Array SAR Analysis Tool 'SAR>vision|Biologics'

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basic information

【Other Features】 ■ Exploration of mutations that significantly impact activity (Logo Plot, Invariant Map, Mutation Cliff) ■ Loading and alignment of sequence data (automatic and manual) ■ Implementation of a numbering algorithm based on ANARCI for automatic numbering of antibodies (compatible with Kabat, Chothia, Enhanced Chothia, IMGT, AHo) ■ Ability to examine hundreds of sequences *For more details, please refer to the PDF document or feel free to contact us.

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Applications/Examples of results

【Usage】 ■ Biopolymers such as nucleic acids, proteins, and peptides that contain non-natural amino acids or chemically modified residues. *For more details, please refer to the PDF document or feel free to contact us.

Detailed information

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  LogoPlot is a general method for summarizing sequence motifs that indicate biological functions. These logos take the form of stacked letters enclosed in rectangles or bars, with heights scaled according to frequencies or some aggregated activities within the dataset. The Y-axis controls the activity field and method used for height scaling. There are two chart styles: sequence logos and sequence bar plots. Sequence logos perform statistics based on a basic set of 20 natural amino acids and scale font sizes. In contrast, sequence bar plots can use any number of monomers for scaling based on the data.

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  The mutation set indicates the relationship of sequence activity at specific positions. It can identify all sequences that are identical except for a single position. The mutation set family forms a series where the substitution pattern at a single position directly correlates with changes in activity. This provides confidence that the correlation is realistic and significant, as all confounding mutations or mutations located elsewhere in the sequence are excluded from the analysis.