関東化学株式会社 List of Products and Services

"ad-MED Vitrigel" is a cell culture insert that uses a collagen Vitrigel membrane useful for tissue reconstruction. It has superior cell adhesion and spreading activity compared to conventional plastic membranes, enabling effective cell culture for various cell types. In addition to liquid-phase to liquid-phase culture, it is also possible to culture under conditions that mimic the in vivo environment, such as liquid-phase to gas-phase culture. Furthermore, the membrane has excellent permeability, making it useful for interaction analysis through co-culture of different cell types. 【Features】 ■ High cell adhesion, allowing for uniform culture seeding ■ Rapid formation of adhesion spots and high cell spreading activity ■ Bidirectional culture through the Vitrigel membrane ■ High-density collagen fiber structure comparable to biological connective tissue ■ Capable of culturing under conditions that mimic the in vivo environment * "Vitrigel" is a registered trademark of the National Agriculture and Food Research Organization. * For more details, please refer to the PDF document or feel free to contact us.

The "Trans-epithelial Electrical Resistance (TEER) Measurement Device" is a TEER measurement device for ad-MED Vitrogel. 【Features】 ■ Stable measurements possible with ad-MED Vitrogel dedicated electrodes ■ Compatible with data storage and analysis via PC ■ Electrode structure that supports temperature measurement with a temperature sensor (sold separately) ■ Allows access to the insert while measuring TEER values

The "Vitrigel-Eye Irritancy Test (Vitrigel-EIT method)" is a testing method used to evaluate the severity of damage caused by the attachment of chemical substances to the eyes. By dropping a chemical substance onto a corneal epithelial model and measuring the change in its TEER value with a specialized measuring device, it is possible to determine the presence or absence of eye irritation from the chemical substance in just 3 minutes. This testing method was included in June 2019 as OECD Test Guideline No. 494, an international standard method, and it is expected to be widely used for safety testing of cosmetics and other products around the world. [Test Method] ■ Drop the test substance onto the corneal model ■ Measure the change in TEER value for 3 minutes ■ Analyze the change in TEER value to determine the presence or absence of eye irritation *For more details, please refer to the external link page or feel free to contact us.

The "ciKIC IEC Maturation Medium" is a culture medium that allows for the maturation of intestinal epithelial cells derived from human iPS cells, enabling the creation of a human intestinal epithelial model. In oral drug pharmacokinetic testing, the Caco-2 cells derived from human colon cancer have traditionally been used as a model for gastrointestinal absorption and metabolism tests; however, there has been a challenge in adequately replicating the functions of the living small intestine. This product allows for the maturation of intestinal epithelial cells derived from human iPS cells, making it possible to create a human intestinal epithelial model that is similar to the living small intestine. 【Features】 ■ Capable of producing high-performance human intestinal epithelial models ■ Wide range of applications *For more details, please refer to the PDF materials or feel free to contact us. 【Keywords】 Drug discovery support, non-clinical trials, pharmacokinetics, gastrointestinal absorption tests, Caco-2, iPS-small intestine model, drug metabolism enzymes, transporters, barrier function, drug-drug interactions, functional foods, health foods, nutrient absorption, intestinal immunity, gut microbiota.

MatriMix is a new three-dimensional culture substrate composed of collagen, laminin E8, and hyaluronic acid. By varying the types, combinations, and concentrations of collagen and laminin E8, it provides a microenvironment suitable for various cells, promoting tissue formation. 【Features】 ■ New three-dimensional culture substrate ■ Clear composition of reagent components ■ Applicable to various culture methods ■ Suitable for organ tissue engineering that mimics the in vivo environment *For more details, please refer to the PDF document or feel free to contact us.