Cross-linked sodium hyaluronate gel - high-density three-dimensional cross-linked network forming material.
Crosslinked Sodium Hyaluronate Gel (Medical Grade) / Adopts Multi-BDDE Crosslinking Technology
High-performance hyaluronic acid gel produced by long-term retention, precise shape support, and medical-grade cross-linking technology.
Crosslinked Sodium Hyaluronate Gel is a high-performance gel material that forms a uniform and stable three-dimensional network structure through a multiple crosslinking technique using BDDE. The degree of crosslinking is precisely controlled within the range of 6-8%, allowing for customization according to specific applications. The high-density crosslinked structure exhibits excellent viscoelasticity, prolonged in-body retention, and shape retention, with a durability expected to last from 6 to 18 months. The residual BDDE level is <1 μg/mL, and the endotoxin levels are strictly managed, ensuring quality that meets medical-grade safety requirements. A variety of grades are available, with viscoelasticity and particle size adjusted for different applications from superficial to deep layers, accommodating diverse formulation and research needs through designed layered characteristics. The superficial grade offers flexibility suitable for delicate linear areas, the mid-layer grade provides natural volume formation, and the deep-layer grade ensures support and stability necessary for three-dimensional shaping. This gel boasts high biocompatibility, excellent hydration capacity, and maintains a stable gel structure, fulfilling both functional and morphological roles. It is suitable for a wide range of applications, including medical aesthetics, viscoelastic supplementation, and anti-adhesion applications in minimally invasive fields.
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basic information
Appearance: Homogeneous transparent gel Crosslinking agent: BDDE (residual <1 μg/mL) Degree of crosslinking: 6–8% (customizable) Concentration: 20–24 mg/mL (common for all layers) ■ Specifications by grade ◎ Superficial Layer - Particle size: 100–300 μm - Recommended use: Correction of fine lines around the eyes and mouth - Duration: 6–12 months - Syringe capacity: 1 mL / 2 mL ◎ Middle Layer - Particle size: 300–600 μm - Recommended use: Wrinkle improvement / Lip enhancement - Duration: 6–12 months - Syringe capacity: 1 mL / 2 mL ◎ Deep Layer - Particle size: 500–800 μm - Recommended use: Contouring of cheeks and jawline - Duration: 6–12 months - Syringe capacity: 1 mL / 2 mL ◎ Ultra-Deep Layer - Particle size: 800–1000 μm - Recommended use: Volume formation / Large capacity applications - Duration: 12–18 months - Syringe capacity: 1 mL / 2 mL / 10 mL
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Applications/Examples of results
Cross-linked sodium hyaluronate gel leverages its high viscoelasticity and stability from a three-dimensional cross-linked network, making it useful in various fields of research and product development. Shallow-layer gels are suitable for applications requiring homogeneity and flexibility in delicate linear areas, while mid-layer types are used in research for natural volume formation and lip-related products. Deep and ultra-deep types are employed in contour design for the entire face, viscoelastic control of large-volume gels, and design research for highly supportive structures. The gel structure, with controlled density and elasticity, is also suitable for evaluations in materials science, such as viscoelastic measurements, safety assessments, flow property analyses, and stress relaxation behavior studies. Additionally, it is adopted as a base material for gel formulations that require hydration retention and moderate viscosity in various research institutions and OEM/ODM manufacturers. The production system and stable supply capability that comply with international standards have been recognized, leading to a wide range of achievements in viscoelastic supplements, materials for minimally invasive fields, anti-adhesion research materials, three-dimensional gel structure development, and biomaterial applications. Custom designs for cross-linking degree, particle size, and viscoelasticity are also available, enabling the construction of optimal physical properties tailored to product concepts.
Company information
Our company is a global raw material and technology solution provider that offers natural-derived ingredients, including herbal medicines and plant-derived extracts, as well as high value-added functional ingredient formulation technologies. We integrate knowledge of traditional natural materials with modern biotechnology and formulation techniques to cater to a wide range of fields, including pharmaceuticals, health foods, functional foods and beverages, cosmetics, personal care, and animal nutrition. Utilizing advanced technologies such as Cocrystal, Liposomal, microencapsulation, particle technology, pellet technology, and granulation technology, we provide customized solutions to address challenges related to the solubility, absorption, stability, flavor, and processability of functional ingredients. Additionally, we supply a diverse range of natural and functional ingredients, including plant extracts, natural flavors, essential oils, amino acids, and peptides. We have established a consistent global supply system that covers raw material procurement, processing, quality control, and export, allowing us to flexibly respond to development projects from small batches to mass production. Through high-quality raw materials, advanced technologies, and specialized support, we assist customers worldwide in product development and business expansion.
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