuticals, chemicals, pesticides, food, medical devices, and more. We conduct in vivo tests using small animals, rabbits, dogs, and monkeys, as well as in vitro tests using bacteria and cells, and various alternative method tests. Additionally, we specialize in the creation of SEND data required for FDA applications for new drugs, and we also undertake work related to SEND conversion and QC for data creation and conversion only. Our facility was the first in Japan to obtain full accreditation from AAALAC International (the Association for Assessment and Accreditation of Laboratory Animal Care International), and we are committed to international standards of animal welfare. We also propose tests necessary for various applications and registrations in compliance with regulations in different countries and regions.
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