Endoglycosidases useful for the analysis and evaluation of antibody drugs and ADCs (antibody-drug conjugates) including biosimilars.
IgGZERO (EndoS) is an endoglycosidase derived from Streptococcus pyogenes that hydrolyzes the N-linked glycans in the Fc region of IgG. It is useful for reducing complexity through rapid deglycosylation of IgG and inactivating the effector functions of the Fc region. This enzyme deglycosylates IgG from various animal species, including human IgG (all subclasses), as well as IgG from mice, rats, monkeys, sheep, goats, cows, and horses. The enzyme specifically hydrolyzes only the glycans in the Fc region of IgG, even in the presence of other glycosylated proteins in solution. It is expressed and produced in E. coli, contains a His tag, and has a molecular weight of 110 kDa. Genovis actively holds web meetings and seminars. Please feel free to contact us for adjustments according to your requests.
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basic information
The enzyme activity of IgGZERO is limited against high-mannose type and hybrid type glycans (Sjögren et al., 2015). If you are interested in an endoglycosidase that hydrolyzes all glycan structures (glycoforms) on IgG, we recommend a product called GlycINATOR. <Main Product Lineup> IgGZERO Enzyme Lyophilized product. Available in 1000 units and 5000 units. Immobilized IgGZERO - deGlycIT Spin column filling. Since IgGZERO is immobilized on agarose beads, it can highly prevent contamination from IgGZERO and obtain the adjusted material. Other Products IgGZERO LE (Low Endotoxin)
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Applications/Examples of results
Subunit analysis of antibody drugs including biosimilars Characterization of antibody-drug conjugates (ADCs) Glycan analysis of the Fc domain of IgG antibodies
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