Real-time visualization of culture and fermentation processes expanding in the bio and food sectors.
Raman spectroscopy can be applied to cell culture and medium component monitoring in the pharmaceutical field, as well as to fermentation processes and quality analysis of dairy products in the food sector. By using probe-type Raman, it is possible to insert the probe directly into the culture medium or fermentation tank, allowing for real-time tracking of component changes while maintaining a sterile environment. Since it can measure complex multi-component systems quickly and non-destructively, it contributes to the optimization of media, understanding of fermentation conditions, and efficiency in quality control.
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basic information
Raman spectroscopy is one of the few spectroscopic techniques that can non-destructively and simultaneously quantify the main components (such as glucose, lactic acid, and amino acids) in culture media and fermentation broths. It can be used by directly inserting a probe into a sterile environment, allowing for real-time monitoring of media optimization and variations in metabolic pathways. In the pharmaceutical field, it is applied to understand the balance of nutrients and waste products in cultured cells, while in the food sector, it is used to evaluate the progress and quality stability of fermentation, significantly contributing to process shortening and improved reproducibility. Additionally, by combining multivariate analysis, it is possible to model the behavior of complex systems and quantitatively manage the risk of quality variations during scale-up. This area is expected to see further development as a technology for visualizing and controlling bioproduction.
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Applications/Examples of results
Raman spectroscopy is one of the few spectroscopic techniques that can simultaneously quantify the main components (such as glucose, lactic acid, and amino acids) in culture media and fermentation broths in a non-destructive manner.
Company information
Our company supports the establishment of measurement methods, analytical techniques, and testing methods (analytical methods) using Raman spectroscopy, centered on vibrational spectroscopy, which can be utilized in quality control areas such as acceptance testing, from research and development fields like the evaluation of the physical properties of pharmaceutical raw materials and the dispersion state of solid formulation particles. We provide support for the development of analytical conditions, testing method settings, and validation. Please feel free to contact us if you have any requests.