Book: Continuous Production of Fine Chemicals and Pharmaceuticals (No. 2272)
2272 Continuous Production
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Book Title: Fine Chemicals, Continuous Production Processes for Pharmaceuticals ---------------------------- ★ Case studies of proof-of-concept experiments at lab/pilot scale and implementation in commercial facilities revealed by leading companies! ★ Development of requirements and management strategies for ICH Q13, and how to respond! ---------------------------- ■ Key Points of This Book Continuous Mixing and Reaction Processes - Design of flow microreactors, scale-up, and measures against flow path blockage - Automation of reaction condition exploration using Bayesian optimization - Case studies on catalyst and process development for continuous production - Continuous culture for biopharmaceutical production Continuous Separation Processes - Selection of operating conditions for continuous crystallization, control of particle size/shape, and productivity improvement - Design of continuous distillation columns and automated exploration of efficient operating conditions - Continuous processing of membrane filtration, rotary filtration, and centrifugation, along with case studies - Continuous separation of proteins, chiral compounds, and viruses for pharmaceutical production Continuous Powder Processes - Continuous granulation, configuration of direct compression systems, and setting of operating conditions
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- Continuous processing of powder supply, granulation, drying, pelletizing, tableting, and coating - Adjustment and evaluation of granule particle size distribution and tablet hardness - Monitoring of mixing uniformity, drying state, drug content, and coating weight Quality monitoring using PAT - Real-time monitoring through Raman spectroscopy and near-infrared spectroscopy - Automation and remote tracking of reactions through online HPLC analysis - Inline real-time measurement of particle size and particle size distribution - Prediction of component concentration in mixtures using soft sensors ---------------------------- ■ Table of Contents Chapter 1: Continuous Mixing and Reaction Processes and Their Examples Chapter 2: Continuous Separation Processes and Their Examples Chapter 3: Continuous Powder Processes and Their Examples Chapter 4: Analysis, Monitoring Technologies, and Data Utilization Examples of Continuous Production Processes Chapter 5: Initiatives for Continuous Production of Pharmaceuticals and Fine Chemicals ---------------------------- ● Publication Date: November 29, 2024 ● Format: A4, 610 pages ● Authors: 57 ● ISBN: 978-4-86798-051-4 ----------------------------
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