フィジオマキナ List of Products and Services

The application of organic electronics is rapidly expanding, bringing about a revolution in fields such as display technology, renewable energy, and wearable electronics. Organic materials, which excel in flexibility, lightweight properties, and cost efficiency, are key components in devices like organic light-emitting diodes, organic field-effect transistors, and organic solar cells, providing a flexible alternative to conventional devices made from rigid materials. There are two types of manufacturing methods for low-molecular organic electronics: dry methods and wet methods. In wet methods, the compatibility of solvents and organic compounds is essential for maintaining the integrity of the final product and the desired electronic properties, making the determination of the solubility of organic compounds a very important factor in selecting solvents. Solubility information can be obtained through several methods, but with Technobis' Crystal16, it is possible to achieve simple results that closely match literature values using the polythermal method.

• Other physical property measurements and component analysis
• Dissolution Tester

We would like to introduce a case study on the application of the membrane permeability measurement system "μFLUX." In our previous research, we developed a sustained-release formulation containing an alkalizer, and we attempted to apply this device to evaluate its usefulness in reducing gastric mucosal damage caused by DC. In this study, we only simulated the pH environment, but incorporating other components such as lipids and proteins is expected to lead to a more accurate evaluation. 【Case Overview】 ■ Study - Evaluated the impact of pH fluctuations in the microenvironment caused by the alkalizer on the membrane permeability of the acidic drug DC using μFLUX. ■ Results - It was demonstrated that μFLUX could be a useful tool not only for evaluating drug absorption but also for assessing the risk of side effects caused by drug accumulation in tissues. *For more details, please download the PDF or feel free to contact us.

• Other measurement and measuring equipment

We would like to introduce a case study on the utilization of the crystallization device "Crystalline." Using this device (manufactured by Technobis), which has a camera function, we confirmed the timing of the transition between crystal forms and whether we could easily set conditions to recover the desired crystal form. In cases like carbamazepine, where the crystal form transitions rapidly, it is necessary to accurately grasp the timing of crystal generation and the transition of crystal forms in order to obtain the crystal form before the transition. By using the camera function of this device, we can observe the situation inside the vial and easily confirm the desired timing. [Test] - Carbamazepine yields needle-like Type II crystals through rapid cooling, which then transition to block-like Type III crystals. - Measurements were conducted using the following program to confirm the timing of Type II crystal generation and the transition to Type III crystals: - Raise the solution temperature to 70°C and confirm that carbamazepine is completely dissolved. - Cool to 20°C at -20°C/min. - Hold at 20°C for 4 hours. *For more details, please download the PDF or feel free to contact us.

• Other Crystallizers

We would like to introduce a case study on the use of the crystallization device "Crystal16." We are considering a method to apply this device to observe the phase separation and re-mixing behavior of mixed solutions. Two types of stirring mechanisms, Bottom Stirrer and Top Stirrer, can be used. When using the Top Stirrer, it was confirmed that the liquid surface can be stirred with sufficient strength, ensuring that the contents of the vial are uniformly mixed and suspended. As the name suggests, this product's main application is to obtain solubility curves through crystallization operations of solids; however, it has also been confirmed that it can be used to determine the critical temperature in mixed solutions. [Background] - In the case of non-miscible mixed solutions, it is generally observed that increasing the temperature makes them easier to mix, while lowering the temperature leads to phase separation. - On the other hand, some mixed solutions become mixed when the temperature is lowered and undergo phase separation as the temperature rises. *For more details, please download the PDF or feel free to contact us.

• Other Crystallizers

This catalog introduces "HUMIMIC" products that support the development of pharmaceuticals, chemicals, and cosmetics. It features "Devices" that function as hubs and control centers for various missions, as well as "Chips" that transfer various organ models to obtain reliable research results. Additionally, we also present "Accessories" that make tasks easier. Please feel free to download and take a look. 【Contents】 ■HUMIMIC Devices ■HUMIMIC Chips ■HUMIMIC Accessories ■Technical Specifications ■Contact *For more details, please refer to the PDF document or feel free to contact us.

• Lab metering pump
• Other experimental equipment and supplies

Technobis products are widely used by pharmaceutical manufacturers around the world. 【ReactALL】 ReactALL is an innovative benchtop multi-reactor system equipped with both novel automatic sampling and overhead stirring functions, making it ideal for medium throughput experiments. This device is specially designed to meet the needs of screening and optimizing chemical reactions, specifically for route scouting and process development and optimization. It can handle uneven reactions sufficiently with a sampling mechanism capable of up to 18 samples during testing, a stirring mechanism that can suspend solids without grinding them, and a built-in camera that monitors and profiles particle size and shape. All of this is achieved using Technobis's SmartCap technology, utilizing standard vials with a reaction liquid volume of 5 to 10 mL. 【Crystal Series】 The Crystal Series is a crystallization device that addresses challenges related to crystallization in general. It enables the efficiency of crystallization operations, investigation of crystal polymorphs, and solubility measurements (creation of solubility curves), all in a simple design that makes it very user-friendly. It allows for the investigation of crystallization under up to 32 conditions at once.

• Reaction Crystallizer

ReactALL, co-developed with Pfizer, is an innovative benchtop multi-reactor system equipped with both novel automatic sampling and overhead stirring functions, making it ideal for medium throughput experiments. This cutting-edge device is specially designed to meet the needs of screening and optimizing chemical reactions, including route scouting and process development and optimization. Due to its medium throughput capability, it allows testing with small amounts of raw materials and reagents. The sampling mechanism can perform up to 18 samples during testing, while the stirring mechanism can suspend solids without grinding them, anticipating actual manufacturing needs. Additionally, an integrated camera allows for monitoring and profiling of particle size and shape, effectively addressing uneven reactions. All of this is achieved using Techobis's SmartCap technology, utilizing standard vials with a reaction volume of 5 to 10 mL. Furthermore, this SmartCap technology ensures that solvent loss during a 20-hour test under heating conditions remains within 10%, providing a highly airtight structure.

• Microreactor

We would like to introduce the "Glove Box" that we handle. In addition to temperature and humidity control, it is also possible to manage oxygen concentration. We offer a range of products including the general and simple "810-Series," the containment type "840-Series" designed for high pharmacological activity, and the "890-Series" specialized in temperature and humidity management. 【Specifications】 ■810-Series - Dimensions: Width 1,100mm × Depth 610mm × Height 790mm ■840-Series - Dimensions: Width 1,830mm × Depth 760mm × Height 1,220mm ■890-Series - Dimensions: Width 1,400mm × Depth 890mm × Height 970mm *For more details, please refer to the related links or feel free to contact us.

• Glove box

The "IVIVC Enhancer" is a product designed to prevent the formation of mounts during dissolution tests conducted with low stirring, simulating biological conditions. The usage is simple: just place the product at the bottom of the vessel and adjust the height of the paddle to 25mm above the product. Testing using a capsule sinker is also possible. 【Features】 ■ Easily usable accessory ■ Capsules can also be used ■ Simulation of the flow of the test solution can be conducted *For more details, please refer to the related links or feel free to contact us.

• Dissolution Tester

The "Model2500/RTD" is a space-saving dissolution tester designed to secure working space as a bus-type dissolution tester. The shaft temperature sensor inside the vessel allows for real-time monitoring of the test liquid's temperature within the vessel. Methods and test records can be saved in the main unit (output is also possible via USB memory). 【Features】 ■ Wireless in-shaft temperature sensor ■ Registration of methods and manufacturing numbers ■ Automatic saving of test results ■ Compact thermocirculator design ■ Various options for dissolution testers *For more details, please refer to the related links or feel free to contact us.

• Dissolution Tester

The "Model2500 select" is a revolutionary basketless dissolution tester that significantly reduces waiting time during dissolution testing thanks to its basketless system. It uses a heater jacket method for heating the test solution, allowing the solution inside the vessel to be heated from room temperature to 37°C in less than 15 minutes. Wireless in-shaft temperature sensor technology monitors temperature control within the vessel. 【Features】 ■ Wireless in-shaft temperature sensor ■ Registration of method and manufacturing number ■ Automatic saving of test results ■ Compact thermocirculator design ■ Various dissolution tester options *For more details, please refer to the related links or feel free to contact us.

• Dissolution Tester

The "Eclipse5300" is an auto-sampler equipped with a filter changer. Since there is no valve switching, it prevents contamination of the test solution and improves the reliability of the tests. The structure, which features a precise syringe and a shortened flow path to sampling, enables more accurate sampling amounts. 【Features】 ■ Valve-less rotary syringe structure ■ Capable of controlling two dissolution testers ■ Easy operation via a color touch screen ■ Filter changer function *For more details, please refer to the related links or feel free to contact us.

• Dissolution Tester

The "ezfill+" is a degassing dispensing device that improves the reproducibility of test liquids through rapid and reliable heating and degassing. The dispensing volume can be set in the range of 250 to 1,000 ml, and the processes of drawing in, heating, degassing, and dispensing the test liquid for each vessel are completed in about 90 seconds. Cleaning the internal tank can also be easily done with just a button operation, reducing the daily maintenance burden. 【Features】 ■ Achieves rapid heating, degassing, and dispensing of test liquids ■ Easy cleaning with a cleaning button ■ Ensures safety in the laboratory ■ Saves records of dispensing results *For more details, please refer to the related links or feel free to contact us.

• Dissolution Tester

"Opt-Diss410" is an in-situ UV optical fiber system that allows for real-time monitoring of the dissolution behavior of formulations at a glance. There is no need for sampling, as it directly measures the absorbance within the vessel in real-time. With the powerful secondary derivative analysis function of the dedicated software, up to two active ingredients can be measured in a single test. 【Features】 ■ Real-time in-situ UV system ■ Multi-component analysis capability ■ Uses ARCH probe ■ Rapid data collection *For more details, please refer to the related links or feel free to contact us.

• Dissolution Tester

The "sensIR3200" is a collapse testing device equipped with various features. The basket used has an automatic endpoint detection function using near-infrared. In this detection function, the use of a disk is not mandatory. Therefore, tests that have been conducted without a disk so far will continue to be performed without a disk, and the detection of the endpoint will be automated. 【Features】 ■ Automatic endpoint detection function ■ Basketless function ■ Automatic saving of test results ■ Multitasking *For more details, please refer to the related links or feel free to contact us.

• Dissolution Tester

The "Media Prep x8/x15" is a device that allows you to prepare test solutions for one dissolution tester (or two for the x15 model) simply by pressing a button during the preparation of the dissolution test. It can perform solution intake, degassing, heating, and dispensing all in one unit. It achieves efficient degassing through vacuum degassing and can safely prepare strong acids. 【Features】 ■ Efficient degassing and dispensing in a short time ■ Equipped with dual liquid mixing function ■ Ensures safety in the laboratory ■ Saves dispensing result records *For more details, please refer to the related links or feel free to contact us.

• Dissolution Tester

"Video-Diss" is a system that allows various tests, including dissolution tests, to be recorded on video by position. It can record video for up to 12 hours, making it possible to capture the testing process during unmanned nighttime hours without missing anything. All positions can be played back simultaneously in a single screen, making it easier to visually identify any unusual dissolution behavior. [Features] ■ Capable of recording tests for up to 12 hours ■ Simultaneous playback function ■ Automatic backup function *For more details, please refer to the related links or feel free to contact us.

• Dissolution Tester

The "Vessel Washer Light" is a cleaning machine specifically designed for vessels used in elution testers. With its compact design, it can be introduced without worrying about placement. It reduces the risk of damage when removing the vessel from the elution tester, and allows for cleaning the vessel while it is attached to the elution tester using a dedicated nozzle. 【Features】 ■ Can clean while the vessel is attached ■ Reduces the risk of contact with the test solution *For more details, please refer to the related links or feel free to contact us.

• Dissolution Tester

We would like to introduce the "accessories for dissolution testers" handled by Physiomatina Co., Ltd. In addition to standard vessels, we offer a wide variety of types including light-shielding vessels, peak vessels, and plastic vessels. We also have accessories available for measuring the Intrinsic Dissolution Rate. Of course, you can choose according to the manufacturer of the dissolution tester you are using. 【Compatible Manufacturers】 ■DISTEK ■Agilent ■ERWEKA ■SOTAX *For more details, please refer to the related links or feel free to contact us.

• Dissolution Tester

"Tomolite v2.0" is a 3D bioprinter that utilizes non-contact tomographic lighting technology to shape delicate cells and biological materials into biological systems without compromising their viability. By using light beams irradiated from multiple angles, photosensitive ink is rapidly solidified in three dimensions. Since the entire structure is irradiated simultaneously, it is possible to create centimeter-scale biological systems in just a few tens of seconds. [Features] - Rapid three-dimensional solidification of photosensitive ink - Ability to create centimeter-scale biological systems in just a few tens of seconds *For more details, please refer to the related links or feel free to contact us.

• Other bio-related products

We would like to introduce the TissUse products that we handle. It is possible to place up to five organs on a single chip, allowing for the evaluation of inter-organ interactions as well as absorption, metabolism, and distribution. Please feel free to contact us when you need assistance. 【Product Lineup】 ■ HUMIMIC Chip2 96-well ■ HUMIMIC Chip2 24-well ■ HUMIMIC Chip3 ■ HUMIMIC Chip3plus ■ HUMIMIC Chip4 *For more details, please refer to the related links or feel free to contact us.

• Other bio-related products

The "Dashboard" is a product that automates the input of necessary values by connecting electronic scales, thickness gauges, and hardness testers to GTP-2. The software automatically generates multiple approaches to the results obtained from measurements. This allows for the evaluation of powders from a greater number of perspectives. 【Features】 ■ Input of values is completed with one click ■ Various plots are automatically generated *For more details, please refer to the related links or feel free to contact us.

• Other Software

"ExtruVis" is a system that automatically measures residence time distribution by connecting a PC with dedicated software installed to a camera. The main tasks before use are alignment and the preparation is very simple. It guides the analysis of recorded measurement values, allowing access to results in just a few seconds. Please feel free to contact us when you need assistance. 【Features】 ■ Simple preparation ■ Effective software *For more details, please refer to the related links or feel free to contact us.

• Other measurement and measuring equipment

The "mini-DT" is a dissolution tester specialized for small volumes. It requires minimal installation space, with a width of 350mm and a depth of 300mm, allowing for testing in 8 positions. You can choose from vessels of 100mL, 150mL, 200mL, and 250mL. 【Features】 ■ Four volume options available ■ Can be connected to Rainbow ■ Space-saving design *For more details, please refer to the related links or feel free to contact us.

• Other measurement and measuring equipment

The "ProMixer" is a powder mixer designed for small volumes that can be used on a tabletop. You can choose between a standard drum type and a V-type. It can be used for volumes ranging from a minimum of 13 to 90 mL, and a maximum of 75 to 450 mL. Please feel free to contact us if you have any inquiries. 【Features】 ■ Two types of drums available ■ Suitable for small volumes *For more details, please refer to the related links or feel free to contact us.

• Other mixing and mixing equipment

"Rainbow" is a system that enables in situ UV monitoring at intervals as short as 2 seconds without the need for sampling by installing probes in test liquids such as vessels and bioreactors. The included AuPRO software is equipped with features that maximize UV monitoring capabilities, such as secondary differential analysis and the Zero Intercept Method, allowing for many tests that were previously difficult to achieve. Please feel free to contact us when you need assistance. 【Features】 ■ Wide range of concentration measurements possible by replacing dedicated probe tips ■ AuPRO software enabling advanced analysis ■ Suitable for a wide range of applications *For more details, please refer to the related links or feel free to contact us.

• Other measurement and measuring equipment

The "μDISS" is a system that combines the Rainbow and Mini-Bath manufactured by Pion. It uses a 25mL glass vial, allowing for solubility measurements with a small volume. Additionally, by using an optional insert, it is also possible to conduct solubility measurements with a minimum of 1mL. Besides solubility measurements, it can also be used for salt screening and supersaturation evaluation. 【Features】 ■ Enables solubility measurements with a small sample ■ Allows for the evaluation of supersaturation duration ■ Supports salt screening *For more details, please refer to the related links or feel free to contact us.

• Other measurement and measuring equipment

The "Sirius T3" is an automatic titration device for measuring the fundamental physical property values of compounds (pKa, logP, solubility). Using titration methods, it accurately measures the basic physical property values of compounds and can handle poorly soluble compounds. Please feel free to contact us when you need assistance. 【Features】 ■ pKa measurement can choose between UV method and potentiometric titration method ■ Supports pKa measurement of poorly soluble compounds ■ Enables evaluation of the lipophilicity of compounds ■ Supports solubility measurement ■ Monitors the precipitation of compounds during measurement *For more details, please refer to the related links or feel free to contact us.

• Electrotitrator

"Crystal16" is a crystallization device that solves issues related to crystallization in general. It allows for the setting of stirring speed, stirring time, starting temperature of the experiment, heating rate, cooling rate, and holding time. Users can set the solvent and sample concentration as experimental conditions. Additionally, it is possible to set the cooling rate and choose the solvent. 【Features】 ■ Capable of setting 16 different crystallization conditions at once ■ Can configure settings to discover crystal polymorphs ■ Selection of stirring shapes is possible ■ Equipped with data analysis software (Crystal Clear) ■ Generates reports in Word format *For more details, please refer to the related links or feel free to contact us.

• Other Crystallizers

"Crystalline" is a crystallization device equipped with measurement capabilities similar to those of Crystal16. It can acquire the Raman spectrum of the produced crystals. Additionally, by confirming crystallization through camera images, various particle information can be obtained. Please feel free to contact us when you need assistance. 【Features】 ■ Capable of setting up to 8 different crystallization conditions at once ■ Equipped with measurement capabilities similar to Crystal16 ■ Capable of acquiring Raman spectra ■ Phenomena within the tube can be confirmed through camera images ■ Equipped with dedicated data analysis software *For more details, please refer to the related links or feel free to contact us.

• Other Crystallizers

Pion's ultra-high pressure homogenizer achieves a maximum operating pressure of 45,000 psi. It enables the creation of extremely small particle sizes (0.1 μm) more uniformly, which was difficult with previous high-pressure homogenizers. Additionally, by significantly reducing the time required for particle generation, it offers overwhelming cost-effectiveness. Furthermore, with a rich lineup of products, it allows for easy scaling up from lab scale to pilot and then to production scale.

• Dispersion/emulsification equipment/homogenizer

By using Inovenso's devices (NS Starter Kit, NS PLUS), it is possible to conduct verification of Electrospinning in a small tabletop space. Additionally, as a leading company in Electrospinning technology, Inovenso offers products that cater to both lab-scale small equipment and manufacturing scale, allowing for scale-up using a series of devices in the Electrospinning method, which requires meticulous condition settings. <NS Starter Kit> Designed for low-cost, small-scale nanofiber research, it prepares nanofibers with a compact body and single nozzle structure. The spinning distance, flow rate, and applied voltage can be easily adjusted via a touch screen. <NS PLUS> It is designed to accommodate the components necessary for an optimized, versatile electrospinning process. This is an ideal solution for small-scale research projects focusing on nanofibers, including solid dispersions.

• Other Physics and Chemistry Equipment

We will reproduce pellets equivalent to those made with Hot Melt Extrusion on a small scale without any loss of samples. By using VCM, it becomes possible to conduct Hot Melt Extrusion verification in a small tabletop space.

• Twin-axis Extruder

This is a system that combines the Pion Corporation's Rainbow with the dedicated Macro FLUX (Bio FLUX) module and the corresponding dissolution tester. By using two probes from the Rainbow, it is possible to measure dissolution on the donor side of the dissolution tester's vessel and absorption on the acceptor side of the dedicated chamber. Unlike µFLUX, this system allows testing in the final dosage forms such as tablets and capsules. The difference between MacroFLUX and BioFLUX lies in the testing volume. MacroFLUX uses a 1,000 mL vessel, while BioFLUX aims for testing with a volume closer to that of a living organism, using a 500 mL vessel.

• Dissolution Tester

*μDISS This is a system that combines the Rainbow and Mini-Bath manufactured by Pion. It uses a 25mL glass vial, allowing for solubility measurements in small volumes. In addition to solubility measurements, it can also be used for salt screening and supersaturation evaluation. *μFLUX This is a system that combines a dedicated H-shaped chamber. By using two probes from the Rainbow, it is possible to evaluate dissolution on the donor side and membrane permeability (absorption) on the acceptor side, separated by an artificial membrane. It allows for the evaluation of the effects of formulations on dissolution and membrane permeability, as well as the impact of meals.

• Dissolution Tester

By placing a probe in test liquids such as vessels and bioreactors, UV monitoring can be performed at intervals as short as 2 seconds without sampling. The included AuPRO software maximizes the functionality of UV monitoring with features such as secondary differential analysis and the Zero Intercept Method (which minimizes the impact of specific components on the results of other components), enabling many tests that were not possible before. Rainbow can be used not only with dissolution testers (some models are not compatible) but also with a dedicated small-volume dissolution tester: the Mini-Bath. Additionally, it can be used in combination with other Pion products such as µFLUX and Macro FLUX for dissolution + membrane permeation testing.

• UV/visible spectrophotometer

The "Scissor N3" is a device that simulates phenomena occurring at the subcutaneous injection site of biopharmaceuticals. The physical behaviors that occur after various administration methods of conventional non-oral drugs are not well understood, but this product can simulate the chemical and various physical stresses that occur in the subcutaneous environment. Each experiment concludes within 24 hours and provides an in vitro model useful for studying bioavailability (BA) in subcutaneous administration. Additionally, it allows for offline analytical work (for example, concentration measurements using HPLC) to measure the concentration of excipients in samples. 【Features】 ■ High precision prediction of subcutaneous administration ■ Easy management of experiments ■ Connection to an auto-sampler (optional) ■ 4-channel exposure adjustment function ■ pH control through feedback loop *For more details, please refer to the catalog or feel free to contact us.

• Other cell research

The "ProMixer" is a drum-type, V-type powder mixer designed for small quantities of powder up to 450mL. The drum-type and V-type mixing containers are designed to allow for uniform mixing without shear stress or heat generation. Additionally, it is equipped with safety features that automatically stop the mixer when the safety cover is opened. 【Features】 ■ Mixing time of 5 to 10 minutes ■ Uniform mixing without shear stress or heat generation ■ Minimal variation in particle size distribution ■ Electro-polished for easy cleaning ■ Control panel allows for setting rotation speed, time, and reverse rotation time *For more details, please request materials or view the PDF data available for download.

• Powder Mixer

*Reproduction of Compression In GTP-2, it is possible to use pestles and mortars of different diameters. By using a mortar with a diameter of 5mm against a maximum load of 500kg, it is possible to reproduce the same pressure as when a 10mm diameter mortar is used at 2t. *Evaluation of Slipperiness By measuring Detachment Stress and Ejection Stress, slipperiness can be quantified. The slipperiness changes according to the amount of lubricant used, but the hardness that changes simultaneously can also be evaluated in the same process, which is a feature of GTP-2. *Measurement of Work Amount In GTP-2, the load information per position of the pestle is recorded at each stage, allowing for the quantification of the work amount generated during the tablet compression. This also enables the quantification of Elastic Recovery (elastic recovery energy).

• Other Tablet Presses